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OncoImmunology Volume 13, 2024 - Issue 1
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Commentary

Immunogenic oncolysis by tigilanol tiglate

Jonathan G. Pola Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris Cité, Sorbonne Université, Paris, France;b Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, FranceCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8355-7562View further author information
ORCID Icon,
Manuela Lizarralde-Guerreroa Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris Cité, Sorbonne Université, Paris, France;b Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France;c Université Paris-Saclay, Faculté de Médecine, Kremlin-Bicêtre, FranceORCID Iconhttps://orcid.org/0009-0004-0737-0941View further author information
ORCID Icon &
Guido Kroemera Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris Cité, Sorbonne Université, Paris, France;b Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France;d Department of Biology, Hôpital Européen Georges Pompidou AP-HP, Institut du Cancer Paris CARPEM, Paris, FranceCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9334-4405View further author information
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Article: 2360230 | Received 20 May 2024, Accepted 22 May 2024, Published online: 27 May 2024

References

  • Kroemer G, Chan TA, Eggermont AMM, Galluzzi L. Immunosurveillance in clinical cancer management. CA Cancer J Clin. 2024;74(2):187–3. doi:10.3322/caac.21818.
  • Catanzaro E, Demuynck R, Naessens F, Galluzzi L, Krysko DV. Immunogenicity of ferroptosis in cancer: a matter of context? Trends Cancer. 2024;10(5):407–416. doi:10.1016/j.trecan.2024.01.013.
  • Meier P, Legrand AJ, Adam D, Silke J. Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity. Nat Rev Cancer. 2024;24(5):299–315. doi:10.1038/s41568-024-00674-x.
  • Kepp O, Marabelle A, Zitvogel L, Kroemer G. Oncolysis without viruses – inducing systemic anticancer immune responses with local therapies. Nat Rev Clin Oncol. 2020;17(1):49–64. doi:10.1038/s41571-019-0272-7.
  • Yamazaki T, Pitt JM, Vetizou M, Marabelle A, Flores C, Rekdal Ø, Kroemer G, Zitvogel L. The oncolytic peptide LTX-315 overcomes resistance of cancers to immunotherapy with CTLA4 checkpoint blockade. Cell Death Differ. 2016;23(6):1004–1015. doi:10.1038/cdd.2016.35.
  • Xie W, Mondragon L, Mauseth B, Wang Y, Pol J, Levesque S, Zhou H, Yamazaki T, Eksteen JJ, Zitvogel L. et al. Tumor lysis with LTX-401 creates anticancer immunity. Oncoimmunol. 2019;8(7):1594555. doi:10.1080/2162402X.2019.1594555.
  • Shalhout SZ, Miller DM, Emerick KS, Kaufman HL. Therapy with oncolytic viruses: progress and challenges. Nat Rev Clin Oncol. 2023;20(3):160–177. doi:10.1038/s41571-022-00719-w.
  • Panizza BJ, de Souza P, Cooper A, Roohullah A, Karapetis CS, Lickliter JD. Phase I dose-escalation study to determine the safety, tolerability, preliminary efficacy and pharmacokinetics of an intratumoral injection of tigilanol tiglate (EBC-46). EBioMedicine. 2019;50:433–441. doi:10.1016/j.ebiom.2019.11.037.
  • Cullen JK, Yap PY, Ferguson B, Bruce ZC, Koyama M, Handoko H, Hendrawan K, Simmons JL, Brooks KM, Johns J. et al. Tigilanol tiglate is an oncolytic small molecule that induces immunogenic cell death and enhances the response of both target and non-injected tumors to immune checkpoint blockade. J Immunother Cancer. 2024;12(4):12. doi:10.1136/jitc-2022-006602.
  • Sharma P, Goswami S, Raychaudhuri D, Siddiqui BA, Singh P, Nagarajan A, Liu J, Subudhi SK, Poon C, Gant KL. et al. Immune checkpoint therapy—current perspectives and future directions. Cell. 2023;186(8):1652–1669. doi:10.1016/j.cell.2023.03.006.

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