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DNA Dynamics and Chromosome Structure

Long-Distance Control of Origin Choice and Replication Timing in the Human β-Globin Locus Are Independent of the Locus Control Region

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Pages 5581-5591 | Received 03 Jan 2000, Accepted 24 Apr 2000, Published online: 28 Mar 2023

REFERENCES

  • Aladjem, M. I., Groudine, M., Brody, L. L., Dieken, E. S., Fournier, R. E., Wahl, G. M., and Epner, E. M.. 1995. Participation of the human beta-globin locus control region in initiation of DNA replication. Science 270:815–819
  • Aladjem, M. I., Rodewald, L. W., Kolman, J. L., and Wahl, G. M.. 1998. Genetic dissection of a mammalian replicator in the human beta-globin locus. Science 281:1005–1009
  • Bender, M., Bulger, M., Close, J., and Groudine, M.. 2000. Globin gene switching and DNaseI sensitivity of the endogenous β globin locus in mice do not require the locus control region. Mol. Cell 5:387–393
  • Bergemann, A. D., and Johnson, E. M.. 1992. The HeLa Pur factor binds single-stranded DNA at a specific element conserved in gene flanking regions and origins of DNA replication. Mol. Cell. Biol. 12:1257–1265
  • Brown, B. A., Padgett, R. W., Hardies, S. C., Hutchison, C. A., and Edgell, M. H.. 1982. Beta-globin transcript found in induced murine erythroleukemia cells is homologous to the beta h0 and beta h1 genes. Proc. Natl. Acad. Sci. USA 79:2753–2757
  • Brown, E. H., Iqbal, M. A., Stuart, S., Hatton, K. S., Valinsky, J., and Schildkraut, C. L.. 1987. Rate of replication of the murine immunoglobulin heavy-chain locus: evidence that the region is part of a single replicon. Mol. Cell. Biol. 7:450–457
  • Bulger, M., van Doorninck, J. H., Saitoh, N., Telling, A., Farrell, C., Bender, M. A., Felsenfeld, G., Axel, R., and Groudine, M.. 1999. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. Proc. Natl. Acad. Sci. USA 96:5129–5134
  • Calza, R. E., Eckhardt, L. A., DelGiudice, T., and Schildkraut, C. L.. 1984. Changes in gene position are accompanied by a change in time of replication. Cell 36:689–696
  • Chang, C. F., Gallia, G. L., Muralidharan, V., Chen, N. N., Zoltick, P., Johnson, E., and Khalili, K.. 1996. Evidence that replication of human neurotropic JC virus DNA in glial cells is regulated by the sequence-specific single-stranded DNA-binding protein Pur alpha. J. Virol. 70:4150–4156
  • DePamphilis, M. L.. 1996. Origins of DNA replication DNA replication in eukaryotic cells. DePamphilis, M. 48–86 Cold Spring Harbor Laboratory Press, Plainview, N.Y
  • Dhar, V., Mager, D., Iqbal, A., and Schildkraut, C. L.. 1988. The coordinate replication of the human beta-globin gene domain reflects its transcriptional activity and nuclease hypersensitivity. Mol. Cell. Biol. 8:4958–4965
  • Dhar, V., Skoultchi, A. I., and Schildkraut, C. L.. 1989. Activation and repression of a beta-globin gene in cell hybrids is accompanied by a shift in its temporal replication. Mol. Cell. Biol. 9:3524–3532
  • Dieken, E. S., Epner, E. M., Fiering, S., Fournier, R. E., and Groudine, M.. 1996. Efficient modification of human chromosomal alleles using recombination-proficient chicken/human microcell hybrids. Nat. Genet. 12:174–182
  • Disteche, C. M., Eicher, E. M., and Latt, S. A.. 1979. Late replication in an X-autosome translocation in the mouse: correlation with genetic inactivation and evidence for selective effects during embryogenesis. Proc. Natl. Acad. Sci. USA 76:5234–5238
  • Driscoll, M. C., Dobkin, C. S., and Alter, B. P.. 1989. Gamma delta beta-thalassemia due to a de novo mutation deleting the 5′ beta-globin gene activation-region hypersensitive sites. Proc. Natl. Acad. Sci. USA 86:7470–7474
  • Epner, E., Forrester, W. C., and Groudine, M.. 1988. Asynchronous DNA replication within the human beta-globin gene locus. Proc. Natl. Acad. Sci. USA 85:8081–8085
  • Epner, E., Reik, A., Cimbora, D., Telling, A., Bender, M. A., Fiering, S., Enver, T., Martin, D. I., Kennedy, M., Keller, G., and Groudine, M.. 1998. The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus. Mol. Cell 2:447–455
