SLC1A3 facilitates Newcastle disease virus replication by regulating glutamine catabolism

References

• Ganar K, Das M, Sinha S, et al. Newcastle disease virus: Current status and our understanding. Virus Res. 2014;184:71–81.
   PubMed Web of Science ®Google Scholar
• Alexander DJ, Aldous EW, Fuller CM The long view: A selective review of 40 years of Newcastle disease research. Avian Pathol. 2012;41:329–335.
   PubMed Web of Science ®Google Scholar
• Brown VR, Bevins SN A review of virulent Newcastle disease viruses in the United States and the role of wild birds in viral persistence and spread. Vet Res. 2017;48:68.
   PubMed Web of Science ®Google Scholar
• Kodama M, Oshikawa K, Shimizu H, et al. A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer. Nat Commun. 2020;11:1320.
   PubMed Web of Science ®Google Scholar
• Sookoian S, Pirola CJ Liver enzymes, metabolomics and genome-wide association studies: From systems biology to the personalized medicine. World J Gastroenterol. 2015;21:711–725.
   PubMed Web of Science ®Google Scholar
• Cluntun AA, Lukey MJ, Cerione RA, et al. Glutamine metabolism in cancer: understanding the heterogeneity. Trends Cancer. 2017;3:169–180.
   PubMed Web of Science ®Google Scholar
• Eagle H, Habel K The nutritional requirements for the propagation of poliomyelitis virus by the HeLa cell. J Exp Med. 1956;104:271–287.
   PubMed Web of Science ®Google Scholar
• Munger J, Bennett BD, Parikh A, et al. Systems-Level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy. Nat Biotechnol. 2008;26:1179–1186.
   PubMed Web of Science ®Google Scholar
• Chambers JW, Maguire TG, Alwine JC Glutamine metabolism is essential for human cytomegalovirus infection. J Virol. 2010;84:1867–1873.
   PubMed Web of Science ®Google Scholar
• Fontaine KA, Camarda R, Lagunoff M Vaccinia virus requires glutamine but not glucose for efficient replication. J Virol. 2014;88:4366–4374.
   PubMed Web of Science ®Google Scholar
• Greseth MD, Traktman P, Alwine JC De Novo fatty acid biosynthesis contributes significantly to establishment of a bioenergetically favorable environment for vaccinia virus infection. PLoS Pathog. 2014;10:e1004021.
   PubMed Web of Science ®Google Scholar
• Mazzon M, Castro C, Roberts LD, et al. A role for vaccinia virus protein C16 in reprogramming cellular energy metabolism. J Gen Virol. 2015;96:395–407.
   PubMed Web of Science ®Google Scholar
• Dai Z, Wu Z, Hang S, et al. Amino acid metabolism in intestinal bacteria and its potential implications for mammalian reproduction. Mol Hum Reprod. 2015;21:389–409.
   PubMed Web of Science ®Google Scholar
• Wu G Functional amino acids in nutrition and health. Amino Acids. 2013;45:407–411.
   PubMed Web of Science ®Google Scholar
• Wu G, Bazer FW, Dai Z, et al. Amino acid nutrition in animals: Protein synthesis and beyond. Annu Rev Anim Biosci. 2014;2:387–417.
   PubMed Web of Science ®Google Scholar
• Bröer S, Bröer A Amino acid homeostasis and signalling in mammalian cells and organisms. Biochem J. 2017;474:1935–1963.
   PubMed Web of Science ®Google Scholar
• Galluzzi L, Kroemer G Amino acid deprivation promotes intestinal homeostasis through autophagy. Oncotarget. 2016;7:29877–29878.
   PubMedGoogle Scholar
• Kanai Y, Clémençon B, Simonin A, et al. The SLC1 high-affinity glutamate and neutral amino acid transporter family. Mol Aspects Med. 2013;34:108–120.
   PubMed Web of Science ®Google Scholar
• Kanai Y, Hediger MA The glutamate/neutral amino acid transporter family SLC1: Molecular, physiological and pharmacological aspects. Pflugers Arch. 2004;447:469–479.
