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DNA Dynamics and Chromosome Structure

The Drosophila melanogaster DmRAD54 Gene Plays a Crucial Role in Double-Strand Break Repair after P-Element Excision and Acts Synergistically with Ku70 in the Repair of X-Ray Damage

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Pages 6269-6275 | Received 22 Apr 1999, Accepted 14 Jun 1999, Published online: 27 Mar 2023

REFERENCES

  • Beall, E. L., A. Admon, and J. Rio 1994. A Drosophila protein homologous to the human p70 Ku autoimmune antigen interacts with the P transposable element inverted repeats. Proc. Natl. Acad. Sci. USA 91:12681–12685.
  • Beall, E. L., and J. Rio 1996. Drosophila IRBP/Ku p70 corresponds to the mutagen-sensitive mus309 gene and is involved in P-element excision in vivo. Genes Dev. 10:921–33.
  • Beall, E. L., and J. Rio 1997. Drosophila P-element transposase is a novel site-specific endonuclease. Genes Dev. 11:2137–2151.
  • Bessho, T., D. Mu, and J. Sancar 1997. Initiation of DNA interstrand cross-link repair in humans: the nucleotide excision repair system makes dual incisions 5′ to the cross-linked base and removes a 22- to 28-nucleotide-long damage-free strand. Mol. Cell. Biol. 17:6822–6830.
  • Bezzubova, O., A. Silbergleit, Y. Yamaguchi-Iwai, S. Takeda, and J. Buerstedde 1997. Reduced X-ray resistance and homologous recombination frequencies in a RAD54−/− mutant of the chicken DT40 cell line. Cell 89:185–193.
  • Boulton, S. J., and J. Jackson 1996. Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double-strand break rejoining and in telomeric maintenance. Nucleic Acids Res. 24:4639–4648.
  • Boulton, S. J., and J. Jackson 1996. Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways. EMBO J. 15:5093–5103.
  • Boyd, J. B., M. D. Golino, and J. Setlow 1976. The mei-9a mutant of Drosophila melanogaster increases mutagen sensitivity and decreases excision repair. Genetics 84:527–544.
  • Boyd, J. B., M. D. Golino, K. E. Shaw, C. J. Osgood, and J. Green 1981. Third-chromosome mutagen-sensitive mutants of Drosophila melanogaster. Genetics 97:607–623.
  • Boyd, J. B., R. D. Snyder, P. V. Harris, J. M. Presley, S. F. Boyd, and J. Smith 1982. Identification of a second locus in Drosophila melanogaster required for excision repair. Genetics 100:239–257.
  • Chu, G. 1997. Double strand break repair. J. Biol. Chem. 272:24097–24100.
  • Cole, R. S. 1973. Repair of DNA containing interstrand crosslinks in Escherichia coli: sequential excision and recombination. Proc. Natl. Acad. Sci. USA 70:1064–1068.
  • Cole, R. S., and J. Sinden 1975. Repair of cross-linked DNA in Escherichia coli. Basic Life Sci. 5B:487–495.
  • Engels, W. R., D. M. Johnson-Schlitz, W. B. Eggleston, and J. Sved 1990. High-frequency P element loss in Drosophila is homolog dependent. Cell 62:515–525.
  • Essers, J., R. W. Hendriks, S. M. Swagemakers, C. Troelstra, J. de Wit, D. Bootsma, J. H. Hoeijmakers, and J. Kanaar 1997. Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination. Cell 89:195–204.
  • Feldmann, H., and J. Winnacker 1993. A putative homologue of the human autoantigen Ku from Saccharomyces cerevisiae. J. Biol. Chem. 268:12895–12900.
  • FlyBase Consortium. 1998. FlyBase—a Drosophila Database, http://flybase.bio.indiana.edu/ Nucleic Acids Res. 26:85–88.
  • Friedberg, E. C., G. C. Walker, W. Siede 1995. DNA repair and mutagenesis. ASM Press, Washington, D.C.
  • Ghabrial, A., R. P. Ray, and J. Schüpbach 1998. okra and spindle-B encode components of the RAD52 DNA repair pathway and affect meiosis and patterning in Drosophila oogenesis. Genes Dev. 12:2711–2723.
  • Gloor, G. B., N. A. Nassif, D. M. Johnson-Schlitz, C. R. Preston, and J. Engels 1991. Targeted gene replacement in Drosophila via P element-induced gap repair. Science 253:1110–1117.
  • Gorbalenya, A. E., and J. Koonin 1993. Helicases: amino acid sequence comparison and structure-function relationships. Curr. Opin. Struct. Biol. 3:419–429.
  • Henderson, D. S., and J. Glover 1998. Chromosome fragmentation resulting from an inability to repair transposase-induced DNA double-strand breaks in PCNA mutants of Drosophila. Mutagenesis 13:57–60.
