21
Views
82
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Repression of c-myc Is Necessary but Not Sufficient for Terminal Differentiation of B Lymphocytes In Vitro

, &
Pages 8684-8695 | Received 25 May 2000, Accepted 04 Sep 2000, Published online: 28 Mar 2023

REFERENCES

  • Adams, J. M., Harris, A. W., Pinkert, C. A., Corcoran, L. M., Alexander, W. S., Cory, S., Palmiter, R. D., and Brinster, R. L.. 1985. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318:533–538
  • Alevizopoulos, K., Vlach, J., Hennecke, S., and Amati, B.. 1997. Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins. EMBO J. 16:5322–5333
  • Angelin-Duclos, C., Cattoretti, G., Chang, D. H., Lin, K.-I., Lin, Y., Yu, J., and Calame, K.. 1999. Role of B-lymphocyte-induced maturation protein-1 in terminal differentiation of B cells and other cell lineages. Cold Spring Harbor Symp. Quant. Biol. 64:61–70
  • Angelin-Duclos, C., Cattoretti G., Lin K.-I., and Calame K.. Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo. J. Immunol., in press.
  • Angelin-Duclos, C., and Calame, K.. 1998. Evidence that immunoglobulin VH-DJ recombination does not require germ line transcription of the recombining variable gene segment. Mol. Cell. Biol. 18:6253–6264
  • Barberis, A., Widenhorn, K., Vitelli, L., and Busslinger, M.. 1990. A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation. Genes Dev. 4:849–859
  • Blackwell, T. K., Kretzner, L., Blackwood, E. M., Eisenman, R. N., and Weintraub, H.. 1990. Sequence-specific DNA binding by the c-Myc protein. Science 250:1149–1151
  • Blackwood, E. M., and Eisenman, R. N.. 1991. Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science 251:1211–1217
  • Brooks, K., Yuan, D., Uhr, J. W., Krammer, P. H., and Vitetta, E. S.. 1983. Lymphokine-induced IgM secretion by clones of neoplastic B cells. Nature 302:825–826
  • Canelles, M., Delgado, M. D., Hyland, K. M., Lerga, A., Richard, C., Dang, C. V., and Leon, J.. 1997. Max and inhibitory c-Myc mutants induce erythroid differentiation and resistance to apoptosis in human myeloid leukemia cells. Oncogene 14:1315–1327
  • Chang, D. H., Angelin-Duclos, C., and Calame, K.. 2000. BLIMP-1: trigger for differentiation of myeloid lineage. Nat. Immunol. 1:169–176
  • Chirgwin, J. M., Przybyla, A. E., MacDonald, R. J., and Rutter, W. J.. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294–5299
  • Cole, M. D., and McMahon, S. B.. 1999. The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation. Oncogene 18:2916–2924
  • Coppola, J. A., and Cole, M. D.. 1986. Constitutive c-myc oncogene expression blocks mouse erythroleukaemia cell differentiation but not commitment. Nature 320:760–763
  • Dang, C. V.. 1999. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol. Cell. Biol. 19:1–11
  • Danielian, P. S., White, R., Hoare, S. A., Fawell, S. E., and Parker, M. G.. 1993. Identification of residues in the estrogen receptor that confer differential sensitivity to estrogen and hydroxytamoxifen. Mol. Endocrinol. 7:232–240
  • Eckhardt, S. G., Dai, A., Davidson, K. K., Forseth, B. J., Wahl, G. M., and Von Hoff, D. D.. 1994. Induction of differentiation in HL60 cells by the reduction of extrachromosomally amplified c-myc. Proc. Natl. Acad. Sci. USA 91:6674–6678
  • Eilers, M.. 1999. Control of cell proliferation by Myc family genes. Mol. Cell 9:1–6