  • Epner, E., Rifkind, R. A., and Marks, P. A.. 1981. Replication of alpha and beta globin DNA sequences occurs during early S phase in murine erythroleukemia cells. Proc. Natl. Acad. Sci. USA 78:3058–3062
  • Forrester, W. C., Epner, E., Driscoll, M. C., Enver, T., Brice, M., Papayannopoulou, T., and Groudine, M.. 1990. A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus. Genes Dev. 4:1637–1649
  • Francastel, C., Walters, M. C., Groudine, M., and Martin, D. I. K.. 1999. A functional enhancer supresses silencing of a transgene and prevents its localization close to centromeric heterochromatin. Cell 99:259–269
  • Gerbi, S. A., and Bielinsky, A. K.. 1997. Replication initiation point mapping. Methods 13:271–280
  • Grosveld, F., van Assendelft, G. B., Greaves, D. R., and Kollias, G.. 1987. Position-independent, high-level expression of the human beta-globin gene in transgenic mice. Cell 51:975–985
  • Groudine, M., Kohwi-Shigematsu, T., Gelinas, R., Stamatoyannopoulos, G., and Papayannopoulou, T.. 1983. Human fetal to adult hemoglobin switching: changes in chromatin structure of the beta-globin gene locus. Proc. Natl. Acad. Sci. USA 80:7551–7555
  • Guinta, D. R., Tso, J. Y., Narayanswami, S., Hamkalo, B. A., and Korn, L. J.. 1986. Early replication and expression of oocyte-type 5S RNA genes in a Xenopus somatic cell line carrying a translocation. Proc. Natl. Acad. Sci. USA 83:5150–5154
  • Hansen, R. S., Canfield, T. K., Lamb, M. M., Gartler, S. M., and Laird, C. D.. 1993. Association of fragile X syndrome with delayed replication of the FMR1 gene. Cell 73:1403–1409
  • Hatton, K. S., Dhar, V., Brown, E. H., Iqbal, M. A., Stuart, S., Didamo, V. T., and Schildkraut, C. L.. 1988. Replication program of active and inactive multigene families in mammalian cells. Mol. Cell. Biol. 8:2149–2158
  • Higgs, D. R.. 1998. Do LCRs open chromatin domains? Cell 95:299–302
  • Holmquist, G. P.. 1987. Role of replication time in the control of tissue-specific gene expression. Am. J. Hum. Genet. 40:151–173
  • Iguchi-Ariga, S. M., Ogawa, N., and Ariga, H.. 1993. Identification of the initiation region of DNA replication in the murine immunoglobulin heavy chain gene and possible function of the octamer motif as a putative DNA replication origin in mammalian cells. Biochim. Biophys. Acta 1172:73–81
  • Itoh, H., Wortman, M. J., Kanovsky, M., Uson, R. R., Gordon, R. E., Alfano, N., and Johnson, E. M.. 1998. Alterations in Pur(alpha) levels and intracellular localization in the CV-1 cell cycle. Cell Growth Differ. 9:651–665
  • Jacob, F., Brenner, S., and Cuzin, F.. 1964. On the regulation of DNA replication in bacteria. Cold Spring Harbor Symp. Quant. Biol. 28:329–348
  • Jones, C., Penny, L., Mattina, T., Yu, S., Baker, E., Voullaire, L., Langdon, W. Y., Sutherland, G. R., Richards, R. I., and Tunnacliffe, A.. 1995. Association of a chromosome deletion syndrome with a fragile site within the proto-oncogene CBL2. Nature 376:145–149
  • Kalejta, R. F., Li, X., Mesner, L. D., Dijkwel, P. A., Lin, H. B., and Hamlin, J. L.. 1998. Distal sequences, but not ori-beta/OBR-1, are essential for initiation of DNA replication in the Chinese hamster DHFR origin. Mol. Cell 2:797–806
  • Karube, T., and Watanabe, S.. 1988. Analysis of the chromosomal DNA replication pattern using the bromodeoxyuridine labeling method. Cancer Res. 48:219–222
  • Kitsberg, D., Selig, S., Keshet, I., and Cedar, H.. 1993. Replication structure of the human beta-globin gene domain. Nature 366:588–590
  • Kobayashi, T., Rein, T., and DePamphilis, M. L.. 1998. Identification of primary initiation sites for DNA replication in the hamster dihydrofolate reductase gene initiation zone. Mol. Cell. Biol. 18:3266–3277
  • Lawlis, S. J., Keezer, S. M., Wu, J. R., and Gilbert, D. M.. 1996. Chromosome architecture can dictate site-specific initiation of DNA replication in Xenopus egg extracts. J. Cell Biol. 135:1207–1218
  • Malott, M., and Leffak, M.. 1999. Activity of the c-myc replicator at an ectopic chromosomal location. Mol. Cell. Biol. 19:5685–5695
