Alantolactone induces apoptosis through ROS-mediated AKT pathway and inhibition of PINK1-mediated mitophagy in human HepG2 cells

References

• Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136:E359–E386.
   PubMed Web of Science ®Google Scholar
• Llovet JM, Zucman-Rossi J, Pikarsky E, et al. Hepatocellular carcinoma. Nat Rev Dis Primers. 2016;2:16018.
   PubMed Web of Science ®Google Scholar
• Worns MA, Galle PR. HCC therapies-lessons learned. Nat Rev Gastroenterol Hepatol. 2014;11:447–452.
   PubMed Web of Science ®Google Scholar
• Zhu AX. Systemic treatment of hepatocellular carcinoma: dawn of a new era? Ann Surg Oncol. 2010;17:1247–1256.
   PubMed Web of Science ®Google Scholar
• Kim SB, Dent R, Im SA, et al. Ipatasertib plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (LOTUS): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Oncol. 2017;18:1360–1372.
   PubMed Web of Science ®Google Scholar
• Wahab A, Gao K, Jia C, et al. Significance of resveratrol in clinical management of chronic diseases. Molecules. 2017;22:1329.
   PubMed Web of Science ®Google Scholar
• Gigliotti CL, Ferrara B, Occhipinti S, et al. Enhanced cytotoxic effect of camptothecin nanosponges in anaplastic thyroid cancer cells in vitro and in vivo on orthotopic xenograft tumours. Drug Deliv. 2017;24:670–680.
   PubMed Web of Science ®Google Scholar
• Trendafilova A, Chanev C, Todorova M. Ultrasound-assisted extraction of alantolactone and isoalantolactone from Inula helenium roots. Phcog Mag. 2010;6:234–237.
   Web of Science ®Google Scholar
• Meng JC, Hu YF, Chen JH, et al. Antifungal highly oxygenated guaianolides and other constituents from Ajania fruticulosa. Phytochemistry 2001;58:1141–1145.
   PubMed Web of Science ®Google Scholar
• Chun J, Choi RJ, Khan S, et al. Alantolactone suppresses inducible nitric oxide synthase and cyclooxygenase-2 expression by down-regulating NF-kappaB, MAPK and AP-1 via the MyD88 signaling pathway in LPS-activated RAW 264.7 cells. Int Immunopharmacol. 2012;14:375–383.
   PubMed Web of Science ®Google Scholar
• Yao Y, Xia D, Bian Y, et al. Alantolactone induces G1 phase arrest and apoptosis of multiple myeloma cells and overcomes bortezomib resistance. Apoptosis. 2015;20:1122–1133.
   PubMed Web of Science ®Google Scholar
• Lei JC, Yu JQ, Yin Y, et al. Alantolactone induces activation of apoptosis in human hepatoma cells. Food Chem Toxicol. 2012;50:3313–3319.
   PubMed Web of Science ®Google Scholar
• Khan M, Yi F, Rasul A, et al. Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction. IUBMB Life. 2012;64:783–794.
   PubMed Web of Science ®Google Scholar
• Khan M, Li T, Ahmad Khan MK, et al. Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction. BioMed Res Int. 2013;2013:1.
   Web of Science ®Google Scholar
• Youle RJ, Narendra DP. Mechanisms of mitophagy. Nat Rev Mol Cell Biol. 2011;12:9–14.
   PubMed Web of Science ®Google Scholar
• Larson-Casey JL, Deshane JS, Ryan AJ, et al. Macrophage akt1 kinase-mediated mitophagy modulates apoptosis resistance and pulmonary fibrosis. Immunity. 2016;44:582–596.
   PubMed Web of Science ®Google Scholar
• Prieto-Dominguez N, Ordonez R, Fernandez A, et al. Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy. J Pineal Res. 2016;61:396–407.
   PubMed Web of Science ®Google Scholar
• He L, Gu K. Tanshinone IIA regulates colorectal cancer apoptosis via attenuation of Parkin‑mediated mitophagy by suppressing AMPK/Skp2 pathways. Mol Med Rep. 2018;18:1692–1703.
   PubMed Web of Science ®Google Scholar
• Kuo YF, Su YZ, Tseng YH, et al. Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells. Free Radic Biol Med. 2010;49:214–226.
   PubMed Web of Science ®Google Scholar
• Shali H, Shabani M, Pourgholi F, et al. Co-delivery of insulin-like growth factor 1 receptor specific siRNA and doxorubicin using chitosan-based nanoparticles enhanced anticancer efficacy in A549 lung cancer cell line. Artif Cells Nanomed Biotechnol. 2018;46:293–302.
   PubMed Web of Science ®Google Scholar
• Ding Y, Wang H, Niu J, et al. Induction of ROS overload by alantolactone prompts oxidative DNA damage and apoptosis in colorectal cancer cells. Int J Mol Sci. 2016;17:558.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Bao YL, Wu Y, et al. Alantolactone induces apoptosis in RKO cells through the generation of reactive oxygen species and the mitochondrial pathway. Mol Med Rep. 2013;8:967–972.
