Analysis of Cyclin D3-cdk4 Complexes in Fibroblasts Expressing and Lacking p27^kip1 and p21^cip1

REFERENCES

• Agrawal, D., Hauser, P., McPherson, F., Dong, F., Garcia, A., and Pledger, W. J.. 1996. Repression of p27kip1 synthesis by platelet-derived growth factor in BALB/c 3T3 cells. Mol. Cell. Biol. 16:4327–4336
   PubMedGoogle Scholar
• Alessi, F., Quarta, S., Savio, M., Riva, F., Rossi, L., Stivala, L. A., Scovassi, A. I., Meijer, L., and Prosperi, E.. 1998. The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity. Exp. Cell Res. 245:8–18
   PubMed Web of Science ®Google Scholar
• Blain, S. W., Montalvo, E., and Massague, J.. 1997. Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4. J. Biol. Chem. 272:25863–25872
   PubMed Web of Science ®Google Scholar
• Brugarolas, J., Chandrasekaran, C., Gordon, J. I., Beach, D., Jacks, T., and Hannon, G. J.. 1995. Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377:552–557
   PubMed Web of Science ®Google Scholar
• Carlson, B. A., Dubay, M. M., Sausville, E. A., Brizuela, L., and Worland, P. J.. 1996. Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells. Cancer Res. 56:2973–2978
   PubMed Web of Science ®Google Scholar
• Chellappan, S. P., Hiebert, S., Mudryj, M., Horowitz, J. M., and Nevins, J. R.. 1991. The E2F transcription factor is a cellular target for the RB protein. Cell 65:1053–1061
   PubMed Web of Science ®Google Scholar
• Cheng, M., Olivier, P., Diehl, J. A., Fero, M., Roussel, M. F., Roberts, J. M., and Sherr, C. J.. 1999. The p21Cip1 and p27Kip1 CDK “inhibitors” are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J. 18:1571–1583
   PubMed Web of Science ®Google Scholar
• Cheng, M., Sexl, V., Sherr, C. J., and Roussel, M. F.. 1998. Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1). Proc. Natl. Acad. Sci. USA 95:1091–1096
   PubMed Web of Science ®Google Scholar
• Coats, S., Flanagan, W. M., Nourse, J., and Roberts, J. M.. 1996. Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle. Science 272:877–880
   PubMed Web of Science ®Google Scholar
• Coats, S., Whyte, P., Fero, M. L., Lacy, S., Chung, G., Randel, E., Firpo, E., and Roberts, J. M.. 1999. A new pathway for mitogen-dependent cdk2 regulation uncovered in p27Kip1-deficient cells. Curr. Biol. 9:163–173
   PubMedGoogle Scholar
• Darnell, J. E.Jr.. 1997. STATs and gene regulation. Science 277:1630–1635
   PubMed Web of Science ®Google Scholar
• De Azevedo, W. F.Jr., Mueller-Dieckmann, H. J., Schulze-Gahmen, U., Worland, P. J., Sausville, E., and Kim, S. H.. 1996. Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase. Proc. Natl. Acad. Sci. USA 93:2735–2740
   PubMed Web of Science ®Google Scholar
• DeGregori, J., Kowalik, T., and Nevins, J. R.. 1995. Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. Mol. Cell. Biol. 15:4215–4224
   PubMed Web of Science ®Google Scholar
• Dong, F., Agrawal, D., Bagui, T., and Pledger, W. J.. 1998. Cyclin D3-associated kinase activity is regulated by p27kip1 in BALB/c-3T3 cells. Mol. Biol. Cell 9:2081–2092
   PubMedGoogle Scholar
• Dulic, V., Kaufmann, W. K., Wilson, S. J., Tlsty, T. D., Lees, E., Harper, J. W., Elledge, S. J., and Reed, S. I.. 1994. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76:1013–1023
   PubMed Web of Science ®Google Scholar
• Ewen, M. E., Sluss, H. K., Sherr, C. J., Matsushime, H., Kato, J., and Livingston, D. M.. 1993. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73:487–497
   PubMed Web of Science ®Google Scholar
• Ewen, M. E., Sluss, H. K., Whitehouse, L. L., and Livingston, D. M.. 1993. TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest. Cell 74:1009–1020
