Ex-vivo assessment of drug response on breast cancer primary tissue with preserved microenvironments

References

• Parkin DM, Fernandez LM. Use of statistics to assess the global burden of breast cancer. Breast J 2006; 12(Suppl 1):S70-80; PMID:16430400; https://doi.org/10.1111/j.1075-122X.2006.00205.x
   PubMed Web of Science ®Google Scholar
• DeRose YS, Wang G, Lin YC, Bernard PS, Buys SS, Ebbert MT, Factor R, Matsen C, Milash BA, Nelson E et al. Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes. Nat Med 2011; 17:1514-20; PMID:22019887; https://doi.org/10.1038/nm.2454
   PubMed Web of Science ®Google Scholar
• Gibson J. Anti-PD-L1 for metastatic triple-negative breast cancer. Lancet Oncol 2015; 16:e264; PMID:25936988; https://doi.org/10.1016/S1470-2045(15)70208-1
   PubMed Web of Science ®Google Scholar
• Emens LA, Braiteh FS, Cassier P, Delord J-P, Eder JP, Fasso M, Xiao Y, Wang Y, Molinero L, Chen DS et al. Abstract 2859: Inhibition of PD-L1 by MPDL3280A leads to clinical activity in patients with metastatic triple-negative breast cancer (TNBC). Cancer Res 2015; 75:2859; https://doi.org/10.1158/1538-7445.AM2015-2859
   Web of Science ®Google Scholar
• Nanda R, Chow LQ, Dees EC, Berger R, Gupta S, Geva R, Pusztai L, Pathiraja K, Aktan G, Cheng JD et al. Pembrolizumab in patients with advanced triple-negative breast cancer: Phase Ib KEYNOTE-012 study. J Clin Oncol 2016; 34:2460-7; PMID:27138582; https://doi.org/10.1200/JCO.2015.64.8931
   PubMed Web of Science ®Google Scholar
• Lieu CH, Tan AC, Leong S, Diamond JR, Eckhardt SG. From bench to bedside: Lessons learned in translating preclinical studies in cancer drug development. J Natl Cancer Inst 2013; 105:1441-56; PMID:24052618; https://doi.org/10.1093/jnci/djt209
   PubMedGoogle Scholar
• Siolas D, Hannon GJ. Patient-derived tumor xenografts: Transforming clinical samples into mouse models. Cancer Res 2013; 73:5315-9; PMID:23733750; https://doi.org/10.1158/0008-5472.CAN-13-1069
   PubMed Web of Science ®Google Scholar
• Gould SE, Junttila MR, de Sauvage FJ. Translational value of mouse models in oncology drug development. Nature Med 2015; 21:431-9; PMID:25951530; https://doi.org/10.1038/nm.3853
   PubMed Web of Science ®Google Scholar
• Mele V, Muraro MG, Calabrese D, Pfaff D, Amatruda N, Amicarella F, Kvinlaug B, Bocelli-Tyndall C, Martin I, Resink TJ et al. Mesenchymal stromal cells induce epithelial-to-mesenchymal transition in human colorectal cancer cells through the expression of surface-bound TGF-beta. Int J Cancer 2014; 134:2583-94; PMID:24214914; https://doi.org/10.1002/ijc.28598
   PubMed Web of Science ®Google Scholar
• Ingber DE. Cancer as a disease of epithelial-mesenchymal interactions and extracellular matrix regulation. Differentiation 2002; 70:547-60; PMID:12492496; https://doi.org/10.1046/j.1432-0436.2002.700908.x
   PubMed Web of Science ®Google Scholar
• Correia AL, Bissell MJ. The tumor microenvironment is a dominant force in multidrug resistance. Drug Resist Updat 2012; 15:39-49; PMID:22335920; https://doi.org/10.1016/j.drup.2012.01.006
   PubMed Web of Science ®Google Scholar
• Junttila MR, de Sauvage FJ. Influence of tumour micro-environment heterogeneity on therapeutic response. Nature 2013; 501:346-54; PMID:24048067; https://doi.org/10.1038/nature12626
   PubMed Web of Science ®Google Scholar
• Cerino G, Gaudiello E, Grussenmeyer T, Melly L, Massai D, Banfi A, Martin I, Eckstein F, Grapow M, Marsano A. Three dimensional multi-cellular muscle-like tissue engineering in perfusion-based bioreactors. Biotechnol Bioeng 2015; 113(1):226-36; PMID:26126766; https://doi.org/10.1002/bit.25688
