Saccharomyces cerevisiae–based probiotic as novel anti-microbial agent for therapy of bacterial vaginosis

References

• Sobel JD. Bacterial vaginosis. Annu Rev Med. 2000;51:349–56. doi:10.1146/annurev.med.51.1.349. PubMed PMID:10774469.
   PubMed Web of Science ®Google Scholar
• Guerra B, Ghi T, Quarta S, et al. Pregnancy outcome after early detection of bacterial vaginosis. Eur J Obstet Gynecol Reprod Biol. 2006, 128(1–2):40–5. doi:10.1016/j.ejogrb.2005.12.024. PubMed PMID:16460868.
   PubMed Web of Science ®Google Scholar
• Leitich H, Bodner-Adler B, Brunbauer M, et al. Bacterial vaginosis as a risk factor for preterm delivery: a meta-analysis. Am J Obstet Gynecol. 2003, 189(1):139–47. PubMed PMID:12861153.
   PubMed Web of Science ®Google Scholar
• Rothman KJ, Funch DP, Alfredson T, et al. Randomized field trial of vaginal douching, pelvic inflammatory disease and pregnancy. Epidemiology. 2003, 14(3):340–8. PubMed PMID:12859036.
   PubMed Web of Science ®Google Scholar
• Jacobsson B, Pernevi P, Chidekel L, et al. Bacterial vaginosis in early pregnancy may predispose for preterm birth and postpartum endometritis. Acta Obstet Gynecol Scand. 2002, 81(11):1006–10. PubMed PMID:12421167.
   PubMed Web of Science ®Google Scholar
• Gallo MF, Macaluso M, Warner L, et al. Bacterial vaginosis, gonorrhea, and chlamydial infection among women attending a sexually transmitted disease clinic: a longitudinal analysis of possible causal links. Ann Epidemiol. 2012, 22(3):213–20. doi:10.1016/j.annepidem.2011.11.005. PubMed PMID:22192490.
   PubMed Web of Science ®Google Scholar
• Brotman RM. Vaginal microbiome and sexually transmitted infections: an epidemiologic perspective. J Clin Invest. 2011, 121(12):4610–7. doi:10.1172/JCI57172. PubMed PMID:22133886; PubMed Central PMCID: PMCPMC3225992.
   PubMed Web of Science ®Google Scholar
• Koumans EH, Sternberg M, Bruce C, et al. The prevalence of bacterial vaginosis in the United States, 2001–2004; associations with symptoms, sexual behaviors, and reproductive health. Sex Transm Dis. 2007, 34(11):864–9. doi:10.1097/OLQ.0b013e318074e565. PubMed PMID:17621244.
   PubMed Web of Science ®Google Scholar
• Ravel J, Gajer P, Abdo Z, et al. Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci U S A. 2011, 108(Suppl 1):4680–7. doi:10.1073/pnas.1002611107. PubMed PMID:20534435; PubMed Central PMCID: PMCPMC3063603.
   PubMed Web of Science ®Google Scholar
• De Backer E, Verhelst R, Verstraelen H, et al. Quantitative determination by real-time PCR of four vaginal Lactobacillus species, Gardnerella vaginalis and Atopobium vaginae indicates an inverse relationship between L. gasseri and L. iners. BMC Microbiol. 2007, 7:115. doi:10.1186/1471-2180-7-115. PubMed PMID:18093311; PubMed Central PMCID: PMCPMC2233628.
   PubMed Web of Science ®Google Scholar
• Verhelst R, Verstraelen H, Claeys G, et al. Cloning of 16S rRNA genes amplified from normal and disturbed vaginal microflora suggests a strong association between Atopobium vaginae, Gardnerella vaginalis and bacterial vaginosis. BMC Microbiol. 2004, 4:16. doi:10.1186/1471-2180-4-16. PubMed PMID:15102329; PubMed Central PMCID: PMCPMC419343.
   PubMed Web of Science ®Google Scholar
• Schwebke JR, Muzny CA, Josey WE. Role of Gardnerella vaginalis in the pathogenesis of bacterial vaginosis: a conceptual model. J Infect Dis. 2014, 210(3):338–43. doi:10.1093/infdis/jiu089. PubMed PMID:24511102.
