Anticancer Potential of Carica papaya through Modulation of Cancer Hallmarks

References

• Bray, F.; Ferlay, J.; Soerjomataram, I.; Siegel, R. L.; Torre, L. A.; Jemal, A. Torre LA and Jemal A. Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J. Clin. 2018, 68(6), 394–424. DOI: 10.3322/caac.21492.
   PubMed Web of Science ®Google Scholar
• Kesika, P.; Sivamaruthi, B. S.; Chaiyasut, C. Health Promoting Effects of Fermented Foods against Cancer: An Updated Concise Review. Food Sci. Technol. 2020. DOI: 10.1590/fst.18220.
   Google Scholar
• Zhao, M.; Zhan, Q. Rehabilitation Treatment of Enteral Nutrition Whey Protein in Lung Cancer Patients in Southern China. Food Sci. Technol. 2020. DOI: 10.1590/fst.22620.
   Web of Science ®Google Scholar
• Ramkisson, S.; Dwarka, D.; Venter, S.; Mellem, J. J. VENTER S and MELLEM JJ. In Vitro Anticancer and Antioxidant Potential of Amaranthus Cruentus Protein and Its Hydrolysates. Food Sci. Technol. 2020, 40(suppl 2), 634–639. DOI: 10.1590/fst.36219.
   Google Scholar
• Cragg, G. M.; Pezzuto, J. M. Natural Products as a Vital Source for the Discovery of Cancer Chemotherapeutic and Chemopreventive Agents. Med. Principles Pract. 2016, 25((suppl 2)\(Suppl.2)), 41–59. DOI: 10.1159/000443404.
   PubMedGoogle Scholar
• Ming, R.; Yu, Q.; Moore, P.; Paull, R. E.; Chen, N. J.; Wang, M.-L.; Zhu, Y. J.; Schuler, M. A.; Jiang, J.; Paterson, A. H.;; et al. Genome of Papaya, a Fast Growing Tropical Fruit Tree. Tree Genet. Genomes. 2012, 8(3), 445–462.
   Web of Science ®Google Scholar
• Shahbandeh, M.; Papaya Production Worldwide from 2000 to 2017. 2020; Available at: https://www.statista.com/statistics/578039/world-papaya-production/.
   Google Scholar
• Ikram, E. H. K.; Stanley, R.; Netzel, M.; Fanning, K. Netzel M and Fanning K. Phytochemicals of Papaya and Its Traditional Health and Culinary Uses – A Review. J. Food Compost. Anal. 2015, 41, 201–211. DOI: 10.1016/j.jfca.2015.02.010.
   Web of Science ®Google Scholar
• Nugroho, A.; Heryani, H.; Choi, J. S.; Park, H.-J. Identification and Quantification of Flavonoids in Carica Papaya Leaf and Peroxynitrite-scavenging Activity. Asian Pac. J. Trop. Biomed. 2017, 7(3), 208–213. DOI: 10.1016/j.apjtb.2016.12.009.
   Web of Science ®Google Scholar
• Canini, A.; Alesiani, D.; D’Arcangelo, G.; Tagliatesta, P. D’arcangelo G and Tagliatesta P. Gas Chromatography–mass Spectrometry Analysis of Phenolic Compounds from Carica Papaya L. Leaf. J. Food Compost. Anal. 2007, 20(7), 584–590. DOI: 10.1016/j.jfca.2007.03.009.
   Web of Science ®Google Scholar
• Andarwulan, N.; Kurniasih, D.; Apriady, R. A.; Rahmat, H.; Roto, A. V.; Bolling, B. W. Roto AV and Bolling BW. Polyphenols, Carotenoids, and Ascorbic Acid in Underutilized Medicinal Vegetables. J. Funct. Foods. 2012, 4(1), 339–347. DOI: 10.1016/j.jff.2012.01.003.
