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Review

Research Advancement of Natural Active Components in Alleviating Lung Damage Induced by PM2.5

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References

  • Cox, L. A.;. Communicating More Clearly about Deaths Caused by Air Pollution. Global Epidemiol. 2019, 1, 100003. DOI: 10.1016/j.gloepi.2019.100003.
  • Odelle, L. H.;. Background PM2.5 Source Apportionment in the Remote Northwestern United States. Atmos. Environ. 2017, 167, 298–308. DOI: 10.1016/j.atmosenv.2017.08.030.
  • Song, Y.; Zhang, Y.; Dai, W. PM2.5 Sources and Their Effects on Human Health in China: Case Report. In Encyclopedia of Environmental Health (Second Edition); 2019; pp 274–281. doi:10.1016/B978-0-444-52272-6.00067-2
  • Chen, X. Y.; Li, F.; Zhang, J.; Zhou, W.; Wang, X.; Fu, H.;. Spatiotemporal Mapping and Multiple Driving Forces Identifying of PM2.5 Variation and Its Joint Management Strategies across China. J. Clean. Prod. 2020, 250, 119534. DOI: 10.1016/j.jclepro.2019.119534.
  • Zhang, J. Y.; Gao, Y.; Han, H.; Zou, C.; Feng, Y.; zhang, H.;. Matrine Suppresses Lung Metastasis of Human Hepatocellular Carcinoma by Directly Targeting Matrix Metalloproteinase-9. Biochem. Biophys. Res. Commun. 2019, 515(1), 57–63. DOI: 10.1016/j.bbrc.2019.04.063.
  • Herath, K. H. I. N. M.; Mihindukulasooriya, S. P.; Kim, H. J.; Kim, A.; Kim, H. J.; Jeon, Y.-J.; Jee, Y.;. Oral Administration of Polyphenol-rich Sargassum Horneri Suppresses Particulate Matter Exacerbated Airway Inflammation in Murine Allergic Asthma: Relevance to the TLR Mediated NF-κB Pathway Inhibition. J. Funct. Foods 2020, 71, 103991. DOI: 10.1016/j.jff.2020.103991.
  • Rodríguez-Urrego, D.; Rodríguez-Urrego, L. Air Quality during the COVID-19: PM2.5 Analysis in the 50 Most Polluted Capital Cities in the World. Environ. Pollut. 2020, 266, 115042. DOI: 10.1016/j.envpol.2020.115042.
  • Alderete, T. L.; Habre, R.; Toledo-Corral, C. M.; Berhane, K.; Chen, Z.; Lurmann, F. W.; Weigensberg, M. J.; Goran, M. I.; Gilliland, F. D.;. Longitudinal Associations between Ambient Air Pollution with Insulin Sensitivity, beta-Cell β-Cell Function, and Adiposity in Los Angeles Latino Children. Diabetes.2017, 66(7), 1789–1796. DOI: 10.2337/db16-1416.
  • Repetto, O.; De, R. E. Coagulation and Fibrinolysis in Gastric Cancer. Ann. N.Y. Acad. Sci. 2017, 1401(1), 27–48. DOI: 10.1111/nyas.13454.
  • Li, J.; Li, W. X.; Bai, C.; Song, Y.; Particulate Matter-induced Epigenetic Changes and Lung Cancer. Clin. Resp. J. 2017, 115, 539–546. DOI:10.1111/crj.12389.
  • Xue, Z. H.; Li, A.; Zhang, X.; Yu, W.; Wang, J.; Zhang, Y.; Gao, X.; Kou, X.;. iTRAQ Based Proteomic Analysis of PM2.5 Induced Lung Damage. RSC Adv. 2019, 9(21), 11707–11717. DOI: 10.1039/C9RA00252A.
  • Feng, S.; Duan, E.; Shi, X.; Zhang, H.; Li, H.; Zhao, Y.; Chao, L.; Zhong, X.; Zhang, W.; Li, R.;, Hydrogen Ameliorates Lung Injury in a Rat Model of Subacute Exposure to Concentrated Ambient PM2.5 Via Aryl Hydrocarbon Receptor. Int. Immunopharmacol. 2019, 77, 105939. DOI: 10.1016/j.intimp.2019.105939.
  • Yue, W. H.; Tong, L.; Liu, X.; Weng, X.; Chen, X.; Wang, D.; Dudley, S. C.; Weir, E. K.; Ding, W.; Lu, Z.;, et al. Short Term Pm2.5 Exposure Caused a Robust Lung Inflammation, Vascular Remodeling, and Exacerbated Transition from Left Ventricular Failure to Right Ventricular Hypertrophy. Redox Biol. 2019, 22, 101161. DOI: 10.1016/j.redox.2019.101161.
  • Zhu, Z. H.; Chen, X.; Sun, J.; Li, Q.; Lian, X.; Li, S.; Wang, Y.; Tian, L.;. Inhibition of Nuclear Thioredoxin Aggregation Attenuates PM2.5-induced NF-κB Activation and Pro-inflammatory Responses. Free Radical Biol. Med. 2019, 130, 206–214. DOI: 10.1016/j.freeradbiomed.2018.10.438.
  • Xue, Z. H.; Wang, J.; Yu, W.; Li, D.; Zhang, Y.; Wan, F.; Kou, X.;. Biochanin A Protects against PM2.5-induced Acute Pulmonary Cell Injury by Interacting with the Target Protein MEK5. Food & Function. Food Funct. 2019, 10(11), 7188–7203. DOI: 10.1039/C9FO01382B.
