Molecular and Cellular Biology, Volume 20, Issue 23 (2000)

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Molecular and Cellular Biology, Volume 20, Issue 23 (2000)

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Article
Upstream Open Reading Frames as Regulators of mRNA Translation
David R. Morris & Adam P. Geballe
Pages: 8635-8642
Published online: 28 Mar 2023
First Page PreviewforUpstream Open Reading Frames as Regulators of mRNA Translation | Full Text | References | PDF (207.3 KB)
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Transcriptional Regulation

Article
Proteasome-Mediated Degradation of the Coactivator p300 Impairs Cardiac Transcription
Coralie Poizat, Vittorio Sartorelli, Gene Chung, Robert A. Kloner & Larry Kedes
Pages: 8643-8654
Published online: 28 Mar 2023
AbstractforProteasome-Mediated Degradation of the Coactivator p300 Impairs Cardiac Transcription | Full Text | References | PDF (1.7 MB)
  • 33 Views
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Article
In Vivo Requirement of Activator-Specific Binding Targets of Mediator
Jin Mo Park, Hye-Suk Kim, Sang Jun Han, Moon-Sun Hwang, Young Chul Lee & Young-Joon Kim
Pages: 8709-8719
Published online: 28 Mar 2023
AbstractforIn Vivo Requirement of Activator-Specific Binding Targets of Mediator | Full Text | References | PDF (2.2 MB)
  • 21 Views
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Article
8-Bromo-Cyclic AMP Induces Phosphorylation of Two Sites in SRC-1 That Facilitate Ligand-Independent Activation of the Chicken Progesterone Receptor and Are Critical for Functional Cooperation between SRC-1 and CREB Binding Protein
Brian G. Rowan, Nefretiti Garrison, Nancy L. Weigel & Bert W. O'Malley
Pages: 8720-8730
Published online: 28 Mar 2023
Abstractfor8-Bromo-Cyclic AMP Induces Phosphorylation of Two Sites in SRC-1 That Facilitate Ligand-Independent Activation of the Chicken Progesterone Receptor and Are Critical for Functional Cooperation between SRC-1 and CREB Binding Protein | Full Text | References | PDF (2.3 MB)
  • 8 Views
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Article
Cell-Type-Specific Regulation of the Retinoic Acid Receptor Mediated by the Orphan Nuclear Receptor TLX
Mime Kobayashi, Ruth T. Yu, Kunio Yasuda & Kazuhiko Umesono
Pages: 8731-8739
Published online: 28 Mar 2023
AbstractforCell-Type-Specific Regulation of the Retinoic Acid Receptor Mediated by the Orphan Nuclear Receptor TLX | Full Text | References | PDF (496.8 KB)
  • 19 Views
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Article
Association with Ets-1 Causes Ligand- and AF2-Independent Activation of Nuclear Receptors
Rosa M. Tolón, Ana I. Castillo, Ana M. Jiménez-Lara & Ana Aranda
Pages: 8793-8802
Published online: 28 Mar 2023
AbstractforAssociation with Ets-1 Causes Ligand- and AF2-Independent Activation of Nuclear Receptors | Full Text | References | PDF (1.8 MB)
  • 20 Views
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Article
Phosphorylation-Induced Dimerization of Interferon Regulatory Factor 7 Unmasks DNA Binding and a Bipartite Transactivation Domain
Isabelle Marié, Eric Smith, Arun Prakash & David E. Levy
Pages: 8803-8814
Published online: 28 Mar 2023
AbstractforPhosphorylation-Induced Dimerization of Interferon Regulatory Factor 7 Unmasks DNA Binding and a Bipartite Transactivation Domain | Full Text | References | PDF (905.2 KB)
  • 49 Views
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Article
MondoA, a Novel Basic Helix-Loop-Helix–Leucine Zipper Transcriptional Activator That Constitutes a Positive Branch of a Max-Like Network
