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Cell Growth and Development

NORF5/HUG1 Is a Component of the MEC1-Mediated Checkpoint Response to DNA Damage and Replication Arrest in Saccharomyces cerevisiae

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Pages 7041-7049 | Received 09 Mar 1999, Accepted 06 Jul 1999, Published online: 28 Mar 2023

REFERENCES

  • Aboussekhra, A., J. E. Vialard, D. E. Morrison, M. A. de la Torre-Ruiz, L. Cernakova, F. Fabre, and J. Lowndes 1996. A novel role for the budding yeast RAD9 checkpoint gene in DNA damage-dependent transcription. EMBO J. 15:3912–3922.
  • Allen, J. B., Z. Zhou, W. Siede, E. C. Friedberg, and J. Elledge 1994. The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes Dev. 8:2401–2415.
  • Ausubel F. M. 1997. Current protocols in molecular biology. John Wiley & Sons, Inc., New York, N.Y.
  • Basrai, M. A., P. Hieter, and J. Boeke 1997. Small open reading frames: beautiful needles in the haystack. Genome Res. 7:768–771.
  • Basrai, M. A., J. Kingsbury, D. Koshland, F. Spencer, and J. Hieter 1996. Faithful chromosome transmission requires Spt4p, a putative regulator of chromatin structure in Saccharomyces cerevisiae. Mol. Cell. Biol. 16:2838–2847.
  • Baudin, A., O. Ozier-Kalogeropoulos, A. Denouel, F. Lacroute, and J. Cullin 1993. A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae. Nucleic Acids Res. 21:3329–3330.
  • Boeke, J. D., F. LaCroute, and J. Fink 1984. A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance. Mol. Gen. Genet. 197:345–346.
  • Brush, G. S., D. M. Morrow, P. Hieter, and J. Kelly 1996. The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast. Proc. Natl. Acad. Sci. USA 93:15075–15080.
  • Cyano2Dbase. 14 January 1999, revision date. ORFs. [Online.] http://www.kazusa.or.jp/tech/sazuka/cyano/proteome.html [23 August 1999, last date accessed.]
  • Desany, B. A., A. A. Alcasabas, J. B. Bachant, and J. Elledge 1998. Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway. Genes Dev. 12:2956–2970.
  • Dujon, B., D. Alexandraki, B. Andre, W. Ansorge, V. Baladron, J. P. Ballesta, A. Banrevi, P. A. Bolle, M. Bolotin-Fukuhara, P. Bossier et al.. 1994. Complete DNA sequence of yeast chromosome XI. Nature 369:371–378.
  • E. coli Genome Center. 5 September 1997, revision date. ORFs. [Online.] E. coli Genome Center, University of Wisconsin, Madison. http://genetics/wisc.edu/ [23 August 1999, last date accessed.]
  • el-Deiry, W. S., T. Tokino, V. E. Velculescu, D. B. Levy, R. Parsons, J. M. Trent, D. Lin, W. E. Mercer, K. W. Kinzler, and J. Vogelstein 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75:817–825.
  • Elledge, S. J. 1996. Cell cycle checkpoints: preventing an identity crisis. Science 274:1664–1672.
  • Elledge, S. J., Z. Zhou, J. B. Allen, and J. Navas 1993. DNA damage and cell cycle regulation of ribonucleotide reductase. Bioessays 15:333–339.
  • Goffeau, A., B. G. Barrell, H. Bussey, R. W. Davis, B. Dujon, H. Feldmann, F. Galibert, J. D. Hoheisel, C. Jacq, M. Johnston, E. J. Louis, H. W. Mewes, Y. Murakami, P. Philippsen, H. Tettelin, and J. Oliver 1996. Life with 6000 genes. Science 274:546, 563–567.
  • Huang, M., and J. Elledge 1997. Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae. Mol. Cell. Biol. 17:6105–6113.
  • Huang, M., Z. Zhou, and J. Elledge 1998. The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor. Cell 94:595–605.
  • Kato, R., and J. Ogawa 1994. An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res. 22:3104–3112.
  • Kenna, M. A., C. B. Brachmann, S. E. Devine, and J. Boeke 1998. Invading the yeast nucleus: a nuclear localization signal at the C terminus of Ty1 integrase is required for transposition in vivo. Mol. Cell. Biol. 18:1115–1124.
  • Kiser, G. L., and J. Weinert 1996. Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function. Mol. Biol. Cell 7:703–718.
  • McClanahan, T., and J. McEntee 1986. DNA damage and heat shock dually regulate genes in Saccharomyces cerevisiae. Mol. Cell. Biol. 6:90–96.
  • MIPS. 9 August 1999, revision date. ORFs. [Online.] Munich Information Centre for Protein Sequences, Martinsfried, Germany. http://www.mips.biochem.mpg.de/proj/yeast/tables/small_orfs.html [23 August 1999, last date accessed.]
  • Morrow, D. M., D. A. Tagle, Y. Shiloh, F. S. Collins, and J. Hieter 1995. TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell 82:831–840.
  • Mumberg, D., R. Muller, and J. Funk 1994. Regulatable promoters of Saccharomyces cerevisiae: comparison of transcriptional activity and their use for heterologous expression. Nucleic Acids Res. 22:5767–5768.
