A comprehensive review of the physicochemical, quality and nutritional properties of Nigella sativa oil

References

• Ramadan, M.; Mörsel, J. T. Oxidative Stability of Black Cumin (Nigella Sativa L.), Coriander (Coriandrum Sativum L.) And Niger (Guizotia Abyssinica Cass.) Crude Seed Oils upon Stripping. Eur. J. Lipid Sci. Technol. 2004, 106(1), 35–43. DOI: 10.1002/ejlt.200300895.
   Web of Science ®Google Scholar
• Mozaffari, F.; Ghorbanli, M.; Babai, A.; Sepehr, M. F. The Effect of Water Stress on the Seed Oil of Nigella Sativa L. J. Essent. Oil Res. 2000, 12(1), 36–38. DOI: 10.1080/10412905.2000.9712036.
   Web of Science ®Google Scholar
• Ramadan, M. F. Nutritional Value, Functional Properties and Nutraceutical Applications of Black Cumin (Nigella Sativa L.)- An Overview. Int. J. Food Sci.Technol. 2007, 42(10), 1208–1218. DOI: 10.1111/j.1365-2621.2006.01417.x.
   Web of Science ®Google Scholar
• Ramadan, M. F.; Wahdan, M. Blending of Corn Oil with Black Cumin (Nigella Sativa) and Coriander (Coriandrum Sativum) Seed Oils: Impact on Functionality, Stability and Radical Scavenging Activity. Food Chem. 2012, 132, 873–879. DOI: 10.1016/j.foodchem.2011.11.054.
   Web of Science ®Google Scholar
• Rajsekhar, S.; Kuldeep, B. Pharmacognosy and Pharmacology of Nigella Sativa-A Review. Int. Res. J. Pharm. 2011, 2(11), 36–39.
   Google Scholar
• Atta, M. B. Some Characteristics of Nigella (Nigella Sativa L.) Seed Cultivated in Egypt and Its Lipid Profile. Food Chem. 2003, 83(1), 63–68. DOI: 10.1016/s0308-8146(03)00038-4.
   Web of Science ®Google Scholar
• Salem, M. Effect of Some Heat Treatment on Nigella Seeds Characteristics. 1-Some Physical and Chemical Properties of NigellaSeed Oil. J. Agric. Res. 2001, 27, 471–486.
   Google Scholar
• Edris, A. E. Evaluation of the Volatile Oils from Different Local Cultivars of Nigella Sativa L. Grown in Egypt with Emphasis on the Effect of Extraction Method on Thymoquinone. J. Essent. Oil. Bear. Pl. 2010, 13(2), 154–164. DOI: 10.1080/0972060X.2010.10643805.
   Web of Science ®Google Scholar
• Cheikh-Rouhou, S.; Besbes, S.; Hentati, B.; Blecker, C.; Deroanne, C.; Attia, H. Nigella Sativa L. Chemical Composition and Physicochemical Characteristics of Lipid Fraction. Food Chem. 2007, 101(2), 673–681. DOI: 10.1016/j.foodchem.2006.02.022.
   Web of Science ®Google Scholar
• Cheikh-Rouhou, S.; Besbes, S.; Lognay, G.; Blecker, C.; Deroanne, C.; Attia, H. Sterol Composition of Black Cumin (Nigella Sativa L.) And Aleppo Pine (Pinus Halepensis MilL.) Seed Oils. J. Food Compos. Anal. 2008, 21(2), 162–168. DOI: 10.1016/j.jfca.2007.09.001.
   Web of Science ®Google Scholar
• Ramadan, M.; Morsel, J.-T. Characterization of Phospholipid Composition of Black Cumin (Nigella Sativa L.) Seed Oil. Nahrung/Food. 2002, 46(4), 240. DOI: 10.1002/1521-3803(20020701)46:4<240::AID-FOOD240>3.0.CO;2-1.
   PubMedGoogle Scholar
• Hamrouni‐Sellami, I.; Elyes Kchouk, M.; Marzouk, B. Lipid and Aroma Composition of Black Cumin (Nigella Sativa L.) Seeds from Tunisia. J. Food Biochem. 2008, 32(3), 335–352. DOI: 10.1111/j.1745-4514.2008.00161.x.