   Web of Science ®Google Scholar
• Lako, J.; Trenerry, V. C.; Wahlqvist, M.; Wattanapenpaiboon, N.; Sotheeswaran, S.; Premier, R. Sotheeswaran S and Premier R. Phytochemical Flavonols, Carotenoids and the Antioxidant Properties of a Wide Selection of Fijian Fruit, Vegetables and Other Readily Available Foods. Food Chem. 2007, 101(4), 1727–1741. DOI: 10.1016/j.foodchem.2006.01.031.
   Web of Science ®Google Scholar
• Kelebek, H.; Selli, S.; Gubbuk, H.; Gunes, E. Gubbuk H and Gunes E. Comparative Evaluation of Volatiles, Phenolics, Sugars, Organic Acids and Antioxidant Properties of Sel-42 and Tainung Papaya Varieties. Food Chem. 2015, 173, 912–919. DOI: 10.1016/j.foodchem.2014.10.116.
   PubMed Web of Science ®Google Scholar
• Shen, Y. H.; Yang, F. Y.; Lu, B. G.; Zhao, W. W.; Jiang, T.; Feng, L.; Chen, X. J.; Ming, R. Exploring the Differential Mechanisms of Carotenoid Biosynthesis in the Yellow Peel and Red Flesh of Papaya. BMC Genom. 2019, 20(1), 49.
   PubMedGoogle Scholar
• Nurul, S. R.; Asmah, R. Evaluation of Antioxidant Properties in Fresh and Pickled Papaya. Int. Food Res. J. 2012, 19(3), 1117–1124.
   Google Scholar
• Gayosso-García Sancho, L. E.; Yahia, E. M.; González-Aguilar, G. A. Identification and Quantification of Phenols, Carotenoids, and Vitamin C from Papaya (Carica Papaya L., Cv. Maradol) Fruit Determined by HPLC-DAD-MS/MS-ESI. Food Res. Int. 2011, 44(5), 1284–1291. DOI: 10.1016/j.foodres.2010.12.001.
   Web of Science ®Google Scholar
• Siriamornpun, S.; Ratseewo, J.; Kaewseejan, N.; Meeso, N. Kaewseejan N and Meeso N. Effect of Osmotic Treatments and Drying Methods on Bioactive Compounds in Papaya and Tomato. RSC Adv. 2015, 5(24), 18579–18587. DOI: 10.1039/C4RA16927A.
   Web of Science ®Google Scholar
• Ugo, N. J.;. Ade AR and Joy AT. Nutrient Composition of Carica Papaya Leaves Extracts. J. Food Sci. Nutr. Res. 2019, 2(2019), 274–282.
   Google Scholar
• Imaga, N. A.; Gbenle, G. O.; Okochi, V. I.; Adenekan, S.; Duro-Emmanuel, T.; Oyeniyi, B.; Dokai, P. N.; Oyenuga, M.; Otumara, A. and Ekeh, F. C. Phytochemical and Antioxidant Nutrient Constituents of Carica Papaya and Parquetina Nigrescens Extracts. Sci. Res. Essays. 2010, 5(16), 2201–2205.
   Google Scholar
• Nwofia, G. E.;. Ojimelukwe P and Eji C. Chemical Composition of Leaves, Fruit Pulp and Seeds in Some Carica Papaya (L) Morphotypes. Int. J. Med. Aromatic Plants. 2012, 2(1), 200–206.
   Google Scholar
• Rossetto, M. R. M.; Oliveira Do Nascimento, J. R.; Purgatto, E.; Fabi, J. P.; Lajolo, F. M.; Cordenunsi, B. R. Benzylglucosinolate, Benzylisothiocyanate, and Myrosinase Activity in Papaya Fruit during Development and Ripening. J. Agric. Food Chem. 2008, 56(20), 9592–9599. DOI: 10.1021/jf801934x.