   PubMed Web of Science ®Google Scholar
• Gilbert NM, Lewis WG, Lewis AL. Clinical features of bacterial vaginosis in a murine model of vaginal infection with Gardnerella vaginalis. PLoS One. 2013;8(3):e59539. doi:10.1371/journal.pone.0059539. PubMed PMID:23527214; PubMed Central PMCID: PMCPMC3602284.
   PubMed Web of Science ®Google Scholar
• Machado D, Castro J, Palmeira-de-Oliveira A, et al. Bacterial Vaginosis Biofilms: Challenges to Current therapies and Emerging solutions. Front Microbiol. 2015;6:1528. doi:10.3389/fmicb.2015.01528. PubMed PMID:26834706; PubMed Central PMCID: PMCPMC4718981.
   PubMed Web of Science ®Google Scholar
• Hardy L, Jespers V, Van den Bulck M, et al. The presence of the putative Gardnerella vaginalis sialidase A gene in vaginal specimens is associated with bacterial vaginosis biofilm. PLoS One. 2017;12(2):e0172522. doi:10.1371/journal.pone.0172522. PubMed PMID:28241058; PubMed Central PMCID: PMCPMC5328246.
   PubMed Web of Science ®Google Scholar
• Prevention CfDCa. Sexually transmitted Diseases treatment guideline, 2015. Atlanta, (GA): Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services; 2015.
   Google Scholar
• Mitchell C, Manhart LE, Thomas K, et al. Behavioral predictors of colonization with Lactobacillus crispatus or Lactobacillus jensenii after treatment for bacterial vaginosis: a cohort study. Infect Dis Obstet Gynecol. 2012;2012:706540. doi:10.1155/2012/706540. PubMed PMID:22693410; PubMed Central PMCID: PMCPMC3369434.
   PubMedGoogle Scholar
• Swidsinski A, Mendling W, Loening-Baucke V, et al. An adherent Gardnerella vaginalis biofilm persists on the vaginal epithelium after standard therapy with oral metronidazole. Am J Obstet Gynecol. 2008, 198(1):97e1–6. doi:10.1016/j.ajog.2007.06.039. PubMed PMID:18005928.
   PubMed Web of Science ®Google Scholar
• Alves P, Castro J, Sousa C, et al. Gardnerella vaginalis outcompetes 29 other bacterial species isolated from patients with bacterial vaginosis, using in an in vitro biofilm formation model. J Infect Dis. 2014, 210(4):593–6. doi:10.1093/infdis/jiu131. PubMed PMID:24596283.
   PubMed Web of Science ®Google Scholar
• Bostwick DG, Woody J, Hunt C, et al. Antimicrobial resistance genes and Modeling of treatment failure in Bacterial Vaginosis: Clinical study of 289 Symptomatic women. J Med Microbiol. 2016;65:377–86. doi:10.1099/jmm.0.000236. PubMed PMID:26887782.
   PubMed Web of Science ®Google Scholar
• McFarland LV. Use of probiotics to correct dysbiosis of normal microbiota following disease or disruptive events: a systematic review. BMJ Open. 2014, 25;4(8):e005047. doi:10.1136/bmjopen-2014-005047. PubMed PMID:25157183; PubMed Central PMCID: PMCPMC4156804.
   PubMed Web of Science ®Google Scholar
• Hummelen R, Fernandes AD, Macklaim JM, et al. Deep sequencing of the vaginal microbiota of women with HIV. PLoS One. 2010;5(8):e12078. doi:10.1371/journal.pone.0012078. PubMed PMID:20711427; PubMed Central PMCID: PMCPMC2920804.
   PubMed Web of Science ®Google Scholar
• Sivignon A, de Vallee A, Barnich N, et al. Saccharomyces cerevisiae CNCM I-3856 prevents colitis induced by AIEC bacteria in the transgenic mouse model mimicking Crohn's disease. Inflamm Bowel Dis. 2015;21(2):276–86. doi:10.1097/MIB.0000000000000280. PubMed PMID:25569734.
