New insights into mechanisms of nuclear translocation of G-protein coupled receptors

References

• Harris JR. The biochemistry and ultrastructure of the nuclear envelope. Biochim Biophys Acta 1978; 515:55-104; PMID:346065; http://dx.doi.org/10.1016/0304-4157(78)90008-4
   PubMed Web of Science ®Google Scholar
• Alber F, Dokudovskaya S, Veenhoff LM, Zhang W, Kipper J, Devos D, Suprapto A, Karni-Schmidt O, Williams R, Chait BT, et al. The molecular architecture of the nuclear pore complex. Nature 2007; 450:695-701; PMID:18046406; http://dx.doi.org/10.1038/nature06405
   PubMed Web of Science ®Google Scholar
• Devos D, Dokudovskaya S, Alber F, Williams R, Chait BT, Sali A, Rout MP. Components of coated vesicles and nuclear pore complexes share a common molecular architecture. PLoS Biol 2004; 2:e380; PMID:15523559; http://dx.doi.org/10.1371/journal.pbio.0020380
   PubMed Web of Science ®Google Scholar
• Schirmer EC, Gerace L. The nuclear membrane proteome: extending the envelope. Trends Biochem Sci 2005; 30:551-8; PMID:16125387; http://dx.doi.org/10.1016/j.tibs.2005.08.003
   PubMed Web of Science ®Google Scholar
• Arib G, Akhtar A. Multiple facets of nuclear periphery in gene expression control. Curr Opin Cell Biol 2011; 23:346-53; PMID:21242077; http://dx.doi.org/10.1016/j.ceb.2010.12.005
   PubMed Web of Science ®Google Scholar
• Korfali N, Wilkie GS, Swanson SK, Srsen V, de Las Heras J, Batrakou DG, Malik P, Zuleger N, Kerr AR, Florens L, et al. The nuclear envelope proteome differs notably between tissues. Nucleus 2012; 3:552-64; PMID:22990521; http://dx.doi.org/10.4161/nucl.22257
   PubMed Web of Science ®Google Scholar
• Fredriksson R, Lagerstrom MC, Lundin LG, Schioth HB. The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol 2003; 63:1256-72; PMID:12761335; http://dx.doi.org/10.1124/mol.63.6.1256
   PubMed Web of Science ®Google Scholar
• Hamm HE. The many faces of G protein signaling. J Biol Chem 1998; 273:669-72; PMID:9422713; http://dx.doi.org/10.1074/jbc.273.2.669
   PubMed Web of Science ®Google Scholar
• Hur EM, Kim KT. G protein-coupled receptor signalling and cross-talk: achieving rapidity and specificity. Cell Signal 2002; 14:397-405; PMID:11882384; http://dx.doi.org/10.1016/S0898-6568(01)00258-3
   PubMed Web of Science ®Google Scholar
• Zhu T, Gobeil F, Vazquez-Tello A, Leduc M, Rihakova L, Bossolasco M, Bkaily G, Peri K, Varma DR, Orvoine R, et al. Intracrine signaling through lipid mediators and their cognate nuclear G-protein-coupled receptors: a paradigm based on PGE2, PAF, and LPA1 receptors. Can J Physiol Pharmacol 2006; 84:377-91; PMID:16902584; http://dx.doi.org/10.1139/y05-147
   PubMed Web of Science ®Google Scholar
• Joyal JS, Bhosle VK, Chemtob S. Subcellular G-protein coupled receptor signaling hints at greater therapeutic selectivity. Expert Opin Ther Targets 2015; 19:717-21; PMID:25976229; http://dx.doi.org/10.1517/14728222.2015.1042365
   PubMed Web of Science ®Google Scholar
• Song S, Rosen KM, Corfas G. Biological function of nuclear receptor tyrosine kinase action. Cold Spring Harb Perspect Biol 2013; 5(7) pii: a009001; PMID:23818495; http://dx.doi.org/10.1101/cshperspect.a009001
   PubMed Web of Science ®Google Scholar
• Maraldi NM, Mazzotti G, Capitani S, Rizzoli R, Zini N, Squarzoni S, Manzoli FA. Morphological evidence of function-related localization of phospholipids in the cell nucleus. Adv Enzyme Regul 1992; 32:73-90; PMID:1496925; http://dx.doi.org/10.1016/0065-2571(92)90009-O
