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Brief Report

Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4+ T cells in cutaneous T-cell lymphoma

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Article: e1641387 | Received 26 Apr 2019, Accepted 02 Jul 2019, Published online: 17 Jul 2019

References

  • Willemze R, Jaffe ES, Burg G, Cerroni L, Berti E, Swerdlow SH, Ralfkiaer E, Chimenti S, Diaz-Perez JL, Duncan LM, et al. WHO-EORTC classification for cutaneous lymphomas. Blood. 2005;105:3768–3785. doi:10.1182/blood-2004-09-3502.
  • Blaizot R, Ouattara E, Fauconneau A, Beylot-Barry M, Pham-Ledard A. Infectious events and associated risk factors in Mycosis Fungoides/Sézary syndrome: a retrospective cohort study. Br J Dermatol. 2018. doi:10.1111/bjd.17073.
  • Odum N, Lindahl LM, Wod M, Krejsgaard T, Skytthe A, Woetmann A, Iversen L, Christensen K. Investigating heredity in cutaneous T-cell lymphoma in a unique cohort of Danish twins. Blood Cancer J. 2017;7:e517–e517. doi:10.1038/bcj.2016.128.
  • Axelrod PI, Lorber B, Vonderheid EC. Infections complicating mycosis fungoides and sézary syndrome. JAMA. 1992;267:1354–1358. doi:10.1001/jama.267.4.507b.
  • Jackow CM, Cather JC, Hearne V, Asano AT, Musser JM, Duvic M. Association of erythrodermic cutaneous T-cell lymphoma, superantigen-positive Staphylococcus aureus, and oligoclonal T-cell receptor V beta gene expansion. Blood. 1997;89:32–40.
  • Nguyen V, Huggins RH, Lertsburapa T, Bauer K, Rademaker A, Gerami P, Guitart J. Cutaneous T-cell lymphoma and Staphylococcus aureus colonization. J Am Acad Dermatol. 2008;59:949–952. doi:10.1016/j.jaad.2008.08.030.
  • Fanok MH, Sun A, Fogli LK, Narendran V, Echstein M, Kannan K, Dolgalev I, Lazaris C, Heguy A, Laird ME, et al. Role of dysregulated cytokine signaling and bacterial triggers in the pathogenesis of cutaneous T-cell lymphoma. J Invest Dermatol. 2018;138:1116–1125. doi:10.1016/j.jid.2017.11.021.
  • Tokura Y, Yagi H, Ohshima A, Kurokawa S, Wakita H, Yokote R, Shirahama S, Flirukawa F, Takigawa M. Cutaneous colonization with staphylococci influences the disease activity of Sézary syndrome: a potential role for bacterial superantigens. Br J Dermatol. 1995;133:6–12. doi:10.1111/j.1365-2133.1995.tb02485.x.
  • Talpur R, Bassett R, Duvic M. Prevalence and treatment of Staphylococcus aureus colonization in patients with mycosis fungoides and Sézary syndrome. Br J Dermatol. 2008;159:105–112. doi:10.1111/j.1365-2133.2008.08612.x.
  • Willerslev-Olsen A, Krejsgaard T, Lindahl L, Bonefeld C, Wasik M, Koralov S, Geisler C, Kilian M, Iversen L, Woetmann A, et al. Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma. Toxins. 2013;5:1402–1421. doi:10.3390/toxins5081402.
  • Grumann D, Nübel U, Bröker BM. Staphylococcus aureus toxins – their functions and genetics. Infect Genet Evol. 2014;21:583–592. doi:10.1016/j.meegid.2013.03.013.
  • Krejsgaard T, Willerslev-Olsen A, Lindahl LM, Bonefeld CM, Koralov SB, Geisler C, Wasik MA, Gniadecki R, Kilian M, Iversen L, et al. Staphylococcal enterotoxins stimulate lymphoma-associated immune dysregulation. Blood. 2014;124:761–770. doi:10.1182/blood-2014-01-551184.
  • Willerslev-Olsen A, Krejsgaard T, Lindahl LM, Litvinov IV, Fredholm S, Petersen DL, Nastasi C, Gniadecki R, Mongan NP, Sasseville D, et al. Staphylococcal enterotoxin A (SEA) stimulates STAT3 activation and IL-17 expression in cutaneous T-cell lymphoma. Blood. 2016;127:1287–1296. doi:10.1182/blood-2015-08-662353.
  • Berube BJ, Bubeck Wardenburg J. Staphylococcus aureus α-toxin: nearly a century of intrigue. Toxins. 2013;5:1140–1166. doi:10.3390/toxins5061140.
  • Wilke GA, Wardenburg JB. Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus α-hemolysin–mediated cellular injury. Proc Natl Acad Sci. 2010;107:13473–13478. doi:10.1073/pnas.1001815107.
  • Virreira Winter S, Zychlinsky A, Bardoel BW. Genome-wide CRISPR screen reveals novel host factors required for Staphylococcus aureus α-hemolysin-mediated toxicity. Sci Rep. 2016;6:24242. doi:10.1038/srep24242.
  • Husmann M, Beckmann E, Boller K, Kloft N, Tenzer S, Bobkiewicz W, Neukirch C, Bayley H, Bhakdi S. Elimination of a bacterial pore-forming toxin by sequential endocytosis and exocytosis. FEBS Lett. 2009;583:337–344. doi:10.1016/j.febslet.2008.12.028.
  • Valeva A, Walev I, Pinkernell M, Walker B, Bayley H, Palmer M, Bhakdi S. Transmembrane β-barrel of staphylococcal α-toxin forms in sensitive but not in resistant cells. Proc Natl Acad Sci. 1997;94:11607–11611. doi:10.1073/pnas.94.21.11607.