Andrew N. Billin, Alanna L. Eilers, Kathryn L. Coulter, Jennifer S. Logan & Donald E. Ayer
Pages: 8845-8854
Published online: 28 Mar 2023
AbstractforMondoA, a Novel Basic Helix-Loop-Helix–Leucine Zipper Transcriptional Activator That Constitutes a Positive Branch of a Max-Like Network | Full Text | References | PDF (815 KB)
  • 81 Views
  • 88 CrossRef citations
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Article
Effects of Histone Tail Domains on the Rate of Transcriptional Elongation through a Nucleosome
R. U. Protacio, G. Li, P. T. Lowary & J. Widom
Pages: 8866-8878
Published online: 28 Mar 2023
AbstractforEffects of Histone Tail Domains on the Rate of Transcriptional Elongation through a Nucleosome | Full Text | References | PDF (1.8 MB)
  • 32 Views
  • 53 CrossRef citations
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Article
A Specificity and Targeting Subunit of a Human SWI/SNF Family-Related Chromatin-Remodeling Complex
Zuqin Nie, Yutong Xue, Dafeng Yang, Sharleen Zhou, Bonnie J. Deroo, Trevor K. Archer & Weidong Wang
Pages: 8879-8888
Published online: 28 Mar 2023
AbstractforA Specificity and Targeting Subunit of a Human SWI/SNF Family-Related Chromatin-Remodeling Complex | Full Text | References | PDF (1.6 MB)
  • 126 Views
  • 231 CrossRef citations
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Article
Cells Degrade a Novel Inhibitor of Differentiation with E1A-Like Properties upon Exiting the Cell Cycle
Satoshi Miyake, William R. Sellers, Michal Safran, Xiaotong Li, Wenqing Zhao, Steven R. Grossman, Jianmin Gan, James A. DeCaprio, Peter D. Adams & William G. Kaelin Jr.
Pages: 8889-8902
Published online: 28 Mar 2023
AbstractforCells Degrade a Novel Inhibitor of Differentiation with E1A-Like Properties upon Exiting the Cell Cycle | Full Text | References | PDF (1.7 MB)
  • 17 Views
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Article
A Novel Rb- and p300-Binding Protein Inhibits Transactivation by MyoD
W. Robb MacLellan, G. Xiao, M. Abdellatif & Michael D. Schneider
Pages: 8903-8915
Published online: 28 Mar 2023
AbstractforA Novel Rb- and p300-Binding Protein Inhibits Transactivation by MyoD | Full Text | References | PDF (1.5 MB)
  • 18 Views
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Article
Functional Interaction between Nucleosome Assembly Proteins and p300/CREB-Binding Protein Family Coactivators
Noriko Shikama, Ho Man Chan, Marija Krstic-Demonacos, Linda Smith, Chang-Woo Lee, William Cairns & Nicholas B. La Thangue
Pages: 8933-8943
Published online: 28 Mar 2023
AbstractforFunctional Interaction between Nucleosome Assembly Proteins and p300/CREB-Binding Protein Family Coactivators | Full Text | References | PDF (2.4 MB)
  • 36 Views
  • 124 CrossRef citations
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Cell Growth and Development

Article
Identification and Characterization of an Activating TrkA Deletion Mutation in Acute Myeloid Leukemia
Gary W. Reuther, Que T. Lambert, Michael A. Caligiuri & Channing J. Der
Pages: 8655-8666
Published online: 28 Mar 2023
AbstractforIdentification and Characterization of an Activating TrkA Deletion Mutation in Acute Myeloid Leukemia | Full Text | References | PDF (3.4 MB)
  • 29 Views
  • 83 CrossRef citations
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Article
Regulation of the Functional Interaction between Cyclin D1 and the Estrogen Receptor
Justin Lamb, Mohamed H. Ladha, Christine McMahon, Robert L. Sutherland & Mark E. Ewen
Pages: 8667-8675
Published online: 28 Mar 2023
AbstractforRegulation of the Functional Interaction between Cyclin D1 and the Estrogen Receptor | Full Text | References | PDF (524.5 KB)
