OncoImmunology, Volume 13, Issue 1 (2024)

Browse this journal
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

OncoImmunology, Volume 13, Issue 1 (2024)

See all volumes and issues
Volume 13, 2024 Vol 12, 2023 Vol 11, 2022 Vol 10, 2021 Vol 9, 2020 Vol 8, 2019 Vol 7, 2018 Vol 6, 2017 Vol 5, 2016 Vol 4, 2015 Vol 3, 2014 Vol 2, 2013 Vol 1, 2012
Download citations Download PDFs

Original research

Article
Activation of endogenous glucocorticoids by HSD11B1 inhibits the antitumor immune response in renal cancer
Hélène Poinot, Eloïse Dupuychaffray, Grégoire Arnoux, Montserrat Alvarez, Jérémie Tachet, Ounss Ezzar, Jonathan Moore, Olivia Bejuy, Eulalia Olesti, Gioele Visconti, Víctor González-Ruiz, Serge Rudaz, Jean-Christophe Tille, Clarissa D. Voegel, Patrycja Nowak-Sliwinska, Carole Bourquin & Aurélien Pommier
Article: 2286820
Published online: 30 Nov 2023
AbstractforActivation of endogenous glucocorticoids by HSD11B1 inhibits the antitumor immune response in renal cancer | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 1657 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
PD-L1-expressing natural killer cells predict favorable prognosis and response to PD-1/PD-L1 blockade in neuroblastoma
Mengjia Song, Yue Huang, Ye Hong, Juan Liu, Jia Zhu, Suying Lu, Juan Wang, Feifei Sun, Junting Huang, Jiaqian Xu, Yan Tang, Jian-Chuan Xia & Yizhuo Zhang
Article: 2289738
Published online: 01 Dec 2023
AbstractforPD-L1-expressing natural killer cells predict favorable prognosis and response to PD-1/PD-L1 blockade in neuroblastoma | Full Text | References | PDF (6.7 MB) | EPUB | Supplemental
  • 1712 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
A phase 2, multicenter, open-label study of anti-LAG-3 ieramilimab in combination with anti-PD-1 spartalizumab in patients with advanced solid malignancies
Chia-Chi Lin, Elena Garralda, Patrick Schöffski, David S. Hong, Lillian L. Siu, Miguel Martin, Michela Maur, Rina Hui, Ross A Soo, Joanne Chiu, Tian Zhang, Brigette Ma, Chrisann Kyi, Daniel SW Tan, Philippe A. Cassier, John Sarantopoulos, Andrew Weickhardt, Richard D. Carvajal, Jennifer Spratlin, Taito Esaki, Fréderic Rolland, Wallace Akerley, Barbara Deschler-Baier, Lawrence Rispoli, Tanay S. Samant, Niladri Roy Chowdhury, Daniel Gusenleitner, Eunice L. Kwak, Vasileios Askoxylakis & Filippo De Braud
Article: 2290787
Published online: 20 Dec 2023
AbstractforA phase 2, multicenter, open-label study of anti-LAG-3 ieramilimab in combination with anti-PD-1 spartalizumab in patients with advanced solid malignancies | Full Text | References | PDF (1 MB) | EPUB | Supplemental
  • 2859 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Cerebrospinal fluid immunological cytokines predict intracranial tumor response to immunotherapy in non-small cell lung cancer patients with brain metastases
Meichen Li, Jing Chen, Hui Yu, Baishen Zhang, Xue Hou, Honghua Jiang, Dan Xie & Likun Chen
Article: 2290790
Published online: 07 Dec 2023
AbstractforCerebrospinal fluid immunological cytokines predict intracranial tumor response to immunotherapy in non-small cell lung cancer patients with brain metastases | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 1503 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Brief report

Brief Report
MHCII restriction demonstrates B cells have very limited capacity to activate tumour-specific CD4+ T cells in vivo
Thomas V. Guy, Alexandra M. Terry, Helen M. McGuire, Elena Shklovskaya & Barbara Fazekas de St Groth
Article: 2290799
Published online: 10 Dec 2023
AbstractforMHCII restriction demonstrates B cells have very limited capacity to activate tumour-specific CD4+ T cells in vivo | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 987 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Original research

Article
LTX-315 and adoptive cell therapy using tumor-infiltrating lymphocytes generate tumor specific T cells in patients with metastatic soft tissue sarcoma
Morten Nielsen, Tine Monberg, Vibeke Sundvold, Benedetta Albieri, Dorrit Hovgaard, Michael Mørk Petersen, Anders Krarup-Hansen, Özcan Met, Ketil Camilio, Trevor Clancy, Richard Stratford, Baldur Sveinbjornsson, Øystein Rekdal, Niels Junker & Inge Marie Svane
Article: 2290900
Published online: 07 Dec 2023
AbstractforLTX-315 and adoptive cell therapy using tumor-infiltrating lymphocytes generate tumor specific T cells in patients with metastatic soft tissue sarcoma | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 1480 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
LFA-1 regulated by IL-2/STAT5 pathway boosts antitumor function of intratumoral CD8+ T cells for improving anti-PD-1 antibody therapy
Jiqi Shan, Wei Jing, Yu Ping, Chunyi Shen, Dong Han, Fengsen Liu, Yaqing Liu, Congcong Li & Yi Zhang
Article: 2293511
Published online: 14 Dec 2023
AbstractforLFA-1 regulated by IL-2/STAT5 pathway boosts antitumor function of intratumoral CD8+ T cells for improving anti-PD-1 antibody therapy | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 1323 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Original Research

Article
CD3-CD8 immune score associated with a clinical score stratifies PDAC prognosis regardless of adjuvant or neoadjuvant chemotherapy
Coralie Schoumacher, Valentin Derangère, Gwladys Gaudillière-Le Dain, Titouan Huppe, David Rageot, Alis Ilie, Angélique Vienot, Christophe Borg, Franck Monnien, Frederic Bibeau, Caroline Truntzer, François Ghiringhelli & For the CGE-Pancreas investigators
Article: 2294563
Published online: 21 Dec 2023
AbstractforCD3-CD8 immune score associated with a clinical score stratifies PDAC prognosis regardless of adjuvant or neoadjuvant chemotherapy | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 913 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Original research

Article
Clusterin protects mature dendritic cells from reactive oxygen species mediated cell death
Alvaro López Malizia, Antonela Merlotti, Pierre-Emmanuel Bonte, Melina Sager, Yago Arribas De Sandoval, Christel Goudot, Fernando Erra Díaz, Pehuén Pereyra-Gerber, Ana Ceballos, Sebastian Amigorena, Jorge Geffner & Juan Sabatte
Article: 2294564
Published online: 18 Dec 2023
AbstractforClusterin protects mature dendritic cells from reactive oxygen species mediated cell death | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 1698 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Original Research