   Web of Science ®Google Scholar
• Longato, E.; Meineri, G.; Peiretti, P. G. Nutritional and Zootechnical Aspects of Nigella Sativa: A Review. J. Anim. Plant Sci. 2015, 25(4), 921–934.
   Web of Science ®Google Scholar
• Ramadan, M. F.; Mörsel, J.-T. Neutral Lipid Classes of Black Cumin (Nigella Sativa L.) Seed Oils. Eur. Food Res. Technol. 2002, 214(3), 202–206. DOI: 10.1007/s00217-001-0423-8.
   Web of Science ®Google Scholar
• Azadmard-Damirchi, S.; Torbati, M. Adulterations in Some Edible Oils and Fats and Their Detection Methods. J. Food Qual. Hazards Control. 2015, 2(2), 38–44.
   Google Scholar
• Khoddami, A.; Ghazali, H. M.; Yassoralipour, A.; Ramakrishnan, Y.; Ganjloo, A. Physicochemical Characteristics of Nigella Seed (Nigella Sativa L.) Oil as Affected by Different Extraction Methods. J. Am. Oil Chem. Soc. 2011, 88(4), 533–540. DOI: 10.1007/S11746-010-1687-6.
   Web of Science ®Google Scholar
• Lopez-Lopez, A.; Castellote-Bargallo, A.; Campoy-Folgoso, C.; Rivero-Urgel, M.; Tormo-Carnice, R.; Infante-Pina, D.; López-Sabater, M. The Influence of Dietary Palmitic Acid Triacylglyceride Position on the Fatty Acid, Calcium and Magnesium Contents of at Term Newborn Faeces. Early. Hum. Dev. 2001, 65, S83–S94. DOI: 10.1016/S0378-3782(01)00210-9.
   PubMed Web of Science ®Google Scholar
• Ramadan, M. F.; Asker, M. M. S.; Tadros, M. Antiradical and Antimicrobial Properties of Cold-Pressed Black Cumin and Cumin Oils. Eur. Food Res. Technol. 2012, 234(5), 833–844. DOI: 10.1007/s00217-012-1696-9.
   Web of Science ®Google Scholar
• Edris, A. E. The Chemical Composition and the Content of Volatile Oil: Potential Factors that Can Contribute to the Oxidative Stability of Nigella Sativa L. Crude Oil. J. Diet. Suppl. 2011, 8(1), 34–42. DOI: 10.3109/19390211.2010.547242.
   PubMedGoogle Scholar
• Rudzińska, M.; Hassanein, M. M. M.; Abdel–Razek, A. G.; Ratusz, K.; Siger, A. Blends of Rapeseed Oil with Black Cumin and Rice Bran Oils for Increasing the Oxidative Stability. J. Food Sci. Technol. 2016, 53(2), 1055–1062. DOI: 10.1007/s13197-015-2140-5.
   PubMed Web of Science ®Google Scholar
• Ramadan, M. F.; Kroh, L. W.; Mörsel, J.-T. Radical Scavenging Activity of Black Cumin (Nigella Sativa L.), Coriander (Coriandrum Sativum L.), And Niger (Guizotia Abyssinica Cass.) Crude Seed Oils and Oil Fractions. J. Agric. Food Chem. 2003, 51(24), 6961–6969. DOI: 10.1021/jf0346713.
   PubMed Web of Science ®Google Scholar
• Nickavar, B.; Mojab, F.; Javidnia, K.; Amoli, M. A. R. Chemical Composition of the Fixed and Volatile Oils of Nigella Sativa L. From Iran. Z. Naturforsch. C Bio. Sci. 2003, 58(9–10), 629–631. DOI: 10.1016/j.indcrop.2013.02.013.
   PubMed Web of Science ®Google Scholar
• Asdadi, A.; Harhar, H.; Gharby, S.; Bouzoubaâ, Z.; Yadini, A.; Moutaj, R.; Hadek, M.; Chebli, B.; Hassani, L. Chemical Composition and Antifungal Activity of Nigella Sativa L. Oil Seed Cultivated in Morocco. Int. J. Pharma. Sci. Invent. 2014, 3, 9–15.