   PubMed Web of Science ®Google Scholar
• Amara AA, Shibl A. Role of Probiotics in health improvement, infection control and disease treatment and management. Saudi Pharm J. 2015; 23(2):107–14. doi:10.1016/j.jsps.2013.07.001. PubMed PMID:25972729; PubMed Central PMCID: PMCPMC4421088.
   PubMed Web of Science ®Google Scholar
• Lim PL, Toh M, Liu SQ. Saccharomyces cerevisiae EC-1118 enhances the survivability of probiotic Lactobacillus rhamnosus HN001 in an acidic environment. Appl Microbiol Biotechnol. 2015;99(16):6803–11. doi:10.1007/s00253-015-6560-y. PubMed PMID:25846337.
   PubMed Web of Science ®Google Scholar
• Cribby S, Taylor M, Reid G. Vaginal microbiota and the use of probiotics. Interdiscip Perspect Infect Dis. 2008;2008:256490. doi:10.1155/2008/256490. PubMed PMID:19343185; PubMed Central PMCID: PMCPMC2662373.
   PubMedGoogle Scholar
• Pericolini E, Gabrielli E, Ballet N, et al. Therapeutic activity of a Saccharomyces cerevisiae-based probiotic and inactivated whole yeast on vaginal candidiasis. Virulence. 2017,8(1):74–90. doi:10.1080/21505594.2016.1213937. PubMed PMID:27435998.
   PubMed Web of Science ®Google Scholar
• Joo HM, Hyun YJ, Myoung KS, et al. Lactobacillus johnsonii HY7042 ameliorates Gardnerella vaginalis-induced vaginosis by killing Gardnerella vaginalis and inhibiting NF-kappaB activation. Int Immunopharmacol. 201111(11):1758–65. doi:10.1016/j.intimp.2011.07.002. PubMed PMID:21798373.
   PubMed Web of Science ®Google Scholar
• Castro J, Henriques A, Machado A, et al. Reciprocal interference between Lactobacillus spp. and Gardnerella vaginalis on initial adherence to epithelial cells. Int J Med Sci. 2013;10(9):1193–8. doi:10.7150/ijms.6304. PubMed PMID:23935396; PubMed Central PMCID: PMCPMC3739018.
   PubMed Web of Science ®Google Scholar
• Verstraelen H, Verhelst R, Claeys G, et al. Longitudinal analysis of the vaginal microflora in pregnancy suggests that L. crispatus promotes the stability of the normal vaginal microflora and that L. gasseri and/or L. iners are more conducive to the occurrence of abnormal vaginal microflora. BMC Microbiol. 2009;9:116. doi:10.1186/1471-2180-9-116. PubMed PMID:19490622; PubMed Central PMCID: PMCPMC2698831.
   PubMed Web of Science ®Google Scholar
• Breshears LM, Edwards VL, Ravel J, et al. Lactobacillus crispatus inhibits growth of Gardnerella vaginalis and Neisseria gonorrhoeae on a porcine vaginal mucosa model. BMC Microbiol. 2015;15:276. doi:10.1186/s12866-015-0608-0. PubMed PMID:26652855; PubMed Central PMCID: PMCPMC4675025.
   PubMed Web of Science ®Google Scholar
• Leprat R, Michel-Briand Y. Extracellular neuraminidase production by a strain of Pseudomonas aeruginosa isolated from cystic fibrosis. Ann Microbiol (Paris). 1980;131B(3):209–22. PubMed PMID:6781392.
   PubMed Web of Science ®Google Scholar
• Lipovac V, Bigalli G, Rosenberg A. Enzymatic action of sialidase of Vibrio cholerae on brain gangliosides above and below the critical micelle concentration. J Biol Chem. 1971;246(24):7641–8. PubMed PMID:5135317.
   PubMed Web of Science ®Google Scholar
• Scanlon KL, Diven WF, Glew RH. Purification and properties of Streptococcus pneumoniae neuraminidase. Enzyme. 1989;41(3):143–50. PubMed PMID:2542012.
