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OncoImmunology Volume 4, 2015 - Issue 6
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CD14+ macrophage-like cells as the linchpin of cervical cancer perpetrated immune suppression and early metastatic spread: A new therapeutic lead?

A Marijne HeerenDepartment of Medical Oncology; VU University Medical Center-Cancer Center Amsterdam; De Boelelaan, Amsterdam, The Netherlands;Center Gynecological Oncology Amsterdam (CGOA); Department of Obstetrics and Gynecology; VU University Medical Center; De Boelelaan, Amsterdam, The Netherlands
,
Gemma G KenterCenter Gynecological Oncology Amsterdam (CGOA); Department of Obstetrics and Gynecology; VU University Medical Center; De Boelelaan, Amsterdam, The Netherlands;Center Gynecological Oncology Amsterdam (CGOA); Department of Gynecology; Netherlands Cancer Institute - Antoni van Leeuwenhoek; Amsterdam, The Netherlands;Center Gynecological Oncology Amsterdam (CGOA); Department of Obstetrics and Gynecology; Academic Medical Center; Amsterdam, The Netherlands
,
Ekaterina S JordanovaCenter Gynecological Oncology Amsterdam (CGOA); Department of Obstetrics and Gynecology; VU University Medical Center; De Boelelaan, Amsterdam, The Netherlands
&
Tanja D de GruijlDepartment of Medical Oncology; VU University Medical Center-Cancer Center Amsterdam; De Boelelaan, Amsterdam, The NetherlandsCorrespondence[email protected]
Article: e1009296 | Received 14 Jan 2015, Accepted 15 Jan 2015, Published online: 22 May 2015

References

  • Heeren AM, Koster BD, Samuels S, Ferns DM, Chondronasiou D, Kenter GG, Jordanova ES, de Gruijl TD. High and interrelated rates of PD-L1+CD14+ antigen-presenting cells and regulatory T cells mark the microenvironment of metastatic lymph nodes from patients with cervical Cancer. Cancer Immunol Res 2014; 3:48-58 PMID:25361854; http://dx.doi.org/10.1158/2326-6066.CIR-14-0149
  • Sombroek CC, Stam AG, Masterson AJ, Lougheed SM, Schakel MJ, Meijer CJ, Pinedo HM, van den Eerthwegh AJ, Scheper RJ, de Gruijl TD. Prostanoids play a major role in the primary tumor-induced inhibition of dendritic cell differentiation. J Immunol 2002; 168:4333-43; PMID:11970975; http://dx.doi.org/10.4049/jimmunol.168.9.4333
  • Heusinkveld M, de Vos van Steenwijk PJ, Goedemans R, Ramwadhdoube TH, Gorter A, Welters MJ, van Hall T, van der Burg SH. M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells. J Immunol 2011; 187:1157-65; PMID:21709158; http://dx.doi.org/10.4049/jimmunol.1100889
  • Lindenberg JJ, van de Ven R, Lougheed SM, Zomer A, Santegoets SJ, Griffioen AW, Hooijberg E, van den Eertwegh AJ, Thijssen VL, Scheper RJ, et al. Functional characterization of a STAT3-dependent dendritic cell-derived CD14 cell population arising upon IL-10-driven maturation. Oncoimmunology 2013; 2:e23837; PMID:23734330; http://dx.doi.org/10.4161/onci.23837
  • de Vos van Steenwijk PJ, Ramwadhdoebe TH, Goedemans R, Doorduijn M, van Ham JJ, Gorter A, van Hall T, Kuijjer ML, van Poelgeest MIE, van der Burg SH, et al. Tumor-infiltrating CD14-positive myeloid cells and CD8-positive T-cells prolong survival in patients with cervical carcinoma. Int J Cancer 2013; 133:2884-94; PMID:23740735
  • Oosterhoff D, Lougheed S, van de Ven R, Lindenberg JJ, van Cruijsen H, Hiddingh L, Kroon J, van den Eertwegh AJ, Hangalapura B, Scheper RJ et al. Tumor-mediated inhibition of human dendritic cell differentiation and function is consistently counteracted by combined p38 MAPK and STAT3 inhibition. Oncoimmunology 2012; 1:649-58; PMID:22934257; http://dx.doi.org/10.4161/onci.20365
  • Dijkgraaf EM, Heusinkveld M, Tummers B, Vogelpoel LT, Goedemans R, Jha V, Nortier JW, Welters MJ, Kroep JR, van der Burg SH. Chemotherapy alters monocyte differentiation to favor generation of cancer-supporting M2 macrophages in the tumor microenvironment. Cancer Res 2013; 73:2480-92; PMID:23436796; http://dx.doi.org/10.1158/0008-5472.CAN-12-3542
  • Jordanova ES, Gorter A, Ayachi O, Prins F, Durrant LG, Kenter GG, van der Burg SH, Fleuren GJ. Human leukocyte antigen class I, MHC class I chain-related molecule A, and CD8+/regulatory T-cell ratio: which variable determines survival of cervical cancer patients? Clin Cancer Res 2008; 14:2028-35; PMID:18381941; http://dx.doi.org/10.1158/1078-0432.CCR-07-4554
  • Battaglia A, Buzzonetti A, Baranello C, Ferrandina G, Martinelli E, Fanfani F, Scambia G, Fattorossi A. Metastatic tumour cells favour the generation of a tolerogenic milieu in tumour draining lymph node in patients with early cervical cancer. Cancer Immunol Immunother 2009; 58:1363-73; PMID:19172271; http://dx.doi.org/10.1007/s00262-008-0646-7
  • Strachan DC, Ruffell B, Oei Y, Bissell MJ, Coussens LM, Pryer N, Daniel D. CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8 T cells. Oncoimmunology 2013; 2:e26968; PMID:24498562; http://dx.doi.org/10.4161/onci.26968

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