   Google Scholar
• Saleh AI-Jassir, M. Chemical Composition and Microflora of Black Cumin (Nigella Sativa L.) Seeds Growing in Saudi Arabia. Food Chem. 1992, 45, 239–242. DOI: 10.1016/0308-8146(92)90153-s.
   Web of Science ®Google Scholar
• Kiralan, M.; Özkan, G.; Bayrak, A.; Ramadan, M. F. Physicochemical Properties and Stability of Black Cumin (Nigella Sativa) Seed Oil as Affected by Different Extraction Methods. Ind. Crops. Prod. 2014, 57, 52–58. DOI: 10.1016/j.indcrop.2014.03.026.
   Web of Science ®Google Scholar
• Nergiz, C.; Ötleş, S. Chemical Composition of Nigella Sativa L. Seeds. Food Chem. 1993, 48(3), 259–261. DOI: 10.1016/0308-8146(92)90153-s.
   Web of Science ®Google Scholar
• Juhaimi, F. A.; Matthaeus, B.; Ghafoor, K.; Elbabiker, E. F.; Ozcan, M. Fatty Acids, Tocopherols, Minerals Contents of Nigella Sativa and Trigonella Foenum-Graecum Seed and Seed Oils. RIV. ITAL. SOSTANZE GR. 2016, 93, 165–171.
   Web of Science ®Google Scholar
• Piras, A.; Rosa, A.; Marongiu, B.; Porcedda, S.; Falconieri, D.; Dessi, M.; Ozcelik, B.; Koca, U. Chemical Composition and in Vitro Bioactivity of the Volatile and Fixed Oils of Nigella Sativa L.Extracted by Supercritical Carbon Dioxide. Ind. Crops. Prod. 2013, 46, 317–323. DOI: 10.1016/j.indcrop.2013.02.013.
   Web of Science ®Google Scholar
• Kiralan, M.; Ulaş, M.; Özaydin, A.; Özdemır, N.; Özkan, G.; Bayrak, A.; Ramadan, M. F. Blends of Cold Pressed Black Cumin Oil and Sunflower Oil with Improved Stability: A Study Based on Changes in the Levels of Volatiles, Tocopherols and Thymoquinone during Accelerated Oxidation Conditions. J. Food Biochem. 2017, 41, e12272. DOI: 10.1111/jfbc.12272.
   Web of Science ®Google Scholar
• Lutterodt, H.; Luther, M.; Slavin, M.; Yin, -J.-J.; Parry, J.; Gao, J.-M.; Yu, L. L. Fatty Acid Profile, Thymoquinone Content, Oxidative Stability, and Antioxidant Properties of Cold-Pressed Black Cumin Seed Oils. LWT-Food Sci. Technol. 2010, 43(9), 1409–1413. DOI: 10.1016/j.lwt.2010.04.009.
   Web of Science ®Google Scholar
• Al- Naqeeb, G.; Ismail, M.; Al-Zubairi, A. S. Fatty Acid Profile, α-Tocopherol Content and Total Antioxidant Activity of Oil Extracted from Nigella Sativa Seeds. Int. J. Pharmacol. 2009, 5, 244–250. DOI: 10.3923/ijp.2009.244.250.
   Google Scholar
• Wang, T.; Hicks, K. B.; Moreau, R. Antioxidant Activity of Phytosterols, Oryzanol, and Other Phytosterol Conjugates. J. Am. Oil Chem. Soc. 2002, 79(12), 1201–1206. DOI: 10.1007/s11746-002-0628-x.
   Web of Science ®Google Scholar
• Azadmard-Damirchi, S.; Dutta, P. C. Novel Solid-Phase Extraction Method to Separate 4-Desmethyl-, 4-Monomethyl-, and 4, 4′-Dimethylsterols in Vegetable Oils. J. Chromatography A. 2006, 1108(2), 183–187. DOI: 10.1016/j.chroma.2006.01.015.