  • Vignal, C.; Pichavant, M.; Alleman, L. Y.; Djouina, M.; Dingreville, F.; Perdrix, E.; Waxin, C.; Ouali Alami, A.; Gower-Rousseau, C.; Desreumaux, P. Effects of Urban Coarse Particles Inhalation on Oxidative and Inflammatory Parameters in the Mouse Lung and Colon. Part. Fibre Toxicol. 2017, 14(1), 46. DOI: 10.1186/s12989-017-0227-z.
  • Dergham, M.; Lepers, C.; Verdin, A.; Cazier, F.; Billet, S.; Courcot, D.; Shirali, P.; Garçon, G. Temporal–spatial Variations of the Physicochemical Characteristics of Air Pollution Particulate Matter (PM2.5–0.3) And Toxicological Effects in Human Bronchial Epithelial Cells (BEAS-2B). Environ. Res. 2015, 137, 256–267. DOI: 10.1016/j.envres.2014.12.015.
  • Li, Y.; Sun, B.; Shi, Y.; Jiang, J.; Du, Z.; Chen, R.; Duan, J.; Sun, Z.;. Subacute Exposure of PM2.5 Induces Airway Inflammation through Inflammatory Cell Infiltration and Cytokine Expression in Rats. Chemosphere 2020, 251, 126423. DOI: 10.1016/j.chemosphere.2020.126423.
  • Bhargava, A.; Shukla, A.; Bunkar, N.; Shandilya, R.; Lodhi, L.; Kumari, R.; Gupta, P. K.; Rahman, A.; Chaudhury, K.; Tiwari, R.;, et al. Exposure to Ultrafine Particulate Matter Induces NF-κβ Mediated Epigenetic Modifications. Environ. Pollut. 2019, 252(A), 39–50. DOI: 10.1016/j.envpol.2019.05.065.
  • Zhao, H.; Yang, B.; Xu, J.; Chen, D.-M.; Xiao, C.-L.;. PM2.5-induced Alterations of Cell Cycle Associated Gene Expression in Lung Cancer Cells and Rat Lung Tissues. Environ. Toxicol. Pharmacol. 2017, 52, 77–82. DOI: 10.1016/j.etap.2017.03.014.
  • Ning, J.; Li, P.; Zhang, B.; Han, B.; Su, X.; Wang, Q.; Wang, X.; Li, B.; Kang, H.; Zhou, L.;, et al. miRNAs Deregulation in Serum of Mice Is Associated with Lung Cancer Related Pathway Deregulation Induced by PM2.5. Environ. Pollut. 2019, 254, 112875. DOI: 10.1016/j.etap.2017.03.014.
  • Li, J. L.; Hu, Y.; Liu, L.; Wang, Q.; Zeng, J.; Chen, C.; PM2.5 Exposure Perturbs Lung Microbiome and Its Metabolic Profile in Mice. Sci. Total Environ. 2020, 721, 137432. DOI: 10.1016/j.scitotenv.2020.137432.
  • Zhao, Y.; Xue, L.; Chen, Q.; Kou, M.; Wang, Z.; Wu, S.; Huang, J.; Guo, X.;. Cardiorespiratory Responses to Fine Particles during Ambient PM2.5 Pollution Waves: Findings from a Randomized Crossover Trial in Young Healthy Adults. Environ. Int. 2020, 139, 105590. DOI: 10.1016/j.envint.2020.105590.
  • Gao, Y.; Ji, H. B. Microscopic Morphology and Seasonal Variation of Health Effect Arising from Heavy Metals in PM2.5 And PM10: One-year Measurement in a Densely Populated Area of Urban Beijing. Atmos. Res. 2018, 212, 213–226. DOI: 10.1016/j.atmosres.2018.04.027.
  • Wong, W.; Chen, B. Z.; Lee, A. Chinese Herbal Medicine Effectively Prolongs the Overall Survival of Pancreatic Cancer Patients: A Case Series. Integr. Cancer Ther. 2019, 18. DOI: 10.1177/1534735419828836.
  • Wu, K.; Liang, T.; Duan, X.; Xu, L.; Zhang, K.; Li, R. Anti-diabetic Effects of Puerarin, Isolated from Pueraria Lobata (Willd.), On Streptozotocin-diabetogenic Mice through Promoting Insulin Expression and Ameliorating Metabolic Function. Food Chem. Toxicol. 2013, 60(10), 341–347. DOI: 10.1016/j.fct.2013.07.077.
  • Wu, Y. H.; Tseng, C. K.; Wu, H. C.; Wei, C.-K.; Lin, C.-K.; Chen, I.-S.; Chang, H.-S.; Lee, J.-C. Avocado (Persea Americana) Fruit Extract (2R, 4R)-1, 2, 4-trihydroxyheptadec-16-yne Inhibits Dengue Virus Replication via Upregulation of NF- κB-dependent Induction of Antiviral Interferon Responses. Sci. Rep. 2019, 9(1), 423. DOI: 10.1038/s41598-018-36714-4.
  • Xu, Z.; Zhang, F.; Bai, C.; Yao, C.; Zhong, H.; Zou, C.; Chen, X.; Sophoridine Induces Apoptosis and S Phase Arrest via ROS-dependent JNK and ERK Activation in Human Pancreatic Cancer Cells. J. Exp. Clin. Res. 2017, 361, 124. DOI:10.1186/s13046-017-0590-5.
  • Xue, H.; Lu, X.; Zheng, P. Highly Suppressing Wild-type HIV-1 and Y181C Mutant HIV-1 Strains by 10-chloromethyl-11-demethyl-12-oxo-calanolide A with Druggable Profile. J Med ChemJournal of Medicinal Chemistry. 2010, 53(3), 1397–1401. DOI: 10.1021/jm901653e10.1016/j.bbrc.2019.04.063.