  • 15 Views
  • 62 CrossRef citations
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Article
Inhibitor of the Tissue-Specific Transcription Factor HNF4, a Potential Regulator in Early Xenopus Development
Gudrun Peiler, Beatrix Böckmann, Hassan Nakhei & Gerhart U. Ryffel
Pages: 8676-8683
Published online: 28 Mar 2023
AbstractforInhibitor of the Tissue-Specific Transcription Factor HNF4, a Potential Regulator in Early Xenopus Development | Full Text | References | PDF (2.2 MB)
  • 13 Views
  • 5 CrossRef citations
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Article
Repression of c-myc Is Necessary but Not Sufficient for Terminal Differentiation of B Lymphocytes In Vitro
Kuo-I Lin, Yi Lin & Kathryn Calame
Pages: 8684-8695
Published online: 28 Mar 2023
AbstractforRepression of c-myc Is Necessary but Not Sufficient for Terminal Differentiation of B Lymphocytes In Vitro | Full Text | References | PDF (2.4 MB)
  • 21 Views
  • 82 CrossRef citations
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Article
Crk1, a Novel Cdc2-Related Protein Kinase, Is Required for Hyphal Development and Virulence in Candida albicans
Jiangye Chen, Song Zhou, Qin Wang, Xi Chen, Ting Pan & Haoping Liu
Pages: 8696-8708
Published online: 28 Mar 2023
AbstractforCrk1, a Novel Cdc2-Related Protein Kinase, Is Required for Hyphal Development and Virulence in Candida albicans | Full Text | References | PDF (5.2 MB)
  • 30 Views
  • 54 CrossRef citations
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Article
Combinatorial Effect of T-Cell Receptor Ligation and CD45 Isoform Expression on the Signaling Contribution of the Small GTPases Ras and Rap1
Jan Czyzyk, David Leitenberg, Tom Taylor & Kim Bottomly
Pages: 8740-8747
Published online: 28 Mar 2023
AbstractforCombinatorial Effect of T-Cell Receptor Ligation and CD45 Isoform Expression on the Signaling Contribution of the Small GTPases Ras and Rap1 | Full Text | References | PDF (348.7 KB)
  • 13 Views
  • 25 CrossRef citations
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Article
Analysis of Cyclin D3-cdk4 Complexes in Fibroblasts Expressing and Lacking p27kip1 and p21cip1
Tapan Kumar Bagui, Rosalind J. Jackson, Deepak Agrawal & W. J. Pledger
Pages: 8748-8757
Published online: 28 Mar 2023
AbstractforAnalysis of Cyclin D3-cdk4 Complexes in Fibroblasts Expressing and Lacking p27kip1 and p21cip1 | Full Text | References | PDF (1.6 MB)
  • 3 Views
  • 41 CrossRef citations
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Article
Damage Tolerance Protein Mus81 Associates with the FHA1 Domain of Checkpoint Kinase Cds1
Michael N. Boddy, Antonia Lopez-Girona, Paul Shanahan, Heidrun Interthal, Wolf-Dietrich Heyer & Paul Russell
Pages: 8758-8766
Published online: 28 Mar 2023
AbstractforDamage Tolerance Protein Mus81 Associates with the FHA1 Domain of Checkpoint Kinase Cds1 | Full Text | References | PDF (1.4 MB)
  • 36 Views
  • 222 CrossRef citations
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Article
Asg7p-Ste3p Inhibition of Pheromone Signaling: Regulation of the Zygotic Transition to Vegetative Growth
Amy F. Roth, Bryce Nelson, Charlie Boone & Nicholas G. Davis
Pages: 8815-8825
Published online: 28 Mar 2023
AbstractforAsg7p-Ste3p Inhibition of Pheromone Signaling: Regulation of the Zygotic Transition to Vegetative Growth | Full Text | References | PDF (1.3 MB)
  • 7 Views
  • 17 CrossRef citations
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Article
Localization and Signaling of Gβ Subunit Ste4p Are Controlled by a-Factor Receptor and thea-Specific Protein Asg7p
Jinah Kim, Eric Bortz, Hualin Zhong, Thomas Leeuw, Ekkehard Leberer, Andrew K. Vershon & Jeanne P. Hirsch
