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PD-L1 immune suppression in cancer: Tumor cells or host cells?

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Article: e1325982 | Received 24 Apr 2017, Accepted 26 Apr 2017, Published online: 28 Jun 2017

References

  • Noguchi T, Ward JP, Gubin MM, Arthur CD, Lee SH, Hundal J, Selby MJ, Graziano RF, Mardis ER, Korman AJ et al. Temporally distinct PD-L1 expression by tumor and host cells contributes to immune escape. Cancer Immunol Res 2017; 5:106-117; PMID:28073774; https://doi.org/10.1158/2326-6066.CIR-16-0391
  • Lau J, Cheung J, Navarro A, Lianoglou S, Haley B, Totpal K, Sanders L, Koeppen H, Caplazi P, McBride J et al. Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice. Nat Commun 2017; 8:14572; PMID: 28220772; https://doi.org/10.1038/ncomms14572
  • Juneja VR, McGuire KA, Manguso RT, LaFleur MW, Collins N, Haining WN, Freeman GJ, Sharpe AH. PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity. J Exp Med 2017; 214:895-904; PMID:28302645; https://doi.org/10.1084/jem.20160801
  • Kleinovink JW, Marijt KA, Schoonderwoerd MJA, van Hall T, Ossendorp F, Fransen MF. PD-L1 expression on malignant cells is no prerequisite for checkpoint therapy. Oncoimmunology 2017; e1294299; PMID:28507803; https://doi.org/10.1080/2162402X.2017.1294299