  • Esposito, F.; Ambrosio, F. A.; Maleddu, R. Chromenone Derivatives as a Versatile Scaffold with Dual Mode of Inhibition of HIV-1 Reverse Transcriptase-associated Ribonuclease H Function and Integrase Activity. Eur J Med ChemEuropean Journal of Medicinal Chemistry. 2019, 182, 111617. DOI: 10.1016/j.ejmech.2019.11161710.1016/j.jff.2020.103991.
  • Estoppey, D.; Lee, C. M.; Janoschke, M. The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase. Cell RepReports. 2017, 19(3), 451–460. DOI: 10.1016/j.celrep.2017.03.07110.1016/j.jff.2020.103991.
  • Niu, S.; Si, L.; Liu, D.; Zhou, A.; Zhang, Z.; Shao, Z.; Wang, S.; Zhang, L.; Zhou, D.; Lin, W. Spiromastilactones: A New Class of Inflenza Virus Inhibitors from Deep-sea Fungus. Eur. J. Med. Chem. 2016, 108, 229–244. DOI: 10.1016/j.ejmech.2015.09.037.
  • Takano, H.; Nakajima, K.; Nagayoshi, Y.; Clinical Associations of Trousseau’s Syndrome Associated with Cerebral Infarction and Ovarian Cancer. Uynecol. Oncol. 2018, 295, e67. DOI:10.3802/jgo.2018.29.e67.
  • Wang, J.; Chen, F.; Liu, Y.; Liu, Y.; Li, K.; Yang, X.; Liu, S.; Zhou, X.; Yang, J. Spirostaphylotrichin X from a Marine-Derived Fungus as an Antiinfluenza Anti-influenza Agent Targeting RNA Polymerase PB2. J Nat ProdJournal of Natural Products. 2018, 81(12), 2722–2730. DOI: 10.1021/acs.jnatprod.8b00656.
  • Zeng, S.; Pottler, M.; Lan, B. Chemoresistance in Pancreatic Cancer. Int. J. Mol. Sci. 2019, 20(18), 4504. DOI: 10.3390/ijms20184504.
  • Zhang, Y. B.; Zhang, X. L.; Chen, N. H. Four Matrine-based Alkaloids with Antiviral Activities against HBV from the Seeds of Sophora Alopecuroides. Org. Lett. 2017, 19(2), 424–427. DOI: 10.1021/acs.orglett.6b03685.
  • Zhang, Y. B.; Luo, D.; Yang, L. Matrine-type Alkaloids from the Roots of Sophora Flavescens and Their Antiviral Activities against the Hepatitis B Virus. J. Org. Chem. 2018, 81, 2259–2265. DOI: 10.1021/acs.joc.6b00804.
  • Zhang, Y. B.; Yang, L.; Luo, D.; Chen, N.-H.; Wu, Z.-N.; Ye, W.-C.; Li, Y.-L.; Wang, G.-C. Sophalines E-I, Five Quinoli‐zidine-based Alkaloids with Antiviral Activities against the Hepatitis B Virus from the Seeds of Sophora Alopecuroides. Org. Lett. 2018, 20(18), 5942–5946. DOI: 10.1021/acs.orglett.8b02637.
  • Zhang, H. J.; Rumschlag-Booms, E.; Guan, Y. F.; Wang, D. Y.; Liu, K. L.; Li, W. F.; Nguyen, V. H.; Cuong, N. M.; Soejarto, D.D.; Fong, H. H. S.; Rong, L;. Potent Inhibitor of Drug-resistant HIV1 Strains Identified from the Medicinal Plant Justicia Gendarussa. J. Nat. Prod. 2017, 80(6), 1798–1807. DOI: 10.1021/acs.jnatprod.7b00004.
  • Huang, Y. S.; Lu, Y.; Chen, C. H. Potent anti-HIV Ingenane Diterpenoids from Euphorbia Ebracteolata. J. Nat. Prod. 2019, 82(6), 1587–1592. DOI: 10.1021/acs.jnatprod.9b00088.
  • Jian, J.; Fan, J.; Yang, H.; Lan, P.; Li, M.; Liu, P.; Gao, H.; Sun, P. Total Synthesis of the Flavonoid Natural Product Houttuynoid A. J. Nat. Prod. 2018, 81(2), 371–377. DOI: 10.1021/acs.jnatprod.7b00791.
  • Wang, W.; Wang, C.; Ding, X. Q.; Pan, Y.; Gu, -T.-T.; Wang, M.-X.; Liu, Y.-L.; Wang, F.-M.; Wang, S.-J.; Kong, L.-D. Quercetin and Allopurinol Reduce Liver Thioredoxin-interacting Protein to Alleviate Inflammation and Lipid Accumulation in Diabetic Rats. Br. J. Pharmacol. 2013, 169(6), 1352–1371. DOI: 10.1111/bph.12226.
  • Ding, L.; Jin, D.; Chen, X. Luteolin Enhances Insulin Sensitivity via Activation of PPAR-gamma PPARγ Transcriptional Activity in Adipocytes. Nutr. Biochem. 2010, 21(10), 941–947. DOI: 10.1016/j.jnutbio.2009.07.009.
  • Zhang, D.; Guo, J.; Zhang, M.; Liu, X.; Ba, M.; Tao, X.; Yu, L.; Guo, Y.; Dai, J. Oxazole-containing Diterpenoids from Cell Cultures of Salvia Miltiorrhiza and Their anti-HIV1 Activities. J. Nat. Prod. 2017, 80(12), 3241–3246. DOI: 10.1021/acs.jnatprod.7b00659.