Pages: 8826-8835
Published online: 28 Mar 2023
AbstractforLocalization and Signaling of Gβ Subunit Ste4p Are Controlled by a-Factor Receptor and thea-Specific Protein Asg7p | Full Text | References | PDF (3.2 MB)
  • 5 Views
  • 23 CrossRef citations
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Article
Macrophages Require Constitutive NF-κB Activation To Maintain A1 Expression and Mitochondrial Homeostasis
Lisa J. Pagliari, Harris Perlman, Hongtao Liu & Richard M. Pope
Pages: 8855-8865
Published online: 28 Mar 2023
AbstractforMacrophages Require Constitutive NF-κB Activation To Maintain A1 Expression and Mitochondrial Homeostasis | Full Text | References | PDF (2.3 MB)
  • 19 Views
  • 122 CrossRef citations
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Article
[URE3] Prion Propagation in Saccharomyces cerevisiae: Requirement for Chaperone Hsp104 and Curing by Overexpressed Chaperone Ydj1p
Hiromitsu Moriyama, Herman K. Edskes & Reed B. Wickner
Pages: 8916-8922
Published online: 28 Mar 2023
Abstractfor[URE3] Prion Propagation in Saccharomyces cerevisiae: Requirement for Chaperone Hsp104 and Curing by Overexpressed Chaperone Ydj1p | Full Text | References | PDF (444.8 KB)
  • 20 Views
  • 213 CrossRef citations
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Article
Constitutive Instability of Muscle Regulatory Factor Myf5 Is Distinct from Its Mitosis-Specific Disappearance, Which Requires a D-Box-Like Motif Overlapping the Basic Domain
Catherine Lindon, Olivier Albagli, Peggy Domeyne, Didier Montarras & Christian Pinset
Pages: 8923-8932
Published online: 28 Mar 2023
AbstractforConstitutive Instability of Muscle Regulatory Factor Myf5 Is Distinct from Its Mitosis-Specific Disappearance, Which Requires a D-Box-Like Motif Overlapping the Basic Domain | Full Text | References | PDF (10.4 MB)
  • 11 Views
  • 24 CrossRef citations
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Article
Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN
Noriaki Nakamura, Shivapriya Ramaswamy, Francisca Vazquez, Sabina Signoretti, Massimo Loda & William R. Sellers
Pages: 8969-8982
Published online: 28 Mar 2023
AbstractforForkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN | Full Text | References | PDF (1.8 MB)
  • 134 Views
  • 435 CrossRef citations
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Article
Insulin-Like Growth Factor-Mediated Muscle Cell Survival: Central Roles for Akt and Cyclin-Dependent Kinase Inhibitor p21
Margaret A. Lawlor & Peter Rotwein
Pages: 8983-8995
Published online: 28 Mar 2023
AbstractforInsulin-Like Growth Factor-Mediated Muscle Cell Survival: Central Roles for Akt and Cyclin-Dependent Kinase Inhibitor p21 | Full Text | References | PDF (10.4 MB)
  • 18 Views
  • 153 CrossRef citations
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Article
SU6656, a Selective Src Family Kinase Inhibitor, Used To Probe Growth Factor Signaling
Robert A. Blake, Martin A. Broome, Xiangdong Liu, Jianming Wu, Mikhail Gishizky, Li Sun & Sara A. Courtneidge
Pages: 9018-9027
Published online: 28 Mar 2023
AbstractforSU6656, a Selective Src Family Kinase Inhibitor, Used To Probe Growth Factor Signaling | Full Text | References | PDF (2.4 MB)
  • 79 Views
  • 474 CrossRef citations
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Article
Sonic hedgehog Promotes G1 Cyclin Expression and Sustained Cell Cycle Progression in Mammalian Neuronal Precursors
Anna Marie Kenney & David H. Rowitch
Pages: 9055-9067
Published online: 28 Mar 2023
