2,247
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Lixisenatide attenuates advanced glycation end products (AGEs)-induced degradation of extracellular matrix in human primary chondrocytes

, , &
Pages 1256-1264 | Received 25 Dec 2018, Accepted 01 Mar 2019, Published online: 03 Apr 2019

References

  • Cross M, Smith E, Hoy D, et al. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis. 2014;73:1323–1330.
  • Qu H, Li J, Wu L, et al. Trichostatin A increases the TIMP-1/MMP ratio to protect against osteoarthritis in an animal model of the disease. Mol Med Rep. 2016;14:2423–2430.
  • Goldring MB, Otero M, Plumb DA, et al. Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis. Eur Cell Mater. 2011;21:202.
  • Nowotny K, Jung T, Höhn A, et al. Advanced glycation end products and oxidative stress in type 2 diabetes mellitus. Biomolecules 2015;5:194–222.
  • Ott C, Jacobs K, Haucke E, et al. Role of advanced glycation end products in cellular signaling. Redox Biology. 2014;2:411–429.
  • Yu Z, Visse R, Inouye M, et al. Defining requirements for collagenase cleavage in collagen type III using a bacterial collagen system. J Biol Chem. 2012;287:22988–22997.
  • Manka SW, Carafoli F, Visse R, et al. Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1. Proc Nat Acad Sci. 2012;109:12461–12466.
  • Antonicelli F, Bellon G, Debelle L, et al. Elastin-elastases and inflamm-aging. Curr Top Dev Biol. 2007;79:99–155.
  • Fields GB. Interstitial collagen catabolism. J Biol Chem. 2013;288:8785–8793.
  • Gudmann NS, Karsdal MA. Type II Collagen. In: Karsdal MA, editor. Biochemistry of Collagens, Laminins and Elastin. Amsterdam, Nederland: Elsevier; 2016. p. 13–20.
  • Ismail HM, Yamamoto K, Vincent TL, et al. Interleukin-1 acts via the JNK-2 signaling pathway to induce aggrecan degradation by human chondrocytes. Arthritis & Rheumatol. 2015;67:1826–1836.
  • Ismail HM, Yamamoto K, Vincent T, et al. A significant role for the JNK pathway in regulating interleukin 1 induced-aggrecan degradation in human articular chondrocytes. Osteoarthritis and Cartilage. 2015;23:A152.
  • Verma P, Dalal K. ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis. J Cell Biochem. 2011;112:3507–3514.
  • Stannus O, Jones G, Cicuttini F, et al. Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults. Osteoarthr Cartil. 2010;18:1441–1447.
  • Forbes JM, Cooper ME, Oldfield MD, et al. Role of advanced glycation end products in diabetic nephropathy. J Am Soc Nephrol. 2003;14:S254–S258.
  • Roman-Blas JA, Jimenez SA. NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis. Osteoarthr Cartil. 2006;14:839–848.
  • Pfeffer MA, Claggett B, Diaz R, et al. Lixisenatide in patients with type 2 diabetes and acute coronary syndrome. N Engl J Med. 2015;373:2247–2257.
  • McClean PL, Hölscher C. Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer’s disease. Neuropharmacology 2014;86:241–258.
  • Vinué Á, Navarro J, Herrero-Cervera A, et al. The GLP-1 analogue lixisenatide decreases atherosclerosis in insulin-resistant mice by modulating macrophage phenotype. Diabetologia 2017;60:1801–1812.
  • Lee YS, Jun HS. Anti-inflammatory effects of GLP-1-based therapies beyond glucose control. Mediators of Inflam. 2016;2016:1.
  • Hansen MS, Tencerova M, Frølich J, et al. Effects of gastric inhibitory polypeptide, glucagon‐like peptide‐1 and glucagon‐like peptide‐1 receptor agonists on Bone Cell Metabolism. Basic Clin Pharmacol Toxicol. 2018;122:25–37.
  • Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007;132:2131–2157.
  • Berenbaum F, Bougault C, Attali C, inventors, Assistance Publique Hopitaux de Paris, assignee. Treatment of osteoarthritis with incretin hormones or analogues thereof. U.S. Patent No. 9,592,272. 2017 March 14.
  • FDA. Sanofi new drug application for lixisenatide accepted for review by FDA; 2013 Feb 19; Available from: Drugs.com/PRNewsire.
  • Kim Y, Zheng X, Ansari Z, et al. Mitochondrial aging defects emerge in directly reprogrammed human neurons due to their metabolic profile. Cell Rep. 2018;23:2550–2558.
  • Smith MD, Triantafillou S, Parker A, et al. Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. J Rheumatol. 1997;24:365–371.
  • Fernandes JC, Martel‐Pelletier J, Pelletier JP. The role of cytokines in osteoarthritis pathophysiology. Biorheology 2002;39:237–246.
  • Makki MS, Haqqi TM. Histone deacetylase inhibitor vorinostat (SAHA) suppresses IL-1β-induced matrix metallopeptidase-13 expression by inhibiting IL-6 in osteoarthritis chondrocyte. Am J Pathol. 2016;186:2701–2708.
  • Heinrich PC, Behrmann I, Serge H, et al. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J. 2003;374:1–20.
  • Lim H, Kim HP. Matrix metalloproteinase-13 expression in IL-1β-treated chondrocytes by activation of the p38 MAPK/c-Fos/AP-1 and JAK/STAT pathways. Arch Pharm Res. 2011;34:109–117.
  • Mohetaer M, Li G, Wang Y, et al. Protective effects of gemigliptin against type II collagen degradation in human chondrocytes. Biomed Pharmacother. 2018;104:590–594.
  • Mengshol JA, Vincenti MP, Coon CI, et al. Interleukin‐1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c‐jun N‐terminal kinase, and nuclear factor κB: differential regulation of collagenase 1 and collagenase 3. Arthritis & Rheumatol. 2000;43:801–811.
  • Zandi E, Rothwarf DM, Delhase M, et al. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell. 1997;91:243–252.