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Research Paper

Enhanced nasopharyngeal infection and shedding associated with an epidemic lineage of emm3 group A Streptococcus

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Pages 1390-1400 | Received 28 Feb 2017, Accepted 26 Apr 2017, Published online: 19 May 2017

References

  • Turner CE, Abbott J, Lamagni T, Holden MT, David S, Jones MD, Game L, Efstratiou A, Sriskandan S. Emergence of a new highly successful acapsular group A Streptococcus clade of genotype emm89 in the United Kingdom. mBio 2015; 6:e00622; PMID:26173696
  • Davies MR, Holden MT, Coupland P, Chen JH, Venturini C, Barnett TC, Zakour NL, Tse H, Dougan G, Yuen KY, et al. Emergence of scarlet fever Streptococcus pyogenes emm12 clones in Hong Kong is associated with toxin acquisition and multidrug resistance. Nat Genet 2015; 47:84-7; PMID:25401300; https://doi.org/10.1038/ng.3147
  • Beres SB, Carroll RK, Shea PR, Sitkiewicz I, Martinez-Gutierrez JC, Low DE, McGeer A, Willey BM, Green K, Tyrrell GJ, et al. Molecular complexity of successive bacterial epidemics deconvoluted by comparative pathogenomics. Proc Natl Acad Sci USA 2010; 107:4371-6; PMID:20142485; https://doi.org/10.1073/pnas.0911295107
  • Health Protection Agency. Enhanced surveillance intitiated for group A streptococcal infections. Health Protection Report 2009a; 3(8). Available at: http://webarchive.nationalarchives.gov.uk/20140714084352/http://www.hpa.org.uk/hpr/archives/2009/news0809.htm#gas0809
  • Health Protection Agency. Group A streptococcal infections: fourth update on seasonal activity, 2008/09. Health Protection Report 2009b; 3(29). Available at: http://webarchive.nationalarchives.gov.uk/20140714084352/http://www.hpa.org.uk/hpr/archives/back_issues.htm
  • Al-Shahib A, Underwood A, Afshar B, Turner CE, Lamagni T, Sriskandan S, Efstratiou A. Emergence of a novel lineage containing a prophage in emm/M3 group A Streptococcus associated with upsurge in invasive disease in the UK. Microb Genom. 2016; 2(6):e000059. https://doi.org/10.1099/mgen.0.000059.
  • Rokas A. Phylogenetic analysis of protein sequence data using the Randomized Axelerated Maximum Likelihood (RAXML) Program. Curr Protoc Mol Biol 2011; Chapter 19:Unit19 11:1-14; PMID:21987055; https://doi.org/10.1002/0471142727.mb1911s96.
  • Turner CE, Sommerlad M, McGregor K, Davies FJ, Pichon B, Chong DL, Farzaneh L, Holden MT, Spratt BG, Efstratiou A, et al. Superantigenic activity of emm3 Streptococcus pyogenes is abrogated by a conserved, naturally occurring smeZ mutation. PloS One 2012; 7:e46376; PMID:23049698; https://doi.org/10.1371/journal.pone.0046376
  • Schrage B, Duan G, Yang LP, Fraser JD, Proft T. Different preparations of intravenous immunoglobulin vary in their efficacy to neutralize streptococcal superantigens: implications for treatment of streptococcal toxic shock syndrome. Clin Infect Dis 2006; 43:743-6; PMID:16912949; https://doi.org/10.1086/507037
  • Li PL, Tiedemann RE, Moffat SL, Fraser JD. The superantigen streptococcal pyrogenic exotoxin C (SPE-C) exhibits a novel mode of action. J Exp Med 1997; 186:375-83; PMID:9236189; https://doi.org/10.1084/jem.186.3.375
  • Alam FM, Turner CE, Smith K, Wiles S, Sriskandan S. Inactivation of the CovR/S virulence regulator impairs infection in an improved murine model of Streptococcus pyogenes nasopharyngeal infection. PloS One 2013; 8:e61655; PMID:23637876; https://doi.org/10.1371/journal.pone.0061655
