Empowering gamma delta T cells with antitumor immunity by dendritic cell-based immunotherapy

References

• Vantourout P, Hayday A. Six-of-the-best: unique contributions of gammadelta T cells to immunology. Nat Rev Immunol 2013; 13:88-100; PMID:23348415; http://dx.doi.org/10.1038/nri3384
   PubMed Web of Science ®Google Scholar
• Hayday AC. Gammadelta T cells and the lymphoid stress-surveillance response. Immunity 2009; 31:184-96; PMID:19699170; http://dx.doi.org/10.1016/j.immuni.2009.08.006
   PubMed Web of Science ®Google Scholar
• Born WK, Kemal Aydintug M, O'Brien RL. Diversity of gammadelta T-cell antigens. Cell Mol Immunol 2013; 10:13-20; PMID:23085946; http://dx.doi.org/10.1038/cmi.2012.45
   PubMed Web of Science ®Google Scholar
• Braza MS, Klein B. Anti-tumour immunotherapy with Vgamma9Vdelta2 T lymphocytes: from the bench to the bedside. Br J Haematol 2013; 160:123-32; PMID:23061882; http://dx.doi.org/10.1111/bjh.12090
   PubMed Web of Science ®Google Scholar
• Fisher JP, Heuijerjans J, Yan M, Gustafsson K, Anderson J. gammadelta T cells for cancer immunotherapy: a systematic review of clinical trials. Oncoimmunology 2014; 3:e27572; PMID:24734216; http://dx.doi.org/10.4161/onci.27572
   PubMed Web of Science ®Google Scholar
• Anguille S, Smits EL, Lion E, van Tendeloo VF, Berneman ZN. Clinical use of dendritic cells for cancer therapy. Lancet Oncol 2014; 15:e257-e67; PMID:24872109; http://dx.doi.org/10.1016/S1470-2045(13)70585-0
   PubMed Web of Science ®Google Scholar
• Fajardo-Moser M, Berzel S, Moll H. Mechanisms of dendritic cell-based vaccination against infection. Intl J Med Microbiol 2008; 298:11-20; PMID:17719274; http://dx.doi.org/10.1016/j.ijmm.2007.07.003
   PubMed Web of Science ®Google Scholar
• Van Gulck E, Vlieghe E, Vekemans M, Van Tendeloo VF, Van De Velde A, Smits E, Anguille S, Cools N, Goossens H, Mertens L et al. mRNA-based dendritic cell vaccination induces potent antiviral T-cell responses in HIV-1-infected patients. AIDS 2012; 26:F1-12; PMID:22156965; http://dx.doi.org/10.1097/QAD.0b013e32834f33e8
   PubMed Web of Science ®Google Scholar
• Massa C, Seliger B. Fast dendritic cells stimulated with alternative maturation mixtures induce polyfunctional and long-lasting activation of innate and adaptive effector cells with tumor-killing capabilities. J Immunol 2013; 190:3328-37; PMID:23447683; http://dx.doi.org/10.4049/jimmunol.1202024
   PubMed Web of Science ®Google Scholar
• Gruenbacher G, Gander H, Rahm A, Nussbaumer W, Romani N, Thurnher M. CD56+ human blood dendritic cells effectively promote TH1-type gammadelta T-cell responses. Blood 2009; 114:4422-31; PMID:19762486; http://dx.doi.org/10.1182/blood-2009-06-227256
   PubMed Web of Science ®Google Scholar
• Ferreira LM. Gammadelta T cells: innately adaptive immune cells? Int Rev Immunol 2013; 32:223-48; PMID:23617235; http://dx.doi.org/10.3109/08830185.2013.783831
   PubMed Web of Science ®Google Scholar
• Sheridan BS, Romagnoli PA, Pham QM, Fu HH, Alonzo F, III, Schubert WD, Freitag NE, Lefrancois L. gammadelta T cells exhibit multifunctional and protective memory in intestinal tissues. Immunity 2013; 39:184-95; PMID:23890071; http://dx.doi.org/10.1016/j.immuni.2013.06.015
   PubMed Web of Science ®Google Scholar
• Jameson JM, Cruz J, Costanzo A, Terajima M, Ennis FA. A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human gammadelta T lymphocytes. Cell Immunol 2010; 264:71-7; PMID:20483407; http://dx.doi.org/10.1016/j.cellimm.2010.04.013