   PubMedGoogle Scholar
• Fricker M, Hollinshead M, White N, Vaux D. Interphase nuclei of many mammalian cell types contain deep, dynamic, tubular membrane-bound invaginations of the nuclear envelope. J Cell Biol 1997; 136:531-44; PMID:9024685; http://dx.doi.org/10.1083/jcb.136.3.531
   PubMed Web of Science ®Google Scholar
• Duvernay MT, Filipeanu CM, Wu G. The regulatory mechanisms of export trafficking of G protein-coupled receptors. Cell Signal 2005; 17:1457-65; PMID:16014327; http://dx.doi.org/10.1016/j.cellsig.2005.05.020
   PubMed Web of Science ®Google Scholar
• Saraste J. Spatial and functional aspects of ER-Golgi Rabs and tethers. Front Cell Dev Biol 2016; 4:28; PMID:27148530; http://dx.doi.org/10.3389/fcell.2016.00028
   PubMed Web of Science ®Google Scholar
• Schindler M, Holland JF, Hogan M. Lateral diffusion in nuclear membranes. J Cell Biol 1985; 100:1408-14; PMID:3988794; http://dx.doi.org/10.1083/jcb.100.5.1408
   PubMed Web of Science ®Google Scholar
• Ungricht R, Klann M, Horvath P, Kutay U. Diffusion and retention are major determinants of protein targeting to the inner nuclear membrane. J Cell Biol 2015; 209:687-703; PMID:26056139; http://dx.doi.org/10.1083/jcb.201409127
   PubMed Web of Science ®Google Scholar
• Wang G, Wu G. Small GTPase regulation of GPCR anterograde trafficking. Trends Pharmacol Sci 2012; 33:28-34; PMID:22015208; http://dx.doi.org/10.1016/j.tips.2011.09.002
   PubMed Web of Science ®Google Scholar
• Iborra FJ, Jackson DA, Cook PR. Coupled transcription and translation within nuclei of mammalian cells. Science 2001; 293:1139-42; PMID:11423616; http://dx.doi.org/10.1126/science.1061216
   PubMed Web of Science ®Google Scholar
• Joyal JS, Nim S, Zhu T, Sitaras N, Rivera JC, Shao Z, Sapieha P, Hamel D, Sanchez M, Zaniolo K, et al. Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis. Nat Med 2014; 20:1165-73; PMID:25216639; http://dx.doi.org/10.1038/nm.3669
   PubMed Web of Science ®Google Scholar
• Di Benedetto A, Sun L, Zambonin CG, Tamma R, Nico B, Calvano CD, et al. Osteoblast regulation via ligand-activated nuclear trafficking of the oxytocin receptor. Proc Natl Acad Sci U S A 2014; 111:16502-7; PMID:25378700; http://dx.doi.org/10.1073/pnas.1419349111
   PubMed Web of Science ®Google Scholar
• Zhang C, Clarke PR. Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts. Science 2000; 288:1429-32; PMID:10827954; http://dx.doi.org/10.1126/science.288.5470.1429
   PubMed Web of Science ®Google Scholar
• Askjaer P, Galy V, Hannak E, Mattaj IW. Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos. Mol Biol Cell 2002; 13:4355-70; PMID:12475958; http://dx.doi.org/10.1091/mbc.E02-06-0346
   PubMed Web of Science ®Google Scholar
• Gorlich D, Kutay U. Transport between the cell nucleus and the cytoplasm. Annu Rev Cell Dev Biol 1999; 15:607-60; PMID:10611974; http://dx.doi.org/10.1146/annurev.cellbio.15.1.607
   PubMed Web of Science ®Google Scholar
• Kalab P, Weis K, Heald R. Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts. Science 2002; 295:2452-6; PMID:11923538; http://dx.doi.org/10.1126/science.1068798
   PubMed Web of Science ®Google Scholar