  • Eilers, M., Schirm, S., and Bishop, J. M.. 1991. The Myc protein activates transcription of the alpha-prothymosin gene. EMBO J. 10:133–141
  • Einat, M., Resnitzky, D., and Kimchi, A.. 1985. Close link between reduction of c-myc expression by interferon and, G0/G1 arrest. Nature 313:597–600
  • Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M., Waters, C. M., Penn, L. Z., and Hancock, D. C.. 1992. Induction of apoptosis in fibroblasts by c-myc protein. Cell 69:119–128
  • Felsher, D. W., and Bishop, J. M.. 1999. Reversible tumorigenesis by Myc in hematopoietic lineages. Mol. Cell 4:199–207
  • Greil, R., Loidl, P., Fasching, B., and Huber, H.. 1992. Differential expression of c-myc mRNA and c-Myc protein during terminal neoplastic B-cell differentiation. Curr. Top. Microbiol. Immunol. 182:215–221
  • Griep, A. E., and Westphal, H.. 1988. Antisense Myc sequences induce differentiation of F9 cells. Proc. Natl. Acad. Sci. USA 85:6806–6810
  • Heikkila, R., Schwab, G., Wickstrom, E., Loke, S. L., Pluznik, D. H., Watt, R., and Neckers, L. M.. 1987. A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1. Nature 328:445–449
  • Hoffman, B., Liebermann, D. A., Selvakumaran, M., and Nguyen, H. Q.. 1996. Role of c-myc in myeloid differentiation, growth arrest and apoptosis. Curr. Top. Microbiol. Immunol. 211:17–27
  • Hoffman-Liebermann, B., and Liebermann, D. A.. 1991. Suppression of c-myc and c-myb is tightly linked to terminal differentiation induced by IL6 or LIF and not growth inhibition in myeloid leukemia cells. Oncogene 6:903–909
  • Huang, S.. 1994. Blimp-1 is the murine homolog of the human transcriptional repressor PRDI-BF1. Cell 78: 9
  • Iritani, B. M., and Eisenman, R. N.. 1999. c-Myc enhances protein synthesis and cell size during B lymphocyte development. Proc. Natl. Acad. Sci. USA 96:13180–13185
  • Johnston, L. A., Prober, D. A., Edgar, B. A., Eisenman, R. N., and Gallant, P.. 1999. Drosophila myc regulates cellular growth during development. Cell 98:779–790
  • Kakkis, E., Riggs, K. J., Gillespie, W., and Calame, K.. 1989. A transcriptional repressor of c-myc. Nature 339:718–721
  • Keller, A. D., and Maniatis, T.. 1991. Identification and characterization of a novel repressor of beta-interferon gene expression. Genes Dev. 5:868–879
  • Knodel, M., Kuss, A. W., Lindemann, D., Berberich, I., and Schimpl, A.. 1999. Reversal of Blimp-1-mediated apoptosis by A1, a member of the Bcl-2 family. Eur. J. Immunol. 29:2988–2998
  • Koff, A., Giordano, A., Desai, D., Yamashita, K., Harper, J. W., Elledge, S., Nishimoto, T., Morgan, D. O., Franza, B. R., and Roberts, J. M.. 1992. Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science 257:1689–1694
  • Lachman, H. M., and Skoultchi, A. I.. 1984. Expression of c-myc changes during differentiation of mouse erythroleukaemia cells. Nature 310:592–594
  • Larsson, L. G., Ivhed, I., Gidlund, M., Pettersson, U., Vennstrom, B., and Nilsson, K.. 1988. Phorbol ester-induced terminal differentiation is inhibited in human U-937 monoblastic cells expressing a v-myc oncogene. Proc. Natl. Acad. Sci. USA 85:2638–2642
  • Larsson, L. G., Schena, M., Carlsson, M., Sallstrom, J., and Nilsson, K.. 1991. Expression of the c-myc protein is down-regulated at the terminal stages during in vitro differentiation of B-type chronic lymphocytic leukemia cells. Blood 77:1025–1032
