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Cell Growth and Development

Activation of c-Jun N-Terminal Kinase 1 by UV Irradiation Is Inhibited by Wortmannin without Affecting c-jun Expression

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Pages 1768-1774 | Received 04 Sep 1998, Accepted 04 Nov 1998, Published online: 27 Mar 2023

REFERENCES

  • Angel, P., K. Bhattari, T. Smeal, and J. Karin 1988. The jun proto-oncogene is positively autoregulated by its product Jun/AP-1. Cell 55:875–885.
  • Angel, P. Personal communication.
  • Berger, J., N. Hayes, D. M. Szalkowski, and J. Zhang 1994. PI 3-kinase activation is required for insulin stimulation of glucose transport into L6 myotubes. Biochem. Biophys. Res. Commun. 205:570–576.
  • Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248–254.
  • Canman, C. E., and J. Kastan 1996. Three paths to stress relief. Nature 384:213–214.
  • Chomczynski, P., and J. Sacchi 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156–159.
  • Coso, A. A., M. Chiariello, J.-C. Yu, H. Teramoto, P. Crespo, N. Xu, T. Miki, and J. Gutkind 1995. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81:1137–1146.
  • Das, K. C., and J. White 1997. Activation of NF-kappaB by antineoplastic agents. Role of protein kinase C. J. Biol. Chem. 272:14914–14920.
  • Derijard, B., M. Hibi, I. H. Wu, T. Barrett, T. Deng, M. Karin, and J. Davis 1994. JNK1: a protein kinase stimulated by UV-light and Ha-ras that binds and phosphorylates the c-jun activation domain. Cell 76:1025–1037.
  • Fokstuen, T., Y. B. Rabo, J. N. Zhou, J. Karlson, A. Platz, M. C. Shoshan, J. Hansson, and J. Linder 1997. The Ras farnesylation inhibitor BZA-5B increases the resistance to cisplatin in a human melanoma cell line. Anticancer Res. 17:2347–2352.
  • Foltz, I. N., R. E. Gerl, J. S. Wieler, M. Luckach, R. A. Salmon, and J. Schrader 1998. Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli. J. Biol. Chem. 273:9344–9351.
  • Friedberg, E. C., G. C. Wallner, W. Siede 1995. DNA repair and mutagenesis. ASM Press, Washington, D.C.
  • Fritz, G., J. G. Hengstler, and J. Kaina 1997. High-dose selection with mafosfamide results in sensitivity to DNA cross-linking agents: characterization of hypersensitive cell lines. Cancer Res. 57:454–460.
  • Fritz, G., B. Kaina, and J. Aktories 1995. The Ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA-damaging treatments. J. Biol. Chem. 270:25172–25177.
  • Fritz, G., and B. Kaina. Unpublished data.
  • Gupta, S., D. Campbell, B. Derijard, and J. Davis 1995. Transcription factor ATF-2 regulation by the JNK signal transduction pathway. Science 267:389–393.
  • Haas, S., and J. Kaina 1995. c-Fos is involved in the cellular defense against the genotoxic effect of UV radiation. Carcinogenesis 16:985–991.
  • Hallahan, D. E., V. P. Sukhatme, M. L. Sherman, S. Virudachalam, D. Kufe, and J. Weichselbaum 1991. Protein kinase C mediates X-ray inducibility of nuclear signal transducers EGR1 and Jun. Proc. Natl. Acad. Sci. USA 88:2156–2160.
  • Hawkins, P. T., A. Eguinoa, R. G. Qiu, D. Stokoe, F. T. Cooke, R. Walters, S. Wennstrom, W. L. Claesson, T. Evans, M. Symons et al.. 1995. PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase. Curr. Biol. 5:393–403.
  • Herr, I., G. van Dam, and J. Angel 1994. Binding of promoter-associated AP-1 is not altered during induction and subsequent repression of the c-jun promoter by TPA and UV-irradiation. Carcinogenesis 15:1105–1113.
  • Herr, I., D. Wilhelm, T. Böhler, P. Angel, and J. Debatin 1997. Activation of CD95 (APO-1/Fas) signaling by ceramide mediated cancer-therapy induced apoptosis. EMBO J. 16:6200–6208.
  • Herskind, C., M. Flentje, P. Peschke, W. J. Lorenz, and J. Hahn 1991. Radiation-induced expression of the c-fos proto-oncogene in normal and tumour-derived cell lines. Radiation research: a twentieth century perspective In J. D. Chapman, W. C. Dewey, G. F. Whitmore (ed.), 1: Academic Press, Inc., San Diego, Calif.
  • Hilberg, F., and J. Wagner 1992. Embryonic stem (ES) cells lacking functional c-jun: consequences for growth and differentiation, AP-1 activity and tumorigenicity. Oncogene 7:2371–2380.
  • Huang, C., W. Ma, G. T. Bowden, and J. Dong 1996. Ultraviolet B-induced activator protein-1 activation does not require epidermal growth factor receptor but is blocked by a dominant negative PKClambda/iota. J. Biol. Chem. 271:31262–31268.
  • Huang, C., W.-Y. Ma, C. A. Ryan, and J. Dong 1997. Proteinase inhibitors I and II from potatoes specifically block UV-induced activator protein-1 activation through a pathway that is independent of extracellular signal-regulated kinase, c-Jun N-terminal kinases and p38 kinase. Proc. Natl. Acad. Sci. USA 94:11957–11962.
