Regulation of Drug and Bile Salt Transporters in Liver and Intestine

References

• Ananthanarayanan M., Balasubramanian N., Makishima M., Mangelsdorf D. J., Suchy F. J. Human bile salt export pump (BSEP) promoter is transactivated by the farnesoid X receptor/bile acid receptor (FXR/BAR). J. Biol. Chem. 2001; 276: 28857–28865
   PubMed Web of Science ®Google Scholar
• Blumberg B., Sabbagh W., Jr., Juguilon H., Bolado J., Jr., van Meter C. M., Ong E. S., Evans R. M. SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes. Dev. 1998; 12: 3195–3205
   PubMed Web of Science ®Google Scholar
• Chawla A., Saez E., Evans R. M. Don't know much bile-ology. Cell 2000; 103: 1–4
   PubMed Web of Science ®Google Scholar
• Chawla A., Repa J. J., Evans R. M., Mangelsdorf D. J. Nuclear receptors and lipid physiology: opening the X-files. Science 2001; 294: 1866–1870
   PubMed Web of Science ®Google Scholar
• Chen F., Ma L., Dawson P. A., Sinal C. J., Sehayek E., Gonzalez F. J., Breslow J., Ananthanarayanan M., Shneider B. L. Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter. J. Biol. Chem. 2003; 278: 19909–19916
   PubMed Web of Science ®Google Scholar
• Cherrington N. J., Hartley D. P., Li N., Johnson D. R., Klaassen C. D. Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats. J. Pharmacol. Exp. Ther. 2002; 300: 97–104
   PubMed Web of Science ®Google Scholar
• Costet P., Luo Y., Wang N., Tall A. R. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J. Biol. Chem. 2000; 275: 28240–28245
   PubMed Web of Science ®Google Scholar
• Craddock A. L., Love M. W., Daniel R. W., Kirby L. C., Walters H. C., Wong M. H., Dawson P. A. Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am. J. Physiol. 1998; 274: G157–G169
   PubMed Web of Science ®Google Scholar
• Denson L. A., Auld K. L., Schiek D. S., McClure M. H., Mangelsdorf D. J., Karpen S. J. Interleukin-1β suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation. J. Biol. Chem. 2000; 275: 8835–8843
   PubMed Web of Science ®Google Scholar
• Denson L. A., Sturm E., Echevarria W., Zimmerman T. L., Makishima M., Mangelsdorf D. J., Karpen S. J. The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp. Gastroenterology 2001; 121: 140–147
   PubMed Web of Science ®Google Scholar
• Dürr D., Stieger B., Kullak-Ublick G. A., Rentsch K. M., Steinert H. C., Meier P. J., Fattinger K. St. John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4. Clin. Pharmacol. Ther. 2000; 68: 598–604
   PubMed Web of Science ®Google Scholar
• Fitzgerald M. L., Moore K. J., Freeman M. W. Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home. J. Mol. Med. 2002; 80: 271–281
   PubMed Web of Science ®Google Scholar
• Geick A., Eichelbaum M., Burk O. Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J. Biol. Chem. 2001; 276: 14581–14587
   PubMed Web of Science ®Google Scholar
• Greiner B., Eichelbaum M., Fritz P., Kreichgauer H. P., von Richter O., Zundler J., Kroemer H. K. The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin. J. Clin. Invest. 1999; 104: 147–153
   PubMed Web of Science ®Google Scholar
• Grober J., Zaghini I., Fujii H., Jones S. A., Kliewer S. A., Willson T. M., Ono T., Besnard P. Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer. J. Biol. Chem. 1999; 274: 29749–29754
   PubMed Web of Science ®Google Scholar
• Guo G. L., Staudinger J., Ogura K., Klaassen C. D. Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16α-carbonitrile is via interaction with pregnane X receptor. Mol. Pharmacol. 2002; 61: 832–839
   PubMed Web of Science ®Google Scholar
• Hagenbuch N., Reichel C., Stieger B., Cattori V., Fattinger K. E., Landmann L., Meier P. J., Kullak-Ublick G. A. Effect of phenobarbital on the expression of bile salt and organic anion transporters of rat liver. J. Hepatol. 2001; 34: 881–887
   PubMed Web of Science ®Google Scholar
• Johne A., Brockmoller J., Bauer S., Maurer A., Langheinrich M., Roots I. Pharmacokinetic interaction of digoxin with an herbal extract from St. John's wort (Hypericum perforatum). Clin. Pharmacol. Ther. 1999; 66: 338–345
   PubMed Web of Science ®Google Scholar