  • Leder, P., Battey, J., Lenoir, G., Moulding, C., Murphy, W., Potter, H., Stewart, T., and Taub, R.. 1983. Translocations among antibody genes in human cancer. Science 222:765–771
  • Li, L. H., Nerlov, C., Prendergast, G., MacGregor, D., and Ziff, E. B.. 1994. c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II. EMBO J. 13:4070–4079
  • Lin, Y., Wong, K., and Calame, K.. 1997. Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation. Science 276:596–599
  • Littlewood, T. D., Hancock, D. C., Danielian, P. S., Parker, M. G., and Evan, G. I.. 1995. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res. 23:1686–1690
  • Maniatis, T., Fritsch, E. F., and Sambrook, J.. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y
  • Martinez-Valdez, H., Guret, C., de Bouteiller, O., Fugier, I., Banchereau, J., and Liu, Y. J.. 1996. Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2. J. Exp. Med. 183:971–977
  • Mateyak, M. K., Obaya, A. J., and Sedivy, J. M.. 1999. c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points. Mol. Cell. Biol. 19:4672–4683
  • McFadden, H. J., and Koshland, M. E.. 1991. Interleukin 2- and interleukin 5-induced changes in the binding of regulatory factors to the J-chain gene promoter. Proc. Natl. Acad. Sci. USA 88:11027–11031
  • Melchers, F.. 1997. B-lymphocyte-lineage cells from early precursors to Ig-secreting plasma cells: targets of regulation by the myc/mad/max families of genes? Curr. Top. Microbiol. Immunol. 224:19–30
  • Messika, E. J., Lu, P. S., Sung, Y. J., Yao, T., Chi, J. T., Chien, Y. H., and Davis, M. M.. 1998. Differential effect of B lymphocyte-induced maturation protein (Blimp-1) expression on cell fate during B cell development. J. Exp. Med. 188:515–525
  • Morse, L., Chen, D., Franklin, D., Xiong, Y., and Chen-Kiang, S.. 1997. Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18(INK4c) and IL-6. Immunity 6:47–56
  • Onizuka, T., Moriyama, M., Yamochi, T., Kuroda, T., Kazama, A., Kanazawa, N., Sato, K., Kato, T., Ota, H., and Mori, S.. 1995. BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts. Blood 86:28–37
  • Packham, G., and Cleveland, J. L.. 1995. c-Myc and apoptosis. Biochim. Biophys. Acta 1242:11–28
  • Pelengaris, S., Littlewood, T., Khan, M., Elia, G., and Evan, G.. 1999. Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion. Mol. Cell 3:565–577
  • Prasad, V. S., LaFond, R. E., Zhou, M., Jacobsen, K. A., Osmond, D. G., and Sidman, C. L.. 1997. Upregulation of endogenous p53 and induction of in vivo apoptosis in B-lineage lymphomas of E(mu)-myc transgenic mice by deregulated c-myc transgene. Mol. Carcinog. 18:66–77
  • Prendergast, G. C.. 1999. Myc and Myb: are the veils beginning to lift? Oncogene 18:2914–2915
  • Prendergast, G. C., and Ziff, E. B.. 1991. Methylation-sensitive sequence-specific DNA binding by the c-Myc basic region. Science 251:186–189
  • Queva, C., McArthur, G. A., Ramos, L. S., and Eisenman, R. N.. 1999. Dwarfism and dysregulated proliferation in mice overexpressing the MYC antagonist MAD1. Cell Growth Differ. 10:785–796
  • Randall, T. D., Heath, A. W., Santos-Argumedo, L., Howard, M. C., Weissman, I. L., and Lund, F. E.. 1998. Arrest of B lymphocyte terminal differentiation by CD40 signaling: mechanism for lack of antibody-secreting cells in germinal centers. Immunity 8:733–742
  • Rao, S., Lowe, M., Herliczek, T. W., and Keyomarsi, K.. 1998. Lovastatin mediated G1 arrest in normal and tumor breast cells is through inhibition of CDK2 activity and redistribution of p21 and p27, independent of p53. Oncogene 17:2393–2402