  • Walev I, Palmer M, Martin E, Jonas D, Weller U, Höhn-Bentz H, Husmann M, Bhakdi S. Recovery of human fibroblasts from attack by the pore-forming alpha-toxin of Staphylococcus aureus. Microb Pathog. 1994;17:187–201. doi:10.1006/mpat.1994.1065.
  • Russo MJ, Bayley H, Toner M. Reversible permeabilization of plasma membranes with an engineered switchable pore. Nat Biotechnol. 1997;15:5.doi: 10.1038/nbt0397-278.
  • Gibson JF, Huang J, Liu KJ, Carlson KR, Foss F, Choi J, Edelson R, Hussong JW, Mohl R, Hill S, et al. Cutaneous T cell lymphoma: current practices in blood assessment and the utility of T-cell receptor Vβ chain restriction. J Am Acad Dermatol. 2016;74:870–877. doi:10.1016/j.jaad.2015.12.018.
  • Nygaard TK, Pallister KB, DuMont AL, DeWald M, Watkins RL, Pallister EQ, Malone C, Griffith S, Horswill AR, Torres VJ, et al. Alpha-toxin induces programmed cell death of human T cells, B cells, and monocytes during USA300 infection. PLoS One. 2012;7:e36532. doi:10.1371/journal.pone.0036532.
  • Macia E, Ehrlich M, Massol R, Boucrot E, Brunner C, Kirchhausen T. Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell. 2006;10:839–850. doi:10.1016/j.devcel.2006.04.002.
  • Yoshimura M, Namiira S, Akamatsu H, Horio T. Antimicrobial effects of phototherapy and photochemotherapy in vivo and in vitro. Br J Dermatol. 1996;135:528–532. doi:10.1111/j.1365-2133.1996.tb03825.x.
  • Vieyra-Garcia P, Fink-Puches R, Porkert S, Lang R, Pöchlauer S, Ratzinger G, Tanew A, Selhofer S, Paul-Gunther S, Hofer A, et al. Evaluation of low-dose, low-frequency oral psoralen–UV-A treatment with or without maintenance on early-stage mycosis fungoides: a randomized clinical trial. JAMA Dermatol. 2019;155:538. doi:10.1001/jamadermatol.2018.5905.
  • Woetmann A, Lovato P, Eriksen KW, Krejsgaard T, Labuda T, Zhang Q, Mathiesen AM, Geisler C, Svejgaard A, Wasik MA, et al. Nonmalignant T cells stimulate growth of T-cell lymphoma cells in the presence of bacterial toxins. Blood. 2007;109:3325–3332. doi:10.1182/blood-2006-02-004234.
  • Ruzin A, Wu Y, Yu L, Yu X-Q, Tabor DE, Mok H, Tkaczyk C, Jensen K, Bellamy T, Roskos L, et al. Characterisation of anti-alpha toxin antibody levels and colonisation status after administration of an investigational human monoclonal antibody, MEDI4893, against Staphylococcus aureus alpha toxin. Clin Transl Immunol. 2018;7:e1009. doi:10.1002/cti2.1009.
  • Kullander J, Forslund O, Dillner J. Staphylococcus aureus and squamous cell carcinoma of the skin. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol. 2009;18:472–478. doi:10.1158/1055-9965.EPI-08-0905.
  • Kaltoft K, Bisballe S, Rasmussen HF, Thestrup-Pedersen K, Thomsen K, Sterry W. A continuous T-cell line from a patient with Sézary syndrome. Arch Dermatol Res. 1987;279:293–298. doi:10.1007/BF00431220.
  • Abrams JT, Lessin S, Ghosh SK, Ju W, Vonderheid EC, Nowell P, Murphy G, Elfenbein B, DeFreitas E. A clonal CD4-positive T-cell line established from the blood of a patient with sézary syndrome. J Invest Dermatol. 1991;96:31–37. doi:10.1111/1523-1747.ep12514693.
  • Davis TH, Morton CC, Miller-Cassman R, Balk SP, Kadin ME. Hodgkin’s disease, lymphomatoid papulosis, and cutaneous T-cell lymphoma derived from a common T-cell clone. N Engl J Med. 1992;326:1115–1122. doi:10.1056/NEJM199204233261704.
  • Netchiporouk E, Gantchev J, Tsang M, Thibault P, Watters AK, Hughes J-DM, Ghazawi FM, Woetmann A, Ødum N, Sasseville D, et al. Analysis of CTCL cell lines reveals important differences between mycosis fungoides/Sézary syndrome vs. HTLV-1+ leukemic cell lines. Oncotarget. 2017;8:95981–95998. doi:10.18632/oncotarget.v8i56.
  • Surewaard BGJ, Thanabalasuriar A, Zeng Z, Tkaczyk C, Cohen TS, Bardoel BW, Jorch SK, Deppermann C, Bubeck Wardenburg J, Davis RP, et al. α-toxin induces platelet aggregation and liver injury during staphylococcus aureus sepsis. Cell Host Microbe. 2018;24:271–284.e3. doi:10.1016/j.chom.2018.06.017.
  • Buus, TB, Willerslev-Olsen A, Fredholm S, Blümel E, Nastasi C, Gluud M, Hu T, Lindahl LM, Iversen L, Fogh H, et al. Single-cell heterogeneity in Sézary syndrome. Blood advances. 2018;2:12.doi: 10.1182/bloodadvances.2018022608
  • Kaltoft K, Bisballe S, Dyrberg T, Boel E, Rasmussen PB, Thestrup-Pedersen K. Establishment of two continuous T-cell strains from a single plaque of a patient with mycosis fungoides. Vitro Cell Dev Biol J Tissue Cult Assoc. 1992;28A:161–167. doi:10.1007/BF02631086.