The split hand in amyotrophic lateral sclerosis: a possible role for the neuromuscular junction

References

• Wilbourn AJ, Sweeney PJ. Dissociated wasting of medial and lateral hand muscles with motor neuron disease. Can J Neurol Sci. 1994;21:S9.
   Google Scholar
• Wilbourn AJ. The “split hand syndrome”. Muscle Nerve. 2000;23:138.
   Google Scholar
• Schelhaas HJ, van de Warrenburg BPC, Kremer HPH, Zwarts MJ. The “split hand” phenomenon: evidence of a spinal origin. Neurology. 2003;61:1619–20.
   Google Scholar
• Voermans NC, Schelhaas HJ, Munneke M, Zwarts MJ. Dissociated small hand muscle atrophy in aging: the 'senile hand' is a split hand. Eur J Neurol. 2006;13:1381–4.
   Google Scholar
• Menon P, Kiernan MC, Vucic S. ALS pathophysiology: insights from the split-hand phenomenon. Clin Neurophysiol. 2014;125:186–93.
   Google Scholar
• Kuwabara S, Mizobuchi K, Ogawara K, Hattori T. Dissociated small hand muscle involvement in amyotrophic lateral sclerosis detected by motor unit number estimates. Muscle Nerve. 1999;22:870–3.
   Google Scholar
• Kuwobara S, Sonoo M, Komori T, Shimizu T, Hirashima F, Inaba A, et al. Dissociated small hand muscle atrophy in amyotrophic lateral sclerosis: frequency, extent and specificity. Muscle Nerve. 2008;37:426–30.
   Google Scholar
• Menon P, Kiernan MC, Yiannikas C, Stroud J, Vucic S. Split-hand index for the diagnosis of amyotrophic lateral sclerosis. Clin Neurophysiol. 2013;134:410–6.
   Google Scholar
• Shibuya K, Misawa S, Nasu S, Sekiguchi Y, Mitsuma S, Beppu M, et al. Split hand syndrome in amyotrophic lateral sclerosis: different excitability changes in the thenar and hypothenar motor axons. J Neurol Neurosurg Psychiatry. 2013;84:969–72.
   Google Scholar
• Weber M, Eisen A, Stewart H, Hirota N. The split hand in ALS has a cortical basis. J Neurol Sci. 2000;180:66–70.
   Google Scholar
• Bae JS, Menon P, Mioshi E, Kiernan MC, Vucic S. Cortical hyperexcitability and the split hand-plus phenomenon: pathophysiological insights in ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2014;15:250–6.
   Google Scholar
• Cengiz B, Mercan M, Kuruoglu R. Spinal excitability changes so not influence mechanisms of the split hand syndrome in ALS. Muscle Nerve. 2018;58:503–8.
   Google Scholar
• Eisen A, Kuwabara S. The split hand syndrome in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2012;83:399–403.
   Google Scholar
• Eisen A, Braak H, Tredici KD, Lemon R, Ludolph AC, Kiernan MC. Cortical influences drive amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2017;88:917–24.
   Google Scholar
• Günther R, Neuwirth C, Koch JC, Lingor P, Braun N, Untucht R, et al. Motor unit number index (MUNIX) of hand muscles is a disease biomarker for adult spinal muscular atrophy. Clin Neurophysiol. 2019;130:315–9.
   Google Scholar
• Stålberg EV, Trontelj JV, Sanders DB. Jitter and impulse blocking. In: Single Fiber EMG. Fiskebackskill. Edshagen Publishing House. 3rd edn. 2010:46–86.
   Google Scholar
• Baumann F, Henderson RD, Tremayne F, Hutchinson N, McCombe PA. Effects of prolonged repetitive stimulation of median, ulnar and peroneal nerves. Muscle Nerve. 2010;41:785–93.
   Google Scholar
• Costa J, Evangelista T, Conceiçao I, de Carvalho M. Repetitive nerve stimulation in myasthenia gravis-relative sensitivity of different muscles. Clin Neurophysiol. 2004;115:2776–82.
   Google Scholar
• Santos MO, Swash M, De Carvalho M. Concentric or monopolar electrode for jitter determination in orbicularis oculi. Clin Neurophysiol. 2018;129:2552–6.
   Google Scholar
• De Carvalho M, Dengler R, Eisen A, England JD, Kaji R, Kimura J, et al. Electrodiagnostic criteria for diagnosis of ALS. Clin Neurophysiol. 2008;119:497–503.
   Google Scholar
• De Carvalho M, Swash M. Fasciculation potentials and earliest changes in motor unit physiology in ALS. J Neurol Neurosurg Psychiatry. 2013;84:963–8.
   Google Scholar
• Stålberg E, Antoni L. Electrophysiological cross section of the motor unit. J Neurol Neurosurg Psychiatry. 1980;43:469–74.
   Google Scholar
• Olney RK, Miller RG. Conduction block in compression neuropathy: recognition and quantification. Muscle Nerve. 1984;7:662–7.
   Google Scholar
• Asawa T, Shindo M, Momoi H. Compound muscle action potentials during repetitive nerve stimulation. Muscle Nerve. 2004;29:724–8.
   Google Scholar
• Lo YL, Dan YF, Leoh TH, Tan YE, Ratnagopal P. Decrement in area of muscle responses to repetitive nerve stimulation. Muscle Nerve. 2003;27:494–6.
   Google Scholar
• Moloney EB, de Winter F, Verhaagen J. ALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the disease. Front Neurosci. 2014;8:00252.
   Google Scholar
• Dupuis L, Loeffler GP. Neuromuscular junction destruction during amyotrophic lateral sclerosis: insights from transgenic models. Curr Opin Pharmacol. 2009;9:341–6.
   Google Scholar
• Li W, Brakefield B, Pan Y, Hunter D, Myckatyn TM, Parsadanian A. Muscle-derived but not centrally derived transgene GDNF is neuroprotective in G93A-SOD1 mouse model of ALS. Exp Neurol. 2007;203:457–71.
   Google Scholar
• Frey D, Schneider C, Xu L, Borg J, Spooren W, Caroni P. Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motor neuron diseases. J Neurosci. 2000;20:2534–42.
   Google Scholar
• Dengler R, Konstanzer A, Kuther G, Hesse S, Wolf W, Struppler A. Amyotrophic lateral sclerosis: macroEMG and twitch forces of single motor units. Muscle Nerve. 1990;13:545–50.
   Google Scholar
• Johnson MA, Polgar J, Weightman D, Appleton D. Data on the distribution of fibre types in 36 human muscles: an autopsy study. J Neurol Sci. 1973;18:111–29.
   Google Scholar
• de Carvalho M, Swash M. Sensitivity of electrophysiological tests for upper and lower motor neuron dysfunction in ALS: a 6-month longitudinal study. Muscle Nerve. 2010;41:208–11.
   Google Scholar
• de Carvalho M, Turkman A, Swash M. Motor responses evoked by transcranial magnetic stimulation and peripheral nerve stimulation in the ulnar innervation in amyotrophic lateral sclerosis: the effect of upper and lower motor neuron lesion. J Neurol Sci. 2003;210:83–90.
   Google Scholar
• Luc-Harkey BA, Harkey MS, Pamukoff DN, Kim RH, Royal TK, Blackburn JT, et al. Greater intracortical inhibition associates with lower quadriceps voluntary activation in individuals with ACL reconstruction. Exp Brain Res. 2017;235:1129–37.
   Google Scholar