CGRP accelerates the pathogenesis of neurological heterotopic ossification following spinal cord injury

References

• Genet F, Jourdan C, Schnitzler A, et al. Troublesome heterotopic ossification after central nervous system damage: a survey of 570 surgeries. PloS One. 2011;6:e16632.
   PubMed Web of Science ®Google Scholar
• Genet F, Kulina I, Vaquette C, et al. Neurological heterotopic ossification following spinal cord injury is triggered by macrophage-mediated inflammation in muscle. J Pathol. 2015;236:229–240.
   PubMed Web of Science ®Google Scholar
• Ranganathan K, Loder S, Agarwal S, et al. Heterotopic ossification: basic-science principles and clinical correlates. J Bone Joint Surg Am. 2015;97:1101–1111.
   PubMed Web of Science ®Google Scholar
• Sakellariou VI, Grigoriou E, Mavrogenis AF, et al. Heterotopic ossification following traumatic brain injury and spinal cord injury: insight into the etiology and pathophysiology. J Musculoskelet Neuronal Interact. 2012;12:230–240.
   PubMed Web of Science ®Google Scholar
• Davies OG, Grover LM, Eisenstein N, et al. Identifying the cellular mechanisms leading to heterotopic ossification. Calcif Tissue Int. 2015;97:432–444.
   PubMed Web of Science ®Google Scholar
• Tannous O, Stall AC, Griffith C, et al. Heterotopic bone formation about the hip undergoes endochondral ossification: a rabbit model. Clin Orthop Relat Res. 2013;471:1584–1592.
   PubMed Web of Science ®Google Scholar
• Garza A, Weinstock J, Robinson P. Absence of the SP/SP receptor circuitry in the substance P-precursor knockout mice or SP receptor, neurokinin (NK)1 knockout mice leads to an inhibited cytokine response in granulomas associated with murine Taenia crassiceps infection. J Parasitol. 2008;94:1253–1258.
   PubMed Web of Science ®Google Scholar
• Tuzmen C, Verdelis K, Weiss L, et al. Crosstalk between substance P and calcitonin gene-related peptide during heterotopic ossification in murine Achilles tendon. J Orthop Res. 2018;36:1444–1455.
   PubMed Web of Science ®Google Scholar
• Salisbury E, Rodenberg E, Sonnet C, et al. Sensory nerve induced inflammation contributes to heterotopic ossification. J Cell Biochem. 2011;112:2748–2758.
   PubMed Web of Science ®Google Scholar
• Wang XY, Guo X, Qu SX, et al. Temporal and spatial CGRP innervation in recombinant human bone morphogenetic protein induced spinal fusion in rabbits. Spine. 2009;34:2363–2368.
   PubMed Web of Science ®Google Scholar
• Sara C, Consuelo A, Massimo N, et al. Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells. Carcinogenesis. 2011;32:686–694.
   PubMed Web of Science ®Google Scholar
• Liu X, Kang H, Shahnazari M, et al. A novel mouse model of trauma induced heterotopic ossification. J Orthop Res. 2014;32:183–188.
   PubMed Web of Science ®Google Scholar
• Poyner DR, Sexton PM, Marshall I, et al. International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev. 2002;54:233–246.
   PubMed Web of Science ®Google Scholar
• Arulmani U, Maassenvandenbrink A, Villalon CM, et al. Calcitonin gene-related peptide and its role in migraine pathophysiology. Eur J Pharmacol. 2004;500:315–330.
   PubMed Web of Science ®Google Scholar
• Debaud C, Salga M, Begot L, et al. Peripheral denervation participates in heterotopic ossification in a spinal cord injury model. PloS One. 2017;12:e0182454.
   PubMed Web of Science ®Google Scholar
• Biswas AA, Goldhamer DJ. FACS fractionation and differentiation of skeletal-muscle resident multipotent Tie2+ progenitors. Methods Mol Biol. 2016;1460:255–267.
   PubMedGoogle Scholar
• Forsberg JA, Pepek JM, Wagner S, et al. Heterotopic ossification in high-energy wartime extremity injuries: prevalence and risk factors. J Bone Joint Surg Am. 2009;91:1084–1091.
   PubMed Web of Science ®Google Scholar
• Joe AWB, Lin Y, Anuradha N, et al. Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis. Nat Cell Biol. 2010;12:153–163.
   PubMed Web of Science ®Google Scholar
• Farup J, Madaro L, Puri PL, et al. Interactions between muscle stem cells, mesenchymal-derived cells and immune cells in muscle homeostasis, regeneration and disease. Cell Death Dis. 2015;6:e1830.
   PubMed Web of Science ®Google Scholar
• Gabi S, Monika WL, Zipora YR. Skeletal muscle satellite cells can spontaneously enter an alternative mesenchymal pathway. J Cell Sci. 2004;117:5393–5404.
   PubMed Web of Science ®Google Scholar
• Yong L, Johnny H. Differentiation of muscle-derived cells into myofibroblasts in injured skeletal muscle. Am J Pathol. 2002;161:895–907.
   PubMed Web of Science ®Google Scholar
• Lees-Shepard JB, Yamamoto M, Biswas AA, et al. Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva. Nat Commun. 2018;9:471.
   PubMed Web of Science ®Google Scholar
• Dey D, Bagarova J, Hatsell SJ, et al. Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification. Sci Transl Med. 2016;8:366ra163.
   PubMed Web of Science ®Google Scholar
• Martin CD, Juan Miguel JA, Ghilardi JR, et al. Organization of a unique net-like meshwork of CGRP + sensory fibers in the mouse periosteum: implications for the generation and maintenance of bone fracture pain. Neurosci Lett. 2007;427:148–152.
   PubMed Web of Science ®Google Scholar
• Jian L, Andris K, Jonas BM, et al. Site-specific CGRP innervation coincides with bone formation during fracture healing and modeling: a study in rat angulated tibia. J Orthop Res. 2010;25:1204–1212.
   Google Scholar
• Kyoko I, Koji H, Hiroshi N, et al. Inhibitory effect of CGRP on osteoclast formation by mouse bone marrow cells treated with isoproterenol. Neurosci Lett. 2005;379:47–51.
   PubMed Web of Science ®Google Scholar
• Zhou B, Zhou Y, Tang K. The effects of substance P on pluripotent tendon cells: an in vitro and in vivo study. J of Musculoskelet Neuronal Interact. 2014;14:349–358.
   PubMed Web of Science ®Google Scholar
• Ackermann PW, Li J, Lundeberg T, et al. Neuronal plasticity in relation to nociception and healing of rat achilles tendon. J Orthop Res. 2003;21:432–441.
   PubMed Web of Science ®Google Scholar
• Bucelli RC, Gonsiorek EA, Kim WY, et al. Statins decrease expression of the proinflammatory neuropeptides calcitonin gene-related peptide and substance P in sensory neurons. J Pharmacol Exp Ther. 2008;324:1172–1180.
   PubMed Web of Science ®Google Scholar
• Tian G, Zhang G, Tan YH. Calcitonin gene-related peptide stimulates BMP-2 expression and the differentiation of human osteoblast-like cells in vitro. Acta Pharmacol Sin. 2013;34:1467–1474.
   PubMed Web of Science ®Google Scholar