   PubMed Web of Science ®Google Scholar
• Zheng J, Liu Y, Lau YL, Tu W. gammadelta-T cells: an unpolished sword in human anti-infection immunity. Cell Mol Immunol 2013; 10:50-7; PMID:23064104; http://dx.doi.org/10.1038/cmi.2012.43
   PubMed Web of Science ®Google Scholar
• Morita CT, Jin C, Sarikonda G, Wang H. Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vgamma2Vdelta2 T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens. Immunol Rev 2007; 215:59-76; PMID:17291279; http://dx.doi.org/10.1111/j.1600-065X.2006.00479.x
   PubMed Web of Science ®Google Scholar
• Aswald JM, Wang XH, Aswald S, Lutynski A, Minden MD, Messner HA, Keating A. Flow cytometric assessment of autologous gammadelta T cells in patients with acute myeloid leukemia: potential effector cells for immunotherapy? Cytometry B Clin Cytom 2006; 70:379-90; PMID:16977635; http://dx.doi.org/10.1002/cyto.b.20115
   PubMed Web of Science ®Google Scholar
• Yuasa T, Sato K, Ashihara E, Takeuchi M, Maita S, Tsuchiya N, Habuchi T, Maekawa T, Kimura S. Intravesical administration of gammadelta T cells successfully prevents the growth of bladder cancer in the murine model. Cancer Immunol Immunother 2009; 58:493-502; PMID:18682944; http://dx.doi.org/10.1007/s00262-008-0571-9
   PubMed Web of Science ®Google Scholar
• Todaro M, D'Asaro M, Caccamo N, Iovino F, Francipane MG, Meraviglia S, Orlando V, La Mendola C, Gulotta G, Salerno A et al. Efficient killing of human colon cancer stem cells by gammadelta T lymphocytes. J Immunol 2009; 182:7287-96; PMID:19454726; http://dx.doi.org/10.4049/jimmunol.0804288
   PubMed Web of Science ®Google Scholar
• Bryant NL, Suarez-Cuervo C, Gillespie GY, Markert JM, Nabors LB, Meleth S, Lopez RD, Lamb LS Jr. Characterization and immunotherapeutic potential of gammadelta T-cells in patients with glioblastoma. Neuro Oncol 2009; 11:357-67; PMID:19211933; http://dx.doi.org/10.1215/15228517-2008-111
   PubMed Web of Science ®Google Scholar
• Rey J, Veuillen C, Vey N, Bouabdallah R, Olive D. Natural killer and gammadelta T cells in haematological malignancies: enhancing the immune effectors. Trends Mol Med 2009; 15:275-84; PMID:19487160; http://dx.doi.org/10.1016/j.molmed.2009.04.005
   PubMed Web of Science ®Google Scholar
• Knight A, Mackinnon S, Lowdell MW. Human Vdelta1 gamma-delta T cells exert potent specific cytotoxicity against primary multiple myeloma cells. Cytotherapy 2012; 14:1110-8; PMID:22800570; http://dx.doi.org/10.3109/14653249.2012.700766
   PubMed Web of Science ®Google Scholar
• Meraviglia S, Eberl M, Vermijlen D, Todaro M, Buccheri S, Cicero G, La Mendola C, Guggino G, D'Asaro M, Orlando V et al. In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients. Clin Exp Immunol 2010; 161:290-7; PMID:20491785
   PubMed Web of Science ®Google Scholar
• Naoe M, Ogawa Y, Takeshita K, Morita J, Shichijo T, Fuji K, Fukagai T, Iwamoto S, Terao S. Zoledronate stimulates gamma delta T cells in prostate cancer patients. Oncol Res 2010; 18:493-501; PMID:20681408; http://dx.doi.org/10.3727/096504010X12671222663638
   PubMed Web of Science ®Google Scholar
• Godder KT, Henslee-Downey PJ, Mehta J, Park BS, Chiang KY, Abhyankar S, Lamb LS. Long term disease-free survival in acute leukemia patients recovering with increased gammadelta T cells after partially mismatched related donor bone marrow transplantation. Bone Marrow Transplan 2007; 39:751-7; PMID:17450185; http://dx.doi.org/10.1038/sj.bmt.1705650