   PubMed Web of Science ®Google Scholar
• Subenthiran, S.; Choon, T. C.; Cheong, K. C.; Thayan, R.; Teck, M. B.; Muniandy, P. K.; Afzan, A.; Abdullah, N. R.; Ismail, Z.; et al. Carica Papaya Leaves Juice Significantly Accelerates the Rate of Increase in Platelet Count among Patients with Dengue Fever and Dengue Haemorrhagic Fever. Evid Based Complement Alternat Med. 2013, 2013, 616737. DOI: 10.1155/2013/616737.
   PubMed Web of Science ®Google Scholar
• La, T. K. Edible Medicinal and Non-Medicinal Plants Volume 1, Fruits, 2012. ed, 1st ed; Springer Netherlands: Imprint: Springer: Dordrecht, 2012.
   Google Scholar
• Block, K. I.; Gyllenhaal, C.; Lowe, L.; et al. Designing a Broad-spectrum Integrative Approach for Cancer Prevention and Treatment. Semi. Cancer Biol. 2015, 35(Suppl(Suppl)), S276–S304.
   PubMedGoogle Scholar
• Hanahan, D.; Weinberg Robert, A. Hallmarks of Cancer: The Next Generation. Cell. 2011, 144(5), 646–674. DOI: 10.1016/j.cell.2011.02.013.
   PubMed Web of Science ®Google Scholar
• Cho, H. J.; Park, J. H. Y. Kaempferol Induces Cell Cycle Arrest in HT-29 Human Colon Cancer Cells. J. Cancer Prev. 2013, 18(3), 257. DOI: 10.15430/JCP.2013.18.3.257.
   PubMedGoogle Scholar
• Xu, W.; Liu, J.; Li, C.; Wu, H.-Z.; Liu, Y.-W. Kaempferol-7- O-β- D-glucoside (KG) Isolated from Smilax China L. Rhizome Induces G 2/M Phase Arrest and Apoptosis on HeLa Cells in a P53-independent Manner. Cancer Lett. 2008, 264(2), 229–240. DOI: 10.1016/j.canlet.2008.01.044.
   PubMed Web of Science ®Google Scholar
• Jeong, J. H.; An, J. Y.; Kwon, Y. T.; Rhee, J. G.; Lee, Y. J. Rhee JG and Lee YJ. Effects of Low Dose Quercetin: Cancer Cell‐specific Inhibition of Cell Cycle Progression. J. Cell. Biochem. 2009, 106(1), 73–82. DOI: 10.1002/jcb.21977.
   PubMed Web of Science ®Google Scholar
• Hashemzaei, M.; Far, A. D.; Yari, A.; Heravi, R. E.; Tabrizian, K.; Taghdisi, S. M.; Sadegh, S. E.; Tsarouhas, K.; Kouretas, D.; Tzanakakis, G.; et al. Anticancer and Apoptosis-inducing Effects of Quercetin in Vitro and in vivo.(Report). Oncol. Rep. 2017, 38(2), 819.
   PubMed Web of Science ®Google Scholar
• Song, W.; Dang, Q.; Xu, D.; Chen, Y.; Zhu, G.; Wu, K.; Zeng, J.; Long, Q.; Wang, X.; He, D.; et al. Kaempferol Induces Cell Cycle Arrest and Apoptosis in Renal Cell Carcinoma through EGFR/p38 Signaling. Oncol. Rep. 2014, 31(3), 1350.
   PubMed Web of Science ®Google Scholar
• Owoyele, B.; Adebukola, O. Funmilayo A and Soladoye A. Anti-inflammatory Activities of Ethanolic Extract of Carica Papaya Leaves. Exp. Ther. Studies. 2008, 16(4), 168–173.
   Google Scholar
• Ahmed, M.; Ramabhimalah, S. Anti-Inflammatory Activity of Aqueous Extract of Carica Papaya Seeds in Albino Rats. Biomed. Pharmacol. J. 2012, 5(1), 173–177. DOI: 10.13005/bpj/340.