   PubMed Web of Science ®Google Scholar
• Fero, M. L., Rivkin, M., Tasch, M., Porter, P., Carow, C. E., Firpo, E., Polyak, K., Tsai, L. H., Broudy, V., Perlmutter, R. M., Kaushansky, K., and Roberts, J. M.. 1996. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27Kip1-deficient mice. Cell 85:733–744
   PubMed Web of Science ®Google Scholar
• Firpo, E. J., Koff, A., Solomon, M. J., and Roberts, J. M.. 1994. Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes. Mol. Cell. Biol. 14:4889–4901
   PubMed Web of Science ®Google Scholar
• Hatakeyama, M., Brill, J. A., Fink, G. R., and Weinberg, R. A.. 1994. Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein. Genes Dev. 8:1759–1771
   PubMed Web of Science ®Google Scholar
• Hengst, L., and Reed, S. I.. 1998. Inhibitors of the Cip/Kip family. Curr. Top. Microbiol. Immunol. 227:25–41
   PubMedGoogle Scholar
• Kato, J., Matsushime, H., Hiebert, S. W., Ewen, M. E., and Sherr, C. J.. 1993. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev. 7:331–342
   PubMed Web of Science ®Google Scholar
• Kato, J. Y., Matsuoka, M., Polyak, K., Massague, J., and Sherr, C. J.. 1994. Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation. Cell 79:487–496
   PubMed Web of Science ®Google Scholar
• Kiyokawa, H., Kineman, R. D., Manova-Todorova, K. O., Soares, V. C., Hoffman, E. S., Ono, M., Khanam, D., Hayday, A. C., Frohman, L. A., and Koff, A.. 1996. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27Kip1. Cell 85:721–732
   PubMed Web of Science ®Google Scholar
• LaBaer, J., Garrett, M. D., Stevenson, L. F., Slingerland, J. M., Sandhu, C., Chou, H. S., Fattaey, A., and Harlow, E.. 1997. New functional activities for the p21 family of CDK inhibitors. Genes Dev. 11:847–862
   PubMed Web of Science ®Google Scholar
• Ladha, M. H., Lee, K. Y., Upton, T. M., Reed, M. F., and Ewen, M. E.. 1998. Regulation of exit from quiescence by p27 and cyclin D1-CDK4. Mol. Cell. Biol. 18:6605–6615
   PubMed Web of Science ®Google Scholar
• Lee, M. H., Reynisdottir, I., and Massague, J.. 1995. Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev. 9:639–649
   PubMed Web of Science ®Google Scholar
• Li, Y., Jenkins, C. W., Nichols, M. A., and Xiong, Y.. 1994. Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21. Oncogene 9:2261–2268
   PubMed Web of Science ®Google Scholar
• Lundberg, A. S., and Weinberg, R. A.. 1998. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol. Cell. Biol. 18:753–761
   PubMed Web of Science ®Google Scholar
• Matsushime, H., Roussel, M. F., Ashmun, R. A., and Sherr, C. J.. 1991. Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 65:701–713
   PubMed Web of Science ®Google Scholar
• Meijer, L., Borgne, A., Mulner, O., Chong, J. P., Blow, J. J., Inagaki, N., Inagaki, M., Delcros, J. G., and Moulinoux, J. P.. 1997. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur. J. Biochem. 243:527–536
   PubMedGoogle Scholar
• Millard, S. S., Yan, J. S., Nguyen, H., Pagano, M., Kiyokawa, H., and Koff, A.. 1997. Enhanced ribosomal association of p27Kip1 mRNA is a mechanism contributing to accumulation during growth arrest. J. Biol. Chem. 272:7093–7098
   PubMedGoogle Scholar
• Nakayama, K., Ishida, N., Shirane, M., Inomata, A., Inoue, T., Shishido, N., Horii, I., Loh, D. Y., and Nakayama, K.. 1996. Mice lacking p27Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85:707–720
   PubMed Web of Science ®Google Scholar
• Nourse, J., Firpo, E., Flanagan, W. M., Coats, S., Polyak, K., Lee, M. H., Massague, J., Crabtree, G. R., and Roberts, J. M.. 1994. Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372:570–573