   PubMed Web of Science ®Google Scholar
• Matthaus, B.; Ozcan, M. M. Fatty Acids, Tocopherol, and Sterol Contents of Some Nigella Species Seed Oil. Czech.J. Food Sci. 2011, 29, 145–150. DOI: 10.17221/206/2008-CJFS.
   Web of Science ®Google Scholar
• Ramadan, M.; Mörsel, J.-T. Direct Isocratic Normal-Phase HPLC Assay of Fat-Soluble Vitamins and ß-Carotene in Oilseeds. Eur. Food Res. Technol. 2002, 214(6), 521–527. DOI: 10.1007/s00217-002-0511-4.
   Web of Science ®Google Scholar
• Mahgoub, S. A.; Ramadan, M. F.; El-Zahar, K. M. Cold Pressed Nigella Sativa Oil Inhibits the Growth of Food Borne Pathogens and Improves the Quality of Domiati Cheese. J. Food Saf. 2013, 33(4), 470–480. DOI: 10.1111/jfs.12078.
   Web of Science ®Google Scholar
• Schwartz, H.; Ollilainen, V.; Piironen, V.; Lampi, A.-M. Tocopherol, Tocotrienol and Plant Sterol Contents of Vegetable Oils and Industrial Fats. J. Food Compost. Anal. 2008, 21(2), 152–161. DOI: 10.1016/j.jfca.2007.07.012.
   Web of Science ®Google Scholar
• D’Antuono, L. F.; Moretti, A.; Lovato, A. F. Seed Yield, Yield Components, Oil Content and Essential Oil Content and Composition of Nigella Sativa L. And Nigella Damascena L. Ind. Crops. Prod. 2002, 15(1), 59–69. DOI: 10.1016/s0926-6690(01)00096-6.
   Web of Science ®Google Scholar
• Wajs, A.; Bonikowski, R.; Kalemba, D. Composition of Essential Oil from Seeds of Nigella Sativa L. Cultivated in Poland. Flavour Fragr. J. 2008, 23(2), 126–132. DOI: 10.1002/ffj.1866.
   Web of Science ®Google Scholar
• Moretti, A.; D’Antuono, L. F.; Elementi, S. Essential Oils of Nigella Sativa L. And NigellaDamascena L. Seeds. J. Essent. Oil Res. 2004, 16, 182–183. DOI: 10.1080/10412905.2004.9698690.
   Web of Science ®Google Scholar
• Benkaci–Ali, F.; Baaliouamer, A.; Meklati, B. Y.; Chemat, F. Chemical Composition of Seed Essential Oils from Algerian Nigella Sativa Extracted by Microwave and Hydrodistillation. Flavour Fragr. J. 2007, 22(2), 148–153. DOI: 10.1002/ffj.1773.
   Web of Science ®Google Scholar
• Kiralan, M. Volatile Compounds of Black Cumin Seeds (Nigella Sativa L.) From Microwave‐Heating and Conventional Roasting. J. Food Sci. 2012, 77(4). DOI: 10.1111/j.1750-3841.2012.02638.x.
   PubMed Web of Science ®Google Scholar
• Juhaimi, F. A.; Figueredo, G.; Özcan, M. M.; Chalard, P. Comparison of Chemical Constituents of Essential Oils of Black Cumin (Nigella Sativa L.). Asian J. Chem. 2013, 25, 10407–10409. DOI: 10.14233/ajchem.
   Google Scholar
• Burits, M.; Bucar, F. Antioxidant Activity of Nigella Sativa Essential Oil. Phytother. Res. 2000, 14(5), 323–328. DOI: 10.1002/1099-1573(200008)14:5<323::AID-PTR621>3.0.CO;2-Q.
   PubMed Web of Science ®Google Scholar
• Kanter, M.; Akpolat, M.; Aktas, C. Protective Effects of the Volatile Oil of Nigella Sativa Seeds on β-cell Damage in Streptozotocin-Induced Diabetic Rats: ALight and Electron Microscopic Study. J. Mol. Histol. 2009, 40(5–6), 379–385. DOI: 10.1007/s10735-009-9251-0.