  • Herrmann, G., T. Lindahl, and J. Schar 1998. Saccharomyces cerevisiae LIF1: a function involved in DNA double-strand break repair related to mammalian XRCC4. EMBO J. 17:4188–4198.
  • Jacoby, D. B., and J. Wensink 1994. Yolk protein factor 1 is a Drosophila homolog of Ku, the DNA-binding subunit of a DNA-dependent protein kinase from humans. J. Biol. Chem. 269:11484–11491.
  • Klein, H. L. 1997. RDH54, a RAD54 homologue in Saccharomyces cerevisiae, is required for mitotic diploid-specific recombination and repair and for meiosis. Genetics 147:1533–1543.
  • Kooistra, R., K. Vreeken, J. B. Zonneveld, A. de Jong, J. C. Eeken, C. J. Osgood, J.-M. Buerstedde, P. H. M. Lohman, and J. Pastink 1997. The Drosophila melanogaster RAD54 homolog, DmRAD54, is involved in the repair of radiation damage and recombination. Mol. Cell. Biol. 17:6097–6104.
  • Lindsley, D. L., G. G. Zimm 1992. The genome of Drosophila melanogaster. Academic Press, San Diego, Calif.
  • Milne, G. T., S. Jin, K. B. Shannon, and J. Weaver 1996. Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae. Mol. Cell. Biol. 16:4189–4198.
  • New, J. H., T. Sugiyama, E. Zaitseva, and J. Kowalczykowski 1998. Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A. Nature 391:407–410.
  • Nickoloff, J. A., and J. Hoekstra 1998. Double-strand break and recombinational repair in Saccharomyces cerevisiae DNA damage and repair In J. A. Nickoloff, M. F. Hoekstra (ed.), I:335–362 Humana Press, Totowa, N.J.
  • O’Hare, K., and J. Rubin 1983. Structures of P transposable elements and their sites of insertion and excision in the Drosophila melanogaster genome. Cell 34:25–35.
  • Petrini, J. H. J., D. A. Bressan, and J. Yao 1997. The RAD52 epistasis group in mammalian double strand break repair. Semin. Immunol. 9:181–188.
  • Petukhova, G., S. Stratton, and J. Sung 1998. Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins. Nature 393:91–94.
  • Robertson, H. M., C. R. Preston, R. W. Phillis, D. M. Johnson-Schlitz, W. K. Benz, and J. Engels 1988. A stable genomic source of P element transposase in Drosophila melanogaster. Genetics 118:461–470.
  • Schar, P., G. Herrmann, G. Daly, and J. Lindahl 1997. A newly identified DNA ligase of Saccharomyces cerevisiae involved in RAD52-independent repair of DNA double-strand breaks. Genes Dev. 11:1912–1924.
  • Shinohara, A., and J. Ogawa 1998. Stimulation by Rad52 of yeast Rad51-mediated recombination. Nature 391:404–407.
  • Shinohara, M., E. Shita-Yamaguchi, J.-M. Buerstedde, H. Shinagawa, H. Ogawa, and J. Shinohara 1997. Characterization of the roles of the Saccharomyces cerevisiae RAD54 gene and a homologue of RAD54, RADH54/TID1, in mitosis and meiosis. Genetics 147:1545–1556.
  • Siede, W., A. A. Friedl, I. Dianova, F. Eckardt-Schupp, and J. Friedberg 1996. The Saccharomyces cerevisiae Ku autoantigen homologue affects radiosensitivity only in the absence of homologous recombination. Genetics 142:91–102.
  • Sung, P. 1994. Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein. Science 265:1241–1243.
  • Sung, P. 1997. Function of yeast Rad52 protein as a mediator between replication protein A and the Rad51 recombinase. J. Biol. Chem. 272:28194–28197.
  • Sung, P. 1997. Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase. Genes Dev. 11:1111–1121.
  • Takata, M., M. S. Sasaki, E. Sonoda, C. Morrison, M. Hashimoto, H. Utsumi, Y. Yamguchi-Iwai, A. Shinohara, and J. Takeda 1998. Homologous recombination and non-homologous end-joining pathways of DNA double strand break repair have overlapping roles in the maintainance of chromosomal integrity in vertebrate cells. EMBO J. 17:5497–5508.
  • Teo, S.-H., and J. Jackson 1997. Identification of Saccharomyces cerevisiae DNA ligase IV: involvement in DNA double-strand break repair. EMBO J. 16:4788–4795.
  • Tsukamoto, Y., and J. Ikeda 1998. Double-strand break repair mediated by DNA end-joining. Genes Cells 3:135–144.
  • Wilson, T. E., U. Grawunder, and J. Lieber 1997. Yeast DNA ligase IV mediates non-homologous DNA end joining. Nature 388:495–498.

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