  • Kaina, B., G. Fritz, and J. Coquerelle 1993. Contribution of O6-alkylguanine and N-alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: new insights gained from studies of genetically engineered mammalian cell lines. Environ. Mol. Mutagen. 22:283–292.
  • Kaina, B., S. Haas, and J. Kappes 1997. A general role for c-Fos in cellular protection against DNA-damaging carcinogens and cytostatic drugs. Cancer Res. 57:2721–2731.
  • Knebel, A., H. J. Rahmsdorf, A. Ullrich, and J. Herrlich 1996. Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents. EMBO J. 15:5314–5325.
  • Liu, Z.-G., R. Baskaran, E. T. Lea-Chou, L. D. Wood, Y. Chen, M. Karin, and J. Wang 1996. Three distinct signaling responses by murine fibroblasts to genotoxic stress. Nature 384:273–276.
  • Livingstone, C., G. Patel, and J. Jones 1995. ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBO J. 14:1785–1797.
  • Minden, A., A. Lin, F.-X. Claret, A. Abo, and J. Karin 1995. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81:1147–1157.
  • Moriguchi, T., F. Toyoshima, M. Masuyama, H. Hanafusa, Y. Gotoh, and J. Nishida 1997. A novel SAPK/JNK kinase, MKK7, stimulated by TNFα and cellular stresses. EMBO J. 16:7045–7053.
  • Nakamura, M., S. Nakashima, Y. Katagiri, and J. Nozawa 1997. Effect of wortmannin and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) on N-formyl-methyionyl-leucyl-phenylanine-induced phospholipase D activation in differentiated HL60 cells: possible involvement of phosphatidyl 3-kinase in phospholipase D activation. Biochem. Pharmacol. 53:1929–1936.
  • Nishina, H., K. D. Fischer, L. Radvanyi, A. Shahinian, R. Hakem, E. A. Rubie, A. Bernstein, T. W. Mak, J. R. Woodgett, and J. Penninger 1997. Stress-signaling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature 385:350–353.
  • Okada, T., Y. Kawano, T. Sakakibara, O. Hazeki, and J. Ui 1994. Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. J. Biol. Chem. 269:3568–3573.
  • Okada, T., L. Sakuma, Y. Fukui, O. Hazeki, and J. Ui 1994. Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase. J. Biol. Chem. 269:3536–3567.
  • Osborne, M. T., and J. Chambers 1996. Role of the stress-activated c-Jun NH2-terminal protein kinase pathway in the cellular response to adriamycin and other chemotherapeutic drugs. J. Biol. Chem. 271:30950–30955.
  • Parker, P. J. 1995. PI 3-kinase puts GTP on the Rac. Curr. Biol. 5:577–579.
  • Price, M. A., F. H. Cruzalegui, and J. Treisman 1996. The p38 and ERK MAP kinase pathways cooperate to activate ternary complex factors and c-fos transcription in response to UV light. EMBO J. 23:6552–6563.
  • Pulverer, B. J., J. M. Kyriakis, J. Avruch, E. Nikolakaki, and J. Woodgett 1991. Phosphorylation of c-jun mediated by MAP kinases. Nature 353:670–674.
  • Radler-Pohl, A., C. Sachsenmaier, S. Gebel, H.-P. Auer, J. T. Bruder, U. Rapp, P. Angel, H. J. Rahmsdorf, and J. Herrlich 1993. UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase. EMBO J. 12:1005–1012.
  • Rosette, C., and J. Karin 1996. Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science 274:1194–1197.
  • Sachsenmaier, C., A. Radler-Pohl, R. Zinck, A. Nordheim, P. Herrlich, and J. Rahmsdorf 1994. Involvement of growth factor receptors in the mammalian UVC response. Cell 78:963–972.
  • Schreiber, M., B. Baumann, M. Cotton, P. Angel, and J. Wagner 1995. Fos is an essential component of the mammalian UV response. EMBO J. 14:5338–5349.
  • Sherman, M. L., R. Datta, D. E. Hallahan, R. R. Weichselbaum, and J. Kufe 1990. Ionizing radiation regulates expression of the c-jun protooncogene. Proc. Natl. Acad. Sci. USA 87:5663–5666.
  • Smeal, T., B. Binetruy, D. Mercola, A. Grover-Bardwick, G. Heidecker, U. R. Rapp, and J. Karin 1992. Oncoprotein-mediated signaling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73. Mol. Cell. Biol. 12:3507–3513.
  • Smeal, T., B. Binetruy, D. A. Mercola, M. Birrer, and J. Karin 1991. Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature 354:494–496.
  • van Dam, H., M. Duyndam, R. Rottier, A. Bosch, L. de Vries-Smits, P. Herrlich, A. Zantema, P. Angel, and J. van-der-Eb 1993. Heterodimer formation of c-Jun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein. EMBO J. 12:479–483.
  • van Dam, H., D. Wilhelm, I. Herr, A. Steffen, P. Herrlich, and J. Angel 1995. ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic stress. EMBO J. 14:1798–1811.
  • Wang, X. Z., and J. Ron 1996. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase. Science 272:1347–1349.
  • Wilhelm, D., K. Bender, A. Knebel, and J. Angel 1997. The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents. Mol. Cell. Biol. 17:4792–4800.
  • Yang, D., C. Tournier, M. Wysk, H.-T. Lu, J. Xu, R. J. Davies, and J. Flavell 1997. Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation and defects in AP-1 transcriptional activity. Proc. Natl. Acad. Sci. USA 94:3004–3009.

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