   PubMed Web of Science ®Google Scholar
• Arriza JL, Fairman WA, Wadiche JI, et al. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J Neurosci. 1994;14:5559–5569.
   PubMed Web of Science ®Google Scholar
• Ralphe JC, Segar JL, Schutte BC, et al. Localization and function of the brain excitatory amino acid transporter type 1 in cardiac mitochondria. J Mol Cell Cardiol. 2004;37:33–41.
   PubMed Web of Science ®Google Scholar
• Ralphe JC, Bedell K, Segar JL, et al. Correlation between myocardial malate/aspartate shuttle activity and EAAT1 protein expression in hyper- and hypothyroidism. Am J Physiol Heart Circ Physiol. 2005;288:H2521–6.
   PubMed Web of Science ®Google Scholar
• Renli Q, Chao S, Jun Y, et al. Changes in fat metabolism of black-bone chickens during early stages of infection with Newcastle disease virus. Animal. 2012;6:1246–1252.
   PubMed Web of Science ®Google Scholar
• Sheng XX, Sun YJ, Zhan Y, et al. The LXR ligand GW3965 inhibits Newcastle disease virus infection by affecting cholesterol homeostasis. Arch Virol. 2016;161:2491–2501.
   PubMed Web of Science ®Google Scholar
• Gong Y, Tang N, Liu P, et al. Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells. Autophagy. 2022;18(7):1503–1521.
   Web of Science ®Google Scholar
• Liu P, Yin Y, Gong Y, et al. In vitro and in vivo metabolomic profiling after infection with virulent Newcastle disease virus. Viruses. 2019;12:11. DOI:10.3390/v12010011
   PubMedGoogle Scholar
• Römer-Oberdörfer A, Werner O, Veits J, et al. Contribution of the length of the HN protein and the sequence of the F protein cleavage site to Newcastle disease virus pathogenicity. J Gen Virol. 2003;84:3121–3129.
   PubMed Web of Science ®Google Scholar
• Sun Y, Ding N, Ding SS, et al. Goose RIG-I functions in innate immunity against Newcastle disease virus infections. Mol Immunol. 2013;53:321–327.
   PubMed Web of Science ®Google Scholar
• Schmittgen TD, Livak KJ Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 2008;3:1101–1108.
   PubMed Web of Science ®Google Scholar
• Sun Y, Zheng H, Yu S, et al. Newcastle disease virus V protein degrades mitochondrial antiviral signaling protein to inhibit host type I interferon production via E3 Ubiquitin Ligase RNF5. J Virol. 2019;93. DOI:10.1128/JVI.00322-19.
   Web of Science ®Google Scholar
• Ren S, Ur Rehman Z, Gao B, et al. ATM-Mediated DNA double-strand break response facilitated oncolytic Newcastle disease virus replication and promoted syncytium formation in tumor cells. PLoS Pathog. 2020;16:e1008514.
   PubMed Web of Science ®Google Scholar
• Wu W, Qu Y, Yu S, et al. Caspase-Dependent cleavage of DDX21 suppresses host innate immunity. Mbio. 2021;12:e0100521.
   PubMed Web of Science ®Google Scholar
• Yi J, Liu C Detecting Newcastle disease virus in combination of RT-PCR with red blood cell absorption. Virol J. 2011;8:202.
   PubMed Web of Science ®Google Scholar
• Hyde R, Taylor PM, Hundal HS Amino acid transporters: Roles in amino acid sensing and signalling in animal cells. Biochem J. 2003;373:1–18.
   PubMed Web of Science ®Google Scholar
• Sanchez EL, Carroll PA, Thalhofer AB, et al. Latent KSHV infected endothelial cells are glutamine addicted and require glutaminolysis for survival. PLoS Pathog. 2015;11:e1005052.
   PubMed Web of Science ®Google Scholar
• Pavlova NN, Thompson CB The emerging hallmarks of cancer metabolism. Cell Metab. 2016;23:27–47.