   PubMed Web of Science ®Google Scholar
• Janu, C.; Kumar, D.; Reshma, M.; Jayamurthy, P.; Sundaresan, A.; Nisha, P. Comparative Study on the Total Phenolic Content and Radical Scavenging Activity of Common Edible Vegetable Oils. J. Food Biochem. 2014, 38(1), 38–49. DOI: 10.1111/jfbc.12023.
   Web of Science ®Google Scholar
• Tynek, M.; Pawłowicz, R.; Gromadzka, J.; Tylingo, R.; Wardencki, W.; Karlovits, G. Virgin Rapeseed Oils Obtained from Different Rape Varieties by Cold Pressed Method–Their Characteristics, Properties, and Differences. Euro. J. Lipid Sci. Technol. 2012, 114(3), 357–366. DOI: 10.1002/ejlt.201100296.
   Web of Science ®Google Scholar
• Szydłowska-Czerniak, A.; Trokowski, K.; Karlovits, G.; Szłyk, E. Effect of Refining Processes on Antioxidant Capacity, Total Contents of Phenolics and Carotenoids in Palm Oils. Food Chem. 2011, 129(3), 1187–1192. DOI: 10.1016/j.foodchem.2011.05.101.
   PubMed Web of Science ®Google Scholar
• Tan, Y.; Chong, C.; Low, K. Crude Palm Oil Characteristics and Chlorophyll Content. J. Sci Food. Agric. 1997, 75(3), 281–288. DOI: 10.1002/(SICI)1097-0010(199711)75:3<281::AID-JSFA875>3.0.CO;2-A.
   Web of Science ®Google Scholar
• Teh, -S.-S.; Birch, J. Physicochemical and Quality Characteristics of Cold-Pressed Hemp, Flax and Canola Seed Oils. J. Food Compos. Anal. 2013, 30(1), 26–31. DOI: 10.1016/j.jfca.2013.01.004.
   Web of Science ®Google Scholar
• Psomiadou, E.; Tsimidou, M. Stability of Virgin Olive Oil. 1. Autoxidation Studies. J. Agric.Food. Chem. 2002, 50(4), 716–721. DOI: 10.1021/jf0108462.
   PubMed Web of Science ®Google Scholar
• Ramadan, M. F.; Mörsel, J. T. Analysis of Glycolipids from Black Cumin (Nigella Sativa L.), Coriander (Coriandrum Sativum L.) And Niger (Guizotia Abyssinica Cass.) Oilseeds. Food Chem. 2003, 80(2), 197–204. DOI: 10.1016/s0308-8146(02)00254-6.
   Web of Science ®Google Scholar
• Ghosheh, O. A.; Houdi, A. A.; Crooks, P. A. High Performance Liquid Chromatographic Analysis of the Pharmacologically Active Quinones and Related Compounds in the Oil of the Black Seed (Nigella Sativa L.). J. Pharm. Biomed. Anal. 1999, 19(5), 757–762. DOI: 10.1016/s0731-7085(98)00300-8.
   PubMed Web of Science ®Google Scholar
• Boseila, A.; Messalam, A. Immunostimulant Effect of Different Fractions of Nigella Sativa L. Seeds against Rabies Vaccine. Nat. Sci. 2011, 9(2), 7.
   Google Scholar
• Kiralan, M.; Ulas, M.; Ozaydin, A.; Ozdemir, N.; Ozkan, G.; Bayrak, A.; Ramadan, M. Changes in Hexanal, Thymoquinone and Tocopherols Levels in Blends from Sunflower and Black Cumin Oils as Affected by Storage at Room Temperature. Riv. Ital. Sostanze Gr. 2016, 93(4), 229–236.
   Web of Science ®Google Scholar
• Vieira, T. M.; Regitano-d’Arce, M. A. Canola Oil Thermal Oxidation during Oven Test and Microwave Heating. LWT-Food Sci. Technol. 2001, 34(4), 215–221. DOI: 10.1006/fstl.2000.0735.