   Google Scholar
• Simone, R. E.; Russo, M.; Catalano, A.; Monego, G.; Froehlich, K.; Boehm, V.; Palozza, P. Lycopene Inhibits NF-kB-Mediated IL-8 Expression and Changes Redox and PPARγ Signalling in Cigarette Smoke–Stimulated Macrophages (Lycopene Inhibition of CSE-Induced IL-8 Production). PLoS ONE. 2011, 6(5), e19652.
   PubMedGoogle Scholar
• Chiang, H.-S.; Wu, W.-B.; Fang, J.-Y.; Chen, D.-F.; Chen, B.-H.; Huang, -C.-C.; Chen, Y.-T.; Hung, C.-F.; et al. Lycopene Inhibits PDGF-BB-induced Signaling and Migration in Human Dermal Fibroblasts through Interaction with PDGF-BB. Life Sci. 2007, 81(21–22), 1509–1517.
   PubMed Web of Science ®Google Scholar
• Muller, A.; Barat, S.; Chen, X.; Bui, K. C.; Bozko, P.; Malek, N. P. and Plentz, R. R. Comparative Study of Antitumor Effects of Bromelain and Papain in Human Cholangiocarcinoma Cell Lines. Report). 2016, 48(5), 2025.
   Google Scholar
• Singh, S. P.; Mathan, S. V.; Dheeraj, A.; Tailor, D.; Singh, R. P.; Acharya, A. Anticancer Effects and Associated Molecular Changes of Carica Papaya. AACR Annual Meeting 2019. Vol. Atlanta 2019.
   Google Scholar
• Hwang, E.-S.; Lee, H. J. Inhibitory Effects of Lycopene on the Adhesion, Invasion, and Migration of SK-Hep1 Human Hepatoma Cells. Experiment. Biol. Med. 2006, 231(3), 322–327. DOI: 10.1177/153537020623100313.
   PubMed Web of Science ®Google Scholar
• Huang, S.; Wang, -L.-L.; Xue, -N.-N.; Li, C.; Guo, -H.-H.; Ren, T.-K.; Zhan, Y.; Li, W.-B.; Zhang, J.; Chen, X.-G.;; et al. Chlorogenic Acid Effectively Treats Cancers through Induction of Cancer Cell Differentiation. Theranostics. 2019, 9(23), 6745.
   PubMed Web of Science ®Google Scholar
• Park, J.; Hwang, S.; Park, J.-H.; Lee, H.-J. Chlorogenic Acid Inhibits Hypoxia-induced Angiogenesis via Down-regulation of the HIF-1α/AKT Pathway. Official J. Int. Soc. Cell. Oncol. 2015, 38(2), 111–118.
   PubMed Web of Science ®Google Scholar
• Tayal, N.; Srivastava, P.; Srivastava, N. Srivastava P and Srivastava N. Anti Angiogenic Activity of Carica Papaya Leaf Extract. J. Pure Appl. Microbiol. 2019, 13(1), 567–571. DOI: 10.22207/JPAM.13.1.64.
   Web of Science ®Google Scholar
• Basu, A.; Haldar, S. Dietary Isothiocyanate Mediated Apoptosis of Human Cancer Cells Is Associated with Bcl-xL Phosphorylation. Int. J. Oncol. 2008, 33(4), 657–663.
   PubMed Web of Science ®Google Scholar
• Zuhrotun Nisa, F.; Astuti, M.; Murdiati, A.; Mubarika H, S. Murdiati A and Mubarika Haryana S. Anti-proliferation and Apoptosis Induction of Aqueous Leaf Extract of Carica Papaya L. On Human Breast Cancer Cells MCF-7. Pak. J. Biol. Sci. 2016, 20(1), 36. DOI: 10.3923/pjbs.2017.36.41.
   Google Scholar
• Rumiyati, S.;. Ariyani. Effect of the Protein Fraction of Carica Papaya L. Leaves on the Expressions of P53 and BCL-2 in Breast Cancer Cells Line. Maj Farm Indones. 2006, 17, 170–176.