Article
Interferon regulatory factor 4 plays a pivotal role in the development of aGVHD-associated colitis
Jochen T. Frueh, Julia Campe, Daniele Yumi Sunaga-Franze, Nikita A. Verheyden, Sakhila Ghimire, Elisabeth Meedt, Denise Haslinger, Sabine Harenkamp, Daniel Staudenraus, Sascha Sauer, Andreas Kreft, Ralf Schubert, Michael Lohoff, Andreas Krueger, Halvard Bonig, Andreas G. Chiocchetti, Robert Zeiser, Ernst Holler & Evelyn Ullrich
Article: 2296712
Published online: 27 Dec 2023
AbstractforInterferon regulatory factor 4 plays a pivotal role in the development of aGVHD-associated colitis | Full Text | References | PDF (13.4 MB) | EPUB | Supplemental
  • 1119 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Unbiased high-dimensional flow cytometry identified NK and DC immune cell signature in Luminal A-type and triple negative breast cancer
Lukas Heger, Gordon F. Heidkamp, Lukas Amon, Falk Nimmerjahn, Tobias Bäuerle, Andreas Maier, Ramona Erber, Arndt Hartmann, Carolin C. Hack, Matthias Ruebner, Hanna Huebner, Peter Fasching, Matthias W. Beckmann & Diana Dudziak
Article: 2296713
Published online: 22 Dec 2023
AbstractforUnbiased high-dimensional flow cytometry identified NK and DC immune cell signature in Luminal A-type and triple negative breast cancer | Full Text | References | PDF (8.3 MB) | EPUB | Supplemental
  • 1460 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Targeting the activin receptor 1C on CD4+ T cells for cancer immunotherapy
Ying Zheng, Andriana Lebid, Liam Chung, Juan Fu, Xiaoxu Wang, Andrea Otrocol, Jelani C. Zarif, Hong Yu, Nicolas J. Llosa & Drew M. Pardoll
Article: 2297503
Published online: 08 Jan 2024
AbstractforTargeting the activin receptor 1C on CD4+ T cells for cancer immunotherapy | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
  • 1717 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Brief Report

Brief Report
The anti-inflammatory cytokine IL-37 improves the NK cell-mediated anti-tumor response
Nadine Landolina, Francesca Romana Mariotti, Andrea Pelosi, Valentina D’Oria, Tiziano Ingegnere, Claudia Alicata, Paola Vacca, Lorenzo Moretta & Enrico Maggi
Article: 2297504
Published online: 26 Dec 2023
AbstractforThe anti-inflammatory cytokine IL-37 improves the NK cell-mediated anti-tumor response | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 1181 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Original Research

Article
Salmonella immunotherapy engineered with highly efficient tumor antigen coating establishes antigen-specific CD8+ T cell immunity and increases in antitumor efficacy with type I interferon combination therapy
Suyang Wang, Michelle Cheng, Chao-Cheng Chen, Chia-Yu Chang, Ya-Chea Tsai, Jr-Ming Yang, TC Wu, Chuan-Hsiang Huang & Chien-Fu Hung
Article: 2298444
Published online: 27 Dec 2023
AbstractforSalmonella immunotherapy engineered with highly efficient tumor antigen coating establishes antigen-specific CD8+ T cell immunity and increases in antitumor efficacy with type I interferon combination therapy | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 1082 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Editorial

Editorial
Single-cell analysis of T lymphocytes infiltrating colorectal carcinoma: the dilemma of specificity
Manuela Lizarralde-Guerrero, Laura Zucaro, Guido Kroemer & Jonathan G. Pol
Article: 2300520
Published online: 04 Jan 2024
AbstractforSingle-cell analysis of T lymphocytes infiltrating colorectal carcinoma: the dilemma of specificity | Full Text | References | PDF (764.9 KB) | EPUB
  • 1228 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Original Research

Article
Extracellular vesicles released by cancer-associated fibroblast-induced myeloid-derived suppressor cells inhibit T-cell function
Carlo P. Ramil, Handan Xiang, Peng Zhang, Aileen Cronin, Lisia Cabral, Zhizhang Yin, Josephine Hai, Huijun Wang, Benjamin Ruprecht, Yanlin Jia, Dongyu Sun, Hongmin Chen & An Chi
Article: 2300882
Published online: 05 Jan 2024
AbstractforExtracellular vesicles released by cancer-associated fibroblast-induced myeloid-derived suppressor cells inhibit T-cell function | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 1820 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
An oncogene regulating chromatin favors response to immunotherapy
Oncogene CHAF1A and immunotherapy outcomes
Leqian Ying, Zhangmin Hu, Yi Lu, Qing Tao, Fen Xiong, Yongqian Shu, Yufei Yang, Xuehan Qiao, Chen Peng, Yuchun Jiang, Miao Han, Min Xu, Xiaoqin Li & Deqiang Wang
Article: 2303195
Published online: 09 Jan 2024
AbstractforAn oncogene regulating chromatin favors response to immunotherapy | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 911 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Platelet-derived microparticles adoptively transfer integrin β3 to promote antitumor effect of tumor-infiltrating T cells
Mimi Zhou, Yali Feng, Xiaoli Zhang, Jianguo Chen, Naijuan Yao, Shan Fu, Tianzhi Ni, Yi Chen, Fei Xie, Sahasrabda Roy, Jinfeng Liu, Yuan Yang, Yingli He, Yingren Zhao & Nan Yang
Article: 2304963
Published online: 16 Jan 2024
AbstractforPlatelet-derived microparticles adoptively transfer integrin β3 to promote antitumor effect of tumor-infiltrating T cells | Full Text | References | PDF (9.4 MB) | EPUB | Supplemental
  • 1077 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Trial Watch

News
Trial watch: local anesthetics in cancer therapy
Killian Carnet Le Provost, Oliver Kepp, Guido Kroemer & Lucillia Bezu
Article: 2308940
Published online: 17 Mar 2024
AbstractforTrial watch: local anesthetics in cancer therapy | Full Text | References | PDF (874.1 KB) | EPUB
  • 750 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Original Research

Article
Noninvasive radiomic biomarkers for predicting pseudoprogression and hyperprogression in patients with non-small cell lung cancer treated with immune checkpoint inhibition
Yikun Li, Peiliang Wang, Junhao Xu, Xiaonan Shi, Tianwen Yin & Feifei Teng
Article: 2312628
Published online: 07 Feb 2024
AbstractforNoninvasive radiomic biomarkers for predicting pseudoprogression and hyperprogression in patients with non-small cell lung cancer treated with immune checkpoint inhibition | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
  • 1063 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Brief Report

