MicroRNA-27b-3p inhibits apoptosis of chondrocyte in rheumatoid arthritis by targeting HIPK2

References

• Prabahar A, Natarajan J. MicroRNA mediated network motifs in autoimmune diseases and its crosstalk between genes, functions and pathways. J Immunol Meth. 2017;440:19–26.
   PubMed Web of Science ®Google Scholar
• Tobon GJ, Youinou P, Saraux A. The environment, geo-epidemiology, and autoimmune disease: Rheumatoid arthritis. J Autoimmun. 2010;35:10–14.
   PubMed Web of Science ®Google Scholar
• Choy E. Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis. Rheumatology 2012;51:v3–11.
   PubMed Web of Science ®Google Scholar
• Smolen JS, Breedveld FC, Burmester GR. Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force. Ann Rheum Dis. 2016;75:3–15.
   PubMed Web of Science ®Google Scholar
• Garnero P, Rousseau JC, Delmas PD. Molecular basis and clinical use of biochemical markers of bone, cartilage, and synovium in joint diseases. Arthritis Rheum. 2000;43:953–968.
   PubMed Web of Science ®Google Scholar
• Henc I, Kokotkiewicz A, Łuczkiewicz P, et al. Naturally occurring xanthone and benzophenone derivatives exert significant anti-proliferative and proapoptotic effects in vitro on synovial fibroblasts and macrophages from rheumatoid arthritis patients. Int Immunopharmacol. 2017;49:148–154.
   PubMed Web of Science ®Google Scholar
• Bustamante MF, Garcia-Carbonell R, Whisenant KD, et al. Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis. Arthritis Res Ther. 2017;19:110.
   PubMed Web of Science ®Google Scholar
• Rohner E, Matziolis G, Perka C, et al. Inflammatory synovial fluid microenvironment drives primary human chondrocytes to actively take part in inflammatory joint diseases. Immunol Res. 2012;52:169–175.
   PubMed Web of Science ®Google Scholar
• Davidson-Moncada J, Papavasiliou FN, Tam W. MicroRNAs of the immune system: roles in inflammation and cancer. Ann N Y Acad Sci. 2010;1183:183–194.
   PubMed Web of Science ®Google Scholar
• Cuppen BV, Rossato M, Fritsch-Stork RD, et al. Can baseline serum microRNAs predict response to TNF-alpha inhibitors in rheumatoid arthritis? Arthritis Res Ther. 2016;18:189.
   PubMed Web of Science ®Google Scholar
• Wang L, Wang C, Jia X, et al. Circulating exosomal miR-17 inhibits the induction of regulatory T cells via suppressing TGFBR II expression in rheumatoid arthritis. Cell Physiol Biochem. 2018;50:1754–1763.
   PubMed Web of Science ®Google Scholar
• Li Z, Li Y, Li Q, et al. Role of miR-9-5p in preventing peripheral neuropathy in patients with rheumatoid arthritis by targeting REST/miR-132 pathway. In Vitro Cell Dev Biol Anim. 2019;55:52–61.
   PubMed Web of Science ®Google Scholar
• Fu D, Xiao C, Xie Y, et al. MiR-3926 inhibits synovial fibroblasts proliferation and inflammatory cytokines secretion through targeting toll like receptor 5. Gene 2019;687:200–206.
   PubMed Web of Science ®Google Scholar
• Ye J, Wu X, Wu D, et al. miRNA-27b targets vascular endothelial growth factor C to inhibit tumor progression and angiogenesis in colorectal cancer. PloS One. 2013;8:e60687.
   PubMed Web of Science ®Google Scholar
• Wang Y, Rathinam R, Walch A, et al. ST14 (suppression of tumorigenicity 14) gene is a target for miR-27b, and the inhibitory effect of ST14 on cell growth is independent of miR-27b regulation. J Biol Chem. 2009;284:23094–23106.