• Jung D., Kullak-Ublick G. A. Hepatocyte nuclear factor 1α: a key mediator of the effect of bile acids on gene expression. Hepatology 2003; 37: 622–631
   PubMed Web of Science ®Google Scholar
• Jung D., Fried M., Kullak-Ublick G. A. Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor α. J. Biol. Chem. 2002a; 277: 30559–30566
   PubMed Web of Science ®Google Scholar
• Jung D., Podvinec M., Meyer U. A., Mangelsdorf D. J., Fried M., Meier P. J., Kullak-Ublick G. A. Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor. Gastroenterology 2002b; 122: 1954–1966
   PubMed Web of Science ®Google Scholar
• Jung D., Fantin A. C., Scheurer U., Fried M., Kullak-Ublick G. A. Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor. 2003, Gut in press
   Google Scholar
• Kast H. R., Goodwin B., Tarr P. T., Jones S. A., Anisfeld A. M., Stoltz C. M., Tontonoz P., Kliewer S., Willson T. M., Edwards P. A. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J. Biol. Chem. 2002; 277: 2908–2915
   PubMed Web of Science ®Google Scholar
• Keppler D., König J. Hepatic canalicular membrane. 5. Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver. FASEB J. 1997; 11: 509–516
   PubMed Web of Science ®Google Scholar
• Kliewer S. A., Lehmann J. M., Willson T. M. Orphan nuclear receptors: shifting endocrinology into reverse. Science 1999; 284: 757–760
   PubMed Web of Science ®Google Scholar
• Kobayashi D., Nozawa T., Imai K., Nezu J., Tsuji A., Tamai I. Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. J. Pharmacol. Exp. Ther. 2003; 306: 703–708
   PubMed Web of Science ®Google Scholar
• Kullak-Ublick G. A., Hagenbuch B., Stieger B., Schteingart C. D., Hofmann A. F., Wolkoff A. W., Meier P. J. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology 1995; 109: 1274–1282
   PubMed Web of Science ®Google Scholar
• Kullak-Ublick G. A., Ismair M. G., Stieger B., Landmann L., Huber R., Pizzagalli F., Fattinger K., Meier P. J., Hagenbuch B. Organic anion transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology 2001; 120: 525–533
   PubMed Web of Science ®Google Scholar
• Lehmann J. M., McKee D. D., Watson M. A., Willson T. M., Moore J. T., Kliewer S. A. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J. Clin. Invest. 1998; 102: 1016–1023
   PubMed Web of Science ®Google Scholar
• Liddle C., Goodwin B. Regulation of hepatic drug metabolism: role of the nuclear receptors PXR and CAR. Semin. Liver Dis. 2002; 22: 115–122
   PubMed Web of Science ®Google Scholar
• Makishima M., Okamoto A. Y., Repa J. J., Tu H., Learned R. M., Luk A., Hull M. V., Lustig K. D., Mangelsdorf D. J., Shan B. Identification of a nuclear receptor for bile acids. Science 1999; 284: 1362–1365
   PubMed Web of Science ®Google Scholar
• Mi L.-Z., Devarakonda S., Harp J. M., Han Q., Pellicciari R., Willson T. M., Khorasanizadeh S., Rastinejad F. Structural basis for bile acid binding and activation of the nuclear receptor FXR. Mol. Cell 2003; 11: 1093–1100
   PubMed Web of Science ®Google Scholar
• Miranda S., Vollrath V., Wielandt A. M., Loyola G., Bronfman M., Chianale J. Overexpression of mdr2 gene by peroxisome proliferators in the mouse liver. J. Hepatol. 1997; 26: 1331–1339
   PubMed Web of Science ®Google Scholar
• Moore L. B., Goodwin B., Jones S. A., Wisely G. B., Serabjit Singh C. J., Willson T. M., Collins J. L., Kliewer S. A. St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. Proc. Natl. Acad. Sci. USA 2000a; 97: 7500–7502
   PubMed Web of Science ®Google Scholar
• Moore L. B., Parks D. J., Jones S. A., Bledsoe R. K., Consler T. G., Stimmel J. B., Goodwin B., Liddle C., Blanchard S. G., Willson T. M., Collins J. L., Kliewer S. A. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J. Biol. Chem. 2000b; 275: 15122–15127
   PubMed Web of Science ®Google Scholar
• Neimark E., Chen F., Shneider B. Bile acid induced negative feedback regulation of the human ileal 7bile acid transporter is mediated by the farnesoid X-receptor (FXR), the short heterodimer partner (SHP), and the retinoid X receptor (RAR/RXR) [abstract]. Gastroenterology 2003; 124(suppl 1)A-689
