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Editorial - Commissioned

Selective inhibition of host cell signaling for rotavirus antivirals: PI3K/Akt/mTOR-mediated rotavirus pathogenesis

Pages 5-8 | Received 30 Jun 2017, Accepted 05 Jul 2017, Published online: 18 Aug 2017

References

  • Parashar UD, Hummelman EG, Bresee JS, Miller MA, Glass RI. Global illness and deaths caused by rotavirus disease in children. Emerg Infect Dis. 2003;9(5):565-72. http://doi.org/10.3201/eid0905.020562. PMID:12737740
  • Centers for Disease, C. Prevention. Rotavirus surveillance–worldwide, 2001-2008. MMWR Morb Mortal Wkly Rep. 2008;57(46):1255-7. PMID:19023263
  • O'Ryan ML, Hermosilla G, Osorio G. Rotavirus vaccines for the developing world. Curr Opin Infect Dis. 2009;22(5):483-9. http://doi.org/10.1097/QCO.0b013e32833040a9. PMID:19623063
  • Patton JT. Rotavirus diversity and evolution in the post-vaccine world. Discov Med. 2012;13(68):85-97. PMID:22284787
  • Barro M, Patton JT. Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3. Proc Natl Acad Sci U S A. 2005;102(11):4114-9. http://doi.org/10.1073/pnas.0408376102. PMID:1541273
  • Barro M, Patton JT. Rotavirus NSP1 inhibits expression of type I interferon by antagonizing the function of interferon regulatory factors IRF3, IRF5, and IRF7. J Virol. 2007;81(9):4473-81. http://doi.org/10.1128/JVI.02498-06. PMID:17301153
  • Feng N, Sen A, Nguyen H, Vo P, Hoshino Y, Deal EM, Greenberg HB. Variation in antagonism of the interferon response to rotavirus NSP1 results in differential infectivity in mouse embryonic fibroblasts. J Virol. 2009;83(14):6987-94. http://doi.org/10.1128/JVI.00585-09. PMID:9420080
  • Graff JW, Mitzel DN, Weisend CM, Flenniken ML, Hardy ME. Interferon regulatory factor 3 is a cellular partner of rotavirus NSP1. J Virol. 2002;76(18):9545-50. http://doi.org/10.1128/JVI.76.18.9545-9550.2002. PMID:12186937
  • Dagenais L, Pastoret PP, Van den Broecke C, Werenne J. Susceptibility of bovine rotavirus to interferon. Brief report. Arch Virol. 1981;70(4):377-9. http://doi.org/10.1007/BF01320253. PMID:6173029
  • Schwers A, Vanden Broecke C, Maenhoudt M, Beduin JM, Werenne J, Pastoret PP. Experimental rotavirus diarrhoea in colostrum-deprived newborn calves: Assay of treatment by administration of bacterially produced human interferon (Hu-IFN alpha 2). Ann Rech Vet. 1985;16(3):213-8. PMID:4062197
  • Lecce JG, Cummins JM, Richards AB. Treatment of rotavirus infection in neonate and weanling pigs using natural human interferon alpha. Mol Biother. 1990:2(4):211-6. PMID:1963065
  • Sen A, Pruijssers AJ, Dermody TS, Garcia-Sastre A, Greenberg HB. The early interferon response to rotavirus is regulated by PKR and depends on MAVS/IPS-1, RIG-I, MDA-5, and IRF3. J Virol. 2011;85(8):3717-32. http://doi.org/10.1128/JVI.02634-10. PMID:21307186
  • Arnold MM, Patton JT. Diversity of interferon antagonist activities mediated by NSP1 proteins of different rotavirus strains. J Virol. 2011;85(5):1970-9. http://doi.org/10.1128/JVI.01801-10. PMID:21177809
  • Holloway G, Truong TT, Coulson BS. Rotavirus antagonizes cellular antiviral responses by inhibiting the nuclear accumulation of STAT1, STAT2, and NF-kappaB. J Virol. 2009;83(10):4942-51. http://doi.org/10.1128/JVI.01450-08. PMID:19244315
  • Qin L, Ren L, Zhou Z, Lei X, Chen L, Xue Q, Liu X, Wang J, Hung T. Rotavirus nonstructural protein 1 antagonizes innate immune response by interacting with retinoic acid inducible gene I. Virol J. 2011;8:526. http://doi.org/10.1186/1743-422X-8-526. PMID:22152002
  • Montero H, Arias CF, Lopez S. Rotavirus Nonstructural Protein NSP3 is not required for viral protein synthesis. J Virol. 2006;80(18):9031-8. http://doi.org/10.1128/JVI.00437-06. PMID:16940515
  • Harb M, Becker MM, Vitour D, Baron CH, Vende P, Brown SC, Bolte S, Arold ST, Poncet D. Nuclear localization of cytoplasmic poly(A)-binding protein upon rotavirus infection involves the interaction of NSP3 with eIF4G and RoXaN. J Virol. 2008;82(22):11283-93. http://doi.org/10.1128/JVI.00872-08. PMID:18799579
  • Vitour D, Lindenbaum P, Vende P, Becker MM, Poncet D. RoXaN, a novel cellular protein containing TPR, LD, and zinc finger motifs, forms a ternary complex with eukaryotic initiation factor 4G and rotavirus NSP3. J Virol. 2004;78(8):3851-62. http://doi.org/10.1128/JVI.78.8.3851-3862.2004. PMID:15047801
  • Lopez S, Arias CF. Rotavirus-host cell interactions: An arms race. Curr Opin Virol. 2012;2(4):389-98. http://doi.org/10.1016/j.coviro.2012.05.001. PMID:22658208