   PubMedGoogle Scholar
• Campana R, Federici S, Ciandrini E, et al. Antagonistic activity of Lactobacillus acidophilus ATCC 4356 on the growth and adhesion/invasion characteristics of human Campylobacter jejuni. Curr Microbiol. 2012;64(4):371–8. doi:10.1007/s00284-012-0080-0. PubMed PMID:22271268.
   PubMed Web of Science ®Google Scholar
• Mappley LJ, Tchorzewska MA, Cooley WA, et al. Lactobacilli antagonize the growth, motility, and adherence of Brachyspira pilosicoli: a potential intervention against avian intestinal spirochetosis. Appl Environ Microbiol. 2011;77(15):5402–11. doi:10.1128/AEM.00185-11. PubMed PMID:21666022; PubMed Central PMCID: PMCPMC3147436.
   PubMed Web of Science ®Google Scholar
• McLean NW, Rosenstein IJ. Characterisation and selection of a Lactobacillus species to re-colonise the vagina of women with recurrent bacterial vaginosis. J Med Microbiol. 2000;49(6):543–52. doi:10.1099/0022-1317-49-6-543. PubMed PMID:10847208.
   PubMed Web of Science ®Google Scholar
• Mastromarino P, Brigidi P, Macchia S, et al. Characterization and selection of vaginal Lactobacillus strains for the preparation of vaginal tablets. J Appl Microbiol. 2002;93(5):884–93. PubMed PMID:12392537.
   PubMed Web of Science ®Google Scholar
• Kaewsrichan J, Peeyananjarassri K, Kongprasertkit J. Selection and identification of anaerobic lactobacilli producing inhibitory compounds against vaginal pathogens. FEMS Immunol Med Microbiol. 2006;48(1):75–83. doi:10.1111/j.1574-695X.2006.00124.x. PubMed PMID:16965354.
   PubMedGoogle Scholar
• van de Wijgert JH, Borgdorff H, Verhelst R, et al. The vaginal microbiota: what have we learned after a decade of molecular characterization?. PLoS One. 2014;9(8):e105998. doi:10.1371/journal.pone.0105998. PubMed PMID:25148517; PubMed Central PMCID: PMCPMC4141851.
   PubMed Web of Science ®Google Scholar
• Srinivasan S, Hoffman NG, Morgan MT, et al. Bacterial communities in women with bacterial vaginosis: high resolution phylogenetic analyses reveal relationships of microbiota to clinical criteria. PLoS One. 2012;7(6):e37818. doi:10.1371/journal.pone.0037818. PubMed PMID:22719852; PubMed Central PMCID: PMCPMC3377712.
   PubMed Web of Science ®Google Scholar
• Macklaim JM, Clemente JC, Knight R, et al. Changes in vaginal microbiota following antimicrobial and probiotic therapy. Microb Ecol Health Dis. 2015;26:27799. doi:10.3402/mehd.v26.27799. PubMed PMID:26282697; PubMed Central PMCID: PMCPMC4539393.
   PubMedGoogle Scholar
• Dover SE, Aroutcheva AA, Faro S, et al. Natural Antimicrobials and their role in Vaginal health: A Short review. Int J Probiotics Prebiotics. 2008;3(4):219–230. PubMed PMID:20657710; PubMed Central PMCID: PMCPMC2908489.
   PubMedGoogle Scholar
• Homayouni A, Bastani P, Ziyadi S, et al. Effects of probiotics on the recurrence of bacterial vaginosis: a review. J Low Genit Tract Dis. 2014;18(1):79–86. doi:10.1097/LGT.0b013e31829156ec. PubMed PMID:24299970.
   PubMed Web of Science ®Google Scholar
• Donnarumma G, Molinaro A, Cimini D, et al. Lactobacillus crispatus L1: high cell density cultivation and exopolysaccharide structure characterization to highlight potentially beneficial effects against vaginal pathogens. BMC Microbiol. 2014;14:137. doi:10.1186/1471-2180-14-137. PubMed PMID:24884965; PubMed Central PMCID: PMCPMC4054921.