AbstractforSonic hedgehog Promotes G1 Cyclin Expression and Sustained Cell Cycle Progression in Mammalian Neuronal Precursors | Full Text | References | PDF (1.9 MB)
  • 55 Views
  • 395 CrossRef citations
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Article
Mutational and Structural Analyses of the Ribonucleotide Reductase Inhibitor Sml1 Define Its Rnr1 Interaction Domain Whose Inactivation Allows Suppression of mec1 andrad53 Lethality
Xiaolan Zhao, Bilyana Georgieva, Andrei Chabes, Vladimir Domkin, Johannes H. Ippel, Jürgen Schleucher, Sybren Wijmenga, Lars Thelander & Rodney Rothstein
Pages: 9076-9083
Published online: 28 Mar 2023
AbstractforMutational and Structural Analyses of the Ribonucleotide Reductase Inhibitor Sml1 Define Its Rnr1 Interaction Domain Whose Inactivation Allows Suppression of mec1 andrad53 Lethality | Full Text | References | PDF (889.7 KB)
  • 15 Views
  • 66 CrossRef citations
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Article
Evidence of Rab3A Expression, Regulation of Vesicle Trafficking, and Cellular Secretion in Response to Heregulin in Mammary Epithelial Cells
Ratna K. Vadlamudi, Rui-An Wang, Amjad H. Talukder, Liana Adam, Randy Johnson & Rakesh Kumar
Pages: 9092-9101
Published online: 28 Mar 2023
AbstractforEvidence of Rab3A Expression, Regulation of Vesicle Trafficking, and Cellular Secretion in Response to Heregulin in Mammary Epithelial Cells | Full Text | References | PDF (5.4 MB)
  • 13 Views
  • 24 CrossRef citations
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Nucleocytoplasmic Communication

Article
Mex67p of Schizosaccharomyces pombe Interacts with Rae1p in Mediating mRNA Export
Jin Ho Yoon, Dona C. Love, Anjan Guhathakurta, John A. Hanover & Ravi Dhar
Pages: 8767-8782
Published online: 28 Mar 2023
AbstractforMex67p of Schizosaccharomyces pombe Interacts with Rae1p in Mediating mRNA Export | Full Text | References | PDF (2.7 MB)
  • 18 Views
  • 53 CrossRef citations
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Article
TAP (NXF1) Belongs to a Multigene Family of Putative RNA Export Factors with a Conserved Modular Architecture
Andrea Herold, Mikita Suyama, João P. Rodrigues, Isabelle C. Braun, Ulrike Kutay, Maria Carmo-Fonseca, Peer Bork & Elisa Izaurralde
Pages: 8996-9008
Published online: 28 Mar 2023
AbstractforTAP (NXF1) Belongs to a Multigene Family of Putative RNA Export Factors with a Conserved Modular Architecture | Full Text | References | PDF (4.3 MB)
  • 84 Views
  • 160 CrossRef citations
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Article
Transforming Growth Factor β-Independent Shuttling of Smad4 between the Cytoplasm and Nucleus
Christophe E. Pierreux, Francisco J. Nicolás & Caroline S. Hill
Pages: 9041-9054
Published online: 28 Mar 2023
AbstractforTransforming Growth Factor β-Independent Shuttling of Smad4 between the Cytoplasm and Nucleus | Full Text | References | PDF (3.1 MB)
  • 54 Views
  • 211 CrossRef citations
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Gene Expression

Article
Runx2 Is a Common Target of Transforming Growth Factor β1 and Bone Morphogenetic Protein 2, and Cooperation between Runx2 and Smad5 Induces Osteoblast-Specific Gene Expression in the Pluripotent Mesenchymal Precursor Cell Line C2C12
Kyeong-Sook Lee, Hyun-Jung Kim, Qing-Lin Li, Xin-Zi Chi, Chisato Ueta, Toshihisa Komori, John M. Wozney, Eung-Gook Kim, Je-Young Choi, Hyun-Mo Ryoo & Suk-Chul Bae
Pages: 8783-8792
Published online: 28 Mar 2023
AbstractforRunx2 Is a Common Target of Transforming Growth Factor β1 and Bone Morphogenetic Protein 2, and Cooperation between Runx2 and Smad5 Induces Osteoblast-Specific Gene Expression in the Pluripotent Mesenchymal Precursor Cell Line C2C12 | Full Text | References | PDF (1.9 MB)