  • Manders, E. M., Stap, J., Brakenhoff, G. J., van Driel, R., and Aten, J. A.. 1992. Dynamics of three-dimensional replication patterns during the S-phase, analysed by double labelling of DNA and confocal microscopy. J. Cell Sci. 103:857–862
  • Nakayasu, H., and Berezney, R.. 1989. Mapping replicational sites in the eucaryotic cell nucleus. J. Cell Biol. 108:1–11
  • O'Keefe, R. T., Henderson, S. C., and Spector, D. L.. 1992. Dynamic organization of DNA replication in mammalian cell nuclei: spatially and temporally defined replication of chromosome-specific alpha-satellite DNA sequences. J. Cell Biol. 116:1095–1110
  • Orr-Weaver, T. L., Johnston, C. G., and Spradling, A. C.. 1989. The role of ACE3 in Drosophila chorion gene amplification. EMBO J. 8:4153–4162
  • Pederson, D., and Heintz, N.. 1994. Transcription factors and DNA replication. R. G. Landes, Austin, Tex
  • Phi-van, L., and Stratling, W. H.. 1999. An origin of bidirectional DNA replication is located within a CpG island at the 3′ end of the chicken lysozyme gene. Nucleic Acids Res. 27:3009–3017
  • Raich, N., Enver, T., Nakamoto, B., Josephson, B., Papayannopoulou, T., and Stamatoyannopoulos, G.. 1990. Autonomous developmental control of human embryonic globin gene switching in transgenic mice. Science 250:1147–1149
  • Reik, A., Telling, A., Zitnik, G., Cimbora, D., Epner, E., and Groudine, M.. 1998. The locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells. Mol. Cell. Biology 18:5992–6000
  • Schübeler, D., Francastel, C., Cimbora, D. M., Reik, A., Martin, D. I. K., and Groudine, M.. 2000. Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human β-globin locus. Genes Dev. 14:940–950
  • Simon, I., and Cedar, H.. 1996. Temporal order of DNA replication DNA replication in eukaryotic cells. DePamphilis, M. 387–408 Cold Spring Harbor Laboratory Press, Plainview, N.Y
  • Simpson, R. T.. 1990. Nucleosome positioning can affect the function of a cis-acting DNA element in vivo. Nature 343:387–389
  • Smith, Z. E., and Higgs, D. R.. 1999. The pattern of replication at a human telomeric region (16p13.3): its relationship to chromosome structure and gene expression. Hum. Mol. Genet. 8:1373–1386
  • Stamatoyannopoulos, G., and Nienhuis, A. W.. 1994. Hemoglobin switching The molecular basis of blood disease. W. B. Stamatoyannopoulos, G., Nienhuis, A. W., Majerus, P. W., and Varmus, H. 107–155 Saunders, Philadelphia, Pa
  • Stillman, B.. 1993. DNA replication: replicator renaissance. Nature 366:506–507
  • Taira, T., Iguchi-Ariga, S. M., and Ariga, H.. 1994. A novel DNA replication origin identified in the human heat shock protein 70 gene promoter. Mol. Cell. Biol. 14:6386–6397
  • Takagi, N.. 1974. Differentiation of X chromosomes in early female mouse embryos. Exp. Cell Res. 86:127–135
  • van der Vliet, P.. 1996. Roles of transcription factors in DNA replication DNA replication in eukaryotic cells. DePamphilis, M. 87–118 Cold Spring Harbor Laboratory Press, Plainview, N.Y
  • Wahrman, J., Richler, C., Neufeld, E., and Friedmann, A.. 1983. The origin of multiple sex chromosomes in the gerbil Gerbillus gerbillus (Rodentia: Gerbillinae). Cytogenet. Cell Genet. 35:161–180
  • Widrow, R. J.. 1999. Ph.D. thesis. University of Washington, Seattle
  • Widrow, R. J., Hansen, R. S., Kawame, H., Gartler, S. M., and Laird, C. D.. 1998. Very late DNA replication in the human cell cycle. Proc. Natl. Acad. Sci. USA 95:11246–11250
  • Wiebauer, K., Gumucio, D. L., Jones, J. M., Caldwell, R. M., Hartle, H. T., and Meisler, M. H.. 1985. A 78-kilobase region of mouse chromosome 3 contains salivary and pancreatic amylase genes and a pseudogene. Proc. Natl. Acad. Sci. USA 82:5446–5449
  • Yagi, M., Gelinas, R., Elder, J. T., Peretz, M., Papayannopoulou, T., Stamatoyannopoulos, G., and Groudine, M.. 1986. Chromatin structure and developmental expression of the human alpha-globin cluster. Mol. Cell. Biol. 6:1108–1116
  • Zitnik, G., Hines, P., Stamatoyannopoulos, G., and Papayannopoulou, T.. 1991. Murine erythroleukemia cell line GM979 contains factors that can activate silent chromosomal human gamma-globin genes. Proc. Natl. Acad. Sci. USA 88:2530–2534

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