  • Siegel, R. L.; Miller, K. D.; Jemal, A. Cancer Statistics, 2020. CA Cancer J. Clin. 2020, 70(1), 7–30. DOI: 10.3322/caac.21590.
  • Tian, C. L.; Zhang, P.; Yang, J.; Zhang, Z.; Wang, H.; Guo, Y.; Liu, M.;. The Protective Effect of the Flavonoid Fraction of Abutilon Theophrastus Medic. Leaves on LPS-induced Acute Lung Injury in Mice via the NF-κB and MAPK Signaling Pathways. Biomed. Pharmacother. 2019, 109, 1024–1031. DOI: 10.1016/j.biopha.2018.10.197.
  • Chu, C. J.; Yao, S.; Chen, J.; Wei, X.; Xia, L.; Chen, D.; Zhang, J.;. Eupatorium Lindleyanum DC. Flavonoids Fraction Attenuates Lipopolysaccharide-induced Acute Lung Injury in Mice. Int. Immunopharmacol. 2016, 39, 23–33. DOI: 10.1016/j.intimp.2016.06.032.
  • Cui, H.; Xu, B.; Wu, T.; Xu, J.; Yuan, Y.; Gu, Q. Potential Antiviral Lignans from the Roots of Saururus Chinensis with Activity against Epstein-Barr Virus Lytic Replication. J. Nat. Prod. 2014, 77(1), 100–110. DOI: 10.1021/np400757k.
  • Fang, P. L.; Cao, Y. L.; Yan, H.; Pan, -L.-L.; Liu, S.-C.; Gong, N.-B.; Lü, Y.; Chen, C.-X.; Zhong, H.-M.; Guo, Y. Lindenane Disesquiterpenoids with anti-HIV-1 Activity from Chloranthus Japonicus. J. Nat. Prod. 2011, 74(6), 1408–1413. DOI: 10.1021/np200087d.
  • Lee, H.; Kang, C.; Jung, E.-S.; Kim, J.-S.; Kim, E.;. Antimetastatic Activity of Polyphenol-rich Extract of Ecklonia Cava through the Inhibition of the Akt Pathway in A549 Human Lung Cancer Cells. Food Chem. 2001, 127(3), 1229–1236. DOI: 10.1016/j.foodchem.2011.02.005.
  • Li, J. J.; Chen, G. D.; Fan, H. X.; Houttuynoid, M.; Zhou, Z.-Q.; Lan, K.-H.; Zhang, H.-P.; Maeda, H.; Yao, X.-S.; Gao, H. Houttuynoid M, an anti-HSV Active Houttuynoid from Houttuynia Cordata Featuring a Bis-hout–tuynin Chain Tethered to a Flavonoid Core. J. Nat. Prod. 2017, 80(11), 3010–3013. DOI: 10.1021/acs.jnatprod.7b00620.
  • Li, T.; Liu, L.; Wu, H.; Chen, S.; Zhu, Q.; Gao, H.; Yu, X.; Wang, Y.; Su, W.; Yao, X. Anti-herpes Simplex Virus Type 1 Activity of Houttuynoid A, a New Flavonoid from Houttuynia Cordata Thunb. Antiviral Res. 2017, 144, 273–280. DOI: 10.1016/j.antiviral.2017.06.010.
  • Lin, Y.; Wang, Q.; Gu, Q.; Zhang, H.; Jiang, C.; Hu, J.; Wang, Y.; Yan, Y.; Xu, J. Semisynthesis of (-)-rutamarin Derivatives and Their Inhibitory Activity on Epstein-Barr Virus Lytic Replication. J. Nat. Prod. 2017, 80(1), 53–60. DOI: 10.1021/acs.jnatprod.6b00415.
  • Na, A. Y.; Yang, E. J.; Jeon, J. M.; Ki, S. H.; Song, K.-S.; Lee, S.; Protective Effect of Isoliquiritigenin against Ethanol-induced Hepatic Steatosis by Regulating the SIRT1-AMPK Pathway. Toxicol. Res. 2018, 341, 23. DOI:10.5487/TR.2018.34.1.023.
  • Su, G. F.; Chen, H.; Sun, X. H.; Baicalein Suppresses Non Small Cell Lung Cancer Cell Proliferation, Invasion and Notch Signaling Pathway. Cancer Biomark. 2018, 223, 1–6. DOI:10.3233/CBM-170673.
  • Zhou, Z. Q.; Tang, M. M.; Liu, Y. Apigenin Inhibits Cell Proliferation, Migration and Invasion by Targeting Akt in the A549 Human Lung Cancer Cell Line. Anticancer Drugs. 2017, 28(4), 446–456. DOI: 10.1016/j.bbrc.2019.05.002.
  • Lien, L. M.; Wang, M. J.; Chen, R. J.; Chiu, H.-C.; Wu, J.-L.; Shen, M.-Y.; Chou, D.-S.; Sheu, J.-R.; Lin, K.-H.; Lu, W.-J. Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways. Phytotherapy Res. 2016, 30(2), 214–221. DOI: 10.1002/ptr.5517.
  • Zhang, H. S.; Zhou, Y.; Wu, M. R. Resveratrol Inhibited Tatinduced HIV-1 LTR Transactivation via NAD-dependent SIRT1 Activity. Life Sci. 2009, 85(13–14), 484–489. DOI: 10.1016/j.lfs.2009.07.014.
  • Song, J.; Zhang, W.; Wang, J. Inhibition of FOXO3a/BIM Signaling Pathway Contributes to the Protective Effect of Salvianolic Acid A against Cerebral Ischemia/reperfusion Injury. Acta. Pharmaceutica Sinica B. 2019, 9(3), 505–515.