   PubMed Web of Science ®Google Scholar
• Santoro R, Olivares AL, Brans G, Wirz D, Longinotti C, Lacroix D, Martin I, Wendt D. Bioreactor based engineering of large-scale human cartilage grafts for joint resurfacing. Biomaterials 2010; 31:8946-52; PMID:20800280; https://doi.org/10.1016/j.biomaterials.2010.08.009
   PubMed Web of Science ®Google Scholar
• Scherberich A, Galli R, Jaquiery C, Farhadi J, Martin I. Three-dimensional perfusion culture of human adipose tissue-derived endothelial and osteoblastic progenitors generates osteogenic constructs with intrinsic vascularization capacity. Stem Cells 2007; 25:1823-9; PMID:17446558; https://doi.org/10.1634/stemcells.2007-0124
   PubMed Web of Science ®Google Scholar
• Martin I, Wendt D, Heberer M. The role of bioreactors in tissue engineering. Trends Biotechnol 2004; 22:80-6; PMID:14757042; https://doi.org/10.1016/j.tibtech.2003.12.001
   PubMed Web of Science ®Google Scholar
• Radisic M, Euloth M, Yang L, Langer R, Freed LE, Vunjak-Novakovic G. High-density seeding of myocyte cells for cardiac tissue engineering. Biotechnol Bioeng 2003; 82:403-14; PMID:12632397; https://doi.org/10.1002/bit.10594
   PubMed Web of Science ®Google Scholar
• Sabatino MA, Santoro R, Gueven S, Jaquiery C, Wendt DJ, Martin I, Moretti M, Barbero A. Cartilage graft engineering by co-culturing primary human articular chondrocytes with human bone marrow stromal cells. J Tissue Eng Regen Med 2012; 9(12):1394-403; PMID:23225781; https://doi.org/10.1002/term.1661
   PubMed Web of Science ®Google Scholar
• Hirt C, Papadimitropoulos A, Muraro MG, Mele V, Panopoulos E, Cremonesi E, Ivanek R, Schultz-Thater E, Droeser RA, Mengus C et al. Bioreactor-engineered cancer tissue-like structures mimic phenotypes, gene expression profiles and drug resistance patterns observed “in vivo.” Biomaterials 2015; 62:138-46; PMID:26051518; https://doi.org/10.1016/j.biomaterials.2015.05.037
   PubMed Web of Science ®Google Scholar
• Fong EL, Santoro M, Farach-Carson MC, Kasper FK, Mikos AG. Tissue engineering perfusable cancer models. Curr Opin Chem Eng 2014; 3:112-7; PMID:24634812; https://doi.org/10.1016/j.coche.2013.12.008
   PubMed Web of Science ®Google Scholar
• Santoro M, Lamhamedi-Cherradi SE, Menegaz BA, Ludwig JA, Mikos AG. Flow perfusion effects on three-dimensional culture and drug sensitivity of ewing sarcoma. Proc Natl Acad Sci U S A 2015; 112:10304-9; PMID:26240353; https://doi.org/10.1073/pnas.1506684112
   PubMed Web of Science ®Google Scholar
• Hsieh CH, Chen YD, Huang SF, Wang HM, Wu MH. The effect of primary cancer cell culture models on the results of drug chemosensitivity assays: the application of perfusion microbioreactor system as cell culture vessel. Biomed Res Int 2015; 2015:470283; PMID:25654105; https://doi.org/10.1155/2015/470283
   PubMed Web of Science ®Google Scholar
• Majumder B, Baraneedharan U, Thiyagarajan S, Radhakrishnan P, Narasimhan H, Dhandapani M, Brijwani N, Pinto DD, Prasath A, Shanthappa BU et al. Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity. Nat Commun 2015; 6:6169; PMID:25721094; https://doi.org/10.1038/ncomms7169
   PubMed Web of Science ®Google Scholar
• Bissell MJ, Radisky D. Putting tumours in context. Nat Rev Cancer 2001; 1:46-54; PMID:11900251; https://doi.org/10.1038/35094059
   PubMed Web of Science ®Google Scholar
• Weigelt B, Bissell MJ. Unraveling the microenvironmental influences on the normal mammary gland and breast cancer. Semin Cancer Biol 2008; 18:311-21; PMID:18455428; https://doi.org/10.1016/j.semcancer.2008.03.013
