2,473
Views
48
CrossRef citations to date
0
Altmetric
Original Research

The immune receptor Tim-3 acts as a trafficker in a Tim-3/galectin-9 autocrine loop in human myeloid leukemia cells

, , , , , , , & show all
Article: e1195535 | Received 15 Apr 2016, Accepted 19 May 2016, Published online: 29 Jun 2016

References

  • Kikushige Y, Miyamoto T. TIM-3 as a novel therapeutic target for eradicating acute myelogenous leukemia stem cells. Int J Hematol 2013; 98:627-633; PMID:24046178; http://dx.doi.org/10.1007/s12185-013-1433-6
  • Kikushige Y, Miyamoto T. Identification of TIM-3 as a Leukemic Stem Cell Surface Molecule in Primary Acute Myeloid Leukemia. Oncology 2015; 89 Suppl 1:28-32; PMID:26551150; http://dx.doi.org/10.1159/000431062
  • Kikushige Y, Miyamoto T, Yuda J, Jabbarzadeh-Tabrizi S, Shima T, Takayanagi S, Niiro H, Yurino A, Miyawaki K, Takenaka K et al. A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression. Cell Stem Cell 2015; 17:341-352; PMID:26279267; http://dx.doi.org/10.1016/j.stem.2015.07.011
  • Gonçalves Silva I, Gibbs BF, Bardelli M, Varani L, Sumbayev VV. Differential expression and biochemical activity of the immune receptor Tim-3 in healthy and malignant human myeloid cells. Oncotarget 2015; 6:33823-33833; PMID:26413815; http://dx.doi.org/10.18632/oncotarget.5257
  • Prokhorov A, Gibbs BF, Bardelli M, Ruegg L, Fasler-Kan E, Varani L, Sumbayev VV. The immune receptor Tim-3 mediates activation of PI3 kinase/mTOR and HIF-1 pathways in human myeloid leukaemia cells. Int J Biochem Cell Biol 2015; 59:11-20; PMID:25483439; http://dx.doi.org/10.1016/j.biocel.2014.11.017
  • Ma CJ, Li GY, Cheng YQ, Wang JM, Ying RS, Shi L, Wu XY, Niki T, Hirashima M, Li CF et al. Cis association of galectin-9 with Tim-3 differentially regulates IL-12/IL-23 expressions in monocytes via TLR signaling. PLoS One 2013; 8:e72488; PMID:23967307; http://dx.doi.org/10.1371/journal.pone.0072488
  • Zhang Y, Ma CJ, Wang JM, Ji XJ, Wu XY, Moorman JP, Yao ZQ. Tim-3 regulates pro- and anti-inflammatory cytokine expression in human CD14+ monocytes. J Leukoc Biol 2012; 91:189-196; PMID:21844165; http://dx.doi.org/10.1189/jlb.1010591
  • Moller-Hackbarth K, Dewitz C, Schweigert O, Trad A, Garbers C, Rose-John S, Scheller J. A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are major sheddases of T cell immunoglobulin and mucin domain 3 (Tim-3). J Biol Chem 2013; 288:34529-34544; PMID:24121505; http://dx.doi.org/10.1074/jbc.M113.488478
  • Clayton KL, Douglas-Vail MB, Nur-ur Rahman AK, Medcalf KE, Xie IY, Chew GM, Tandon R, Lanteri MC, Norris PJ, Deeks SG et al. Soluble T cell immunoglobulin mucin domain 3 is shed from CD8+ T cells by the sheddase ADAM10, is increased in plasma during untreated HIV infection, and correlates with HIV disease progression. J Virol 2015; 89:3723-3736; PMID:25609823; http://dx.doi.org/10.1128/JVI.00006-15
  • Golden-Mason L, McMahan RH, Strong M, Reisdorph R, Mahaffey S, Palmer BE, Cheng L, Kulesza C, Hirashima M, Niki T et al. Galectin-9 functionally impairs natural killer cells in humans and mice. J Virol 2013; 87:4835-4845; PMID:23408620; http://dx.doi.org/10.1128/JVI.01085-12
  • Wang F, He W, Zhou H, Yuan J, Wu K, Xu L, Chen ZK. The Tim-3 ligand galectin-9 negatively regulates CD8+ alloreactive T cell and prolongs survival of skin graft. Cell Immunol 2007; 250:68-74; PMID:18353298; http://dx.doi.org/10.1016/j.cellimm.2008.01.006
  • Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004; 4:499-511; PMID:15229469; http://dx.doi.org/10.1038/nri1391