  • Kasper KJ, Xi W, Rahman AK, Nooh MM, Kotb M, Sundberg EJ, Madrenas J, McCormick JK. Molecular requirements for MHC class II alpha-chain engagement and allelic discrimination by the bacterial superantigen streptococcal pyrogenic exotoxin C. J Immunol 2008; 181:3384-92; PMID:18714010; https://doi.org/10.4049/jimmunol.181.5.3384
  • Norrby-Teglund A, Nepom GT, Kotb M. Differential presentation of group A streptococcal superantigens by HLA class II DQ and DR alleles. Eur J Immunol 2002; 32:2570-7; PMID:12207341; https://doi.org/10.1002/1521-4141(200209)32:9%3c2570::AID-IMMU2570%3e3.0.CO;2-E
  • Loh JM, Adenwalla N, Wiles S, Proft T. Galleria mellonella larvae as an infection model for group A Streptococcus. Virulence 2013; 4:419-28; PMID:23652836; https://doi.org/10.4161/viru.24930
  • Olsen RJ, Watkins ME, Cantu CC, Beres SB, Musser JM. Virulence of serotype M3 Group A Streptococcus strains in wax worms (Galleria mellonella larvae). Virulence 2011; 2:111-9; PMID:21258213; https://doi.org/10.4161/viru.2.2.14338
  • Sriskandan S, Unnikrishnan M, Krausz T, Dewchand H, Van Noorden S, Cohen J, Altmann DM. Enhanced susceptibility to superantigen-associated streptococcal sepsis in human leukocyte antigen-DQ transgenic mice. J Infect Dis 2001; 184:166-73; PMID:11424013; https://doi.org/10.1086/322018
  • Kasper KJ, Zeppa JJ, Wakabayashi AT, Xu SX, Mazzuca DM, Welch I, Baroja ML, Kotb M, Cairns E, Cleary PP, et al. Bacterial superantigens promote acute nasopharyngeal infection by Streptococcus pyogenes in a human MHC Class II-dependent manner. PLoS Pathog 2014; 10:e1004155; PMID:24875883; https://doi.org/10.1371/journal.ppat.1004155
  • Unnikrishnan M, Altmann DM, Proft T, Wahid F, Cohen J, Fraser JD, Sriskandan S. The bacterial superantigen streptococcal mitogenic exotoxin Z is the major immunoactive agent of Streptococcus pyogenes. J Immunol 2002; 169:2561-9; PMID:12193726; https://doi.org/10.4049/jimmunol.169.5.2561
  • Sumby P, Barbian KD, Gardner DJ, Whitney AR, Welty DM, Long RD, Bailey JR, Parnell MJ, Hoe NP, Adams GG, et al. Extracellular deoxyribonuclease made by group A Streptococcus assists pathogenesis by enhancing evasion of the innate immune response. Proc Natl Acad Sci USA 2005; 102:1679-84; PMID:15668390; https://doi.org/10.1073/pnas.0406641102
  • Virtaneva K, Graham MR, Porcella SF, Hoe NP, Su H, Graviss EA, Gardner TJ, Allison JE, Lemon WJ, Bailey JR, et al. Group A Streptococcus gene expression in humans and cynomolgus macaques with acute pharyngitis. Infect Immun 2003; 71:2199-207; PMID:12654842; https://doi.org/10.1128/IAI.71.4.2199-2207.2003
  • Nozawa T, Furukawa N, Aikawa C, Watanabe T, Haobam B, Kurokawa K, Maruyama F, Nakagawa I. CRISPR inhibition of prophage acquisition in Streptococcus pyogenes. PloS One 2011; 6:e19543; PMID:21573110; https://doi.org/10.1371/journal.pone.0019543
  • Louwen R, Staals RH, Endtz HP, van Baarlen P, van der Oost J. The role of CRISPR-Cas systems in virulence of pathogenic bacteria. Microbiol Mol Biol Rev 2014; 78:74-88; PMID:24600041; https://doi.org/10.1128/MMBR.00039-13
  • Lamagni TL, Efstratiou A, Dennis J, Nair P, Kearney J, George R, on behalf of the nation incident management team. Increase in invasive group A streptococcal infections in England, Wales and Northern Ireland, 2008-9. Eurosurveillance 2009; 14:19110; PMID:19215717
  • Luca-Harari B, Darenberg J, Neal S, Siljander T, Strakova L, Tanna A, Creti R, Ekelund K, Koliou M, Tassios PT, et al; Strep-EURO Study Group. Clinical and microbiological characteristics of severe Streptococcus pyogenes disease in Europe. J Clin Microbiol 2009; 47:1155-65; PMID:19158266; https://doi.org/10.1128/JCM.02155-08