   PubMed Web of Science ®Google Scholar
• DeBerardinis RJ, Chandel NS Fundamentals of cancer metabolism. Sci Adv. 2016;2:e1600200.
   PubMed Web of Science ®Google Scholar
• Altman BJ, Stine ZE, Dang CV From Krebs to clinic: Glutamine metabolism to cancer therapy. Nat Rev Cancer. 2016;16:619–634.
   PubMed Web of Science ®Google Scholar
• Tajan M, Hock AK, Blagih J, et al. A role for p53 in the adaptation to Glutamine starvation through the expression of SLC1A3. Cell Metab. 2018;28:721–36.e6.
   PubMed Web of Science ®Google Scholar
• Karki P, Kim C, Smith K, et al. Transcriptional regulation of the Astrocytic Excitatory Amino Acid Transporter 1 (EAAT1) via NF-κB and Yin Yang 1 (YY1). J Biol Chem. 2015;290:23725–23737.
   PubMed Web of Science ®Google Scholar
• Karki P, Hong P, Johnson J Jr., et al. Arundic acid increases expression and function of Astrocytic Glutamate Transporter EAAT1 via the ERK, Akt, and NF-κB Pathways. Mol Neurobiol. 2018;55:5031–5046.
   PubMed Web of Science ®Google Scholar
• Vander Heiden MG, Cantley LC, Thompson CB Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science. 2009;324:1029–1033.
   PubMed Web of Science ®Google Scholar
• Yuneva M, Zamboni N, Oefner P, et al. Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J Cell Biol. 2007;178:93–105.
   PubMed Web of Science ®Google Scholar
• Hensley CT, Wasti AT, DeBerardinis RJ Glutamine and cancer: Cell biology, physiology, and clinical opportunities. J Clin Invest. 2013;123:3678–3684.
   PubMed Web of Science ®Google Scholar
• Vastag L, Koyuncu E, Grady SL, et al. Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism. PLoS Pathog. 2011;7:e1002124.
   PubMed Web of Science ®Google Scholar
• Fontaine KA, Sanchez EL, Camarda R, et al. Dengue virus induces and requires glycolysis for optimal replication. J Virol. 2015;89:2358–2366.
   PubMed Web of Science ®Google Scholar
• Mejlvang J, Olsvik H, Svenning S, et al. Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy. J Cell Biol. 2018;217:3640–3655.
   PubMed Web of Science ®Google Scholar
• Mizushima N, Komatsu M Autophagy: Renovation of cells and tissues. Cell. 2011;147:728–741.
   PubMed Web of Science ®Google Scholar
• Kim KH, Lee MS Autophagy–a key player in cellular and body metabolism. Nat Rev Endocrinol. 2014;10:322–337.
   PubMed Web of Science ®Google Scholar
• Meng C, Zhou Z, Jiang K, et al. Newcastle disease virus triggers autophagy in U251 glioma cells to enhance virus replication. Arch Virol. 2012;157:1011–1018.
   PubMed Web of Science ®Google Scholar
• Kaira K, Oriuchi N, Imai H, et al. L-Type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms. Cancer Sci. 2008;99:2380–2386.
   PubMed Web of Science ®Google Scholar
• Lewerenz J, Hewett SJ, Huang Y, et al. The cystine/glutamate antiporter system x(c)(-) in health and disease: From molecular mechanisms to novel therapeutic opportunities. Antioxid Redox Signal. 2013;18:522–555.
   PubMed Web of Science ®Google Scholar
• Wang F, Gómez-Sintes R, Boya P Lysosomal membrane permeabilization and cell death. Traffic. 2018;19:918–931.
   PubMed Web of Science ®Google Scholar
• Thai M, Graham NA, Braas D, et al. Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication. Cell Metab. 2014;19:694–701.
   PubMed Web of Science ®Google Scholar
• Kan X, Yin Y, Song C, et al. Newcastle-Disease-Virus-Induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells. iScience. 2021;24:102837.
   PubMed Web of Science ®Google Scholar