   Google Scholar
• Abou-Gharbia, H. A.; Shehata, A. A. Y.; Shahidi, F. Effect of Processing on Oxidative Stability and Lipid Classes of Sesame Oil. Food. Res. Int. 2000, 33(5), 331–340. DOI: 10.1016/s0963-9969(00)00052-1.
   Web of Science ®Google Scholar
• Choe, E.; Min, D. B. Mechanisms and Factors for Edible Oil Oxidation. Comp. Rev. Food Sci. Food Saf. 2006, 5(4), 169–186. DOI: 10.1111/j.1541-4337.2006.00009.x.
   Web of Science ®Google Scholar
• Mazaheri, Y.; Torbati, M.; Azadmard-Damirchi, S.; Savage, G. P. Effect of Roasting and Microwave Pre-Treatments of Nigella Sativa L. Seeds on Lipase Activity and the Quality of the Oil. Food Chem. 2018, 274, 480–486. DOI: 10.1016/j.foodchem.2018.09.001.
   PubMed Web of Science ®Google Scholar
• Ramadan, M. F. Healthy Blends of High Linoleic Sunflower Oil with Selected Cold Pressed Oils: Functionality, Stability and Antioxidative Characteristics. Ind. Crops. Prod. 2013, 43, 65–72. DOI: 10.1016/s0963-9969(00)00052-1.
   Web of Science ®Google Scholar
• Moreau, R.; Kamal-Eldin, A. Gourmet and Health-Promoting Speciality Oils; AOCS Press, Urbana, IL, 2009.
   Google Scholar
• Arya, S.; Ramanujam, S.; Vijayaraghavan, P. Refractive Index as an Objective Method for Evaluation of Rancidity in Edible Oils and Fats. J. Am. Chem. Soc. 1969, 46(1), 28–30. DOI: 10.1007/BF02632705.
   Google Scholar
• Alimentarius, C. Codex Standard for Named Vegetable Oils. Codex Stan. 1999, 210, 11–25.
   Google Scholar
• Dos Santos, R. C.; De Melo Filho, A. A.; Chagas, E. A.; Takahashi, J. A.; Montero, I. F.; Holanda, L. C.; Ribeiro, P. R. E.; Dos Santos, G. F.; de Melo, A. C. G. R. Chemical Characterization of Oils and Fats from Amazonian Fruits by 1H NMR. Chemical Engineering Transactions, 2018, 64, 235–240. DOI: 10.20944/preprints201705.0078.v1.
   Google Scholar
• Fasina, O.; Colley, Z. Viscosity and Specific Heat of Vegetable Oils as a Function of Temperature: 35 C to 180 C. Int. J. Food Prop. 2008, 11(4), 738–746. DOI: 10.1080/10942910701586273.
   Web of Science ®Google Scholar
• Knobloch, K.; Pauli, A.; Iberl, B.; Weigand, H.; Weis, N. Antibacterial and Antifungal Properties of Essential Oil Components. J. Essent. Oil Res. 1989, 1(3), 119–128. DOI: 10.1080/10412905.1989.9697767.
   Google Scholar
• Gholamnezhad, Z.; Havakhah, S.; Boskabady, M. H. Preclinical and Clinical Effects of Nigella Sativa and Its Constituent, Thymoquinone-A Review. J. Ethnopharmacol. 2016, 190, 372–386. DOI: 10.1016/j.jep.2016.06.061.
   PubMed Web of Science ®Google Scholar
• Chaieb, K.; Kouidhi, B.; Jrah, H.; Mahdouani, K.; Bakhrouf, A. Antibacterial Activity of Thymoquinone, an Active Principle of Nigella Sativa and Its Potency to Prevent Bacterial Biofilm Formation. BMC Complement. Altern. Med. 2011, 11, 29. DOI: 10.1186/1472-6882-11-29.
   PubMed Web of Science ®Google Scholar
• Halawani, E. Antibacterial Activity of Thymoquinone and Thymohydroquinones of Nigella Sativa L. And Their Interaction with Some Antibiotics. Adv. Biolog Res. 2009, 3(5–6), 148–152. DOI: 10.1186/1472-6882-11-29.
