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Cell Growth and Development

Suppression of STAT5 Functions in Liver, Mammary Glands, and T Cells in Cytokine-Inducible SH2-Containing Protein 1 Transgenic Mice

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Pages 6396-6407 | Received 16 Feb 1999, Accepted 22 Jun 1999, Published online: 27 Mar 2023

REFERENCES

  • Adams, T. E., J. A. Hansen, R. Starr, N. A. Nicola, D. J. Hilton, and J. Billestrup 1998. Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling. J. Biol. Chem. 273:1285–1287.
  • Bix, M., Z. E. Wang, B. Thiel, N. J. Schork, and J. Locksley 1998. Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism. J. Exp. Med. 188:2289–2299.
  • Cella, N., B. Groner, and J. Hynes 1998. Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocorticoid receptor in mammary cells. Mol. Cell. Biol. 18:1783–1792.
  • Darnell, J. E. Jr.. 1997. STATs and gene regulation. Science 277:1630–1635.
  • Durbin, J. E., R. Hackenmiller, M. C. Simon, and J. Levy 1996. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84:443–450.
  • Endo, T. A., M. Masuhara, M. Yokouchi, R. Suzuki, H. Sakamoto, K. Mitsui, A. Matsumoto, S. Tanimura, M. Ohtsubo, H. Misawa, T. Miyazaki, N. Leonor, T. Taniguchi, T. Fujita, Y. Kanakura, S. Komiya, and J. Yoshimura 1997. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387:921–924.
  • Feldman, G. M., L. A. Rosenthal, X. Liu, M. P. Hayes, A. Wynshaw-Boris, W. J. Leonard, L. Hennighausen, and J. Finbloom 1997. STAT5a deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression. Blood 90:1768–1776.
  • Helman, D., Y. Sandowski, Y. Cohen, A. Matsumoto, A. Yoshimura, S. Merchav, and J. Gertler 1998. Cytokine-inducible SH2 protein (CIS3) and JAK2 binding protein (JAB) abolish prolactin receptor-mediated STAT5 signaling. FEBS Lett. 441:287–291.
  • Ihle, J. N. 1996. STATs: signal transducers and activators of transcription. Cell 84:331–334.
  • Ikawa, M., S. Yamada, T. Nakanishi, and J. Okabe 1999. Green fluorescent protein (GFP) as a vital marker in mammals. Curr. Top. Dev. Biol. 44:1–20.
  • Imada, K., E. T. Bloom, H. Nakajima, J. A. Horvath-Arcidiacono, G. B. Udy, H. W. Davey, and J. Leonard 1998. Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity. J. Exp. Med. 188:2067–2074.
  • Jiao, H., K. Berrada, W. Yang, M. Tabrizi, L. C. Platanias, and J. Yi 1996. Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1. Mol. Cell. Biol. 16:6985–6992.
  • Kaplan, M. H., Y.-L. Sun, T. Hoey, and J. Grusby 1996. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382:174–177.
  • Klingmuller, U., U. Lorenz, L. C. Cantley, B. G. Neel, and J. Lodish 1995. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell 80:729–738.
  • Kubo, M., J. Ransom, D. Webb, Y. Hashimoto, T. Tada, and J. Nakayama 1997. T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6. EMBO J. 16:4007–4020.
  • Liu, X., G. W. Robinson, and J. Hennighausen 1996. Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation. Mol. Endocrinol. 10:1496–1506.
  • Liu, X., G. W. Robinson, K.-U. Wagner, L. Garrett, A. Wynshaw-Boris, and J. Hennighausen 1997. Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev. 11:179–186.
  • Masuhara, M., H. Sakamoto, A. Matsumoto, R. Suzuki, H. Yasukawa, K. Mitsui, T. Wakioka, S. Tanimura, A. Sasaki, H. Misawa, M. Yokouchi, M. Ohtsubo, and J. Yoshimura 1997. Cloning and characterization of novel CIS family genes. Biochem. Biophys. Res. Commun. 239:439–446.
  • Matsumoto, A., M. Masuhara, K. Mitsui, M. Yokouchi, M. Ohtsubo, H. Misawa, A. Miyajima, and J. Yoshimura 1997. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Blood 89:3148–3154.
  • Meraz, M. A., J. M. White, K. C. F. Sheehan, E. A. Bach, S. J. Rodig, A. S. Dighe, D. H. Kaplan, J. K. Riley, A. C. Greenlund, D. Campbell, K. Carver-Moore, R. N. DuBois, R. Clark, M. Aguet, and J. Schreiber 1996. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84:431–442.
  • Moriggl, R., D. J. Topham, S. Teglund, V. Sexl, C. McKay, D. Wang, A. Hoffmeyer, J. van Deursen, M. Y. Sangster, K. D. Bunting, G. C. Grosveld, and J. Ihle 1999. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10:249–259.
  • Naka, T., M. Narazaki, M. Hirata, T. Matsumoto, S. Minamoto, A. Aono, N. Nishimoto, T. Kajita, T. Taga, K. Yoshizaki, S. Akira, and J. Kishimoto 1997. Structure and function of a new STAT-induced STAT inhibitor. Nature 387:924–929.