   PubMed Web of Science ®Google Scholar
• Zafarullah M, Li WQ, Sylvester J, et al. Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci. 2003;60:6–20.
   PubMed Web of Science ®Google Scholar
• Song Y, Kong L, Sun B, et al. Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells. Cell Biol Int. 2017;41:1367–1378.
   PubMed Web of Science ®Google Scholar
• Wei R, Cao J, Yao S. Matrine promotes liver cancer cell apoptosis by inhibiting mitophagy and PINK1/Parkin pathways. Cell Stress Chaperones. 2018;23:1295–1309.
   PubMed Web of Science ®Google Scholar
• King KL, Cidlowski JA. Cell cycle regulation and apoptosis. Annu Rev Physiol. 1998;60:601–617.
   PubMed Web of Science ®Google Scholar
• Malumbres M, Barbacid M. Is Cyclin D1-CDK4 kinase a bona fide cancer target? Cancer Cell. 2006;9:2–4.
   PubMed Web of Science ®Google Scholar
• Cicenas J, Valius M. The CDK inhibitors in cancer research and therapy. J Cancer Res Clin Oncol. 2011;137:1409–1418.
   PubMed Web of Science ®Google Scholar
• Yang C, Yang J, Sun M, et al. Alantolactone inhibits growth of K562/adriamycin cells by downregulating Bcr/Abl and P-glycoprotein expression. IUBMB Life. 2013;65:435–444.
   PubMed Web of Science ®Google Scholar
• Cui L, Bu W, Song J, et al. Apoptosis induction by alantolactone in breast cancer MDA-MB-231 cells through reactive oxygen species-mediated mitochondrion-dependent pathway. Arch Pharm Res. 2018;41:299–313.
   PubMed Web of Science ®Google Scholar
• Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature. 2001;411:342–348.
   PubMed Web of Science ®Google Scholar
• Estaquier J, Vallette F, Vayssiere JL, et al. The mitochondrial pathways of apoptosis. Adv Exp Med Biol. 2012;942:157–183.
   PubMed Web of Science ®Google Scholar
• Jin Z, El-Deiry WS. Overview of cell death signaling pathways. Cancer Biol Ther. 2005;4:139–163.
   PubMed Web of Science ®Google Scholar
• Benhar M, Engelberg D, Levitzki A. ROS, stress-activated kinases and stress signaling in cancer. EMBO Rep. 2002;3:420–425.
   PubMed Web of Science ®Google Scholar
• Xu J, Zhang G, Tong Y, et al. Corilagin induces apoptosis, autophagy and ROS generation in gastric cancer cells in vitro. Int J Mol Med. 2019;43:967–979.
   PubMed Web of Science ®Google Scholar
• Lai ZQ, Ip SP, Liao HJ, et al. Brucein D, a naturally occurring tetracyclic triterpene quassinoid, induces apoptosis in pancreatic cancer through ROS-associated PI3K/Akt signaling pathway. Front Pharmacol. 2017;8:936.
   PubMed Web of Science ®Google Scholar
• Pei X, Xiao J, Wei G, et al. Oenothein B inhibits human non-small cell lung cancer A549 cell proliferation by ROS-mediated PI3K/Akt/NF-κB signaling pathway. Chem Biol Interact. 2019;298:112–120.
   PubMed Web of Science ®Google Scholar
• Zhang L, Zhao Y, Guo L. 17beta-estradiol protects INS-1 insulinoma cells from mitophagy via G protein-coupled estrogen receptors and the PI3K/Akt signaling pathway. Int J Mol Med. 2018;41:2839–2846.
   PubMed Web of Science ®Google Scholar
• Sun M, Wang S, Jiang L, et al. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis and impaired mitophagy in HepG2 cells. J Agric Food Chem. 2018;66:12376–12384.
   PubMed Web of Science ®Google Scholar
• Sun DZ, Song CQ, Xu YM, et al. Involvement of PINK1/Parkin-mediated mitophagy in paraquat- induced apoptosis in human lung epithelial-like A549 cells. Toxicol In Vitro. 2018;53:148–159.
   PubMed Web of Science ®Google Scholar
• Zhang C, Yu X, Gao J, et al. PINK1/Parkin-mediated mitophagy was activated against 1,4-Benzoquinone-induced apoptosis in HL-60 cells. Toxicol In Vitro. 2018;50:217–224.
   PubMed Web of Science ®Google Scholar
• Zhang HT, Mi L, Wang T, et al. PINK1/Parkin-mediated mitophagy play a protective role in manganese induced apoptosis in SH-SY5Y cells. Toxicol In Vitro. 2016;34:212–219.
   PubMed Web of Science ®Google Scholar