   PubMed Web of Science ®Google Scholar
• Kalyan S, Kabelitz D. Defining the nature of human gammadelta T cells: a biographical sketch of the highly empathetic. Cell Mol Immunol 2013; 10:21-9; PMID:23085947; http://dx.doi.org/10.1038/cmi.2012.44
   PubMed Web of Science ®Google Scholar
• Thedrez A, Sabourin C, Gertner J, Devilder MC, Allain-Maillet S, Fournie JJ, Scotet E, Bonneville M. Self/non-self discrimination by human gammadelta T cells: simple solutions for a complex issue? Immunol Rev 2007; 215:123-35; PMID:17291284; http://dx.doi.org/10.1111/j.1600-065X.2006.00468.x
   PubMed Web of Science ®Google Scholar
• Toutirais O, Cabillic F, Le Friec G, Salot S, Loyer P, Le Gallo M, Desille M, de La Pintiere CT, Daniel P, Bouet F et al. DNAX accessory molecule-1 (CD226) promotes human hepatocellular carcinoma cell lysis by Vgamma9Vdelta2 T cells. EurJ Immunol 2009; 39:1361-8; PMID:19404979; http://dx.doi.org/10.1002/eji.200838409
   PubMed Web of Science ®Google Scholar
• Beetz S, Marischen L, Kabelitz D, Wesch D. Human gamma delta T cells: candidates for the development of immunotherapeutic strategies. Immunol Res 2007; 37:97-111; PMID:17695246; http://dx.doi.org/10.1007/BF02685893
   PubMed Web of Science ®Google Scholar
• Brandes M, Willimann K, Moser B. Professional antigen-presentation function by human gammadelta T Cells. Science 2005; 309:264-8; PMID:15933162; http://dx.doi.org/10.1126/science.1110267
   PubMed Web of Science ®Google Scholar
• Moser B, Eberl M. gammadelta T-APCs: a novel tool for immunotherapy? Cell Mol Life Sci 2011; 68:2443-52; PMID:21573785; http://dx.doi.org/10.1007/s00018-011-0706-6
   PubMed Web of Science ®Google Scholar
• Capietto AH, Martinet L, Fournie JJ. How tumors might withstand gammadelta T-cell attack. Cell Mol Life Sci 2011; 68:2433-42; PMID:21547501; http://dx.doi.org/10.1007/s00018-011-0705-7
   PubMed Web of Science ®Google Scholar
• Martinet L, Poupot R, Fournie JJ. Pitfalls on the roadmap to gammadelta T cell-based cancer immunotherapies. Immunol Lett 2009; 124:1-8; PMID:19465238; http://dx.doi.org/10.1016/j.imlet.2009.03.011
   PubMed Web of Science ®Google Scholar
• Ye J, Ma C, Hsueh EC, Eickhoff CS, Zhang Y, Varvares MA, Hoft DF, Peng G. Tumor-derived gammadelta regulatory T cells suppress innate and adaptive immunity through the induction of immunosenescence. J Immunol 2013; 190:2403-14; PMID:23355732; http://dx.doi.org/10.4049/jimmunol.1202369
   PubMed Web of Science ®Google Scholar
• Ye J, Ma C, Wang F, Hsueh EC, Toth K, Huang Y, Mo W, Liu S, Han B, Varvares MA et al. Specific recruitment of gammadelta regulatory T cells in human breast cancer. Cancer Res 2013; 73:6137-48; PMID:23959855; http://dx.doi.org/10.1158/0008-5472.CAN-13-0348
   PubMed Web of Science ®Google Scholar
• Yi Y, He HW, Wang JX, Cai XY, Li YW, Zhou J, Cheng YF, Jin JJ, Fan J, Qiu SJ. The functional impairment of HCC-infiltrating gammadelta T cells, partially mediated by regulatory T cells in a TGFbeta- and IL-10-dependent manner. J Hepatol 2013; 58:977-83; PMID:23262246; http://dx.doi.org/10.1016/j.jhep.2012.12.015
   PubMed Web of Science ®Google Scholar
• Gaafar A, Aljurf MD, Al-Sulaiman A, Iqniebi A, Manogaran PS, Mohamed GE, Al-Sayed A, Alzahrani H, Alsharif F, Mohareb F et al. Defective gammadelta T-cell function and granzyme B gene polymorphism in a cohort of newly diagnosed breast cancer patients. Exp Hematol 2009; 37:838-48; PMID:19446661; http://dx.doi.org/10.1016/j.exphem.2009.04.003