Brief Report
Immune checkpoint blockade improves the activation and function of circulating mucosal-associated invariant T (MAIT) cells in patients with non-small cell lung cancer
Patrik Sundström, Nikita Dutta, William Rodin, Andreas Hallqvist, Sukanya Raghavan & Marianne Quiding Järbrink
Article: 2312631
Published online: 06 Feb 2024
AbstractforImmune checkpoint blockade improves the activation and function of circulating mucosal-associated invariant T (MAIT) cells in patients with non-small cell lung cancer | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 925 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Special Report

Report
A bispecific anti-PD-1 and PD-L1 antibody induces PD-1 cleavage and provides enhanced anti-tumor activity
Diana I. Albu, Benjamin J. Wolf, Yan Qin, Xianzhe Wang, Amy Daniel Ulumben, Mei Su, Vivian Li, Eirene Ding, Jose Angel Gonzalo, Jason Kong, Ruturaj Jadhav, Nelly Kuklin, Alberto Visintin, Bing Gong & Thomas J. Schuetz
Article: 2316945
Published online: 16 Feb 2024
AbstractforA bispecific anti-PD-1 and PD-L1 antibody induces PD-1 cleavage and provides enhanced anti-tumor activity | Full Text | References | PDF (6.3 MB) | EPUB | Supplemental
  • 2248 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Brief Report

Brief Report
Arginase-1 specific CD8+ T cells react toward malignant and regulatory myeloid cells
Hannah Jorinde Glöckner, Evelina Martinenaite, Thomas Landkildehus Lisle, Jacob Grauslund, Shamaila Ahmad, Özcan Met, Per Thor Straten & Mads Hald Andersen
Article: 2318053
Published online: 22 Feb 2024
AbstractforArginase-1 specific CD8+ T cells react toward malignant and regulatory myeloid cells | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
  • 878 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Original Research

Article
Intratumoral T-cell receptor repertoire composition predicts overall survival in patients with pancreatic ductal adenocarcinoma
Vikram S. Pothuri, Graham D. Hogg, Leah Conant, Nicholas Borcherding, C. Alston James, Jacqueline Mudd, Greg Williams, Yongwoo David Seo, William G. Hawkins, Venu G. Pillarisetty, David G. DeNardo & Ryan C. Fields
Article: 2320411
Published online: 15 Mar 2024
AbstractforIntratumoral T-cell receptor repertoire composition predicts overall survival in patients with pancreatic ductal adenocarcinoma | Full Text | References | PDF (8.4 MB) | EPUB | Supplemental
  • 1909 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Lactate/GPR81 recruits regulatory T cells by modulating CX3CL1 to promote immune resistance in a highly glycolytic gastric cancer
Jin Su, Xinyuan Mao, Lingzhi Wang, Zhian Chen, Weisheng Wang, Cuiyin Zhao, Guoxin Li, Weihong Guo & Yanfeng Hu
Article: 2320951
Published online: 26 Feb 2024
AbstractforLactate/GPR81 recruits regulatory T cells by modulating CX3CL1 to promote immune resistance in a highly glycolytic gastric cancer | Full Text | References | PDF (9.5 MB) | EPUB | Supplemental
  • 1203 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Trial Watch

News
Trial watch: bispecific antibodies for the treatment of relapsed or refractory large B-cell lymphoma
Giulio Cassanello, Alejandro Luna de Abia & Lorenzo Falchi
Article: 2321648
Published online: 03 Mar 2024
AbstractforTrial watch: bispecific antibodies for the treatment of relapsed or refractory large B-cell lymphoma | Full Text | References | PDF (773.1 KB) | EPUB
  • 2418 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Original Research

Article
Expression of GPX4 by oncolytic vaccinia virus can significantly enhance CD8+T cell function and its impact against pancreatic ductal adenocarcinoma
Wei Wei, Linqing Tian, Xiaoyan Zheng, Lei Zhong, Yuan Chen, Hui Dong, Guibing Zhang, Shibing Wang & Xiangmin Tong
Article: 2322173
Published online: 27 Feb 2024
AbstractforExpression of GPX4 by oncolytic vaccinia virus can significantly enhance CD8+T cell function and its impact against pancreatic ductal adenocarcinoma | Full Text | References | PDF (7.5 MB) | EPUB | Supplemental
  • 1033 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Prognostic impact of the bone marrow tumor microenvironment, HLA-I and HLA-Ib expression in MDS and CMML progression to sAML
Marcus Bauer, Nadja Jäkel, Andreas Wilfer, Anja Haak, Markus Eszlinger, Katalin Kelemen, Monika Haemmerle, Haifa Kathrin Al-Ali, Barbara Seliger & Claudia Wickenhauser
Article: 2323212
Published online: 06 Mar 2024
AbstractforPrognostic impact of the bone marrow tumor microenvironment, HLA-I and HLA-Ib expression in MDS and CMML progression to sAML | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 641 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Are tumor-associated carbohydrates the missing link between the gut microbiome and response to immune checkpoint inhibitor treatment in cancer?
Zoltan Szallasi, Aurel Prosz, Zsofia Sztupinszki & Judit Moldvay
Article: 2324493
Published online: 04 Mar 2024
AbstractforAre tumor-associated carbohydrates the missing link between the gut microbiome and response to immune checkpoint inhibitor treatment in cancer? | Full Text | References | PDF (745.3 KB) | EPUB
  • 683 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Author’s View

Reply
Transmembrane TNF-TNFR2 signaling as a critical immunoregulatory node in pancreatic cancer
Erin M. Dickey, Anna Bianchi, Haleh Amirian, Peter J. Hosein, Denise Faustman, Roberta Brambilla & Jashodeep Datta
Article: 2326694
Published online: 12 Mar 2024
AbstractforTransmembrane TNF-TNFR2 signaling as a critical immunoregulatory node in pancreatic cancer | Full Text | References | PDF (1.4 MB) | EPUB
  • 915 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

News

News
Trial watch: dexmedetomidine in cancer therapy
Killian Carnet Le Provost, Oliver Kepp, Guido Kroemer & Lucillia Bezu
Article: 2327143
Published online: 11 Mar 2024
AbstractforTrial watch: dexmedetomidine in cancer therapy | Full Text | References | PDF (3.2 MB) | EPUB
  • 1534 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Original Research