   Google Scholar
• Kim, M. E.; Ha, T. K.; Yoon, J. H.; Lee, J. S. Yoon JH and Lee JS. Myricetin Induces Cell Death of Human Colon Cancer Cells via BAX/BCL2-dependent Pathway. Anticancer Res. 2014, 34(2), 701–706.
   PubMed Web of Science ®Google Scholar
• Phillips, P. A.; Sangwan, V.; Borja-Cacho, D.; Dudeja, V.; Vickers, S. M.; Saluja, A. K. Vickers SM and Saluja AK. Myricetin Induces Pancreatic Cancer Cell Death via the Induction of Apoptosis and Inhibition of the Phosphatidylinositol 3-kinase (PI3K) Signaling Pathway. Cancer Lett. 2011, 308(2), 181–188. DOI: 10.1016/j.canlet.2011.05.002.
   PubMed Web of Science ®Google Scholar
• Zhang, X.-H.; Chen, S.-Y.; Tang, L.; Shen, Y.-Z.; Luo, L.; Xu, C.-W.; Liu, Q.; Li, D.; et al. Myricetin Induces Apoptosis in HepG2 Cells through Akt/p70S6K/bad Signaling and Mitochondrial Apoptotic Pathway. Anti-Cancer Agents Med. Chem. 2013, 13(10), 1575.
   PubMed Web of Science ®Google Scholar
• Zheng, A.-W.; Chen, Y.-Q.; Zhao, L.-Q.; Feng, J.-G. Myricetin Induces Apoptosis and Enhances Chemosensitivity in Ovarian Cancer cells.(Report). Oncol. Letters. 2017, 13(6), 4974. DOI: 10.3892/ol.2017.6031.
   PubMed Web of Science ®Google Scholar
• Han, H.; Kim, H.; Kim, H. Lycopene Inhibits Activation of Epidermal Growth Factor Receptor and Expression of Cyclooxygenase-2 in Gastric Cancer Cells. Nutrients. 2019, 11(9), 2113. DOI: 10.3390/nu11092113.
   PubMed Web of Science ®Google Scholar
• Liew, S.-Y.; Stanbridge, E. J.; Yusoff, K.; Shafee, N. Yusoff K and Shafee N. Hypoxia Affects Cellular Responses to Plant Extracts. J. Ethnopharmacol. 2012, 144(2), 453–456. DOI: 10.1016/j.jep.2012.09.024.
   PubMed Web of Science ®Google Scholar
• Coothankandaswamy, V.; Liu, Y.; Mao, S.-C.; Morgan, J. B.; Mahdi, F.; Jekabsons, M. B.; Nagle, D. G.; Zhou, Y.-D.; et al. The Alternative Medicine Pawpaw and Its Acetogenin Constituents Suppress Tumor Angiogenesis via the HIF-1/VEGF Pathway. J. Nat. Prod. 2010, 73(5), 956.
   PubMed Web of Science ®Google Scholar
• Sahin, M.; Şahin, E.; Gümüşlü, S. Sahin E and Gümüşlü S. Effects of Lycopene and Apigenin on Human Umbilical Vein Endothelial Cells in Vitro under Angiogenic Stimulation. Acta Histochem. 2012, 114(2), 94–100. DOI: 10.1016/j.acthis.2011.03.004.
   PubMed Web of Science ®Google Scholar
• Johnson, D. G.; Schneider-Broussard, R. Role of E2F in Cell Cycle Control and Cancer. Front. Biosci. 1998, 3(4), d447–d448. DOI: 10.2741/A291.
   PubMedGoogle Scholar
• Tarek, A.; Anindya, D. P21 in Cancer: Intricate Networks and Multiple Activities. Nat. Rev. Cancer. 2009, 9(6), 400. DOI: 10.1038/nrc2657.