• King MC, Lusk CP, Blobel G. Karyopherin-mediated import of integral inner nuclear membrane proteins. Nature 2006; 442:1003-7; PMID:16929305; http://dx.doi.org/10.1038/nature05075
   PubMed Web of Science ®Google Scholar
• Kalderon D, Richardson WD, Markham AF, Smith AE. Sequence requirements for nuclear location of simian virus 40 large-T antigen. Nature 1984; 311:33-8; PMID:6088992; http://dx.doi.org/10.1038/311033a0
   PubMed Web of Science ®Google Scholar
• Robbins J, Dilworth SM, Laskey RA, Dingwall C. Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence. Cell 1991; 64:615-23; PMID:1991323; http://dx.doi.org/10.1016/0092-8674(91)90245-T
   PubMed Web of Science ®Google Scholar
• Kosugi S, Hasebe M, Matsumura N, Takashima H, Miyamoto-Sato E, Tomita M, Yanagawa H. Six classes of nuclear localization signals specific to different binding grooves of importin alpha. J Biol Chem 2009; 284:478-85; PMID:19001369; http://dx.doi.org/10.1074/jbc.M807017200
   PubMed Web of Science ®Google Scholar
• Lu D, Yang H, Shaw G, Raizada MK. Angiotensin II-induced nuclear targeting of the angiotensin type 1 (AT1) receptor in brain neurons. Endocrinology 1998; 139:365-75; PMID:9421435
   PubMed Web of Science ®Google Scholar
• Lee DK, Lanca AJ, Cheng R, Nguyen T, Ji XD, Gobeil F, Jr, Chemtob S, George SR, O'Dowd BF. Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors. J Biol Chem 2004; 279:7901-8; PMID:14645236; http://dx.doi.org/10.1074/jbc.M306377200
   PubMed Web of Science ®Google Scholar
• Cattaneo F, Parisi M, Fioretti T, Sarnataro D, Esposito G, Ammendola R. Nuclear localization of Formyl-Peptide Receptor 2 in human cancer cells. Arch Biochem Biophys 2016; 603:10-9; PMID:27177968; http://dx.doi.org/10.1016/j.abb.2016.05.006
   PubMed Web of Science ®Google Scholar
• Nielsen CK, Campbell JI, Ohd JF, Morgelin M, Riesbeck K, Landberg G, Sjölander A. A novel localization of the G-protein-coupled CysLT1 receptor in the nucleus of colorectal adenocarcinoma cells. Cancer Res 2005; 65:732-42; PMID:15705869
   PubMed Web of Science ®Google Scholar
• Marrache AM, Gobeil F, Jr, Bernier SG, Stankova J, Rola-Pleszczynski M, Choufani S, Bkaily G, Bourdeau A, Sirois MG, Vazquez-Tello A, et al. Proinflammatory gene induction by platelet-activating factor mediated via its cognate nuclear receptor. J Immunol 2002; 169:6474-81; PMID:12444157; http://dx.doi.org/10.4049/jimmunol.169.11.6474
   PubMed Web of Science ®Google Scholar
• Bhosle VK, Rivera JC, Zhou TE, Omri S, Sanchez M, Hamel D, Zhu T, Rouget R, Rabea AA, Hou X, et al. Nuclear localization of platelet-activating factor receptor controls retinal neovascularization. Cell Discov 2016; 2:16017; PMID:27462464; http://dx.doi.org/10.1038/celldisc.2016.17
   PubMedGoogle Scholar
• Lam MH, Briggs LJ, Hu W, Martin TJ, Gillespie MT, Jans DA. Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha. J Biol Chem 1999; 274:7391-8; PMID:10066803; http://dx.doi.org/10.1074/jbc.274.11.7391
   PubMed Web of Science ®Google Scholar
• Beguelin W, Diaz Flaque MC, Proietti CJ, Cayrol F, Rivas MA, Tkach M, Rosemblit C, Tocci JM, Charreau EH, Schillaci R, et al. Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Mol Cell Biol 2010; 30:5456-72; PMID:20876300; http://dx.doi.org/10.1128/MCB.00012-10
   PubMed Web of Science ®Google Scholar
• Chook YM, Suel KE. Nuclear import by karyopherin-betas: recognition and inhibition. Biochim Biophys Acta 2011; 1813:1593-606; PMID:21029754; http://dx.doi.org/10.1016/j.bbamcr.2010.10.014