Article
STING is significantly increased in high-grade glioma with high risk of recurrence
Meishi Zhong, Manmei Long, Chenjie Han, Saiyan Ji & Qingyuan Yang
Article: 2327682
Published online: 20 Mar 2024
AbstractforSTING is significantly increased in high-grade glioma with high risk of recurrence | Full Text | References | PDF (6.3 MB) | EPUB | Supplemental
  • 829 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Lymphatic endothelial cell-mediated accumulation of CD177+Treg cells suppresses antitumor immunity in human esophageal squamous cell carcinoma
Min Ma, Liang Li, Shu-Han Yang, Chuan Huang, Weitao Zhuang, Shujie Huang, Xin Xia, Yong Tang, Zijun Li, Zhi-Bin Zhao, Qingyun Chen, Guibin Qiao & Zhe-Xiong Lian
Article: 2327692
Published online: 20 Mar 2024
AbstractforLymphatic endothelial cell-mediated accumulation of CD177+Treg cells suppresses antitumor immunity in human esophageal squamous cell carcinoma | Full Text | References | PDF (6.1 MB) | EPUB | Supplemental
  • 1275 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Humoral complementomics – exploration of noninvasive complement biomarkers as predictors of renal cancer progression
Margot Revel, Mikel Rezola Artero, Houcine Hamidi, Anne Grunenwald, Loris Blasco, Yann A. Vano, Stephane Marie Oudard, Rafael Sanchez-Salas, Petr Macek, Lara Rodriguez Sanchez, Xavier Cathelineau, Benoit Vedié, Catherine Sautes-Fridman, Wolf Herman Fridman, Lubka T. Roumenina & Marie-Agnes Dragon-Durey
Article: 2328433
Published online: 13 Mar 2024
AbstractforHumoral complementomics – exploration of noninvasive complement biomarkers as predictors of renal cancer progression | Full Text | References | PDF (6.5 MB) | EPUB | Supplemental
  • 1118 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Co-inhibition of TGF-β and PD-L1 pathways in a metastatic colorectal cancer mouse model triggers interferon responses, innate cells and T cells, alongside metabolic changes and tumor resistance
Reshmi Nair, Tamsin R. M. Lannagan, Rene Jackstadt, Anna Andrusaite, John Cole, Caitlin Boyne, Robert J. B. Nibbs, Owen J. Sansom & Simon Milling
Article: 2330194
Published online: 20 Mar 2024
AbstractforCo-inhibition of TGF-β and PD-L1 pathways in a metastatic colorectal cancer mouse model triggers interferon responses, innate cells and T cells, alongside metabolic changes and tumor resistance | Full Text | References | PDF (4.4 MB) | EPUB | Supplemental
  • 1392 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Combination of T cell-redirecting strategies with a bispecific antibody blocking TGF-β and PD-L1 enhances antitumor responses
Antonio Tapia-Galisteo, Iñigo Sánchez-Rodríguez, Javier Narbona, Patricia Iglesias-Hernández, Saray Aragón-García, Anaïs Jiménez-Reinoso, Marta Compte, Shaukat Khan, Takeshi Tsuda, Patrick Chames, Javier Lacadena, Luis Álvarez-Vallina & Laura Sanz
Article: 2338558
Published online: 13 Apr 2024
AbstractforCombination of T cell-redirecting strategies with a bispecific antibody blocking TGF-β and PD-L1 enhances antitumor responses | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 1552 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Author’s View

Reply
PD-L1+ macrophages suppress T cell-mediated anticancer immunity
Peng Liu, Liwei Zhao, Guido Kroemer & Oliver Kepp
Article: 2338951
Published online: 04 Apr 2024
AbstractforPD-L1+ macrophages suppress T cell-mediated anticancer immunity | Full Text | References | PDF (777.7 KB) | EPUB
  • 1016 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Original Research

Article
CCR2 and CCR5 co-inhibition modulates immunosuppressive myeloid milieu in glioma and synergizes with anti-PD-1 therapy
Ayush Pant, Brandon Hwa-Lin Bergsneider, Siddhartha Srivastava, Timothy Kim, Aanchal Jain, Sadhana Bom, Pavan Shah, Nivedha Kannapadi, Kisha Patel, John Choi, Kwang Bog Cho, Rohit Verma, Caren Yu-Ju Wu, Henry Brem, Betty Tyler, Drew M. Pardoll, Christina Jackson & Michael Lim
Article: 2338965
Published online: 04 Apr 2024
AbstractforCCR2 and CCR5 co-inhibition modulates immunosuppressive myeloid milieu in glioma and synergizes with anti-PD-1 therapy | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 1263 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Redoxhigh phenotype mediated by KEAP1/STK11/SMARCA4/NRF2 mutations diminishes tissue-resident memory CD8+ T cells and attenuates the efficacy of immunotherapy in lung adenocarcinoma
Xue-Wu Wei, Chang Lu, Yi-Chen Zhang, Xue Fan, Chong-Rui Xu, Zhi-Hong Chen, Fen Wang, Xiao-Rong Yang, Jia-Yi Deng, Ming-Yi Yang, Qing Gou, Shi-Qi Mei, Wei-Chi Luo, Ri-Wei Zhong, Wen-Zhao Zhong, Jin-Ji Yang, Xu-Chao Zhang, Hai-Yan Tu, Yi-Long Wu & Qing Zhou
Article: 2340154
Published online: 09 Apr 2024
AbstractforRedoxhigh phenotype mediated by KEAP1/STK11/SMARCA4/NRF2 mutations diminishes tissue-resident memory CD8+ T cells and attenuates the efficacy of immunotherapy in lung adenocarcinoma | Full Text | References | PDF (6.3 MB) | EPUB | Supplemental
  • 1310 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
The potential role of CMC1 as an immunometabolic checkpoint in T cell immunity
Yuwen Chen, Jie Gao, Mingyue Ma, Ke Wang, Fangming Liu, Feiyu Yang, Xin Zou, Zhouli Cheng & Duojiao Wu
Article: 2344905
Published online: 23 Apr 2024
AbstractforThe potential role of CMC1 as an immunometabolic checkpoint in T cell immunity | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
  • 803 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Immune checkpoint therapy responders display early clonal expansion of tumor infiltrating lymphocytes
Joel Kidman, Rachael M. Zemek, John-William Sidhom, Debora Correa, Nicola Principe, Fezaan Sheikh, Vanessa S. Fear, Catherine A. Forbes, Abha Chopra, Louis Boon, Ayham Zaitouny, Emma de Jong, Robert A. Holt, Matt Jones, Michael J. Millward, Timo Lassmann, Alistair R.R. Forrest, Anna K. Nowak, Mark Watson, Richard A. Lake, W. Joost Lesterhuis & Jonathan Chee
Article: 2345859
Published online: 26 Apr 2024
AbstractforImmune checkpoint therapy responders display early clonal expansion of tumor infiltrating lymphocytes | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 1081 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Expression of CD39 is associated with T cell exhaustion in ovarian cancer and its blockade reverts T cell dysfunction
Witt Marius, Oliveira-Ferrer Leticia, Koch-Nolte Friedrich, Menzel Stephan, Hell Louisa, Sturmheit Tabea, Seubert Elisa, Weimer Pauline, Ding Yi, Minyue Qi, Schmalfeldt Barbara, Bokemeyer Carsten, Fiedler Walter, Wellbrock Jasmin & Brauneck Franziska
Article: 2346359
Published online: 09 May 2024
AbstractforExpression of CD39 is associated with T cell exhaustion in ovarian cancer and its blockade reverts T cell dysfunction | Full Text | References | PDF (10.2 MB) | EPUB | Supplemental
  • 1220 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Review