   PubMed Web of Science ®Google Scholar
• Casella, M. L.; Parody, J. P.; Ceballos, M. P.; Quiroga, A. D.; Ronco, M. T.; Francés, D. E.; Monti, J. A.; Pisani, G. B.; Carnovale, C. E.; Carrillo, M. C.; et al. Quercetin Prevents Liver Carcinogenesis by Inducing Cell Cycle Arrest, Decreasing Cell Proliferation and Enhancing Apoptosis. Mol. Nutr. Food Res. 2014, 58(2), 289–300.
   PubMed Web of Science ®Google Scholar
• Rivera‐Pastrana, D. M.; Yahia, E. M.; González‐Aguilar, G. A. Phenolic and Carotenoid Profiles of Papaya Fruit (Carica Papaya L.) And Their Contents under Low Temperature Storage. J. Sci. Food Agric. 2010, 90(14), 2358–2365. DOI: 10.1002/jsfa.4092.
   PubMed Web of Science ®Google Scholar
• Ugo, C.; Gerhard, C. Cell Adhesion and Signalling by Cadherins and Ig-CAMs in Cancer. Nat. Rev. Cancer. 2004, 4(2), 118. DOI: 10.1038/nrc1276.
   PubMed Web of Science ®Google Scholar
• Li, T.; Yan, G.; Bai, Y.; Wu, M.; Fang, G.; Zhang, M.; Xie, Y.; Borjigidai, A.; Fu, B.; et al. Papain Bioinspired Gold Nanoparticles Augmented the Anticancer Potency of 5-FU against Lung Cancer. J. Exp. Nanosci. 2020, 15(1), 109–128.
   Web of Science ®Google Scholar
• Chin-Shiu, H.; Shih, M.-K.; Cheng-Hung, C.; Miao-Lin, H. Lycopene Inhibits Cell Migration and Invasion and Upregulates Nm23-H1 in a Highly Invasive Hepatocarcinoma, SK-Hep-1 Cells1. J. Nutr. 2005, 135(9), 2119–2123. DOI: 10.1093/jn/135.9.2119.
   PubMed Web of Science ®Google Scholar
• Huang, C.-S.; Fan, Y.-E.; Lin, C.-Y.; Hu, M.-L. Lycopene Inhibits Matrix Metalloproteinase-9 Expression and Down-regulates the Binding Activity of Nuclear Factor-kappa B and Stimulatory Protein-1. J. Nutr. Biochem. 2007, 18(7), 449–456. DOI: 10.1016/j.jnutbio.2006.08.007.
   PubMed Web of Science ®Google Scholar
• Foshay, K. M.; Gallicano, G. I. miR-17 Family miRNAs are Expressed during Early Mammalian Development and Regulate Stem Cell Differentiation. Dev. Biol. 2009, 326(2), 431–443. DOI: 10.1016/j.ydbio.2008.11.016.
   PubMed Web of Science ®Google Scholar
• Li, B.-K.; Huang, P.-Z.; Qiu, J.-L.; Liao, Y.-D.; Hong, J.; Yuan, Y.-F. Upregulation of microRNA-106b Is Associated with Poor Prognosis in Hepatocellular Carcinoma. Diagn. Pathol. 2014, 9(1), 226. DOI: 10.1186/s13000-014-0226-4.
   PubMedGoogle Scholar
• Zheng, R.; Pan, L.; Gao, J.; Ye, X.; Chen, L.; Zhang, X.; Tang, W.; Zheng, W. Prognostic Value of miR-106b Expression in Breast Cancer Patients. J. Surg. Res. 2015, 195(1), 158–165.
   PubMed Web of Science ®Google Scholar
• Warburg, O.;. On the Origin of Cancer Cells. Science (New York, NY). 1956, 123(3191), 309. DOI: 10.1126/science.123.3191.309.
   Google Scholar
• Warburg, O.;. On Respiratory Impairment in Cancer Cells. Science (New York, NY). 1956, 124(3215), 269.