  • Sonar, V. P.; Corona, A.; Distinto, S. Natural Product-inspired Esters and Amides of Ferulic and Caffeic Acid as Dual Inhibitors of HIV-1 Reverse Transcriptase. Eur. J. Med. Chem. 2017, 130, 248–260. DOI: 10.1016/j.ejmech.2017.02.054.
  • Mandalari, G.; Bisignano, C.; D’arrigo, M. A Timicrobial Potential of Polyphenols Extracted from Almond Skins. Lett Appl. Microbiol. 2010, 51(1), 83–89. DOI: 10.1111/j.1472-765X.2010.02862.x.
  • Manna, S.; Mukherjee, S.; Roy, A.; Das, S.; Panda, C. K.;. Tea Polyphenols Can Restrict Benzo[a]pyrene-induced Lung Carcinogenesis by Altered Expression of P53-associated Genes and H-ras, C-myc and Cyclin D1. J. Nutr. Biochem. 2009, 20(5), 337–349. DOI: 10.1016/j.jnutbio.2008.04.001.
  • Stojkovic, D.; Petrovic, J.; Sokovic, M.; Glamočlija, J.; Kukić-Marković, J.; Petrović, S. In Situ Antioxidant and Antimicrobial Activities of Naturally Occurring Caffeic Acid,p-coumaric Acid and Rutin,using Food Systems. J. Sci. Food Agric. 2013, 93(13), 3205–3208. DOI: 10.1002/jsfa.6156.
  • Tome-Carneiro, J.; Visioli, F. Polyphenol-based Nutraceuticals for the Prevention and Treatment of Cardiovascular Disease: Review of Human Evidence. Phytomedicine. 2016, 23(11), 1145–1174. DOI: 10.1016/j.phymed.2015.10.018.
  • Barona, J.; Aristizabal, J. C.; Blesso, C. N.; Volek, J. S.; Fernandez, M. L. Grape Polyphenols Reduce Blood Pressure and Increase Flow-mediated Vasodilation in Men with Metabolic Syndrome. J. Nutr. 2012, 142(9), 1626–1632. DOI: 10.3945/jn.112.162743.
  • Agarwal, C.; Sharma, Y.; Zhao, J.; A Polyphenolic Fraction from Grape Seeds Causes Irreversible Growth Inhibition of Breast Carcinoma MDA-MB468 Cells by Inhibiting Mitogen- Activated Protein Kinases Activation and Inducing G1 Arrest and Differentiation. Clin. Cancer Res. 2000, 67, 2921–2930. DOI:10.1159/000007301.
  • Bizzarri, B. M.; Botta, L.; Regioselective, C. E. IBX-mediated Synthesis of Coumarin Derivatives with Antioxidant and Anti-influenza Activities. J. Nat. Prod. 2017, 80, 3247–3254. DOI: 10.1021/acs.jnatprod.7b00665.
  • Cao, F.; Shao, C. L.; Chen, M.; Zhang, M.-Q.; Xu, K.-X.; Meng, H.; Wang, C.-Y. Antiviral C25 Epimers of 26-ace–toxy Steroids from the South China Sea Gorgonian Echinogorgia Rebekka. J. Nat. Prod. 2014, 77(6), 1488–1493. DOI: 10.1021/np500252q.
  • Chauthe, S. K.; Bharate, S. B.; Sabde, S.; Mitra, D.; Bhutani, K. K.; Singh, I. P. Biomimetic Synthesis and anti-HIV Activity of Dimeric Phloroglucinols. Bioorg. Med. Chem. 2010, 18(5), 2029–2036. DOI: 10.1016/j.bmc.2010.01.023.
  • Chen, M.; Shao, C. L.; Meng, H.; She, Z.-G.; Wang, C.-Y. Anti-respiratory Syncytia Virus Prenylated Dihydroquinolone Derivatives from the Gorgonian-derived Fungus Aspergillus. J. Nat. Prod. 2014, 77(12), 2720–2724. DOI: 10.1021/np500650t.
  • Chen, S. G.; Cheng, M. L.; Chen, K. H.; Horng, J.-T.; Liu, -C.-C.; Wang, S.-M.; Sakurai, H.; Leu, Y.-L.; Wang, S.-D.; Ho, H.-Y. Antiviral Activities of Schizonepeta Tenuifolia Briq. Against Enterovirus 71 in Vitro and in Vivo. Sci. Rep. 2017, 7(1), 935. DOI: 10.1038/s41598-017-01110-x.
  • Cho, Y.; Lee, J. H.; Kim, J. H.; Lee, S.-Y.; Yoo, S.; Jung, M.-K.; Kim, S. J.; Yoo, H. J.; Pack, C.-G.; Rho, J. K. Matrine Suppresses KRAS-driven Pancreatic Cancer Growth by Inhibiting Autophagy -mediated Energy Metabolism. Mol. Oncol. 2018, 12(7), 1203–1215. DOI: 10.1002/1878-0261.12324.
  • Ozdal, T.; Sela, D. A.; Xiao, J.; Boyacioglu, D.; Chen, F.; Capanoglu, E. The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility. Nutrients. 2016, 8(2), 78. DOI: 10.3390/nu8020078.
  • Prasad, S.; Tyagi, A. K. Curcumin and Its Analogues: A Potential Natural Compound against HIV Infection and AIDS. Food Funct. 2015, 6(11), 3412–3419. DOI: 10.1039/c5fo00485c.