   PubMed Web of Science ®Google Scholar
• Hirt C, Papadimitropoulos A, Mele V, Muraro MG, Mengus C, Iezzi G, Terracciano L, Martin I, Spagnoli GC. “In vitro” 3D models of tumor-immune system interaction. Adv Drug Deliv Rev 2014; 79-80:145-54; PMID:24819215; https://doi.org/10.1016/j.addr.2014.05.003
   PubMed Web of Science ®Google Scholar
• Guven S, Mehrkens A, Saxer F, Schaefer DJ, Martinetti R, Martin I, Scherberich A. Engineering of large osteogenic grafts with rapid engraftment capacity using mesenchymal and endothelial progenitors from human adipose tissue. Biomaterials 2011; 32:5801-9; PMID:21605897; https://doi.org/10.1016/j.biomaterials.2011.04.064
   PubMed Web of Science ®Google Scholar
• Zardavas D, Irrthum A, Swanton C, Piccart M. Clinical management of breast cancer heterogeneity. Nat Rev Clin Oncol 2015; 12:381-94; PMID:25895611; https://doi.org/10.1038/nrclinonc.2015.73
   PubMed Web of Science ®Google Scholar
• Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E, Martinez P, Matthews N, Stewart A, Tarpey P et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 2012; 366:883-92; PMID:22397650; https://doi.org/10.1056/NEJMoa1113205
   PubMed Web of Science ®Google Scholar
• Shah SP, Roth A, Goya R, Oloumi A, Ha G, Zhao Y, Turashvili G, Ding J, Tse K, Haffari G et al. The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature 2012; 486:395-9; PMID:22495314; https://doi.org/10.1038/nature10933
   PubMed Web of Science ®Google Scholar
• Navin N, Kendall J, Troge J, Andrews P, Rodgers L, McIndoo J, Cook K, Stepansky A, Levy D, Esposito D et al. Tumour evolution inferred by single-cell sequencing. Nature 2011; 472:90-4; PMID:21399628; https://doi.org/10.1038/nature09807
   PubMed Web of Science ®Google Scholar
• Yachida S, Jones S, Bozic I, Antal T, Leary R, Fu B, Kamiyama M, Hruban RH, Eshleman JR, Nowak MA et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 2010; 467:1114-7; PMID:20981102; https://doi.org/10.1038/nature09515
   PubMed Web of Science ®Google Scholar
• Moya-Horno I, Cortes J. The expanding role of pertuzumab in the treatment of HER2-positive breast cancer. Breast Cancer (Dove Med Press) 2015; 7:125-32. PMID:26056489; https://doi.org/10.2147/BCTT.S61579
   PubMed Web of Science ®Google Scholar
• Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, Powderly JD, Carvajal RD, Sosman JA, Atkins MB et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012; 366:2443-54; PMID:22658127; https://doi.org/10.1056/NEJMoa1200690
   PubMed Web of Science ®Google Scholar
• Muenst S, Soysal SD, Tzankov A, Hoeller S. The PD-1/PD-L1 pathway: Biological background and clinical relevance of an emerging treatment target in immunotherapy. Expert Opin Ther Targets 2015; 19:201-11; PMID:25491730; https://doi.org/10.1517/14728222.2014.980235
   PubMed Web of Science ®Google Scholar
• Nanda R CL, Dees E. A phase Ib study of pembrolizumab (MK-3475) in patients with advanced triple-negative breast cancer. Presented at 2014 San Antonio Breast Cancer Symposium 2014:Dec 9–13. Journal of Clinical Oncology 34, no. 21 (July 2016) 2460-2467; https://doi.org/10.1200/JCO.2015.64.8931
   Google Scholar
• Franco NH, Olsson IA. Scientists and the 3 Rs: Attitudes to animal use in biomedical research and the effect of mandatory training in laboratory animal science. Lab Anim 2014; 48:50-60; PMID:23940123; https://doi.org/10.1177/0023677213498717
   PubMed Web of Science ®Google Scholar