   PubMed Web of Science ®Google Scholar
• Ni M, Martire D, Scotet E, Bonneville M, Sanchez F, Lafont V. Full restoration of Brucella-infected dendritic cell functionality through Vgamma9Vdelta2 T helper type 1 crosstalk. PloS One 2012; 7:e43613
   PubMed Web of Science ®Google Scholar
• Dunne MR, Madrigal-Estebas L, Tobin LM, Doherty DG. (E)-4-hydroxy-3-methyl-but-2 enyl pyrophosphate-stimulated Vgamma9Vdelta2 T cells possess T helper type 1-promoting adjuvant activity for human monocyte-derived dendritic cells. Cancer Immunol Immunother 2010; 59:1109-20; PMID:20306041; http://dx.doi.org/10.1007/s00262-010-0839-8
   PubMed Web of Science ®Google Scholar
• Martino A, Poccia F. Gamma delta T cells and dendritic cells: close partners and biological adjuvants for new therapies. Curr Mol Med 2007; 7:658-73; PMID:18045144; http://dx.doi.org/10.2174/156652407782564345
   PubMed Web of Science ®Google Scholar
• Casetti R, Martino A. The plasticity of gamma delta T cells: innate immunity, antigen presentation and new immunotherapy. Cell Mol Immunol 2008; 5:161-70; PMID:18582397; http://dx.doi.org/10.1038/cmi.2008.20
   PubMed Web of Science ®Google Scholar
• Takamizawa M, Fagnoni F, Mehta-Damani A, Rivas A, Engleman EG. Cellular and molecular basis of human gamma delta T cell activation. Role of accessory molecules in alloactivation. J Clin Invest 1995; 95:296-303; PMID:7814628; http://dx.doi.org/10.1172/JCI117654
   PubMed Web of Science ®Google Scholar
• Ye Z, Haley S, Gee AP, Henslee-Downey PJ, Lamb LS, Jr. In vitro interactions between gamma deltaT cells, DC, and CD4+ T cells; implications for the immunotherapy of leukemia. Cytotherapy 2002; 4:293-304; PMID:12194726; http://dx.doi.org/10.1080/146532402320219817
   PubMed Web of Science ®Google Scholar
• Devilder MC, Maillet S, Bouyge-Moreau I, Donnadieu E, Bonneville M, Scotet E. Potentiation of antigen-stimulated V gamma 9V delta 2 T cell cytokine production by immature dendritic cells (DC) and reciprocal effect on DC maturation. J Immunol 2006; 176:1386-93; PMID:16424165; http://dx.doi.org/10.4049/jimmunol.176.3.1386
   PubMed Web of Science ®Google Scholar
• Fiore F, Castella B, Nuschak B, Bertieri R, Mariani S, Bruno B, Pantaleoni F, Foglietta M, Boccadoro M, Massaia M. Enhanced ability of dendritic cells to stimulate innate and adaptive immunity on short-term incubation with zoledronic acid. Blood 2007; 110:921-7; PMID:17403919; http://dx.doi.org/10.1182/blood-2006-09-044321
   PubMed Web of Science ®Google Scholar
• Gober HJ, Kistowska M, Angman L, Jeno P, Mori L, De Libero G. Human T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells. J Exp Med 2003; 197:163-8; PMID:12538656; http://dx.doi.org/10.1084/jem.20021500
   PubMed Web of Science ®Google Scholar
• Kunzmann V, Bauer E, Feurle J, Weissinger F, Tony HP, Wilhelm M. Stimulation of gammadelta T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma. Blood 2000; 96:384-92; PMID:10887096
   PubMed Web of Science ®Google Scholar
• Soriano-Sarabia N, Sandvold H, Jomaa H, Kubin T, Bein G, Hackstein H. Primary MHC-class II(+) cells are necessary to promote resting Vdelta2 cell expansion in response to (E)-4-hydroxy-3-methyl-but-2-enyl-pyrophosphate and isopentenyl pyrophosphate. J Immunol 2012; 189:5212-22; PMID:23105138; http://dx.doi.org/10.4049/jimmunol.1200093
   PubMed Web of Science ®Google Scholar