  • Fois, B.; Bianco, G.; Sonar, V. P.; Distinto, S.; Maccioni, E.; Meleddu, R.; Melis, C.; Marras, L.; Pompei, R.; Floris, C. Phenylpropenoids from Bupleurum Fruticosum as Anti-human Rhinovirus Species a Selective Capsid Binder. J. Nat. Prod. 2017, 80(10), 2799–2806. DOI: 10.1021/acs.jnatprod.7b00648.
  • Li, Y. H.; Wu, Z. Y.; Tang, S. Evolution of Matrinic Ethanol Derivatives as anti-HCV Agents from Matrine Skeleton. Bioorg. Med. Chem. Lett. 2017, 27(9), 1962–1966. DOI: 10.1016/j.bmcl.2017.03.025.
  • Park, S. H.; Sung, J. H.; Kim, E. J.; Chung, N. Berberine Induces Apoptosis via ROS Generation in PANC-1 and MIA-PaCa2 Pancreatic Cell Lines. Braz. J. Med. Biol. Res. 2015, 48(2), 111–119. DOI: 10.1590/1414-431X20144293.
  • Vendrely, V.; Amintas, S.; Noel, C.; Moranvillier, I.; Lamrissi, I.; Rousseau, B.; Coulibaly, S.; Bedel, A.; Moreau-Gaudry, F.; Buscail, E. Combination Treatment of Resveratrol and Capsaicin Radiosensitizes Pancreatic Tumor Cells by Unbalancing DNA Repair Response to Radiotherapy Towards Cell Death. Cancer Lett. 2019, 451, 1–10. DOI: 10.1016/j.canlet.2019.02.038.
  • Zhang, Y. B.; Fei, H. X.; Guo, J. Dauricine Suppresses the Growth of Pancreatic Cancer in Vivo by Modulating the Hedgehog Signaling Pathway. Oncol. Lett. 2019, 18(5), 4403–4414. DOI: 10.3892/ol.2019.10790.
  • Jiang, G.; Mendes, E. A.; Kaiser, P.; Wong, D. P.; Tang, Y.; Cai, I.; Fenton, A.; Melcher, G. P.; Hildreth, J. E. K.; Thompson, G. R. Synergistic Reactivation of Latent HIV Expression by Ingenol-3-angelate, PEP005, Targeted NF-κB Signaling in Combination with JQ1 Induced p-TEFb Activation. PLoS Pathog. 2015, 11(7), e1005066. DOI: 10.1371/journal.ppat.1005066.
  • Jin, Z. Q.; Hao, J.; Yang, X. Higenamine Enhances the Antitumor Effects of Cucurbitacin B in Breast Cancer by Inhibiting the Interaction of AKT and CDK2. Oncol. Rep. 2018, 40(4), 2127–2136. DOI: 10.3892/or.2018.6629.
  • Wang, L.; Zhao, L.; Wei, G.; Saur, D.; Seidler, B.; Wang, J.; Wang, C.; Qi, T. Homohar Ringtonine Could Induce Quick Protein Synthesis of PSMD11 through Activating MEK1/ERK1/2 Signaling Pathway in Pancreatic Cancer Cells. J. Cell. Biochem. 2018, 119(8), 6644–6656. DOI: 10.1002/jcb.26847.
  • Zhang, X.; Liu, Q.; Zhang, N.; Li, Q.; Liu, Z.; Li, Y.; Gao, L.; Wang, Y.; Deng, H.; Song, D. Discovery and Evolution of Aloperine Derivatives as Novel Anti-filovirus Agents through Targeting Entry Stage. Eur. J. Med. Chem. 2018, 149, 45–55. DOI: 10.1016/j.ejmech.2018.02.061.
  • Zhang, X.; Lv, X. Q.; Tang, S.; Mei, L.; Li, Y.; Zhang, J.; Jiang, J.; Peng, Z.; Song, D. Discovery and Evolution of Aloperine Derivatives as a New Family of HCV Inhibitors with Novel Mechanism. Eur. J. Med. Chem. 2018, 143, 1053–1065. DOI: 10.1016/j.ejmech.2017.12.002.
  • Feng, T.; Chen, H.; Peng, Y. Neferine Induces Apoptosis of Pancreatic Cancer Cells through P38 MAPK/JNK Activation. Trop. J. Pharm. Res. 2019, 18(8), 1615–1619.
  • He, X.; Wang, Y.; Luo, R. H. Dimeric Pyranonaphthoquinone Glycosides with anti-HIV and Cytotoxic Activities from a Soil-derived Streptomyces. J. Nat. Prod. 2019, 82(7), 1813–1819. DOI: 10.1021/acs.jnatprod.9b00022.
  • Hong, Z.; Wang, Z.; Zhou, B. Effects of Evodiamine on PI3K/Akt and MAPK/ERK Signaling Pathways in Pancreatic Cancer Cells. Int. J. Oncol. 2020, 56(3), 783–793. DOI: 10.3892/ijo.2020.4956.
  • Hu, Y.; Ren, J.; Wang, L.; Zhao, X.; Zhang, M.; Shimizu, K.; Zhang, C.;. Protective Effects of Total Alkaloids from Dendrobium Crepidatum against LPS-induced Acute Lung Injury in Mice and Its Chemical Components. Phytochemistry 2018, 149, 12–23. DOI: 10.1016/j.phytochem.2018.02.006.
  • Huang, M.; Xin, W. Matrine Inhibiting Pancreatic Cells Epithelial-mesenchymal Transition and Invasion through ROS/NF -κB/MMPs Pathway. Life Sci. 2018, 192, 55–61. DOI: 10.1016/j.lfs.2017.11.024.
  • Shaer, N. A.;. Can Crude Alkaloids Extract of Rhazya Stricta Induce Apoptosis in Pancreatic Cancer: In Vitro Study? Pathophysiol Pathophysiology. 2019, 26(1), 97–101. DOI: 10.1016/j.pathophys.2018.09.001.