   PubMed Web of Science ®Google Scholar
• Lee BJ, Cansizoglu AE, Suel KE, Louis TH, Zhang Z, Chook YM. Rules for nuclear localization sequence recognition by karyopherin beta 2. Cell 2006; 126:543-58; PMID:16901787; http://dx.doi.org/10.1016/j.cell.2006.05.049
   PubMed Web of Science ®Google Scholar
• Pickard BW, Hodsman AB, Fraher LJ, Watson PH. Type 1 parathyroid hormone receptor (PTH1R) nuclear trafficking: association of PTH1R with importin alpha1 and beta. Endocrinology 2006; 147:3326-32; PMID:16574786; http://dx.doi.org/10.1210/en.2005-1408
   PubMed Web of Science ®Google Scholar
• Favre N, Camps M, Arod C, Chabert C, Rommel C, Pasquali C. Chemokine receptor CCR2 undergoes transportin1-dependent nuclear translocation. Proteomics 2008; 8:4560-76; PMID:18846510; http://dx.doi.org/10.1002/pmic.200800211
   PubMed Web of Science ®Google Scholar
• Don-Salu-Hewage AS, Chan SY, McAndrews KM, Chetram MA, Dawson MR, Bethea DA, Hinton CV. Cysteine (C)-x-C receptor 4 undergoes transportin 1-dependent nuclear localization and remains functional at the nucleus of metastatic prostate cancer cells. PLoS One 2013; 8:e57194; PMID:23468933; http://dx.doi.org/10.1371/journal.pone.0057194
   PubMed Web of Science ®Google Scholar
• Mizuno-Yamasaki E, Rivera-Molina F, Novick P. GTPase networks in membrane traffic. Annu Rev Biochem 2012; 81:637-59; PMID:22463690; http://dx.doi.org/10.1146/annurev-biochem-052810-093700
   PubMed Web of Science ®Google Scholar
• Johnson DC, Baines JD. Herpesviruses remodel host membranes for virus egress. Nat Rev Microbiol 2011; 9:382-94; PMID:21494278; http://dx.doi.org/10.1038/nrmicro2559
   PubMed Web of Science ®Google Scholar
• Burns LT, Wente SR. Trafficking to uncharted territory of the nuclear envelope. Curr Opin Cell Biol 2012; 24:341-9; PMID:22326668; http://dx.doi.org/10.1016/j.ceb.2012.01.009
   PubMed Web of Science ®Google Scholar
• Miaczynska M, Christoforidis S, Giner A, Shevchenko A, Uttenweiler-Joseph S, Habermann B, et al. APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. Cell 2004; 116:445-56; PMID:15016378; http://dx.doi.org/10.1016/S0092-8674(04)00117-5
   PubMed Web of Science ®Google Scholar
• Maltese WA, Soule G, Gunning W, Calomeni E, Alexander B. Mutant Rab24 GTPase is targeted to nuclear inclusions. BMC Cell Biol 2002; 3:25; PMID:12323076; http://dx.doi.org/10.1186/1471-2121-3-25
   PubMed Web of Science ®Google Scholar
• Horgan CP, McCaffrey MW. The dynamic Rab11-FIPs. Biochem Soc Trans 2009; 37:1032-6; PMID:19754446; http://dx.doi.org/10.1042/BST0371032
   PubMed Web of Science ®Google Scholar
• Fielding AB, Schonteich E, Matheson J, Wilson G, Yu X, Hickson GR, Srivastava S, Baldwin SA, Prekeris R, Gould GW. Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. EMBO J 2005; 24:3389-99; PMID:16148947; http://dx.doi.org/10.1038/sj.emboj.7600803
   PubMed Web of Science ®Google Scholar
• Campa CC, Hirsch E. Rab11 and phosphoinositides: A synergy of signal transducers in the control of vesicular trafficking. Adv Biol Regul 2016; pii: S2212–4926(16)30043-4; PMID:27658318; http://dx.doi.org/10.1016/j.jbior.2016.09.002
   PubMedGoogle Scholar
• Lim YS, Tang BL. A role for Rab23 in the trafficking of Kif17 to the primary cilium. J Cell Sci 2015; 128:2996-3008; PMID:26136363; http://dx.doi.org/10.1242/jcs.163964
