2,060
Views
14
CrossRef citations to date
0
Altmetric
Research Article

6-Gingerols (6G) reduces hypoxia-induced PC-12 cells apoptosis and autophagy through regulation of miR-103/BNIP3

, , , , &
Pages 1653-1661 | Received 04 Mar 2019, Accepted 04 Apr 2019, Published online: 02 May 2019

References

  • Zhao ZY, Gao YY, Gao L, et al. Protective effects of bellidifolin in hypoxia-induced in pheochromocytoma cells (PC12) and underlying mechanisms. J Toxicol Env Health Part A. 2017;80:1187–1192.
  • Yang Y, Rosenberg GA. Blood-brain barrier breakdown in acute and chronic cerebrovascular disease. Stroke 2011;42:3323–3328.
  • Zhou Y, Lu M, Du RH, et al. MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease. Mol Neurodegen. 2016;11:28.
  • Fedin AI. The efficacy of cortexin and memantinol (memantine) in the treatment of cognitive impairment in patients with chronic cerebral ischemia. Z Nevrol Psikhiatr im SS Korsakova. 2018;118:30–36.
  • Zheng WX, Cao XL, Wang F, et al. Baicalin inhibiting cerebral ischemia/hypoxia-induced neuronal apoptosis via MRTF-A-mediated transactivity. Euro J Pharmacol. 2015;767:201–210.
  • Li Y, Xu B, Xu M, et al. 6-Gingerol protects intestinal barrier from ischemia/reperfusion-induced damage via inhibition of p38 MAPK to NF-kappaB signalling. Pharmacol Res. 2017;119:137–148.
  • Choi JG, Kim SY, Jeong M, et al. Pharmacotherapeutic potential of ginger and its compounds in age-related neurological disorders. Pharmacol Ther. 2018;182:56–69.
  • Lv X, Xu T, Wu Q. 6-Gingerol activates PI3K/Akt and inhibits apoptosis to attenuate myocardial ischemia/reperfusion injury. Evidence-Based Compl Alter Med. 2018;2018:9024034.
  • Wang S, Tian M, Yang R, et al. 6-Gingerol ameliorates behavioral changes and atherosclerotic lesions in ApoE(–/–) mice exposed to chronic mild stress. Cardiovasc Toxicol. 2018;18:420–430.
  • Zhang F, Zhang JG, Yang W, et al. 6-Gingerol attenuates LPS-induced neuroinflammation and cognitive impairment partially via suppressing astrocyte overactivation. Biomed Pharmacother. 2018;107:1523–1529.
  • Ouyang YB, Stary CM, Yang GY, et al. microRNAs: innovative targets for cerebral ischemia and stroke. Curr Drug Targ. 2013;14:90–101.
  • Wan Y, Jin HJ, Zhu YY, et al. MicroRNA-149-5p regulates blood-brain barrier permeability after transient middle cerebral artery occlusion in rats by targeting S1PR2 of pericytes. FASEB J. 2018;32:3133–3148.
  • Wang J, Zhang Y, Xu F. Function and mechanism of microRNA-210 in acute cerebral infarction. Exp Ther Med. 2018;15:1263–1268.
  • Shi FP, Wang XH, Zhang HX, et al. MiR-103 regulates the angiogenesis of ischemic stroke rats by targeting vascular endothelial growth factor (VEGF). Iran J Basic Med Sci. 2018;21:318–324.
  • Althaus J, Bernaudin M, Petit E, et al. Expression of the gene encoding the pro-apoptotic BNIP3 protein and stimulation of hypoxia-inducible factor-1alpha (HIF-1alpha) protein following focal cerebral ischemia in rats. Neurochem Int. 2006;48:687–695.
  • Zhen Y, Ding C, Sun J, et al. Activation of the calcium-sensing receptor promotes apoptosis by modulating the JNK/p38 MAPK pathway in focal cerebral ischemia-reperfusion in mice. Am J Translat Res. 2016;8:911–921.
  • Wang Q, Li L, Li CY, et al. SIRT3 protects cells from hypoxia via PGC-1alpha- and MnSOD-dependent pathways. Neuroscience 2015;286:109–121.
  • Hartwig K, Fackler V, Jaksch-Bogensperger H, et al. Cerebrolysin protects PC12 cells from CoCl2-induced hypoxia employing GSK3beta signaling. Int J Develop Neurosci. 2014;38:52–58.
  • Chio CC, Wei L, Chen TG, et al. Neuron-derived orphan receptor 1 transduces survival signals in neuronal cells in response to hypoxia-induced apoptotic insults. J Neurosurg. 2016;124:1654–1664.
  • Song S, Tan J, Miao Y, et al. Intermittent-hypoxia-induced autophagy activation through the ER-stress-related PERK/eIF2alpha/ATF4 pathway is a protective response to pancreatic beta-cell apoptosis. Cell Physiol Biochem. 2018;51:2955–2971.
  • Tanida I, Ueno T, Kominami E. LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol. 2004;36:2503–2518.
  • Kim CY, Seo Y, Lee C, et al. Neuroprotective effect and molecular mechanism of [6]-Gingerol against scopolamine-induced amnesia in C57BL/6 mice. Evidence-Based Compl Alter Med. 2018;2018:8941564.
  • Chen Z, Lai TC, Jan YH, et al. Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis. J Clin Invest. 2013;123:1057–1067.
  • Dykstra-Aiello C, Jickling GC, Ander BP, et al. Altered expression of long noncoding RNAs in blood after ischemic stroke and proximity to putative stroke risk loci. Stroke 2016;47:2896–2903.
  • Zhao X, Liu L, Li R, et al. Hypoxia-inducible factor 1-alpha (HIF-1alpha) induces apoptosis of human uterosacral ligament fibroblasts through the death receptor and mitochondrial pathways. Med Sci Monit. 2018;24:8722–8733.
  • Singh A, Azad M, Shymko MD, et al. The BH3 only Bcl-2 family member BNIP3 regulates cellular proliferation. PLoS One. 2018;13:e0204792.
  • Vande Velde C, Cizeau J, Dubik D, et al. BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. Mol Cell Biol. 2000;20:5454–5468.
  • Kanzawa T, Zhang L, Xiao L, et al. Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene 2005;24:980–991.
  • Broom OJ, Widjaya B, Troelsen J, et al. Mitogen activated protein kinases: a role in inflammatory bowel disease? Clin Exper Immunol. 2009;158:272–280.
  • Suganuma T, Workman JL. MAP kinases and histone modification. J Mol Cell Biol. 2012;4:348–350.
  • Lan A, Liao X, Mo L, et al. Hydrogen sulfide protects against chemical hypoxia-induced injury by inhibiting ROS-activated ERK1/2 and p38MAPK signaling pathways in PC12 cells. PLoS One. 2011;6:e25921.
  • Shi C, Cai Y, Li Y, et al. Yap promotes hepatocellular carcinoma metastasis and mobilization via governing cofilin/F-actin/lamellipodium axis by regulation of JNK/Bnip3/SERCA/CaMKII pathways. Redox Biol. 2018;14:59–71.