   PubMed Web of Science ®Google Scholar
• Aletaha D, Neogi T, Silman AJ, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010;62:2569–2581.
   PubMed Web of Science ®Google Scholar
• El Miedany Y. Co-morbidity index in rheumatoid arthritis: time to think. Clin Rheumatol. 2015;34:1995–2000.
   PubMed Web of Science ®Google Scholar
• Kim BH, Yoon BR, Kim EK, et al. Alleviation of collagen-induced arthritis by the benzoxathiole derivative BOT-4-one in mice: Implication of the Th1- and Th17-cell-mediated immune responses. Biochem Pharmacol. 2016;110–111:47–57.
   PubMed Web of Science ®Google Scholar
• Tavasolian F, Abdollahi E, Rezaei R, et al. Altered expression of microRNAs in rheumatoid arthritis. J Cell Biochem. 2018;119:478–487.
   PubMed Web of Science ®Google Scholar
• Churov AV, Oleinik EK, Knip M. MicroRNAs in rheumatoid arthritis: altered expression and diagnostic potential. Autoimmun Rev. 2015;14:1029–1037.
   PubMed Web of Science ®Google Scholar
• Tang Y, Luo X, Cui H, et al. MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis Rheum. 2009;60:1065–1075.
   PubMed Web of Science ®Google Scholar
• Pincus T, Sokka T, Wolfe F. Premature mortality in patients with rheumatoid arthritis: evolving concepts. Arthritis Rheum. 2001;44:1234–1236.
   PubMed Web of Science ®Google Scholar
• Kloosterman WP, Plasterk RH. The diverse functions of microRNAs in animal development and disease. Dev Cell. 2006;11:441–450.
   PubMed Web of Science ®Google Scholar
• Zhou Q, Haupt S, Kreuzer JT, et al. Decreased expression of miR-146a and miR-155 contributes to an abnormal Treg phenotype in patients with rheumatoid arthritis. Ann Rheum Dis. 2015;74:1265–1274.
   PubMed Web of Science ®Google Scholar
• Nakamachi Y, Kawano S, Takenokuchi M, et al. MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthritis Rheum. 2009;60:1294–1304.
   PubMed Web of Science ®Google Scholar
• Semaan N, Frenzel L, Alsaleh G, et al. miR-346 controls release of TNF-α protein and stability of its mRNA in rheumatoid arthritis via tristetraprolin stabilization. PLoS One. 2011;6:e19827.
   PubMed Web of Science ®Google Scholar
• Saul VV, Schmitz ML. Posttranslational modifications regulate HIPK2, a driver of proliferative diseases. J Mol Med. 2013;91:1051–1058.
   PubMed Web of Science ®Google Scholar
• Blaquiere JA, Verheyen EM. Homeodomain-interacting protein kinases: diverse and complex roles in development and disease. Curr Top Dev Biol. 2017;123:73–103.
   PubMed Web of Science ®Google Scholar
• Huang Y, Tong J, He F, et al. MiR-141 regulates TGF-β1-induced epithelial-mesenchymal transition through repression of HIPK2 expression in renal tubular epithelial cells. Int J Mol Med. 2015;35:311–318.
   PubMed Web of Science ®Google Scholar
• D’Orazi G, Cecchinelli B, Bruno T, et al. Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol. 2002;4:11–19.
   PubMed Web of Science ®Google Scholar
• Hofmann TG, Moller A, Sirma H, et al. Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol. 2002;4:1–10.
   PubMed Web of Science ®Google Scholar
• Puca R, Nardinocchi L, Givol D, et al. Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells. Oncogene 2010;29:4378–4387.
   PubMed Web of Science ®Google Scholar
• Li Y, Lai-Han Leung E, Pan H, et al. Identification of potential genetic causal variants for rheumatoid arthritis by whole-exome sequencing. Oncotarget 2017;8:111119–111129.
   PubMedGoogle Scholar