   Google Scholar
• Khan, A.; Chen, H.; Tania, M.; Zhang, D. Anticancer Activities of Nigella Sativa (Black Cumin). Afr. J. Tradit. Complement. Altern. Med. 2011, 8, 226–232. DOI: 10.4314/ajtcam.v8i5S.10.
   PubMed Web of Science ®Google Scholar
• Edris, A. E. Anti-Cancer Properties of Nigella Spp. Essential Oils and Their Major Constituents, Thymoquinone and β-elemene. Curr. Clin. Pharmacol. 2009, 4(1), 43–46. DOI: 10.2174/157488409787236137.
   PubMedGoogle Scholar
• Badary, O. A.; AI-Shabanah, O. A.; Nagi, M. N.; AI-Rikabi, A. C.; Elmazar, M. M. A. Inhibition of Benzo (A) pyrene-Induced for Estomach Carcinogenesis in Mice by Thymoquinone. Eur. J. Cancer Prev. 1999, 8(5), 435–440.
   PubMed Web of Science ®Google Scholar
• El‐Mahdy, M. A.; Zhu, Q.; Wang, Q. E.; Wani, G.; Wani, A. A. Thymoquinone Induces Apoptosis through Activation of Caspase‐8 and Mitochondrial Events in P53‐Null Myeloblastic Leukemia HL‐60 Cells. Int. J. Canc. 2005, 117, 409–417. DOI: 10.1002/ijc.21205.
   PubMed Web of Science ®Google Scholar
• El-Najjar, N.; Chatila, M.; Moukadem, H.; Vuorela, H.; Ocker, M.; Gandesiri, M.; Schneider-Stock, R.; Gali-Muhtasib, H. Reactive Oxygen Species Mediate Thymoquinone-Induced Apoptosis and Activate ERK and JNK Signaling. Apoptosis. 2010, 15, 183–195. DOI: 10.1007/s10495-009-0421-z.
   PubMed Web of Science ®Google Scholar
• Gheita, T. A.; Kenawy, S. A. Effectiveness of Nigella Sativa Oil in the Management of Rheumatoid Arthritis Patients: A Placebo Controlled Study. Phytother. Res. 2012, 26, 1246–1248. DOI: 10.1002/ptr.3679.
   PubMed Web of Science ®Google Scholar
• Houghton, P. J.; Zarka, R.; De Las Heras, B.; Hoult, J. Fixed Oil of Nigella Sativa and Derived Thymoquinone Inhibit Eicosanoid Generation in Leukocytes and Membrane Lipid Peroxidation. Planta Med. 1995, 61(01), 33–36. DOI: 10.1055/s-2006-957994.
   PubMedGoogle Scholar
• Kirui, P.K.; Cameron, J.; Benghuzzi, H.A; Tucci, M.; Patel, R.; Adah, F., Russell, G. Effects of Sustained Delivery of Thymoqiunone on Bone Healing of Male Rats. Biomed. Sci. Instrum. 2004, 40, 111–116.
   PubMedGoogle Scholar
• Cheikh-Rouhou, S.; Besbes, S.; Hentati, B.; Blecker, C.; Deroanne, C.; Attia, H.; Nigella Sativa, L. Chemical Composition and Physicochemical Characteristics of Lipid Fraction. Food Chem. 2007, 101(2), 673–681. DOI: 10.1016/j.foodchem.2006.02.022.
   Web of Science ®Google Scholar
• Worthen, D. R.; Ghosheh, O. A.; Crooks, P. The in Vitro Anti-Tumor Activity of Some Crude and Purified Components of Black Seed. Nigella Sativa L. Anticancer Res. 1998, 18(3A), 1527–1532.
   PubMed Web of Science ®Google Scholar
• Morsi, N. M. Antimicrobial Effect of Crude Extracts of Nigella Sativa on Multiple Antibiotics-Resistant Bacteria. Acta Microbiol. Pol. 2000, 49(1), 63–74.