• Martino A, Casetti R, Sacchi A, Poccia F. Central memory Vgamma9Vdelta2 T lymphocytes primed and expanded by bacillus Calmette-Guerin-infected dendritic cells kill mycobacterial-infected monocytes. J Immunol 2007; 179:3057-64; PMID:17709520; http://dx.doi.org/10.4049/jimmunol.179.5.3057
   PubMed Web of Science ®Google Scholar
• Meraviglia S, Caccamo N, Salerno A, Sireci G, Dieli F. Partial and ineffective activation of V gamma 9V delta 2 T cells by Mycobacterium tuberculosis-infected dendritic cells. J Immunol 2010; 185:1770-6; PMID:20592281; http://dx.doi.org/10.4049/jimmunol.1000966
   PubMed Web of Science ®Google Scholar
• Sacchi A, Rinaldi A, Tumino N, Casetti R, Agrati C, Turchi F, Bordoni V, Cimini E, Martini F. HIV infection of monocytes-derived dendritic cells inhibits Vgamma9Vdelta2 T cells functions. PloS One 2014; 9:e111095; PMID:25340508; http://dx.doi.org/10.1371/journal.pone.0111095
   PubMedGoogle Scholar
• von Lilienfeld-Toal M, Sievers E, Bodemuller V, Mihailescu C, Marten A, Gorschluter M, Schmidt-Wolf IG. Coculture with dendritic cells promotes proliferation but not cytotoxic activity of gamma/delta T cells. Immunol Lett 2005; 99:103-8; PMID:15894118; http://dx.doi.org/10.1016/j.imlet.2005.02.001
   PubMed Web of Science ®Google Scholar
• Van den Bergh JM, Van Tendeloo VF, Smits EL. Interleukin-15: New kid on the block for antitumor combination therapy. Cytokine Growth Factor Rev 2014; 26(1):15-24; PMID:25306466; http://dx.doi.org/10.1016/j.cytogfr.2014.09.001
   PubMed Web of Science ®Google Scholar
• Caccamo N, Meraviglia S, Ferlazzo V, Angelini D, Borsellino G, Poccia F, Battistini L, Dieli F, Salerno A. Differential requirements for antigen or homeostatic cytokines for proliferation and differentiation of human Vgamma9Vdelta2 naive, memory and effector T cell subsets. Eur J Immunol 2005; 35:1764-72; PMID:15915537; http://dx.doi.org/10.1002/eji.200525983
   PubMed Web of Science ®Google Scholar
• Harris KM. Monocytes differentiated with GM-CSF and IL-15 initiate Th17 and Th1 responses that are contact-dependent and mediated by IL-15. J Leukocyte Biol 2011; 90:727-34; PMID:21724805; http://dx.doi.org/10.1189/jlb.0311132
   PubMed Web of Science ®Google Scholar
• Anguille S, Lion E, Van den Bergh J, Van Acker HH, Willemen Y, Smits EL, Van Tendeloo VF, Berneman ZN. Interleukin-15 dendritic cells as vaccine candidates for cancer immunotherapy. Hum Vaccin Immunother 2013; 9:1956-61; PMID:23778748; http://dx.doi.org/10.4161/hv.25373
   PubMed Web of Science ®Google Scholar
• Anguille S, Smits EL, Cools N, Goossens H, Berneman ZN, Van Tendeloo VF. Short-term cultured, interleukin-15 differentiated dendritic cells have potent immunostimulatory properties. J Transl Med 2009; 7:109; PMID:20021667; http://dx.doi.org/10.1186/1479-5876-7-109
   PubMed Web of Science ®Google Scholar
• Dubsky P, Saito H, Leogier M, Dantin C, Connolly JE, Banchereau J, Palucka AK. IL-15-induced human DC efficiently prime melanoma-specific naive CD8+ T cells to differentiate into CTL. Eur J Immunol 2007; 37:1678-90; PMID:17492620; http://dx.doi.org/10.1002/eji.200636329
   PubMed Web of Science ®Google Scholar
• Jonuleit H, Kuhn U, Muller G, Steinbrink K, Paragnik L, Schmitt E, Knop J, Enk AH. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol 1997; 27:3135-42; PMID:9464798; http://dx.doi.org/10.1002/eji.1830271209
   PubMed Web of Science ®Google Scholar