   PubMed Web of Science ®Google Scholar
• Williams CL. The polybasic region of Ras and Rho family small GTPases: a regulator of protein interactions and membrane association and a site of nuclear localization signal sequences. Cell Signal 2003; 15:1071-80; PMID:14575862; http://dx.doi.org/10.1016/S0898-6568(03)00098-6
   PubMed Web of Science ®Google Scholar
• Mahalakshmi RN, Ng MY, Guo K, Qi Z, Hunziker W, Beguin P. Nuclear localization of endogenous RGK proteins and modulation of cell shape remodeling by regulated nuclear transport. Traffic 2007; 8:1164-78; PMID:17605760; http://dx.doi.org/10.1111/j.1600-0854.2007.00599.x
   PubMed Web of Science ®Google Scholar
• Cullen PJ. Endosomal sorting and signalling: an emerging role for sorting nexins. Nat Rev Mol Cell Biol 2008; 9:574-82; PMID:18523436; http://dx.doi.org/10.1038/nrm2427
   PubMed Web of Science ®Google Scholar
• Simunovic M, Voth GA, Callan-Jones A, Bassereau P. When physics takes over: BAR proteins and membrane curvature. Trends Cell Biol 2015; 25:780-92; PMID:26519988; http://dx.doi.org/10.1016/j.tcb.2015.09.005
   PubMed Web of Science ®Google Scholar
• Heydorn A, Sondergaard BP, Ersboll B, Holst B, Nielsen FC, Haft CR, Whistler J, Schwartz TW. A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP). J Biol Chem 2004; 279:54291-303; PMID:15452121; http://dx.doi.org/10.1074/jbc.M406169200
   PubMed Web of Science ®Google Scholar
• Nisar S, Kelly E, Cullen PJ, Mundell SJ. Regulation of P2Y1 receptor traffic by sorting Nexin 1 is retromer independent. Traffic 2010; 11:508-19; PMID:20070609; http://dx.doi.org/10.1111/j.1600-0854.2010.01035.x
   PubMed Web of Science ®Google Scholar
• Gonzalez-Granado JM, Navarro-Puche A, Molina-Sanchez P, Blanco-Berrocal M, Viana R, Font de Mora J, et al. Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope. PLoS One 2014; 9:e115571; PMID:25535984; http://dx.doi.org/10.1371/journal.pone.0115571
   PubMed Web of Science ®Google Scholar
• Zhu CH, Morse LR, Battaglino RA. SNX10 is required for osteoclast formation and resorption activity. J Cell Biochem 2012; 113:1608-15; PMID:22174188
   PubMed Web of Science ®Google Scholar
• Xu J, Xu T, Wu B, Ye Y, You X, Shu X, Pei D, Liu J. Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation. J Biol Chem 2013; 288:16598-605; PMID:23615901; http://dx.doi.org/10.1074/jbc.M112.449306
   PubMed Web of Science ®Google Scholar
• Kang DS, Tian X, Benovic JL. Role of beta-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking. Curr Opin Cell Biol 2014; 27:63-71; PMID:24680432; http://dx.doi.org/10.1016/j.ceb.2013.11.005
   PubMed Web of Science ®Google Scholar
• Vilardaga JP, Gardella TJ, Wehbi VL, Feinstein TN. Non-canonical signaling of the PTH receptor. Trends Pharmacol Sci 2012; 33:423-31; PMID:22709554; http://dx.doi.org/10.1016/j.tips.2012.05.004
   PubMed Web of Science ®Google Scholar
• Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, Lefkowitz RJ. beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis. J Biol Chem 2001; 276:42509-13; PMID:11533043; http://dx.doi.org/10.1074/jbc.M108399200
   PubMed Web of Science ®Google Scholar
• Macia E, Partisani M, Paleotti O, Luton F, Franco M. Arf6 negatively controls the rapid recycling of the beta2 adrenergic receptor. J Cell Sci 2012; 125:4026-35; PMID:22611259; http://dx.doi.org/10.1242/jcs.102343