• Wendt D, Stroebel S, Jakob M, John GT, Martin I. Uniform tissues engineered by seeding and culturing cells in 3D scaffolds under perfusion at defined oxygen tensions. Biorheology 2006; 43:481-8; PMID:16912419
   PubMed Web of Science ®Google Scholar
• Cioffi M, Kuffer J, Strobel S, Dubini G, Martin I, Wendt D. Computational evaluation of oxygen and shear stress distributions in 3D perfusion culture systems: Macro-scale and micro-structured models. J Biomech 2008; 41:2918-25; PMID:18789444; https://doi.org/10.1016/j.jbiomech.2008.07.023
   PubMed Web of Science ®Google Scholar
• Braccini A, Wendt D, Jaquiery C, Jakob M, Heberer M, Kenins L, Wodnar-Filipowicz A, Quarto R, Martin I. Three-dimensional perfusion culture of human bone marrow cells and generation of osteoinductive grafts. Stem Cells 2005; 23:1066-72; PMID:16002780; https://doi.org/10.1634/stemcells.2005-0002
   PubMed Web of Science ®Google Scholar
• Radisic M, Deen W, Langer R, Vunjak-Novakovic G. Mathematical model of oxygen distribution in engineered cardiac tissue with parallel channel array perfused with culture medium containing oxygen carriers. Am J Physiol Heart Circ Physiol 2005; 288:H1278-89; PMID:15539422; https://doi.org/10.1152/ajpheart.00787.2004
   PubMed Web of Science ®Google Scholar
• Hutcheson IR, Goddard L, Barrow D, McClelland RA, Francies HE, Knowlden JM, Nicholson RI, Gee JM. Fulvestrant-induced expression of ErbB3 and ErbB4 receptors sensitizes oestrogen receptor-positive breast cancer cells to heregulin beta1. Breast Cancer Res 2011; 13:R29; PMID:21396094; https://doi.org/10.1186/bcr2848
   PubMed Web of Science ®Google Scholar
• Dacheva D, Dodova R, Popov I, Goranova T, Mitkova A, Mitev V, Kaneva R. Validation of an NGS approach for diagnostic BRCA1/BRCA2 mutation testing. Mol Diagn Ther 2015; 19:119-30; PMID:25893891; https://doi.org/10.1007/s40291-015-0136-5
   PubMed Web of Science ®Google Scholar
• Simen BB, Yin L, Goswami CP, Davis KO, Bajaj R, Gong JZ, Peiper SC, Johnson ES, Wang ZX. Validation of a next-generation-sequencing cancer panel for use in the clinical laboratory. Arch Pathol Lab Med 2015; 139:508-17; PMID:25356985; https://doi.org/10.5858/arpa.2013-0710-OA
   PubMed Web of Science ®Google Scholar
• Cibulskis K, Lawrence MS, Carter SL, Sivachenko A, Jaffe D, Sougnez C, Gabriel S, Meyerson M, Lander ES, Getz G. Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Nat Biotechnol 2013; 31:213-9; PMID:23396013; https://doi.org/10.1038/nbt.2514
   PubMed Web of Science ®Google Scholar
• Koboldt DC, Zhang Q, Larson DE, Shen D, McLellan MD, Lin L, Miller CA, Mardis ER, Ding L, Wilson RK. VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing. Genome Res 2012; 22:568-76; PMID:22300766; https://doi.org/10.1101/gr.129684.111
   PubMed Web of Science ®Google Scholar
• Saunders CT, Wong WS, Swamy S, Becq J, Murray LJ, Cheetham RK. Strelka: Accurate somatic small-variant calling from sequenced tumor-normal sample pairs. Bioinformatics 2012; 28:1811-7; PMID:22581179; https://doi.org/10.1093/bioinformatics/bts271
   PubMed Web of Science ®Google Scholar
• Narzisi G, O'Rawe JA, Iossifov I, Fang H, Lee YH, Wang Z, Wu Y, Lyon GJ, Wigler M, Schatz MC. Accurate de novo and transmitted indel detection in exome-capture data using microassembly. Nat Methods 2014; 11:1033-6; PMID:25128977; https://doi.org/10.1038/nmeth.3069
   PubMed Web of Science ®Google Scholar
• Robinson JT, Thorvaldsdottir H, Winckler W, Guttman M, Lander ES, Getz G, Mesirov JP. Integrative genomics viewer. Nat Biotechnol 2011; 29:24-6; PMID:21221095; https://doi.org/10.1038/nbt.1754
   PubMed Web of Science ®Google Scholar