   PubMedGoogle Scholar
• Heshmati, J.; Namazi, N.; Memarzadeh, M.-R.; Taghizadeh, M.; Kolahdooz, F. Nigella Sativa Oil Affects Glucose Metabolism and Lipid Concentrations in Patients with Type Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial. Food Res. Int. 2015, 70, 87–93. DOI: 10.1016/j.foodres.2015.01.030.
   Web of Science ®Google Scholar
• Fallah Huseini, H.; Amini, M.; Mohtashami, R.; Ghamarchehre, M. E.; Sadeqhi, Z.; Kianbakht, S.; Fallah Huseini, A. Blood Pressure Lowering Effect of Nigella Sativa L. Seed Oil in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Phytother. Res. 2013, 27, 1849–1853. DOI: 10.1002/ptr.4944.
   PubMed Web of Science ®Google Scholar
• Khattab, M. M.; Nagi, M. N. Thymoquinone Supplementation Attenuates Hypertension and Renal Damage in Nitric Oxide Deficient Hypertensive Rats. Phytother. Res. 2007, 21(5), 410–414. DOI: 10.1002/ptr.2083.
   PubMed Web of Science ®Google Scholar
• Sacks, F. M.; Kass, E. H. Low Blood Pressure in Vegetarians: Effects of Specific Foods and Nutrients. Am. J. Clin. Nutr. 1988, 48, 795–800. DOI: 10.1093/ajcn/48.3.795.
   PubMed Web of Science ®Google Scholar
• Psaltopoulou, T.; Naska, A.; Orfanos, P.; Trichopoulos, D.; Mountokalakis, T.; Trichopoulou, A. Olive Oil, the Mediterranean Diet, and Arterial Blood Pressure: The Greek European Prospective Investigation into Cancer and Nutrition (EPIC) Study. Am. J. Clin. Nutr. 2004, 80, 1012–1018. DOI: 10.1093/ajcn/80.4.1012.
   PubMed Web of Science ®Google Scholar
• Alonso, A.; Ruiz-Gutierrez, V.; Martínez-González, M. A. Monounsaturated Fatty Acids, Olive Oil and Blood Pressure: Epidemiological, Clinical and Experimental Evidence. Public. Health. Nutr. 2006, 9(2), 251–257. DOI: 10.1079/PHN2005836P.
   PubMed Web of Science ®Google Scholar
• Medina-Remón, A.; Zamora-Ros, R.; Rotchés-Ribalta, M.; Andres-Lacueva, C.; Martínez-González, M. A.; Covas, M. I.; Corella, D.; Salas-Salvadó, J.; Gómez-Gracia, E.; Ruiz-Gutiérrez, V.; et al. Total Polyphenol Excretion and Blood Pressure in Subjects at High Cardiovascular Risk. Nutr. Metab. Cardiovasc. Dis. 2011, 21, 323–331. DOI: 10.1016/j.numecd.2009.10.019.
   PubMed Web of Science ®Google Scholar
• Jamal, A.; Hmza, A.; Omar, E.; Adnan, A.; Osman, M. T. Nigella Sativa Oil Has Significant Repairing Ability of Damaged Pancreatic Tissue Occurs in Induced Type 1 Diabetes Mellitus. Global J. Pharmacol. 2013, 7, 14–19. DOI: 10.5829/idosi.gjp.2013.7.1.7383.
   Google Scholar
• Wienkotter, N.; Hopner, D.; Schutte, U.; Bauer, K.; Begrow, F.; El-Dakhakhny, M.; Verspohl, E. J. The Effect of Nigellone and Thymoquinone on Inhibiting Trachea Contraction and Mucociliary Clearance. Planta Med. 2008, 74, 105–108. DOI: 10.1055/s-2008-1034280.
   PubMed Web of Science ®Google Scholar
• Chakravarty, N. Inhibition of Histamine Release from Mast Cells by Nigellone. Ann. Allergy. 1993, 70, 237–242.
   PubMedGoogle Scholar
• Ahmad, J.; Khan, R. A.; Malik, M. A. A. Study of Nigella Sativa Oil in the Management of Wheeze Associated Lower Respiratory Tract Illness in Children. Afr J. Pharm. Pharmacol. 2010, 4, 436–439.
   Google Scholar