   PubMed Web of Science ®Google Scholar
• Kang J, Shi Y, Xiang B, Qu B, Su W, Zhu M, Zhang M, Bao G, Wang F, Zhang X, et al. A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Cell 2005; 123:833-47; PMID:16325578; http://dx.doi.org/10.1016/j.cell.2005.09.011
   PubMed Web of Science ®Google Scholar
• Scott MG, Le Rouzic E, Perianin A, Pierotti V, Enslen H, Benichou S, Marullo S, Benmerah A. Differential nucleocytoplasmic shuttling of beta-arrestins. Characterization of a leucine-rich nuclear export signal in beta-arrestin2. J Biol Chem 2002; 277:37693-701; PMID:12167659; http://dx.doi.org/10.1074/jbc.M207552200
   PubMed Web of Science ®Google Scholar
• DeFea KA, Zalevsky J, Thoma MS, Dery O, Mullins RD, Bunnett NW. beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J Cell Biol 2000; 148:1267-81; PMID:10725339; http://dx.doi.org/10.1083/jcb.148.6.1267
   PubMed Web of Science ®Google Scholar
• Mosca TJ, Schwarz TL. The nuclear import of Frizzled2-C by Importins-beta11 and alpha2 promotes postsynaptic development. Nat Neurosci 2010; 13:935-43; PMID:20601947; http://dx.doi.org/10.1038/nn.2593
   PubMed Web of Science ®Google Scholar
• Valdehita A, Bajo AM, Fernandez-Martinez AB, Arenas MI, Vacas E, Valenzuela P, Ruíz-Villaespesa A, Prieto JC, Carmena MJ. Nuclear localization of vasoactive intestinal peptide (VIP) receptors in human breast cancer. Peptides 2010; 31:2035-45; PMID:20691743; http://dx.doi.org/10.1016/j.peptides.2010.07.024
   PubMed Web of Science ®Google Scholar
• Savard M, Barbaz D, Belanger S, Muller-Esterl W, Bkaily G, D'Orleans-Juste P, Coté J, Bovenzi V, Gobeil F Jr. Expression of endogenous nuclear bradykinin B2 receptors mediating signaling in immediate early gene activation. J Cell Physiol 2008; 216:234-44; PMID:18264983; http://dx.doi.org/10.1002/jcp.21398
   PubMed Web of Science ®Google Scholar
• Charo DN, Ho M, Fajardo G, Kawana M, Kundu RK, Sheikh AY, Finsterbach TP, Leeper NJ, Ernst KV, Chen MM, et al. Endogenous regulation of cardiovascular function by apelin-APJ. Am J Physiol Heart Circ Physiol 2009; 297:H1904-13; PMID:19767528; http://dx.doi.org/10.1152/ajpheart.00686.2009
   PubMed Web of Science ®Google Scholar
• Gobeil F, Jr., Bernier SG, Vazquez-Tello A, Brault S, Beauchamp MH, Quiniou C, Marrache AM, Checchin D, Sennlaub F, Hou X, et al. Modulation of pro-inflammatory gene expression by nuclear lysophosphatidic acid receptor type-1. J Biol Chem 2003; 278:38875-83; PMID:12847111; http://dx.doi.org/10.1074/jbc.M212481200
   PubMed Web of Science ®Google Scholar
• Waters CM, Saatian B, Moughal NA, Zhao Y, Tigyi G, Natarajan V, Pyne S, Pyne NJ. Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA1) in mammalian cells. Biochem J 2006; 398:55-62; PMID:16716145; http://dx.doi.org/10.1042/BJ20060155
   PubMed Web of Science ®Google Scholar
• Estrada R, Wang L, Jala VR, Lee JF, Lin CY, Gray RD, Haribabu B, Lee MJ. Ligand-induced nuclear translocation of S1P(1) receptors mediates Cyr61 and CTGF transcription in endothelial cells. Histochem Cell Biol 2009; 131:239-49; PMID:18936953; http://dx.doi.org/10.1007/s00418-008-0521-9
   PubMed Web of Science ®Google Scholar
• Lynch JM, Henson PM. The intracellular retention of newly synthesized platelet-activating factor. J Immunol 1986; 137:2653-61; PMID:3093579
   PubMed Web of Science ®Google Scholar