   Google Scholar
• Warburg, O.;. The Metabolism of Tumours: Investigations from the Kaiser Wilhelm Institute for Biology, Berlin-Dahlem. J. Am. Med. Assoc. 1931, 96(23), 1982.
   Google Scholar
• Deberardinis, R. J.; Lum, J. J.; Hatzivassiliou, G.; Thompson, C. B. Hatzivassiliou G and Thompson CB. The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation. Cell Metab. 2008, 7(1), 11–20. DOI: 10.1016/j.cmet.2007.10.002.
   PubMed Web of Science ®Google Scholar
• Jones, R. G.; Thompson, C. B. Tumor Suppressors and Cell Metabolism: A Recipe for Cancer growth.(Report). Genes Dev. 2009, 23(5), 537–548. DOI: 10.1101/gad.1756509.
   PubMed Web of Science ®Google Scholar
• Hanahan, D.; Folkman, J. Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis. 861996, 353–364.
   Google Scholar
• Ferrara, N.;. Vascular Endothelial Growth Factor. Arterioscler., Thromb., Vasc. Biol. 2009, 29(6), 789–791. DOI: 10.1161/ATVBAHA.108.179663.
   PubMed Web of Science ®Google Scholar
• Gabhann, F. M.; Popel, A. S. Systems Biology of Vascular Endothelial Growth Factors. Microcirculation. 2008, 15(8), 715–738. DOI: 10.1080/10739680802095964.
   PubMed Web of Science ®Google Scholar
• Carmeliet, P.;. VEGF as a Key Mediator of Angiogenesis in Cancer. Oncology. 2005, 69(3), 4–10. DOI: 10.1159/000088478.
   PubMed Web of Science ®Google Scholar
• Simona, N.; Gorgoulis, V. G.; Halazonetis, T. D.; Vassilis, G.G.; Thanos, D.H. Genomic Instability — An Evolving Hallmark of Cancer. Nat. Rev. Mol. Cell Biol. 2010, 11(3), 220. DOI: 10.1038/nrm2858.
   PubMed Web of Science ®Google Scholar
• Ciccia, A.; Elledge, S. J. The DNA Damage Response: Making It Safe to Play with Knives. Mol. Cell. 2010, 40(2), 179–204. DOI: 10.1016/j.molcel.2010.09.019.
   PubMed Web of Science ®Google Scholar
• Stephen, P. J.; Jiri, B. The DNA-damage Response in Human Biology and Disease. Nature. 2009, 461(7267), 1071. DOI: 10.1038/nature08467.
   PubMed Web of Science ®Google Scholar
• Kastan, M. B.;. DNA Damage Responses: Mechanisms and Roles in Human Disease: 2007 G.H.A. Clowes Memorial Award Lecture. Mol Cancer Res. 2008, 6(4), 517. DOI: 10.1158/1541-7786.MCR-08-0020.
   PubMed Web of Science ®Google Scholar
• Harper, J. W.; Elledge, S. J. The DNA Damage Response: Ten Years After. Mol. Cell. 2007, 28(5), 739–745. DOI: 10.1016/j.molcel.2007.11.015.
   PubMed Web of Science ®Google Scholar
• Friedberg, E. C.; Aguilera, A.; Gellert, M.; Hanawalt, P. C.; Hays, J. B.; Lehmann, A. R.; Lindahl, T.; Lowndes, N.; Sarasin, A.; Wood, R. D.; et al. DNA Repair: From Molecular Mechanism to Human Disease. DNA Repair. 2006, 5(8), 986–996.
   PubMed Web of Science ®Google Scholar
• Salk, J. J.; Fox, E. J.; Loeb, L. A. Fox EJ and Loeb LA. Mutational Heterogeneity in Human Cancers: Origin and Consequences. Annu Rev Pathol Mech Dis. 2010, 5(1), 51–75. DOI: 10.1146/annurev-pathol-121808-102113.
   PubMedGoogle Scholar