Review Article
Principles of risk assessment in colon cancer: immunity is key
Assia Hijazi & Jérôme Galon
Article: 2347441
Published online: 30 Apr 2024
AbstractforPrinciples of risk assessment in colon cancer: immunity is key | Full Text | References | PDF (913.8 KB) | EPUB
  • 627 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Original Research

Article
Memory-like differentiation enhances NK cell responses against colorectal cancer
Nancy D. Marin, Michelle Becker-Hapak, Wilbur M. Song, Quazim A. Alayo, Lynne Marsala, Naomi Sonnek, Melissa M. Berrien-Elliott, Mark Foster, Jennifer A. Foltz, Jennifer Tran, Pamela Wong, Celia C. Cubitt, Patrick Pence, Kimberly Hwang, Alice Y. Zhou, Miriam T. Jacobs, Timothy Schappe, David A. Russler-Germain, Ryan C. Fields, Matthew A. Ciorba & Todd A. Fehniger
Article: 2348254
Published online: 07 May 2024
AbstractforMemory-like differentiation enhances NK cell responses against colorectal cancer | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
  • 1383 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Characterization of innate lymphoid cell subsets infiltrating melanoma and epithelial ovarian tumors
Douglas C. Chung, Maryam Ghaedi, Kathrin Warner, Azin Sayad, Samuel D. Saibil, Marcus Q. Bernardini, Blaise A. Clarke, Patricia A. Shaw, Marcus O. Butler, Alexandra Easson, Sorana Morrissy, Ben X. Wang, Linh Nguyen, Pamela S. Ohashi & Nicolas Jacquelot
Article: 2349347
Published online: 10 May 2024
AbstractforCharacterization of innate lymphoid cell subsets infiltrating melanoma and epithelial ovarian tumors | Full Text | References | PDF (5.2 MB) | EPUB | Supplemental
  • 908 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Brief report

Article
Distinct autoantibody profiles across checkpoint inhibitor types and toxicities
Hong Mu-Mosley, Mitchell S. von Itzstein, Farjana Fattah, Jialiang Liu, Chengsong Zhu, Yang Xie, Edward K. Wakeland, Jason Y. Park, Brad S. Kahl, Catherine S. Diefenbach & David E. Gerber
Article: 2351255
Published online: 09 May 2024
AbstractforDistinct autoantibody profiles across checkpoint inhibitor types and toxicities | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 821 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Original Research

Article
CPT1C-positive cancer-associated fibroblast facilitates immunosuppression through promoting IL-6-induced M2-like phenotype of macrophage
Rongyuan Wei, Junquan Song, Hongda Pan, Xiaowen Liu & Jianpeng Gao
Article: 2352179
Published online: 10 May 2024
AbstractforCPT1C-positive cancer-associated fibroblast facilitates immunosuppression through promoting IL-6-induced M2-like phenotype of macrophage | Full Text | References | PDF (5.3 MB) | EPUB | Supplemental
  • 721 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Peripheral CX3CR1+ T cells combined with PD-1 blockade therapy potentiates the anti-tumor efficacy for lung cancer
Congcong Li, Zhen Zhang, Qianfeng Cai, Qitai Zhao, Han Wu, JunRu Li, Yaqing Liu, Xuan Zhao, Jinyan Liu, Yu Ping, Jiqi Shan, Shengli Yang & Yi Zhang
Article: 2355684
Published online: 22 May 2024
AbstractforPeripheral CX3CR1+ T cells combined with PD-1 blockade therapy potentiates the anti-tumor efficacy for lung cancer | Full Text | References | PDF (5 MB) | EPUB | Supplemental
  • 718 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
HIF2A mediates lineage transition to aggressive phenotype of cancer-associated fibroblasts in lung cancer brain metastasis
Muyuan You, Minjie Fu, Zhewei Shen, Yuan Feng, Licheng Zhang, Xianmin Zhu, Zhengping Zhuang, Ying Mao & Wei Hua
Article: 2356942
Published online: 20 May 2024
AbstractforHIF2A mediates lineage transition to aggressive phenotype of cancer-associated fibroblasts in lung cancer brain metastasis | Full Text | References | PDF (9.7 MB) | EPUB | Supplemental
  • 891 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
CXCL10 and IL15 co-expressing chimeric antigen receptor T cells enhance anti-tumor effects in gastric cancer by increasing cytotoxic effector cell accumulation and survival
Siyue Nie, Yujie Song, Kun Hu, Wei Zu, Fengjiao Zhang, Lixia Chen, Qiang Ma, Zishan Zhou & Shunchang Jiao
Article: 2358590
Published online: 24 May 2024
AbstractforCXCL10 and IL15 co-expressing chimeric antigen receptor T cells enhance anti-tumor effects in gastric cancer by increasing cytotoxic effector cell accumulation and survival | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
  • 734 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Commentary

Comment
Immunogenic oncolysis by tigilanol tiglate
Jonathan G. Pol, Manuela Lizarralde-Guerrero & Guido Kroemer
Article: 2360230
Published online: 27 May 2024
AbstractforImmunogenic oncolysis by tigilanol tiglate | Full Text | References | PDF (747.5 KB) | EPUB
  • 503 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Comment
Clinically relevant GABARAP deficiency abrogates bortezomib-induced immunogenic cell death in multiple myeloma
Liwei Zhao, Zhe Shen, Guido Kroemer & Oliver Kepp
Article: 2360275
Published online: 27 May 2024
AbstractforClinically relevant GABARAP deficiency abrogates bortezomib-induced immunogenic cell death in multiple myeloma | Full Text | References | PDF (619.6 KB) | EPUB
  • 558 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Original research