   Google Scholar
• Nóe B., Hagenbuch B., Stieger B., Meier P. J. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc. Natl. Acad. Sci. USA 1997; 94: 10346–10350
   PubMed Web of Science ®Google Scholar
• Parks D. J., Blanchard S. G., Bledsoe R. K., Chandra G., Consler T. G., Kliewer S. A., Stimmel J. B., Willson T. M., Zavacki A. M., Moore D. D., Lehmann J. M. Bile acids: natural ligands for an orphan nuclear receptor. Science 1999; 284: 1365–1368
   PubMed Web of Science ®Google Scholar
• Paulusma C. C., Oude Elferink R. P. The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man. J. Mol. Med. 1997; 75: 420–428
   PubMed Web of Science ®Google Scholar
• Paulusma C. C., Kool M., Bosma P. J., Scheffer G. L., Ter Borg F., Scheper R. J., Tytgat G. N. J., Borst P., Baas F., Oude Elferink R. P. J. A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome. Hepatology 1997; 25: 1539–1542
   PubMed Web of Science ®Google Scholar
• Piscitelli S. C., Burstein A. H., Chaitt D., Alfaro R. M., Falloon J. Indinavir concentrations and St. John's wort. Lancet 2000; 355: 547–548
   PubMed Web of Science ®Google Scholar
• Repa J. J., Turley S. D., Lobaccaro J. A., Medina J., Li L., Lustig K., Shan B., Heyman R. A., Dietschy J. M., Mangelsdorf D. J. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 2000; 289: 1524–1529
   PubMed Web of Science ®Google Scholar
• Repa J. J., Berge K. E., Pomajzl C., Richardson J. A., Hobbs H., Mangelsdorf D. J. Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors α and β. J. Biol. Chem. 2002; 277: 18793–18800
   PubMed Web of Science ®Google Scholar
• Ruschitzka F., Meier P. J., Turina M., Luscher T. F., Noll G. Acute heart transplant rejection due to Saint John's wort. Lancet 2000; 355: 548–549
   PubMed Web of Science ®Google Scholar
• Saeki T., Ueda K., Tanigawara Y., Hori R., Komano T. Human P-glycoprotein transports cyclosporin A and FK506. J. Biol. Chem. 1993; 268: 6077–6080
   PubMed Web of Science ®Google Scholar
• Schuetz E. G., Beck W. T., Schuetz J. D. Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol. Pharmacol. 1996; 49: 311–318
   PubMed Web of Science ®Google Scholar
• Schuetz E. G., Strom S., Yasuda K., Lecureur V., Assem M., Brimer C., Lamba J., Kim R. B., Ramachandran V., Komoroski B. J., Venkataramanan R., Cai H., Sinal C. J., Gonzalez F. J., Schuetz J. D. Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. J. Biol. Chem. 2001; 276: 39411–39418
   PubMed Web of Science ®Google Scholar
• Staudinger J. L., Goodwin B., Jones S. A., Hawkins-Brown D., MacKenzie K. I., LaTour A., Liu Y., Klaassen C. D., Brown K. K., Reinhard J., Willson T. M., Koller B. H., Kliewer S. A. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc. Natl. Acad. Sci. USA 2001; 98: 3369–3374
   PubMed Web of Science ®Google Scholar
• Synold T. W., Dussault I., Forman B. M. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat. Med. 2001; 7: 584–590
   PubMed Web of Science ®Google Scholar
• Taniguchi K., Wada M., Kohno K., Nakamura T., Kawabe T., Kawakami M., Kagotani K., Okumura K., Akiyama S.-I., Kuwano M. A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res. 1996; 56: 4124–4129
   PubMed Web of Science ®Google Scholar
• Urizar N. L., Liverman A. B., Dodds D. T., Silva F. V., Ordentlich P., Yan Y., Gonzalez F. J., Heyman R. A., Mangelsdorf D. J., Moore D. D. A natural product that lowers cholesterol as an antagonist ligand for FXR. Science 2002; 296: 1703–1706
   PubMed Web of Science ®Google Scholar
• Walters H. C., Craddock A. L., Fusegawa H., Willingham M. C., Dawson P. A. Expression, transport properties, and chromosomal location of organic anion transporter subtype 3. Am. J. Physiol. 2000; 279: G1188–G1200
   PubMed Web of Science ®Google Scholar
• Wang H., Chen J., Hollister K., Sowers L. C., Forman B. M. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol. Cell 1999; 3: 543–553
   PubMed Web of Science ®Google Scholar
• Waxman D. J. P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. Arch. Biochem. Biophys. 1999; 369: 11–23
   PubMed Web of Science ®Google Scholar