  • Nakajima, H., X.-W. Liu, A. Wynshaw-Boris, L. A. Rosenthal, K. Imada, D. S. Finbloom, L. Hennighausen, and J. Leonard 1997. An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor α chain induction. Immunity 7:691–701.
  • Niwa, H., K. Yamamura, and J. Miyazaki 1991. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108:193–199.
  • Norstedt, G., and J. Palmiter 1984. Secretory rhythm of growth hormone regulates sexual differentiation of mouse liver. Cell 36:805–812.
  • O’Shea, J. J. 1997. Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet? Immunity 7:1–11.
  • Ripperger, J. A., S. Fritz, K. Richter, G. M. Hocke, F. Lottspeich, and J. Fey 1995. Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements. J. Biol. Chem. 270:29998–30006.
  • Sakamoto, H., H. Yasukawa, M. Masuhara, S. Tanimura, A. Sasaki, K. Yuge, M. Ohtsubo, S. Ohtsuka, T. Fujita, T. Ohta, Y. Furukawa, S. Iwase, H. Yamada, and J. Yoshimura 1998. A Janus kinase inhibitor, JAB, is an interferon-γ inducible gene and confers resistance to interferons. Blood 92:1668–1676.
  • Shimoda, K., J. van Deursen, M. Y. Sangster, S. R. Sarawar, R. T. Carson, R. A. Tripp, C. Chu, F. W. Quelle, T. Nosaka, D. A. Vignali, P. C. Doherty, G. Grosveld, W. E. Paul, and J. Ihle 1996. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380:630–633.
  • Shultz, L. D., P. A. Schweitzer, T. V. Rajan, T. Yi, J. N. Ihle, R. J. Matthews, M. L. Thomas, and J. Beier 1993. Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell 73:1445–1454.
  • Starr, R., T. A. Willson, E. M. Viney, L. J. Murray, J. R. Rayner, B. J. Jenkins, T. J. Gonda, W. S. Alexander, D. Metcalf, N. A. Nicola, and J. Hilton 1997. A family of cytokine-inducible inhibitors of signalling. Nature 387:917–921.
  • Suzuki, R., H. Sakamoto, H. Yasukawa, M. Masuhara, T. Wakioka, A. Sasaki, K. Yuge, S. Komiya, A. Inoue, and J. Yoshimura 1998. CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells. Oncogene 17:2271–2278.
  • Takeda, K., T. Tanaka, W. Shi, M. Matsumoto, M. Minami, S. Kashiwamura, K. Nakanishi, N. Yoshida, T. Kishimoto, and J. Akira 1996. Essential role of Stat6 in IL-4 signalling. Nature 380:627–630.
  • Takeda, K., K. Noguchi, W. Shi, T. Tanaka, M. Matsumoto, N. Yoshida, T. Kishimoto, and J. Akira 1997. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc. Natl. Acad. Sci. USA 94:3801–3804.
  • Teglund, S., C. McKay, E. Schuetz, J. M. van Deursen, D. Straopodis, D. Wang, M. Brown, S. Bodner, G. Grosveld, and J. Ihle 1998. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 93:841–852.
  • Udy, G. B., R. P. Towers, R. G. Snell, R. J. Wilkins, S.-H. Park, P. A. Ram, D. J. Waxman, and J. Davey 1997. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc. Natl. Acad. Sci. USA 94:7239–7242.
  • Verdier, F., S. Chretien, O. Muller, P. Varlet, A. Yoshimura, S. Gisselbrecht, C. Lacombe, and J. Mayeux 1998. Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated CIS protein. J. Biol. Chem. 273:28185–28190.
  • Welte, T., D. Leitenberg, B. N. Dittel, B. K. al-Ramadi, B. Xie, Y. E. Chin, C. A. Janeway Jr., A. L. M. Bothwell, K. Bottomly, and J. Fu 1999. STAT5 interaction with the T cell receptor complex and stimulation of T cell proliferation. Science 283:222–225.
  • Yamashita, M., K. Hashimoto, M. Kimura, M. Kubo, and J. Nakayama 1998. Requirement for p56 (lck) tyrosine kinase activation in Th subset differentiation. Int. Immunol. 10:577–591.
  • Yasukawa, H., H. Misawa, H. Sakamoto, M. Masuhara, A. Sasaki, T. Wakioka, A. Ohtsuka, T. Imaizumi, T. Matsuda, J. N. Ihle, and J. Yoshimura 1999. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 18:1309–1320.
  • Yoshimura, A., T. Ohkubo, T. Kiguchi, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, T. Hara, and J. Miyajima 1995. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 14:2816–2826.
  • Yoshimura, A., M. Ichihara, I. Kinjyo, M. Moriyama, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, T. Hara, and J. Miyajima 1996. Mouse oncostatin M: an immediate early response gene induced by multiple cytokines through the JAKs/STAT5 pathway. EMBO J. 15:1055–1063.
  • Yoshimura, A. 1998. The CIS/JAB family: novel negative regulators of JAK signaling pathways. Leukemia 12:1851–1857.

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