Article
Exploring immune status in peripheral blood and tumor tissue in association with survival in patients with multi-organ metastatic colorectal cancer
Lotte Bakkerus, Beatriz Subtil, Hetty J. Bontkes, Elske C. Gootjes, Martine Reijm, Manon Vullings, Kiek Verrijp, John-Melle Bokhorst, Carmen Woortman, Iris D. Nagtegaal, Marianne A. Jonker, Hans J. van der Vliet, Cornelis Verhoef, Mark A.J. Gorris, I. Jolanda M. de Vries, Tanja D. de Gruijl, Henk M.W. Verheul, Tineke E. Buffart & Daniele V. F. Tauriello
Article: 2361971
Published online: 10 Jun 2024
AbstractforExploring immune status in peripheral blood and tumor tissue in association with survival in patients with multi-organ metastatic colorectal cancer | Full Text | References | PDF (5.8 MB) | EPUB | Supplemental
  • 548 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
CD20 expression regulates CD37 levels in B-cell lymphoma – implications for immunotherapies
Malgorzata Bobrowicz, Aleksandra Kusowska, Marta Krawczyk, Andriy Zhylko, Christopher Forcados, Aleksander Slusarczyk, Joanna Barankiewicz, Joanna Domagala, Matylda Kubacz, Michal Šmída, Lenka Dostalova, Katsiaryna Marhelava, Klaudyna Fidyt, Monika Pepek, Iwona Baranowska, Anna Szumera-Cieckiewicz, Else Marit Inderberg, Sébastien Wälchli, Monika Granica, Agnieszka Graczyk-Jarzynka, Martyna Majchrzak, Marcin Poreba, Carina Lynn Gehlert, Matthias Peipp, Malgorzata Firczuk, Monika Prochorec-Sobieszek & Magdalena Winiarska
Article: 2362454
Published online: 04 Jun 2024
AbstractforCD20 expression regulates CD37 levels in B-cell lymphoma – implications for immunotherapies | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 674 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
β-Lapachone promotes the recruitment and polarization of tumor-associated neutrophils (TANs) toward an antitumor (N1) phenotype in NQO1-positive cancers
Soumya Tumbath, Lingxiang Jiang, Xiaoguang Li, Taolan Zhang, Kashif Rafiq Zahid, Ye Zhao, Hao Zhou, Zhijun Yin, Tao Lu, Shu Jiang, Yaomin Chen, Xiang Chen, Yang-Xin Fu & Xiumei Huang
Article: 2363000
Published online: 04 Jun 2024
Abstractforβ-Lapachone promotes the recruitment and polarization of tumor-associated neutrophils (TANs) toward an antitumor (N1) phenotype in NQO1-positive cancers | Full Text | References | PDF (5.7 MB) | EPUB | Supplemental
  • 573 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
HUNK as a key regulator of tumor-associated macrophages in triple negative breast cancer
Nicole Ramos Solis, Anthony Cannon, Tinslee Dilday, Melissa Abt, Adrian L. Oblak, Adam C. Soloff, Mark H. Kaplan & Elizabeth S. Yeh
Article: 2364382
Published online: 05 Jun 2024
AbstractforHUNK as a key regulator of tumor-associated macrophages in triple negative breast cancer | Full Text | References | PDF (4.6 MB) | EPUB | Supplemental
  • 583 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Author’s View

Reply
Improving STING agonist-based cancer therapy by inhibiting the autophagy-related protein VPS34
Elisabetta Bartolini, Kris Van Moer & Bassam Janji
Article: 2364958
Published online: 11 Jun 2024
AbstractforImproving STING agonist-based cancer therapy by inhibiting the autophagy-related protein VPS34 | Full Text | References | PDF (1 MB) | EPUB
  • 519 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Original Research

Article
CD28-CD57+ T cells from head and neck cancer patients produce high levels of cytotoxic granules and type II interferon but are not senescent
Brendan L.C. Kinney, Brianna Brammer, Vikash Kansal, Connor J. Parrish, Haydn T. Kissick, Yuan Liu, Nabil F. Saba, Zachary S. Buchwald, Mark W. El-Deiry, Mihir R. Patel, Brian J. Boyce, Azeem S. Kaka, Jennifer H. Gross, H. Michael Baddour, Amy Y. Chen & Nicole C. Schmitt
Article: 2367777
Published online: 14 Jun 2024
AbstractforCD28-CD57+ T cells from head and neck cancer patients produce high levels of cytotoxic granules and type II interferon but are not senescent | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 467 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Brief Report

Brief Report
ALCAM-mediated cDC1 CD8 T cells interactions are suppressed in advanced lung tumors
Luciano G. Morosi, Giulia M. Piperno, Lucía López, Roberto Amadio, Sonal Joshi, Alessandra Rustighi, Giannino Del Sal & Federica Benvenuti
Article: 2367843
Published online: 14 Jun 2024
AbstractforALCAM-mediated cDC1 CD8 T cells interactions are suppressed in advanced lung tumors | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
  • 673 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Original research

Article
Loss of β2-integrin function results in metabolic reprogramming of dendritic cells, leading to increased dendritic cell functionality and anti-tumor responses
Heidi Harjunpää, Riku Somermäki, Guillem Saldo Rubio, Manlio Fusciello, Sara Feola, Imrul Faisal, Anni I Nieminen, Liang Wang, Marc Llort Asens, Hongxia Zhao, Ove Eriksson, Vincenzo Cerullo & Susanna C Fagerholm
Article: 2369373
Published online: 21 Jun 2024
AbstractforLoss of β2-integrin function results in metabolic reprogramming of dendritic cells, leading to increased dendritic cell functionality and anti-tumor responses | Full Text | References | PDF (5 MB) | EPUB | Supplemental
  • 534 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Near-infrared duocarmycin photorelease from a Treg-targeted antibody-drug conjugate improves efficacy of PD-1 blockade in syngeneic murine tumor models
Hiroshi Fukushima, Aki Furusawa, Seiichiro Takao, Ebaston Thankarajan, Michael P Luciano, Syed Muhammad Usama, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Motofumi Suzuki, Miyu Kano, Peter L Choyke, Martin J Schnermann & Hisataka Kobayashi
Article: 2370544
Published online: 20 Jun 2024
AbstractforNear-infrared duocarmycin photorelease from a Treg-targeted antibody-drug conjugate improves efficacy of PD-1 blockade in syngeneic murine tumor models | Full Text | References | PDF (4.4 MB) | EPUB | Supplemental
  • 678 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Identification of RNA-binding protein hnRNP C targeting the 3’UTR of the TAP-associated glycoprotein tapasin in melanoma
Yuan Wang & Barbara Seliger
Article: 2370928
Published online: 27 Jun 2024
AbstractforIdentification of RNA-binding protein hnRNP C targeting the 3’UTR of the TAP-associated glycoprotein tapasin in melanoma | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
  • 272 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Brief Report

Brief Report
ADA/CD26 axis increases intra-tumor PD-1+CD28+CD8+ T-cell fitness and affects NSCLC prognosis and response to ICB
Ornella Franzese, Belinda Palermo, Giuseppe Frisullo, Mariangela Panetta, Giulia Campo, Daniel D’Andrea, Isabella Sperduti, Riccardo Taje, Paolo Visca & Paola Nisticò
Article: 2371051
Published online: 21 Jun 2024
AbstractforADA/CD26 axis increases intra-tumor PD-1+CD28+CD8+ T-cell fitness and affects NSCLC prognosis and response to ICB | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 440 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Original Research