   PubMed Web of Science ®Google Scholar
• Tamrakar R, Yamada T, Furuta I, et al. Association between Lactobacillus species and bacterial vaginosis-related bacteria, and bacterial vaginosis scores in pregnant Japanese women. BMC Infect Dis. 2007;7:128. doi:10.1186/1471-2334-7-128. PubMed PMID:17986357; PubMed Central PMCID: PMCPMC2212641.
   PubMed Web of Science ®Google Scholar
• Teixeira GS, Carvalho FP, Arantes RM, et al. Characteristics of Lactobacillus and Gardnerella vaginalis from women with or without bacterial vaginosis and their relationships in gnotobiotic mice. J Med Microbiol. 2012;61(Pt 8):1074–81. doi:10.1099/jmm.0.041962-0. PubMed PMID:22539000.
   PubMed Web of Science ®Google Scholar
• Adeniyi-Jones C, Groves DJ, Mannethu A, et al. Hemophilus vaginalis bacteremia. Can Med Assoc J. 1980;122(4):424–6. PubMed PMID:6966179; PubMed Central PMCID: PMCPMC1801800.
   PubMed Web of Science ®Google Scholar
• Reimer LG, Reller LB. Gardnerella vaginalis bacteremia: a review of thirty cases. Obstet Gynecol. 1984;64(2):170–2. PubMed PMID:6610845.
   PubMed Web of Science ®Google Scholar
• Johnson AP, Boustouller YL. Extra-vaginal infection caused by Gardnerella vaginalis. Epidemiol Infect. 1987;98(2):131–7. PubMed PMID:3493915; PubMed Central PMCID: PMCPMC2235249.
   PubMed Web of Science ®Google Scholar
• Briselden AM, Moncla BJ, Stevens CE, et al. Sialidases (neuraminidases) in bacterial vaginosis and bacterial vaginosis-associated microflora. J Clin Microbiol. 1992;30(3):663–6. PubMed PMID:1551983; PubMed Central PMCID: PMCPMC265128.
   PubMed Web of Science ®Google Scholar
• Moncla BJ, Chappell CA, Debo BM, et al. The Effects of Hormones and Vaginal Microflora on the Glycome of the Female Genital tract: Cervical-Vaginal fluid. PLoS One. 2016;11(7):e0158687. doi:10.1371/journal.pone.0158687. PubMed PMID:27437931; PubMed Central PMCID: PMCPMC4954690.
   PubMed Web of Science ®Google Scholar
• Lewis WG, Robinson LS, Gilbert NM, et al. Degradation, foraging, and depletion of mucus sialoglycans by the vagina-adapted Actinobacterium Gardnerella vaginalis. J Biol Chem. 2013;288(17):12067–79. doi:10.1074/jbc.M113.453654. PubMed PMID:23479734; PubMed Central PMCID: PMCPMC3636892.
   PubMed Web of Science ®Google Scholar
• Kurtzman CP, Robnett CJ. Identification of clinically important ascomycetous yeasts based on nucleotide divergence in the 5′ end of the large-subunit (26S) ribosomal DNA gene. J Clin Microbiol. 1997;35(5):1216–23. PubMed PMID:9114410; PubMed Central PMCID: PMCPMC232732.
   PubMed Web of Science ®Google Scholar
• Kurtzman CP, Robnett CJ. Identification and phylogeny of ascomycetous yeasts from analysis of nuclear large subunit (26S) ribosomal DNA partial sequences. Antonie Van Leeuwenhoek. 1998, May;73(4):331–71. PubMed PMID:9850420.
   PubMed Web of Science ®Google Scholar
• ECF S. Animal feedingstuffs, CEN/TS 15790:2008. PCR typing of probiotic strains of Saccharomyces cerevisiae (yeast). 2009. PubMed PMID:ISBN 978-0-580-61806-2.
   Google Scholar
• Verdenelli MC, Coman MM, Cecchini C, et al. Evaluation of antipathogenic activity and adherence properties of human Lactobacillus strains for vaginal formulations. J Appl Microbiol. 2014;116(5):1297–307. doi:10.1111/jam.12459. PubMed PMID:24552173.
   PubMed Web of Science ®Google Scholar