• Shrestha N, Ida JA, Lubinski AS, Pallin M, Kaplan G, Haslett PA. Regulation of acquired immunity by gamma delta T-cell/dendritic-cell interactions. Ann N Y Acad Sci 2005; 1062:79-94; PMID:16461791; http://dx.doi.org/10.1196/annals.1358.011
   PubMed Web of Science ®Google Scholar
• Devilder MC, Allain S, Dousset C, Bonneville M, Scotet E. Early triggering of exclusive IFN-gamma responses of human Vgamma9Vdelta2 T cells by TLR-activated myeloid and plasmacytoid dendritic cells. J Immunol 2009; 183:3625-33; PMID:19710464; http://dx.doi.org/10.4049/jimmunol.0901571
   PubMed Web of Science ®Google Scholar
• Kunzmann V, Kretzschmar E, Herrmann T, Wilhelm M. Polyinosinic-polycytidylic acid-mediated stimulation of human gammadelta T cells via CD11c dendritic cell-derived type I interferons. Immunology 2004; 112:369-77; PMID:15196204; http://dx.doi.org/10.1111/j.1365-2567.2004.01908.x
   PubMed Web of Science ®Google Scholar
• Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, Boucontet L, Apetoh L, Ghiringhelli F, Casares N et al. Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. J Exp Med 2011; 208:491-503; PMID:21383056; http://dx.doi.org/10.1084/jem.20100269
   PubMed Web of Science ®Google Scholar
• Wakita D, Sumida K, Iwakura Y, Nishikawa H, Ohkuri T, Chamoto K, Kitamura H, Nishimura T. Tumor-infiltrating IL-17-producing gammadelta T cells support the progression of tumor by promoting angiogenesis. EurJ Immunol 2010; 40:1927-37; PMID:20397212; http://dx.doi.org/10.1002/eji.200940157
   PubMed Web of Science ®Google Scholar
• Kunzmann V, Smetak M, Kimmel B, Weigang-Koehler K, Goebeler M, Birkmann J, Becker J, Schmidt-Wolf IG, Einsele H, Wilhelm M. Tumor-promoting versus tumor-antagonizing roles of gammadelta T cells in cancer immunotherapy: results from a prospective phase I/II trial. J Immunother 2012; 35:205-13; PMID:22306909; http://dx.doi.org/10.1097/CJI.0b013e318245bb1e
   PubMed Web of Science ®Google Scholar
• Nieda M, Terunuma H, Eiraku Y, Deng X, Nicol AJ. Effective induction of melanoma-antigen-specific CD8+ T cells via Vgamma9gammadeltaT cell-expansion by CD56 Interferon-alpha-induced dendritic cells. Exp Dermatol 2014; 24(1):35-41; PMID:25363560; http://dx.doi.org/10.1111/exd.12581
   PubMed Web of Science ®Google Scholar
• Takahara M, Miyai M, Tomiyama M, Mutou M, Nicol AJ, Nieda M. Copulsing tumor antigen-pulsed dendritic cells with zoledronate efficiently enhance the expansion of tumor antigen-specific CD8+ T cells via Vgamma9gammadelta T cell activation. J Leukocyte Biol 2008; 83:742-54; PMID:18156189; http://dx.doi.org/10.1189/jlb.0307185
   PubMed Web of Science ®Google Scholar
• Traxlmayr MW, Wesch D, Dohnal AM, Funovics P, Fischer MB, Kabelitz D, Felzmann T. Immune suppression by gammadelta T-cells as a potential regulatory mechanism after cancer vaccination with IL-12 secreting dendritic cells. J Immunother 2010; 33:40-52; PMID:19952957; http://dx.doi.org/10.1097/CJI.0b013e3181b51447
   PubMed Web of Science ®Google Scholar
• Cabillic F, Toutirais O, Lavoue V, de La Pintiere CT, Daniel P, Rioux-Leclerc N, Turlin B, Monkkonen H, Monkkonen J, Boudjema K et al. Aminobisphosphonate-pretreated dendritic cells trigger successful Vgamma9Vdelta2 T cell amplification for immunotherapy in advanced cancer patients. Cancer Immunol Immunother 2010; 59:1611-9; PMID:20582413; http://dx.doi.org/10.1007/s00262-010-0887-0
   PubMed Web of Science ®Google Scholar
