REFERENCES
- Baeuerle, P. A., and J. Henkel 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141–179.
- Baldwin, A. S. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649–683.
- Berghe, W. V., S. Plaisance, E. Boone, K. De Bosscher, M. L. Schmitz, W. Fiers, and J. Haegeman 1998. p38 and the extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-κB p65 transactivation mediated by tumor necrosis factor. J. Biol. Chem. 273:3285–3290.
- Berra, E., M. T. Diaz-Meco, J. Lozano, S. Frutos, M. M. Municio, P. Sanchez, L. Sanz, and J. Moscat 1995. Evidence for a role of MEK and MAPK during signal transduction by protein kinase C ζ. EMBO J. 14:6157–6163.
- Berra, E., et al. Unpublished data.
- Bjorkoy, G., A. Overvatn, M. T. Díaz-Meco, J. Moscat, and J. Johansen 1995. Evidence for a bifurcation of the mitogenic signaling pathway activated by ras and phosphatidylcholine-hydrolyzing. J. Biol. Chem. 270:21299–21306.
- Chu, Z.-L., T. A. McKinsey, L. Liu, J. J. Gentry, M. H. Malim, and J. Ballard 1997. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control. Proc. Natl. Acad. Sci. USA 94:10057–10062.
- Diaz-Meco, M. T., E. Berra, M. M. Municio, L. Sanz, J. Lozano, I. Dominguez, V. Diaz-Golpe, M. T. Lain de Lera, J. Alcamí, C. V. Payá, F. Arenzana-Seisdedos, J.-L. Virelizier, and J. Moscat 1993. A dominant negative protein kinase C ζ subspecies blocks NF-κB activation. Mol. Cell. Biol. 13:4770–4775.
- Díaz-Meco, M. T., J. Lozano, M. M. Municio, E. Berra, S. Frutos, L. Sanz, and J. Moscat 1994. ζPKC induces phosphorylation and inactivation of IκB-α in vitro. EMBO J. 13:2842–2848.
- Diaz-Meco, M. T., M. M. Municio, P. Sanchez, J. Lozano, and J. Moscat 1996. Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype λ/ι and stimulates its kinase activity in vitro and in vivo. Mol. Cell. Biol. 16:105–114.
- Diaz-Meco, M. T., et al. Unpublished data.
- DiDonato, J. A., M. Hayakawa, D. M. Rothwarf, E. Zandi, and J. Karin 1997. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388:548–554.
- Dominguez, I., L. Sanz, F. Arenzana-Seisdedos, M. T. Diaz-Meco, J.-L. Virelizier, and J. Moscat 1993. Inhibition of protein kinase Cζ subspecies blocks the activation of an NF-κB-like activity in Xenopus laevis oocytes. Mol. Cell. Biol. 13:1290–1295.
- Folgueira, L., J. A. McElhinny, G. D. Bren, W. S. MacMorran, M. T. Diaz-Meco, J. Moscat, and J. Paya 1996. Protein kinase C-ζ mediates NF-κB activation in human immunodeficiency virus-infected monocytes. J. Virol. 70:223–231.
- Hsu, H., J. Huang, H.-B. Shu, V. Baichwal, and J. Goeddel 1996. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4:387–396.
- Israël, A. 1997. IκB kinase all zipped up. Nature 388:519–521.
- Kelliher, M. A., S. Grimm, Y. Ishida, F. Kuo, B. Z. Stanger, and J. Leder 1998. The death domain kinase RIP mediates the TNF-induced NF-κB signal. Immunity 8:297–303.
- Lallena, M.-J., et al. Unpublished data.
- Lee, F. S., J. Hagler, Z. J. Chen, and J. Maniatis 1997. Activation of the IκBα kinase complex by MEKK1, a kinase of the JNK pathway. Cell 88:213–222.
- Lenardo, M., and J. Baltimore 1989. NF-κB: a pleiotropic mediator of inducible and tissue-specific gene control. Cell 58:227–229.
- Ling, L., Z. Cao, and J. Goeddel 1998. NF-κB-inducing kinase activates IKKα by phosphorylation of Ser-176. Proc. Natl. Acad. Sci. USA 95:3792–3797.
- Liu, Z., H. Hsu, D. V. Goeddel, and J. Karin 1996. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 87:565–576.
- Lozano, J., E. Berra, M. M. Municio, M. T. Diaz-Meco, I. Dominguez, L. Sanz, and J. Moscat 1994. Protein kinase C ζ isoform is critical for κB-dependent promoter activation by sphingomyelinase. J. Biol. Chem. 269:19200–19202.
- Malinin, N. L., M. P. Boldin, A. V. Kovalenko, and J. Wallach 1997. MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1. Nature 385:540–544.
- McElhinny, J. A., S. A. Trushin, G. D. Bren, N. Chester, and J. Paya 1996. Casein kinase II phosphorylates IκBα at S-283, S-289, S-293, and T-291 and is required for its degradation. Mol. Cell. Biol. 16:899–906.
- Mercurio, F., H. Zhu, B. W. Murray, A. Shevchenko, B. L. Bennett, J. W. Li, D. B. Young, M. Barbosa, M. Mann, A. Manning, and J. Rao 1997. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science 278:860–866.
- Müller, G., M. Ayoub, P. Storz, J. Rennecke, D. Fabbro, and J. Pfizenmaier 1995. PKCζ is a molecular switch in signal transduction of TNFα, bifunctionally regulated by ceramide and arachidonic acid. EMBO J. 14:1961–1969.
- Nakano, H., M. Shindo, S. Sakon, S. Nishinaka, M. Mihara, H. Yagita, and J. Okumura 1998. Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc. Natl. Acad. Sci. USA 95:3537–3542.
- Nishikawa, K., A. Toker, F.-J. Johannes, Z. Songyang, and J. Cantley 1997. Determination of the specific substrate sequence motifs of protein kinase C isozymes. J. Biol. Chem. 272:952–960.
- Paya, C. V., et al. Unpublished data.
- Réginer, C. H., H. Y. Song, X. Gao, D. V. Goeddel, Z. Cao, and J. Rothe 1997. Identification and characterization of an IκB kinase. Cell 90:373–383.
- Rzymkiewicz, D. M., T. Tetsuka, D. Daphna-Iken, S. Srivastava, and J. Morrison 1996. Interleukin-1β activates protein kinase Cζ in renal mesangial cells. J. Biol. Chem. 271:17241–17246.
- Schönwasser, D. C., R. M. Marais, C. J. Marshall, and J. Parker 1998. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol. Cell. Biol. 18:790–798.
- Sontag, E., J. M. Sontag, and J. Garcia 1997. Protein phosphatase 2A is a critical regulator of protein kinase Cζ signaling targeted by SV40 small t to promote cell growth and NF-κB activation. EMBO J. 16:5662–5671.
- Stancovski, I., and J. Baltimore 1997. NF-κB activation: the IκB kinase revealed? Cell 91:299–302.
- Thanos, D., and J. Maniatis 1995. NF-κB: a lesson in family values. Cell 80:529–532.
- Verma, I. M., J. K. Stevenson, E. M. Schwarz, D. VanAntwerp, and J. Miyamoto 1995. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9:2723–2735.
- Verma, I. M., and J. Stevenson 1997. IκB kinase: beginning, not the end. Proc. Natl. Acad. Sci. USA 94:11758–11760.
- Woronicz, J. D., X. Gao, Z. Cao, M. Rothe, and J. Goeddel 1997. IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK. Science 278:866–869.
- Zandi, E., D. M. Rothwarf, M. Delhase, M. Hayakawa, and J. Karin 1997. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell 91:243–252.