  • Abdel- Lateef, E.; Mahmoud, F.; Hammam, O.; El-Ahwany, E.; El-Wakil, E.; Kandil, S.; Abu Taleb, H.; El-Sayed, M.; Hassenein, H. Bioactive Chemical Constituents of Curcuma Longa L.rhizomes Extract Inhibit the Growth of Human Hepatoma Cell Line (Hepg2). Acta Pharm. 2016, 66(3), 387–398. DOI: 10.1515/acph-2016-0028.
  • Abrams, S. L.; Follo, M. Y.; Steelman, L. S.; Lertpiriyapong, K.; Cocco, L.; Ratti, S.; Martelli, A. M.; Candido, S.; Libra, M.; Murata, R. M. Abilities of Berberine and Chemically Modified Berberines to Inhibit Proliferation of Pancreatic Cancer Cells. Adv. Biol. Regul. 2019, 71, 172–182. DOI: 10.1016/j.jbior.2018.10.003.
  • Awale, S.; Dibwe, D. F.; Balachandran, C.; Feineis, D.; Lombe, B. K.; Bringmann, G. Ancistrolikokine E3, a 5, 8′-coupled Naphthylisoquinoline Alkaloid, Eliminates the Tolerance of Cancer Cells to Nutrition Starvation by Inhibition of the Akt/mTOR/autophagy Signaling Pathway. J. Nat. Prod. 2018, 81(10), 2282–2291. DOI: 10.1021/acs.jnatprod.8b00733.
  • Bhagya, N.; Chandrashekar, K. R.; Prabhu, A.; Rekha, P. D.; Tetrandrine Isolated from Cyclea Peltata Induces Cytotoxicity and Apoptosis through ROS and Caspase Pathways in Breast and Pancreatic Cancer Cells. In Vitro Cell Dev. Biol. Anim. 2019, 555, 331–340. DOI:10.1007/s11626-019-00332-9.
  • Dong, R.; Chen, P.; Chen, Q. Inhibition of Pancreatic Cancer Stem Cells by Rauwolfia Vomitoria Extract. Oncol. Rep. 2018, 40(6), 3144–3154. DOI: 10.3892/or.2018.6713.
  • Singh, K.; Dong, Q.; Timirishanmugam, P. S.; Koul, S.; Koul, H. K. Tetrandrine Inhibits Deregulated Cell Cycle in Pancreatic Cancer Cells: Differential Regulation of p21Cip1/Waf1, p27Kip1 and Cyclin D1. Cancer Lett. 2018, 425, 164–173. DOI: 10.1016/j.canlet.2018.03.042.
  • Ma, Y.; Yu, W.; Shrivastava, A.; Alemi, F.; Lankachandra, K.; Srivastava, R. K.; Shankar, S. Sanguinarine Inhibits Pancreatic Cancer Stem Cell Characteristics by Inducing Oxidative Stress and Suppressing Sonic hedgehog-Gli-Nanog Pathway. Carcinogenesis. 2017, 38(10), 1047–1056. DOI: 10.1093/carcin/bgx070.
  • Maharaj, V.; Kavatsurwa, S. M.; Shamburger, W. Anti-austerity Activity against Pancreatic Cancer Cells and Antiplasmodial Properties of Naphthylisoquinoline Alkaloids and Their Analogues. Planta Med. 2019, 85(18), 224.
  • Mohan, V.; Agarwal, R.; Singh, R. P. A Novel Alkaloid, Evodiamine Causes Nuclear Localization of Cytochrome-c and Induces Apoptosis Independent of P53 in Human Lung Cancer Cells. Biochem. Biophys. Res. Commun. 2016, 477(4), 1065–1071. DOI: 10.1016/j.bbrc.2016.07.037.
  • Yang, J.; He, D.; Peng, Y. Matrine Suppresses the Migration and Invasion of NSCLC Cells by Inhibiting PAX2-induced Epithelial-mesenchymal Transition. Onco. Targets Ther. 2017, 10, 5209–5217. DOI: 10.2147/OTT.S149609.
  • Stanely, M. P. R. P.; Kannan, N.; K.Protective Effect of Rutin of Lipids, Lipoproteins, Lipid Metabolizing Enzymes and Glycoproteins in Streptozotocin-induced Diabetic Rats. Pharm. Pharmacol. 2006, 5810, 1373–1383. DOI:10.1211/jpp.58.10.0011.
  • Wang, Y. J.; Pan, K. L.; Hsieh, T. C. Diosgenin, a Plant-derived Sapogenin, Exhibits Antiviral Activity in Vitro against Hepatitis C Virus. J. Nat. Prod. 2011, 74(4), 580–584. DOI: 10.1021/np100578u.
  • Zhang, H. J.; Rumschlag-Booms, E.; Guan, Y. F.; Liu, K.-L.; Wang, D.-Y.; Li, W.-F.; Nguyen, V. H.; Cuong, N. M.; Soejarto, D. D.; Fong, H. H. S. Anti-HIV Diphyllin Glycosides from Justicia Gendarussa. Phytochemistry. 2017, 136, 94–100. DOI: 10.1016/j.phytochem.2017.01.005.
  • Liu, Q.; Li, W.; Huang, L. Identification, Structural Modification, and Dichotomous Effects on Human Immunodeficiency Virus Type 1 (HIV-1) Replication of Ingenane Esters from Euphorbia Kansui. Eur. J. Med. Chem. 2018, 156, 618–627. DOI: 10.1016/j.ejmech.2018.07.020.