• Castella B, Riganti C, Fiore F, Pantaleoni F, Canepari ME, Peola S, Foglietta M, Palumbo A, Bosia A, Coscia M et al. Immune modulation by zoledronic acid in human myeloma: an advantageous cross-talk between Vgamma9Vdelta2 T cells, alphabeta CD8+ T cells, regulatory T cells, and dendritic cells. J Immunol 2011; 187:1578-90; PMID:21753152; http://dx.doi.org/10.4049/jimmunol.1002514
   PubMed Web of Science ®Google Scholar
• Thompson K, Rogers MJ. Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro. J Bone Miner Res 2004; 19:278-88; PMID:14969398; http://dx.doi.org/10.1359/JBMR.0301230
   PubMed Web of Science ®Google Scholar
• Fowler DW, Copier J, Dalgleish AG, Bodman-Smith MD. Tripartite immune cell co-operation in the Bacillus Calmette Guerin-induced activation of gammadelta T cells. Immunol Cell Biol 2013; 91:461-8; PMID:23797069; http://dx.doi.org/10.1038/icb.2013.30
   PubMed Web of Science ®Google Scholar
• Fowler DW, Copier J, Wilson N, Dalgleish AG, Bodman-Smith MD. Mycobacteria activate gammadelta T-cell anti-tumour responses via cytokines from type 1 myeloid dendritic cells: a mechanism of action for cancer immunotherapy. Cancer Immunol Immunother 2012; 61:535-47; PMID:22002242; http://dx.doi.org/10.1007/s00262-011-1121-4
   PubMed Web of Science ®Google Scholar
• Sanseverino I, Purificato C, Varano B, Conti L, Gessani S, Gauzzi MC. STAT3-silenced human dendritic cells have an enhanced ability to prime IFNgamma production by both alphabeta and gammadelta T lymphocytes. Immunobiology 2014; 219:503-11; PMID:24674241; http://dx.doi.org/10.1016/j.imbio.2014.02.012
   PubMed Web of Science ®Google Scholar
• Collins C, Wolfe J, Roessner K, Shi C, Sigal LH, Budd RC. Lyme arthritis synovial gammadelta T cells instruct dendritic cells via fas ligand. J Immunol 2005; 175:5656-65; PMID:16237055; http://dx.doi.org/10.4049/jimmunol.175.9.5656
   PubMed Web of Science ®Google Scholar
• Conti L, Casetti R, Cardone M, Varano B, Martino A, Belardelli F, Poccia F, Gessani S. Reciprocal activating interaction between dendritic cells and pamidronate-stimulated gammadelta T cells: role of CD86 and inflammatory cytokines. J Immunol 2005; 174:252-60; PMID:15611247; http://dx.doi.org/10.4049/jimmunol.174.1.252
   PubMed Web of Science ®Google Scholar
• Gordon JR, Ma Y, Churchman L, Gordon SA, Dawicki W. Regulatory dendritic cells for immunotherapy in immunologic diseases. Front Immunol 2014; 5:7; PMID:24550907; http://dx.doi.org/10.3389/fimmu.2014.00007
   PubMed Web of Science ®Google Scholar
• Kitawaki T, Kadowaki N, Fukunaga K, Kasai Y, Maekawa T, Ohmori K, Kondo T, Maekawa R, Takahara M, Nieda M et al. A phase I/IIa clinical trial of immunotherapy for elderly patients with acute myeloid leukaemia using dendritic cells co-pulsed with WT1 peptide and zoledronate. Brit J Haematol 2011; 153:796-9; PMID:21477159; http://dx.doi.org/10.1111/j.1365-2141.2010.08490.x
   PubMed Web of Science ®Google Scholar
• Dar AA, Patil RS, Chiplunkar SV. Insights into the Relationship between Toll Like Receptors and Gamma Delta T Cell Responses. Front Immunol 2014; 5:366; PMID:25132835; http://dx.doi.org/10.3389/fimmu.2014.00366
   PubMed Web of Science ®Google Scholar
• Ribot JC, Ribeiro ST, Correia DV, Sousa AE, Silva-Santos B. Human gammadelta thymocytes are functionally immature and differentiate into cytotoxic type 1 effector T cells upon IL-2/IL-15 signaling. J Immunol 2014; 192:2237-43; PMID:24489097; http://dx.doi.org/10.4049/jimmunol.1303119
   PubMed Web of Science ®Google Scholar