  • Reichert, M., and Eick, D.. 1999. Analysis of cell cycle arrest in adipocyte differentiation. Oncogene 18:459–466
  • Ren, B., Chee, K. J., Kim, T. H., and Maniatis, T.. 1999. PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. Genes Dev. 13:125–137
  • Rinkenberger, J. L., Wallin, J. J., Johnson, K. W., and Koshland, M. E.. 1996. An interleukin-2 signal relieves BSAP (Pax5)-mediated repression of the immunoglobulin J chain gene. Immunity 5:377–386
  • Roy, A. L., Carruthers, C., Gutjahr, T., and Roeder, R. G.. 1993. Direct role for Myc in transcription initiation mediated by interactions with TFII-I. Nature 365:359–361
  • Ruzek, M. C., and Mathur, A.. 1995. Plasma cells tumors decrease CD23 mRNA expression in vivo in murine splenic B cells. Eur. J. Immunol. 25:2228–2233
  • Sakamuro, D., and Prendergast, G. C.. 1999. New Myc-interacting proteins: a second Myc network emerges. Oncogene 18:2942–2954
  • Sawyers, C. L., Callahan, W., and Witte, O. N.. 1992. Dominant negative MYC blocks transformation by ABL oncogenes. Cell 70:901–910
  • Shrivastava, A., and Calame, K.. 1995. Association with c-Myc: an alternated mechanism for c-Myc function. Curr. Top. Microbiol. Immunol. 194:273–282
  • Shrivastava, A., Saleque, S., Kalpana, G., Goff, S., Artandi, S., and Calame, K.. 1993. c-Myc association inhibits transcriptional regulator Yin-Yang-1. Science 262:1889–1892
  • Shrivastava, A., Yu, J., Artandi, S., and Calame, K.. 1996. YY1 and c-Myc associate in vivo in a manner that depends on c-Myc levels. Proc. Natl. Acad. Sci. USA 93:10638–10641
  • Sidman, C. L., Shaffer, D. J., Jacobsen, K., Vargas, S. R., and Osmond, D. G.. 1993. Cell populations during tumorigenesis in Eu-myc transgenic mice. Leukemia 7:887–895
  • Silacci, P., Mottet, A., Steimle, V., Reith, W., and Mach, B.. 1994. Developmental extinction of major histocompatibility complex class II gene expression in plasmocytes is mediated by silencing of the transactivator gene CIITA. J. Exp. Med. 180:1329–1336
  • Soro, P. G., Morales, A. P., Martinez, M. J., Morales, A. S., Copin, S. G., Marcos, M. A., and Gaspar, M. L.. 1999. Differential involvement of the transcription factor Blimp-1 in T cell-independent and -dependent B cell differentiation to plasma cells. J. Immunol. 163:611–617
  • Steiner, P., Philipp, A., Lukas, J., Godden-Kent, D., Pagano, M., Mittnacht, S., Bartek, J., and Eilers, M.. 1995. Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes. EMBO J. 14:4814–4826
  • Turner, C. A.Jr., Mack, D. H., and Davis, M. M.. 1994. Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell 77:297–306
  • Weber, C., Erl, W., and Weber, P. C.. 1995. Lovastatin induces differentiation of Mono Mac 6 cells. Cell. Biochem. Funct. 13:273–277
  • Yokoyama, K., and Imamoto, F.. 1987. Transcriptional control of the endogenous myc protooncogene by antisense RNA. Proc. Natl. Acad. Sci. USA 84:7363–7367
  • Yu, J., Angelin-Duclos, C., Greenwood, J., Liao, J., and Calame, K.. 2000. Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase. Mol. Cell. Biol. 20:2592–2603
  • Yuan, D., and Tucker, P. W.. 1982. Effect of lipopolysaccharide stimulation on the transcription and translation of messenger RNA for cell surface immunoglobulin M. J. Exp. Med. 156:962–974

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.