  • Mair, C. E.; Grienke, U.; Wilhelm, A.; Urban, E.; Zehl, M.; Schmidtke, M.; Rollinger, J. M. Anti-influenza Triterpene Saponins from the Bark of Burkea Africana. J. Nat. Prod. 2018, 81(3), 515–523. DOI: 10.1021/acs.jnatprod.7b00774.
  • Nothias-Scaglia, L. F.; Pannecouque, C.; Renucci, F.; Delang, L.; Neyts, J.; Roussi, F.; Costa, J.; Leyssen, P.; Litaudon, M.; Paolini, J. Antiviral Activity of Diterpene of Esters on Chikungunya Virus and HIV Replication. J. Nat. Prod. 2015, 78(6), 1277–1283. DOI: 10.1021/acs.jnatprod.5b00073.
  • Pandeló José, D.; Bartholomeeusen, K.; da Cunha, R. D.; Abreu, C. M.; Glinski, J.; Da Costa, T. B. F.; Bacchi Rabay, A. F. M.; Pianowski Filho, L. F.; Dudycz, L. W.; Ranga, U. Reactivation of Latent HIV-1 by New Semi-synthetic Ingenol Esters. Virology. 2014, 462-463, 328–339. DOI: 10.1016/j.virol.2014.05.033.
  • Li, L.; Fu, -W.-W.; Wu, R.-T.; Song, Y.-H.; Wu, W.-Y.; Yin, S.-H.; Li, W.-J.; Xie, M.-Y.;. Protective Effect of Ganoderma Atrum Polysaccharides in Acute Lung Injury Rats and Its Metabolomics. Int. J. Biol. Macromol. 2020, 142, 693–704. DOI: 10.1016/j.ijbiomac.2019.10.010.
  • Ribeiro, J. P.; Kalb, A. C.; Campos, P. P.; Cruz, A. R. H. D. L.; Martinez, P. E.; Gioda, A.; Souza, M. M. D.; Gioda, C. R. Toxicological Effects of Particulate Matter (PM2.5) On Rats: Bioaccumulation, Antioxidant Alterations, Lipid Damage, and ABC Transporter Activity. Chemosphere. 2016, 163, 569–577. DOI: 10.1016/j.chemosphere.2016.07.094.
  • Tian, C. L.; Chang, Y.; Zhang, Z.; Wang, H.; Xiao, S.; Cui, C.; Liu, M.;. Extraction Technology, Component Analysis, Antioxidant, Antibacterial, Analgesic and Anti-inflammatory Activities of Flavonoids Fraction from Tribulus Terrestris L. Leaves. Heliyon.2019, 5(8), e02234. DOI: 10.1016/j.heliyon.2019.e02234.
  • Rengarajan, S.; Melanathuru, V.; Govindasamy, C.; Chinnadurai, V.; Elsadek, M. F.;. Antioxidant Activity of Flavonoid Compounds Isolated from the Petals of Hibiscus Rosa Sinensis. J. King Saud Univ. Sci. 2020, 32(3), 2236–2242. DOI: 10.1016/j.jksus.2020.02.028.
  • Yan, Z. M.; Zhong, Y.; Duan, Y.; Chen, Q.; Li, F.;. Antioxidant Mechanism of Tea Polyphenols and Its Impact on Health Benefits. Anim. Nutr. 2020, 6(2), 115–123. DOI: 10.1016/j.aninu.2020.01.001.
  • Ghosh, S.; Karin, M. Missing Pieces in the NF-κB Puzzle. Cell. 2002, 109(2), 2. DOI: 10.1016/S0092-8674(0200703-1).
  • Rui, W.; Guan, L.; Zhang, F.; Zhang, W.; Ding, W. PM2.5 -induced Oxidative Stress Increases Adhesion Molecules Expression in Human Endothelial Cells through the ERK/AKT/NF-κB-dependent Pathway. J. Appl. Toxicol. 2016, 36(1), 48–59. DOI: 10.1002/jat.3143.
  • Hu, T.; Lin, Q.; Guo, T.; Yang, T.; Zhou, W.; Deng, X.; Yan, J.-K.; Luo, Y.; Ju, M.; Luo, F.;, et al. Polysaccharide Isolated from Phellinus Linteus Mycelia Exerts Anti-inflammatory Effects via MAPK and PPAR Signaling Pathways. Carbohydr. Polym. 2018, 200, 487–497. DOI: 10.1016/j.carbpol.2018.08.021.
  • Mikael, C.; Gonzalez, S. F.; Welin, J.; Fuxe, J.;. Epithelial-mesenchymal Transition in Cancer Metastasis through the Lymphatic System. Mol. Oncol. 2017, 11(7), 781–791. DOI: 10.1002/1878-0261.12092.
  • Yao, L.; Wang, S.; Wei, P.; Bao, K.; Yuan, W.; Wang, X.; Zheng, J.; Hong, M.;. Huangqi–Fangfeng Protects against Allergic Airway Remodeling through Inhibiting Epithelial–mesenchymal Transition Process in Mice via Regulating Epithelial Derived TGF-β1. Phytomedicine 2019, 64, 153076. DOI: 10.1016/j.phymed.2019.153076.
  • Yang, D.; Cao, X.; Wang, F.; Jiang, H.; Feng, D.; Guo, H.; Du, L.; Jin, Y.; Chen, Y.; Yin, X.;, et al. LFG-500, a Novel Synthetic Flavonoid, Suppresses Epithelial–mesenchymal Transition in Human Lung Adenocarcinoma Cells by Inhibiting NLRP3 in Inflammatory Microenvironment. Cancer Lett. 2017, 400, 137–148. DOI: 10.1016/j.canlet.2017.04.035.

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