   PubMed Web of Science ®Google Scholar
• Parry, D., Mahony, D., Wills, K., and Lees, E.. 1999. Cyclin D-cdk subunit arrangement is dependent on the availability of competing INK and p21 class inhibitors. Mol. Cell. Biol. 19:1775–1783
   PubMed Web of Science ®Google Scholar
• Planas-Silva, M. D., and Weinberg, R. A.. 1997. The restriction point and control of cell proliferation. Curr. Opin. Cell Biol. 9:768–772
   PubMed Web of Science ®Google Scholar
• Pledger, W. J., Stiles, C. D., Antoniades, H. N., and Scher, C. D.. 1978. An ordered sequence of events is required before BALB/c-3T3 cells become committed to DNA synthesis. Proc. Natl. Acad. Sci. USA 75:2839–2843
   PubMed Web of Science ®Google Scholar
• Polyak, K., Kato, J. Y., Solomon, M. J., Sherr, C. J., Massague, J., Roberts, J. M., and Koff, A.. 1994. p27kip1, a cyclin-Cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest. Genes Dev. 8:9–22
   PubMed Web of Science ®Google Scholar
• Poon, R. Y., Toyoshima, H., and Hunter, T.. 1995. Redistribution of the CDK inhibitor p27 between different cyclin-CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation. Mol. Biol. Cell 6:1197–1213
   PubMed Web of Science ®Google Scholar
• Rivard, N., L'Allemain, G., Bartek, J., and Pouyssegur, J.. 1996. Abrogation of p27Kip1 by cDNA antisense suppresses quiescence (G0 state) in fibroblasts. J. Biol. Chem. 271:18337–18341
   PubMed Web of Science ®Google Scholar
• Ruas, M., and Peters, G.. 1998. The p16INK4a/CDKN2A tumor suppressor and its relatives. Biochim. Biophys. Acta 1378:F115–F177
   PubMed Web of Science ®Google Scholar
• Russo, A. A., Jeffrey, P. D., Patten, A. K., Massague, J., and Pavletich, N. P.. 1996. Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature 382:325–331
   PubMed Web of Science ®Google Scholar
• Sherr, C. J.. 1996. Cancer cell cycles. Science 274:1672–1677
   PubMed Web of Science ®Google Scholar
• Sherr, C. J., and Roberts, J. M.. 1999. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13:1501–1512
   PubMed Web of Science ®Google Scholar
• Sherr, C. J., and Roberts, J. M.. 1995. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9:1149–1163
   PubMed Web of Science ®Google Scholar
• Solomon, M. J., Harper, J. W., and Shuttleworth, J.. 1993. CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15. EMBO J. 12:3133–3142
   PubMed Web of Science ®Google Scholar
• Toyoshima, H., and Hunter, T.. 1994. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78:67–74
   PubMed Web of Science ®Google Scholar
• Weinberg, R. A.. 1995. The retinoblastoma protein and cell cycle control. Cell 81:323–330
   PubMed Web of Science ®Google Scholar
• Winston, J., Dong, F., and Pledger, W. J.. 1996. Differential modulation of G1 cyclins and the Cdk inhibitor p27kip1 by platelet-derived growth factor and plasma factors in density-arrested fibroblasts. J. Biol. Chem. 271:11253–11260
   PubMedGoogle Scholar
• Winston, J. T., and Pledger, W. J.. 1993. Growth factor regulation of cyclin D1 mRNA expression through protein synthesis-dependent and -independent mechanisms. Mol. Biol. Cell 4:1133–1144
   PubMed Web of Science ®Google Scholar
• Zhang, H., Hannon, G. J., and Beach, D.. 1994. p21-containing cyclin kinases exist in both active and inactive states. Genes Dev. 8:1750–1758
   PubMed Web of Science ®Google Scholar
• Zhang, X., Wharton, W., Donovan, M., Coppola, D., Croxton, R., Cress, W. D., and Pledger, W. J.. 2000. Density-dependent growth inhibition of fibroblasts ectopically expressing p27kip1. Mol. Biol. Cell 11:2117–2130
   PubMedGoogle Scholar