• Wright CD, Wu SC, Dahl EF, Sazama AJ, O'Connell TD. Nuclear localization drives alpha1-adrenergic receptor oligomerization and signaling in cardiac myocytes. Cell Signal 2012; 24:794-802; PMID:22120526; http://dx.doi.org/10.1016/j.cellsig.2011.11.014
   PubMed Web of Science ®Google Scholar
• Bkaily G, Sleiman S, Stephan J, Asselin C, Choufani S, Kamal M, Jacques D, Gobeil F Jr, D'Orléans-Juste P. Angiotensin II AT1 receptor internalization, translocation and de novo synthesis modulate cytosolic and nuclear calcium in human vascular smooth muscle cells. Can J Physiol Pharmacol 2003; 81:274-87; PMID:12733826; http://dx.doi.org/10.1139/y03-007
   PubMed Web of Science ®Google Scholar
• Wang L, Wang Z, Yang B, Yang Q, Wang L, Sun Y. CXCR4 nuclear localization follows binding of its ligand SDF-1 and occurs in metastatic but not primary renal cell carcinoma. Oncol Rep 2009; 22:1333-9; PMID:19885584
   PubMed Web of Science ®Google Scholar
• Bkaily G, Choufani S, Hassan G, El-Bizri N, Jacques D, D'Orleans-Juste P. Presence of functional endothelin-1 receptors in nuclear membranes of human aortic vascular smooth muscle cells. J Cardiovasc Pharmacol 2000; 36:S414-7; PMID:11078437; http://dx.doi.org/10.1097/00005344-200036051-00121
   PubMed Web of Science ®Google Scholar
• Boivin B, Chevalier D, Villeneuve LR, Rousseau E, Allen BG. Functional endothelin receptors are present on nuclei in cardiac ventricular myocytes. J Biol Chem 2003; 278:29153-63; PMID:12756260; http://dx.doi.org/10.1074/jbc.M301738200
   PubMed Web of Science ®Google Scholar
• Jacques D, Descorbeth M, Abdel-Samad D, Provost C, Perreault C, Jules F. The distribution and density of ET-1 and its receptors are different in human right and left ventricular endocardial endothelial cells. Peptides 2005; 26:1427-35; PMID:16042982; http://dx.doi.org/10.1016/j.peptides.2005.03.048
   PubMed Web of Science ®Google Scholar
• Mathew D, Ataman B, Chen J, Zhang Y, Cumberledge S, Budnik V. Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2. Science 2005; 310:1344-7; PMID:16311339; http://dx.doi.org/10.1126/science.1117051
   PubMed Web of Science ®Google Scholar
• Doufexis M, Storr HL, King PJ, Clark AJ. Interaction of the melanocortin 2 receptor with nucleoporin 50: evidence for a novel pathway between a G-protein-coupled receptor and the nucleus. FASEB J 2007; 21:4095-100; PMID:17625072; http://dx.doi.org/10.1096/fj.06-7927com
   PubMed Web of Science ®Google Scholar
• Ferrandon S, Feinstein TN, Castro M, Wang B, Bouley R, Potts JT, Gardella TJ, Vilardaga JP. Sustained cyclic AMP production by parathyroid hormone receptor endocytosis. Nat Chem Biol 2009; 5:734-42; PMID:19701185; http://dx.doi.org/10.1038/nchembio.206
   PubMed Web of Science ®Google Scholar
• Benard G, Massa F, Puente N, Lourenco J, Bellocchio L, Soria-Gomez E, Matias I, Delamarre A, Metna-Laurent M, Cannich A, et al. Mitochondrial CB(1) receptors regulate neuronal energy metabolism. Nat Neurosci 2012; 15:558-64; PMID:22388959; http://dx.doi.org/10.1038/nn.3053
   PubMed Web of Science ®Google Scholar
• Sergin I, Jong Y-JI, Harmon SK, Kumar V, O'Malley KL. Sequences within the C-terminus of the metabotropic glutamate receptor, mGluR5, are responsible for inner nuclear membrane localization. J Biol Chem 2017; pii: jbc.M116.757724; PMID:28096465; http://dx.doi.org/10.1074/jbc.M116.757724
   Google Scholar