  • Navas, T. A., Z. Zhou, and J. Elledge 1995. DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint. Cell 80:29–39.
  • Pati, D., C. Keller, M. Groudine, and J. Plon 1997. Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA. Mol. Cell. Biol. 17:3037–3046.
  • Paulovich, A. G., R. U. Margulies, B. M. Garvik, and J. Hartwell 1997. RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage. Genetics 145:45–62.
  • Reith, W., C. Herrero-Sanchez, M. Kobr, P. Silacci, C. Berte, E. Barras, S. Fey, and J. Mach 1990. MHC class II regulatory factor RFX has a novel DNA-binding domain and a functionally independent dimerization domain. Genes Dev. 4:1528–1540.
  • Reith, W., C. Ucla, E. Barras, A. Gaud, B. Durand, C. Herrero-Sanchez, M. Kobr, and J. Mach 1994. RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. Mol. Cell. Biol. 14:1230–1244.
  • Ruby, S. W., and J. Szostak 1985. Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents. Mol. Cell. Biol. 5:75–84.
  • Sagenet. 7 March 1999, revision date. ORFs. [Online.] http://www.sagenet.org/NORF/NORF.html [23 August 1999, last date accessed.]
  • Sanchez, Y., B. A. Desany, W. J. Jones, Q. Liu, B. Wang, and J. Elledge 1996. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271:357–360.
  • Sanger Website. 13 August 1999, revision date. ORFs. [Online.] http://www.songer.ac.uk/Projects/C_elegans [23 August 1999, last date accessed.]
  • Santocanale, C., and J. Diffley 1998. A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication Nature 395:615–618.
  • Savitsky, K., S. Sfez, D. A. Tagle, Y. Ziv, A. Sartiel, F. S. Collins, Y. Shiloh, and J. Rotman 1995. The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Hum. Mol. Genet. 4:2025–2032.
  • Shiloh, Y. 1997. Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart. Annu. Rev. Genet. 31:635–662.
  • Shirahige, K., Y. Hori, K. Shiraishi, M. Yamashita, K. Takahashi, C. Obuse, T. Tsurimoto, and J. Yoshikawa 1998. Regulation of DNA-replication origins during cell-cycle progression. Nature 395:618–621.
  • Siede, W., A. S. Friedberg, and J. Friedberg 1993. RAD9-dependent G1 arrest defines a second checkpoint for damaged DNA in the cell cycle of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 90:7985–7989.
  • Sikorski, R. S., and J. Hieter 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19–27.
  • Stanford Genome Database. 17 July 1999, revision date. ORFs. [Online.] Department of Genetics, Stanford University School of Medicine, Stanford, Calif. http://genome-www.stanford.edu/Saccharomyces/ [23 August 1999, last date accessed.]
  • Stanford Genome Database. 17 July 1999, revision date. ORFs. [Online.] http://genome-www.stanford.edu/Saccharomyces/newORF.html [23 August 1999, last date accessed.]
  • Sun, Z., D. S. Fay, F. Marini, M. Foiani, and J. Stern 1996. Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes Dev. 10:395–406.
  • Tzamarias, D., and J. Struhl 1995. Distinct TPR motifs of Cyc8 are involved in recruiting the Cyc8-Tup1 corepressor complex to differentially regulated promoters. Genes Dev. 9:821–831.
  • Vallen, E. A., and J. Cross 1999. Interaction between the MEC1-dependent DNA synthesis checkpoint and G1 cyclin function in Saccharomyces cerevisiae. Genetics 151:459–471.
  • Velculescu, V. E., L. Zhang, B. Vogelstein, and J. Kinzler 1995. Serial analysis of gene expression. Science 270:484–487.
  • Velculescu, V. E., L. Zhang, W. Zhou, J. Vogelstein, M. A. Basrai, D. E. Bassett Jr., P. Hieter, B. Vogelstein, and J. Kinzler 1997. Characterization of the yeast transcriptome. Cell 88:243–251.
  • Weinert, T. 1998. DNA damage checkpoints update: getting molecular. Curr. Opin. Genet. Dev. 8:185–193.
  • Weinert, T. A., and J. Hartwell 1993. Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint. Genetics 134:63–80.
  • Weinert, T. A., and J. Hartwell 1988. The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science 241:317–322.
  • Weinert, T. A., G. L. Kiser, and J. Hartwell 1994. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev. 8:652–665.
  • Zakian, V. A. 1995. ATM-related genes: what do they tell us about functions of the human gene? Cell 82:685–687.
  • Zhao, X., E. G. Muller, and J. Rothstein 1998. A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol. Cell 2:329–340.
  • Zheng, P., D. S. Fay, J. Burton, H. Xiao, J. L. Pinkham, and J. Stern 1993. SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase. Mol. Cell. Biol. 13:5829–5842.
  • Zhou, Z., and J. Elledge 1993. DUN1 encodes a protein kinase that controls the DNA damage response in yeast. Cell 75:1119–1127.

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