  • Halasz P, Holloway G, Turner SJ, Coulson BS. Rotavirus replication in intestinal cells differentially regulates integrin expression by a phosphatidylinositol 3-kinase-dependent pathway, resulting in increased cell adhesion and virus yield. J Virol. 2008;82(1):148-60. http://doi.org/10.1128/JVI.01980-07. PMID:17942548
  • Yin Y, Dang W, Zhou X, Xu L, Wang W, Cao W, Chen S, Su J, Cai X, Xiao S, Peppelenbosch MP, Pan Q. PI3K-Akt-mTOR axis sustains rotavirus infection via the 4E-BP1 mediated autophagy pathway and represents an antiviral target. Virulence. 2017;1-16. http://doi.org/10.1080/21505594.2017.1326443. PMID:28475412
  • Administration, U S F D, FDA approves Rapamune to treat LAM, a very rare lung disease. 2015.
  • Bagchi P, Dutta D, Chattopadhyay S, Mukherjee A, Halder UC, Sarkar S, Kobayashi N, Komoto F, Taniguchi K, Chawla-Sarkar M. Rotavirus nonstructural protein 1 suppresses virus-induced cellular apoptosis to facilitate viral growth by activating the cell survival pathways during early stages of infection. J Virol. 2010;84(13):6834-45. http://doi.org/10.1128/JVI.00225-10. PMID:20392855
  • Bagchi P, Nandi S, Nayak MK, Chawla-Sarkar M. Molecular mechanism behind rotavirus NSP1-mediated PI3 kinase activation: Interaction between NSP1 and the p85 subunit of PI3 kinase. J Virol. 2013;87(4):2358-62. http://doi.org/10.1128/JVI.02479-12. PMID:23221569
  • Kindrachuk J, Wahl-Jensen V, Safronetz D, Trost B, Hoenen T, Arsenault R, Feldmann F, Traynor D, Postnikova E, Kusalik A, Napper S, Blaney JE, Feldmann H, Jahrling PB. Ebola virus modulates transforming growth factor beta signaling and cellular markers of mesenchyme-like transition in hepatocytes. J Virol. 2014;88(17):9877-92. http://doi.org/10.1128/JVI.01410-14. PMID:24942569
  • Kindrachuk J, Ork B, Hart BJ, Mazur S, Holbrook MR, Frieman MB, Traynor D, Johnson RF, Dyall J, Kuhn JH, Olinger GG, Hensley LE, Jahrling PB. Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis. Antimicrob Agents Chemother. 2015;59(2):1088-99. http://doi.org/10.1128/AAC.03659-14. PMID:25487801
  • Kindrachuk J, Arsenault R, Kusalik A, Kindrachuk KN, Trost B, Napper F, Jahrling P. B, Blaney JE. Systems kinomics demonstrates Congo Basin monkeypox virus infection selectively modulates host cell signaling responses as compared to West African monkeypox virus. Mol Cell Proteomics. 2012;11(6):M111 015701. http://doi.org/10.1074/mcp.M111.015701. PMID:22205724
  • Soares JA, Leite FG, Andrade LG, Torres AA, De Sousa LP, Barcelos LS, Teixeira MM, Ferreira PC, Kroon EG, Souto-Padron T, Bonjardim CA. Activation of the PI3K/Akt pathway early during vaccinia and cowpox virus infections is required for both host survival and viral replication. J Virol. 2009;83(13):6883-99. http://doi.org/10.1128/JVI.00245-09. PMID:19386722
  • Urata S, Ngo N, de la Torre JC. The PI3K/Akt pathway contributes to arenavirus budding. J Virol. 2012;86(8):4578-85. http://doi.org/10.1128/JVI.06604-11. PMID:22345463
  • Esfandiarei M, Luo H, Yanagawa B, Suarez A, Dabiri D, Zhang J, McManus BM. Protein kinase B/Akt regulates coxsackievirus B3 replication through a mechanism which is not caspase dependent. J Virol. 2004;78(8):4289-98. http://doi.org/10.1128/JVI.78.8.4289-4298.2004. PMID:15047842
  • McFarlane S, Aitken J, Sutherland JS, Nicholl MJ, Preston VG, Preston CM. Early induction of autophagy in human fibroblasts after infection with human cytomegalovirus or herpes simplex virus 1. J Virol. 2011;85(9):4212-21. http://doi.org/10.1128/JVI.02435-10. PMID:21325419
  • Wang P, Guo QS, Wang ZW, Qian HX. HBx induces HepG-2 cells autophagy through PI3K/Akt-mTOR pathway. Mol Cell Biochem. 2013;372(1–2):161-8. http://doi.org/10.1007/s11010-012-1457-x. PMID:23001846
  • Wu S, Yuan L, Zhang Y, Liu F, Li G, Wen K, Kocher J, Yang X, Sun J. Probiotic Lactobacillus rhamnosus GG mono-association suppresses human rotavirus-induced autophagy in the gnotobiotic piglet intestine. Gut Pathog. 2013;5(1);22. http://doi.org/10.1186/1757-4749-5-22. PMID:23924832
  • Allison M. NCATS launches drug repurposing program. Nat Biotechnol. 2012;30(7):571-2. http://doi.org/10.1038/nbt0712-571a. PMID:22781662
  • Zhang J, Salminen A, Yang X, Luo Y, Wu Q, White M, Greenhaw J, Ren L, Bryant M, Salminen W, Papoian T, Mattes W, Shi Q. Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria. Arch Toxicol. 2017;91(8):2921-2938; PMID:28032146; http://doi.org/10.1007/s00204-016-1918-1
  • Dorlo TP, Balasegaram M, Beijnen JH, de Vries PJ. Miltefosine: A review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis. J Antimicrob Chemother. 2012;67(11):2576-97. http://doi.org/10.1093/jac/dks275. PMID:22833634