  • Broudy VC. Stem cell factor and hematopoiesis. Blood 1997; 90:1345-1364; PMID:9269751
  • Hsu YL, Wang MY, Ho LJ, Huang CY, Lai JH. Up-regulation of galectin-9 induces cell migration in human dendritic cells infected with dengue virus. J Cell Mol Med 2015; 19:1065-1076; PMID:25754930; http://dx.doi.org/10.1111/jcmm.12500
  • Khaznadar Z, Henry G, Setterblad N, Agaugue S, Raffoux E, Boissel N, Dombret H, Toubert A, Dulphy N. Acute myeloid leukemia impairs natural killer cells through the formation of a deficient cytotoxic immunological synapse. Eur J Immunol 2014; 44:3068-3080; PMID:25041786; http://dx.doi.org/10.1002/eji.201444500
  • Tandon R, Chew GM, Byron MM, Borrow P, Niki T, Hirashima M, Barbour JD, Norris PJ, Lanteri MC, Martin JN et al. Galectin-9 is rapidly released during acute HIV-1 infection and remains sustained at high levels despite viral suppression even in elite controllers. AIDS Res Hum Retroviruses 2014; 30:654-664; PMID:24786365; http://dx.doi.org/10.1089/aid.2014.0004
  • Chabot S, Kashio Y, Seki M, Shirato Y, Nakamura K, Nishi N, Nakamura T, Matsumoto R, Hirashima M. Regulation of galectin-9 expression and release in Jurkat T cell line cells. Glycobiology 2002; 12:111-118; PMID:11886844; http://dx.doi.org/10.1093/glycob/12.2.111
  • Yoon SJ, Lee MJ, Shin DC, Kim JS, Chwae YJ, Kwon MH, Kim K, Park S. Activation of mitogen activated protein kinase-Erk kinase (MEK) increases T cell immunoglobulin mucin domain-3 (TIM-3) transcription in human T lymphocytes and a human mast cell line. Mol Immunol 2011; 48:1778-1783; PMID:21621846; http://dx.doi.org/10.1016/j.molimm.2011.05.004
  • Sahin U, Weskamp G, Kelly K, Zhou HM, Higashiyama S, Peschon J, Hartmann D, Saftig P, Blobel CP. Distinct roles of ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J Cell Biol 2004; 164:769-779; PMID:14993236; http://dx.doi.org/10.1083/jcb.200307137
  • Porakishvili N, Roschupkina T, Kalber T, Jewell AP, Patterson K, Yong K, Lydyard PM. Expansion of CD4+ T cells with a cytotoxic phenotype in patients with B-chronic lymphocytic leukaemia (B-CLL). Clin Exp Immunol 2001; 126:29-36; PMID:11678896; http://dx.doi.org/10.1046/j.1365-2249.2001.01639.x
  • Moritoki M, Kadowaki T, Niki T, Nakano D, Soma G, Mori H, Kobara H, Masaki T, Kohno M, Hirashima M. Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3. PLoS One 2013; 8:e60807; PMID:23585851; http://dx.doi.org/10.1371/journal.pone.0060807
  • Wang C, Liu J, Wang L, Geng X. Solubilization and refolding with simultaneous purification of recombinant human stem cell factor. Appl Biochem Biotechnol 2008; 144:181-189; PMID:18456949; http://dx.doi.org/10.1007/s12010-007-8112-0
  • Yasinska IM, Gibbs BF, Lall GS, Sumbayev VV. The HIF-1 transcription complex is essential for translational control of myeloid hematopoietic cell function by maintaining mTOR phosphorylation. Cell Mol Life Sci 2014; 71:699-710; PMID:23872956; http://dx.doi.org/10.1007/s00018-013-1421-2
  • Chaplen FW, Fahl WE, Cameron DC. Detection of methylglyoxal as a degradation product of DNA and nucleic acid components treated with strong acid. Anal Biochem 1996; 236:262-269; PMID:8660503; http://dx.doi.org/10.1006/abio.1996.0165
  • Chaplen FW, Fahl WE, Cameron DC. Method for determination of free intracellular and extracellular methylglyoxal in animal cells grown in culture. Anal Biochem 1996; 238:171-178; PMID:8660607; http://dx.doi.org/10.1006/abio.1996.0271
  • Thornalley PJ. The glyoxalase system in health and disease. Mol Aspects Med 1993; 14:287-371; PMID:8277832; http://dx.doi.org/10.1016/0098-2997(93)90002-U