Article
Candidate tumor-specific CD8+ T cell subsets identified in the malignant pleural effusion of advanced lung cancer patients by single-cell analysis
Yusuke Sugita, Daisuke Muraoka, Ayako Demachi-Okamura, Hiroyasu Komuro, Katsuhiro Masago, Eiichi Sasaki, Yasunori Fukushima, Takuya Matsui, Shuichi Shinohara, Yusuke Takahashi, Reina Nishida, Chieko Takashima, Teppei Yamaguchi, Yoshitsugu Horio, Kana Hashimoto, Ichidai Tanaka, Hiroshi Hamana, Hiroyuki Kishi, Daiki Miura, Yuki Tanaka, Kousuke Onoue, Kazuhide Onoguchi, Yoshiko Yamashita, Richard Stratford, Trevor Clancy, Rui Yamaguchi, Hiroaki Kuroda, Hironori Ishibashi, Kenichi Okubo & Hirokazu Matsushita
Article: 2371556
Published online: 28 Jun 2024
AbstractforCandidate tumor-specific CD8+ T cell subsets identified in the malignant pleural effusion of advanced lung cancer patients by single-cell analysis | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 534 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
A phase 2 study of spartalizumab (PDR001) among patients with recurrent or metastatic esophageal squamous cell carcinoma (KCSG HN18-17, K-MASTER project 12)
Dong Ki Lee, Sook Ryun Park, Yeul Hong Kim, Yun-Gyoo Lee, Su-Jin Shin, Beung-Chul Ahn, Sung Sook Lee, Sun Min Lim, Hye Ryun Kim, Byoung Chul Cho & Min Hee Hong
Article: 2371563
Published online: 24 Jun 2024
AbstractforA phase 2 study of spartalizumab (PDR001) among patients with recurrent or metastatic esophageal squamous cell carcinoma (KCSG HN18-17, K-MASTER project 12) | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 436 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Original research

Article
CD161+CD127+CD8+ T cell subsets can predict the efficacy of anti-PD-1 immunotherapy in non-small cell lung cancer with diabetes mellitus
Jingjing Qu, Yuekang Li, Binggen Wu, Qian Shen, Lijun Chen, Wenjia Sun, Bo Wang, Lixiong Ying, Li Wu, Hong Zhou, Jianya Zhou & Jianying Zhou
Article: 2371575
Published online: 27 Jun 2024
AbstractforCD161+CD127+CD8+ T cell subsets can predict the efficacy of anti-PD-1 immunotherapy in non-small cell lung cancer with diabetes mellitus | Full Text | References | PDF (9.8 MB) | EPUB | Supplemental
  • 545 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Modulation of blood T cell polyfunctionality and HVEM/BTLA expression are critical determinants of clinical outcome in anti-PD1-treated metastatic melanoma patients
Stéphane Dalle, Estelle Verronese, Axelle N’Kodia, Christine Bardin, Céline Rodriguez, Thibault Andrieu, Anais Eberhardt, Gabriel Chemin, Uzma Hasan, Myrtille Le-Bouar, Julie Caramel, Mona Amini-Adle, Nathalie Bendriss-Vermare, Bertrand Dubois, Christophe Caux & Christine Ménétrier-Caux
Article: 2372118
Published online: 26 Jun 2024
AbstractforModulation of blood T cell polyfunctionality and HVEM/BTLA expression are critical determinants of clinical outcome in anti-PD1-treated metastatic melanoma patients | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
  • 342 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Brief Report

Brief Report
Cytokine release syndrome after treatment with immune checkpoint inhibitors: an observational cohort study of 2672 patients from Karolinska University Hospital in Sweden
Osama Hamida, Frans Karlsson, Andreas Lundqvist, Marco Gerling & Lisa L. Liu
Article: 2372875
Published online: 03 Jul 2024
AbstractforCytokine release syndrome after treatment with immune checkpoint inhibitors: an observational cohort study of 2672 patients from Karolinska University Hospital in Sweden | Full Text | References | PDF (788.4 KB) | EPUB | Supplemental
  • 378 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Brief Report
Complete response of metastatic microsatellite-stable BRAF V600E colorectal cancer to first-line oxaliplatin-based chemotherapy and immune checkpoint blockade
Anne Hansen Ree, Eirik Høye, Ying Esbensen, Ann-Christin R. Beitnes, Anne Negård, Linn Bernklev, Linn Kruse Tetlie, Åsmund A. Fretland, Hanne M. Hamre, Christian Kersten, Eva Hofsli, Marianne G. Guren, Halfdan Sorbye, Hilde L. Nilsen, Kjersti Flatmark & Sebastian Meltzer
Article: 2372886
Published online: 28 Jun 2024
AbstractforComplete response of metastatic microsatellite-stable BRAF V600E colorectal cancer to first-line oxaliplatin-based chemotherapy and immune checkpoint blockade | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
  • 626 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Original Research

Article
Short-term cultured tumor fragments to study immunotherapy combinations based on CD137 (4-1BB) agonism
Iñaki Eguren-Santamaría, Inmaculada Rodríguez, Claudia Herrero-Martin, Eva Fernández de Piérola, Arantza Azpilikueta, Sandra Sánchez-Gregorio, Elixabet Bolaños, Gabriel Gomis, Paula Molero-Glez, Enrique Chacón, José Ángel Mínguez, Santiago Chiva, Fernando Diez-Caballero, Carlos de Andrea, Álvaro Teijeira, Miguel F. Sanmamed & Ignacio Melero
Article: 2373519
Published online: 09 Jul 2024
AbstractforShort-term cultured tumor fragments to study immunotherapy combinations based on CD137 (4-1BB) agonism | Full Text | References | PDF (4.3 MB) | EPUB | Supplemental
  • 368 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Novel mRNA adjuvant ImmunER enhances prostate cancer tumor-associated antigen mRNA therapy via augmenting T cell activity
Zhen Xu, Ze-Xiu Xiao, Jing Wang, Hao-Wei Qiu, Fei Cao, Shi-Qiang Zhang, Yuan-Dong Xu, Han-Qi Lei, Heng Xia, Yun-Ru He, Gao-Feng Zha & Jun Pang
Article: 2373526
Published online: 27 Jun 2024
AbstractforNovel mRNA adjuvant ImmunER enhances prostate cancer tumor-associated antigen mRNA therapy via augmenting T cell activity | Full Text | References | PDF (10.5 MB) | EPUB | Supplemental
  • 755 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Characterization of double-negative T cells in colorectal cancers and their corresponding lymph nodes
Kazumi Okamura, Lifang Wang, Satoshi Nagayama, Makiko Yamashita, Tomohiro Tate, Saki Matsumoto, Manabu Takamatsu, Shigehisa Kitano, Kazuma Kiyotani & Yusuke Nakamura
Article: 2373530
Published online: 04 Jul 2024
AbstractforCharacterization of double-negative T cells in colorectal cancers and their corresponding lymph nodes | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 741 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Faecalibacterium prausnitzii strain EXL01 boosts efficacy of immune checkpoint inhibitors
Marius Bredon, Camille Danne, Hang Phuong Pham, Pauline Ruffié, Alban Bessede, Nathalie Rolhion, Laura Creusot, Loic Brot, Iria Alonso, Philippe Langella, Lisa Derosa, Alexis B. Cortot, Bertrand Routy, Laurence Zitvogel, Nicola Segata & Harry Sokol
Article: 2374954
Published online: 01 Jul 2024
AbstractforFaecalibacterium prausnitzii strain EXL01 boosts efficacy of immune checkpoint inhibitors | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 1323 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
SIGLEC15, negatively correlated with PD-L1 in HCC, could induce CD8+ T cell apoptosis to promote immune evasion
Zheng Chen, Mincheng Yu, Bo Zhang, Lei Jin, Qiang Yu, Shuang Liu, Binghai Zhou, Jiuliang Yan, Wentao Zhang, Xiaoqiang Li, Yongfeng Xu, Yongsheng Xiao, Jian Zhou, Jia Fan, Mien-Chie Hung, Qinghai Ye, Hui Li & Lei Guo
Article: 2376264
Published online: 09 Jul 2024
AbstractforSIGLEC15, negatively correlated with PD-L1 in HCC, could induce CD8+ T cell apoptosis to promote immune evasion | Full Text | References | PDF (5.3 MB) | EPUB | Supplemental
  • 415 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Original research