  • 222 Views
  • 688 CrossRef citations
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Article
Novel Upf2p Orthologues Suggest a Functional Link between Translation Initiation and Nonsense Surveillance Complexes
Joshua T. Mendell, Susan M. Medghalchi, Ross G. Lake, Erick N. Noensie & Harry C. Dietz
Pages: 8944-8957
Published online: 28 Mar 2023
AbstractforNovel Upf2p Orthologues Suggest a Functional Link between Translation Initiation and Nonsense Surveillance Complexes | Full Text | References | PDF (3.7 MB)
  • 35 Views
  • 116 CrossRef citations
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Article
Human H/ACA Small Nucleolar RNPs and Telomerase Share Evolutionarily Conserved Proteins NHP2 and NOP10
Vanda Pogačić, François Dragon & Witold Filipowicz
Pages: 9028-9040
Published online: 28 Mar 2023
AbstractforHuman H/ACA Small Nucleolar RNPs and Telomerase Share Evolutionarily Conserved Proteins NHP2 and NOP10 | Full Text | References | PDF (4.1 MB)
  • 36 Views
  • 162 CrossRef citations
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Dna Dynamics and Chromosome Structure

Article
DNA Integration by Ty Integrase in yku70Mutant Saccharomyces cerevisiae Cells
Markus Kiechle, Anna A. Friedl, Palaniyandi Manivasakam, Friederike Eckardt-Schupp & Robert H. Schiestl
Pages: 8836-8844
Published online: 28 Mar 2023
AbstractforDNA Integration by Ty Integrase in yku70Mutant Saccharomyces cerevisiae Cells | Full Text | References | PDF (490.1 KB)
  • 5 Views
  • 7 CrossRef citations
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Article
Rdp1, a Novel Zinc Finger Protein, Regulates the DNA Damage Response of rhp51+ from Schizosaccharomyces pombe
Young Sam Shim, Yeun Kyu Jang, Myung Sil Lim, Jung Sup Lee, Rho Hyun Seong, Seung Hwan Hong & Sang Dai Park
Pages: 8958-8968
Published online: 28 Mar 2023
AbstractforRdp1, a Novel Zinc Finger Protein, Regulates the DNA Damage Response of rhp51+ from Schizosaccharomyces pombe | Full Text | References | PDF (2.1 MB)
  • 21 Views
  • 7 CrossRef citations
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Article
Coupled Homologous and Nonhomologous Repair of a Double-Strand Break Preserves Genomic Integrity in Mammalian Cells
Christine Richardson & Maria Jasin
Pages: 9068-9075
Published online: 28 Mar 2023
AbstractforCoupled Homologous and Nonhomologous Repair of a Double-Strand Break Preserves Genomic Integrity in Mammalian Cells | Full Text | References | PDF (1.8 MB)
  • 15 Views
  • 179 CrossRef citations
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Article
Heterogeneous Nuclear Ribonucleoproteins C1 and C2 Associate with the RNA Component of Human Telomerase
Lance P. Ford, Jae Myoung Suh, Woodring E. Wright & Jerry W. Shay
Pages: 9084-9091
Published online: 28 Mar 2023
AbstractforHeterogeneous Nuclear Ribonucleoproteins C1 and C2 Associate with the RNA Component of Human Telomerase | Full Text | References | PDF (1.2 MB)
  • 21 Views
  • 56 CrossRef citations
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Mammalian Genetic Models With Minimal Or Complex Phenotypes

Article
Mice with an Increased Glucocorticoid Receptor Gene Dosage Show Enhanced Resistance to Stress and Endotoxic Shock
Holger M. Reichardt, Thorsten Umland, Anton Bauer, Oliver Kretz & Günther Schütz
Pages: 9009-9017
Published online: 28 Mar 2023
AbstractforMice with an Increased Glucocorticoid Receptor Gene Dosage Show Enhanced Resistance to Stress and Endotoxic Shock | Full Text | References | PDF (2 MB)
  • 57 Views
  • 167 CrossRef citations
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