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OncoImmunology Volume 4, 2015 - Issue 5
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Restoration of defective cross-presentation in tumors by gemcitabine

Alison M McDonnellSchool of Medicine and Pharmacology; The University of Western Australia; Nedlands, WA, Australia;National Centre for Asbestos Related Diseases; Nedlands, WA, AustraliaCorrespondence[email protected]
,
W Joost LesterhuisSchool of Medicine and Pharmacology; The University of Western Australia; Nedlands, WA, Australia;National Centre for Asbestos Related Diseases; Nedlands, WA, Australia
,
Andrea KhongSchool of Medicine and Pharmacology; The University of Western Australia; Nedlands, WA, Australia;National Centre for Asbestos Related Diseases; Nedlands, WA, Australia
,
Anna K NowakSchool of Medicine and Pharmacology; The University of Western Australia; Nedlands, WA, Australia;National Centre for Asbestos Related Diseases; Nedlands, WA, Australia;Department of Medical Oncology; Sir Charles Gairdner Hospital; Nedlands, WA, Australia
,
Richard A LakeSchool of Medicine and Pharmacology; The University of Western Australia; Nedlands, WA, Australia;National Centre for Asbestos Related Diseases; Nedlands, WA, Australia
,
Andrew J CurrieSchool of Medicine and Pharmacology; The University of Western Australia; Nedlands, WA, Australia;School of Veterinary and Life Sciences, Murdoch University, Murdoch, WA, Australia
&
Bruce WS RobinsonSchool of Medicine and Pharmacology; The University of Western Australia; Nedlands, WA, Australia;National Centre for Asbestos Related Diseases; Nedlands, WA, Australia
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Article: e1005501 | Received 28 Dec 2014, Accepted 30 Dec 2014, Published online: 21 May 2015

References

  • McDonnell AM, Robinson BW, Currie AJ. Tumor antigen cross-presentation and the dendritic cell: where it all begins? Clin Dev Immunol 2010; 2010: 539519; PMID:20976125; http://dx.doi.org/10.1155/2010/539519
  • Anyaegbu CC, Lake RA, Heel K, Robinson BW, Fisher SA. Chemotherapy enhancescross-presentation of nuclear tumor antigens. PLoS One 2014; 22: 9(9).
  • Brown MD, van der Most R, Vivian JB, Lake RA, Larma I, Robinson BW, Currie AJ. Loss of antigen cross-presentation after complete tumor resection is associated with the generation of protective tumor-specific CD8(+) T-cell immunity. Oncoimmunology 2012; 1: 1084–94; PMID:23170256; http://dx.doi.org/10.4161/onci.20924
  • McDonnell AM, Currie AJ, Brown M, Kania K, Wylie B, Cleaver A, Lake R, Robinson BW. Tumor cells, rather than dendritic cells, deliver antigen to the lymph node for cross-presentation. OncoImmunology 2012; 1: 840–6; PMID:23162751; http://dx.doi.org/10.4161/onci.20493
  • Marzo AL, Kinnear BF, Lake RA, Frelinger JJ, Collins EJ, Robinson BW, Scott B. Tumor-specific CD4+ T cells have a major “post-licensing” role in CTL mediated anti-tumor immunity. J Immunol 2000; 165: 6047–55; PMID:11086036; http://dx.doi.org/10.4049/jimmunol.165.11.6047
  • McDonnell AM, Lesterhuis WJ, Khong A, Nowak AK, Lake RA, Currie AJ, Robinson BW. Tumor-infiltrating dendritic cells exhibit defective cross-presentation of tumor antigens, but is reversed by chemotherapy. Eur J Immunol doi:10.1002/eji.201444722
  • Boissonnas A, Licata F, Poupel L, Jacquelin S, Fetler L, Krumeich S, Théry C, Amigorena S, Combadière C. CD8+ tumor-infiltrating T cells are trapped in the tumor-dendritic cell network. Neoplasia 2013; 15: 85–94; PMID:23359264
  • McDonnell AM, Nowak AK, Lake RA. Contribution of the immune system to the chemotherapeutic response. Semin Immunopathol 2011; 33: 353–67; PMID:21274535; http://dx.doi.org/10.1007/s00281-011-0246-z
  • Ma Y, Adjemian S, Mattarollo SR, Yamazaki T, Aymeric L, Yang H, Portela Catani JP, Hannani D, Duret H, Steegh K, et al. Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells. Immunity 2013; 38: 729–41; PMID:23562161; http://dx.doi.org/10.1016/j.immuni.2013.03.003
  • Lesterhuis WJ, Salmons J, Nowak AK, Rozali EN, Khong A, Dick IM, Harken JA, Robinson BW, Lake RA. Synergistic effect of CTLA-4 blockade and cancer chemotherapy in the induction of anti-tumor immunity. PLoS One 2013; 23: 8(4): e61895; http://dx.doi.org/10.1371/journal.pone.0061895

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