Article
Differential impact of genetic deletion of TIGIT or PD-1 on melanoma-specific T-lymphocytes
Gwenann Cadiou, Tiffany Beauvais, Lucine Marotte, Sylvia Lambot, Cécile Deleine, Caroline Vignes, Malika Gantier, Melanie Hussong, Samuel Rulli, Anne Jarry, Sylvain Simon, Bernard Malissen & Nathalie Labarriere
Article: 2376782
Published online: 08 Jul 2024
AbstractforDifferential impact of genetic deletion of TIGIT or PD-1 on melanoma-specific T-lymphocytes | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 440 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Interplay between oncolytic measles virus, macrophages and cancer cells induces a proinflammatory tumor microenvironment
Camille Chatelain, Laurine Berland, Marion Grard, Nicolas Jouand, Judith Fresquet, Joëlle Nader, Ugo Hirigoyen, Tacien Petithomme, Chantal Combredet, Elvire Pons-Tostivint, Delphine Fradin, Lucas Treps, Christophe Blanquart, Nicolas Boisgerault, Frédéric Tangy & Jean-François Fonteneau
Article: 2377830
Published online: 10 Jul 2024
AbstractforInterplay between oncolytic measles virus, macrophages and cancer cells induces a proinflammatory tumor microenvironment | Full Text | References | PDF (8.3 MB) | EPUB | Supplemental
  • 320 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Review

Review Article
Human NK cells and cancer
Claudia Cantoni, Michela Falco, Massimo Vitale, Gabriella Pietra, Enrico Munari, Daniela Pende, Maria Cristina Mingari, Simona Sivori & Lorenzo Moretta
Article: 2378520
Published online: 16 Jul 2024
AbstractforHuman NK cells and cancer | Full Text | References | PDF (929.2 KB) | EPUB
  • 321 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Review Article
In-depth analysis of the interplay between oncogenic mutations and NK cell-mediated cancer surveillance in solid tumors
Cecilia Pesini, Laura Artal, Jorge Paúl Bernal, Diego Sánchez Martinez, Julián Pardo & Ariel Ramírez-Labrada
Article: 2379062
Published online: 18 Jul 2024
AbstractforIn-depth analysis of the interplay between oncogenic mutations and NK cell-mediated cancer surveillance in solid tumors | Full Text | References | PDF (2.7 MB) | EPUB
  • 155 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Original research

Article
Selective lysis of acute myeloid leukemia cells by CD34/CD3 bispecific antibody through the activation of γδ T-cells
Faisal Al Agrafi, Ahmed Gaballa, Paula Hahn, Lucas C. M. Arruda, Adrian C. Jaramillo, Maartje Witsen, Sören Lehmann, Björn Önfelt, Michael Uhlin & Arwen Stikvoort
Article: 2379063
Published online: 27 Jul 2024
AbstractforSelective lysis of acute myeloid leukemia cells by CD34/CD3 bispecific antibody through the activation of γδ T-cells | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
  • 0 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
S100A10 promotes cancer metastasis via recruitment of MDSCs within the lungs
Juan Li, Can Zhou, Xiaoqian Gao, Tan Tan, Miao Zhang, Yazhao Li, He Chen, Ruiqi Wang, Bo Wang, Jie Liu & Peijun Liu
Article: 2381803
Published online: 24 Jul 2024
AbstractforS100A10 promotes cancer metastasis via recruitment of MDSCs within the lungs | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
  • 0 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
CXCR1/2 antagonism inhibits neutrophil function and not recruitment in cancer
Jeff W. Kwak, Helena Q. Nguyen, Alex Camai, Grace M. Huffman, Surapat Mekvanich, Naia N. Kenney, Xiaodong Zhu, Timothy W. Randolph & A. McGarry Houghton
Article: 2384674
Published online: 26 Jul 2024
AbstractforCXCR1/2 antagonism inhibits neutrophil function and not recruitment in cancer | Full Text | References | PDF (8.8 MB) | EPUB | Supplemental
  • 0 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Comment

Comment
Targeted opening of the blood–brain barrier facilitates doxorubicin/anti-PD-1-based chemoimmunotherapy of glioblastoma
Jonathan G. Pol, Manuela Lizarralde-Guerrero, Andrea Checcoli & Guido Kroemer
Article: 2385124
Published online: 27 Jul 2024
AbstractforTargeted opening of the blood–brain barrier facilitates doxorubicin/anti-PD-1-based chemoimmunotherapy of glioblastoma | Full Text | References | PDF (616.5 KB) | EPUB
  • 0 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Explore articles

Explore the most recently published articles

Selective lysis of acute myeloid leukemia cells by CD34/CD3 bispecific antibody through the activation of γδ T-cells
Faisal Al Agrafi et al.
Article | Published online: 27 Jul 2024
Open Access
Targeted opening of the blood–brain barrier facilitates doxorubicin/anti-PD-1-based chemoimmunotherapy of glioblastoma
Jonathan G. Pol et al.
Comment | Published online: 27 Jul 2024
Open Access
CXCR1/2 antagonism inhibits neutrophil function and not recruitment in cancer
Jeff W. Kwak et al.
Article | Published online: 26 Jul 2024
Open Access
S100A10 promotes cancer metastasis via recruitment of MDSCs within the lungs
Juan Li et al.
Article | Published online: 24 Jul 2024
Open Access
View all latest articles