Mice Lacking the Nkx6.2 (Gtx) Homeodomain Transcription Factor Develop and Reproduce Normally

REFERENCES

• Awatramani, R., S. Scherer, J. Grinspan, E. Collarini, R. Skoff, D. O'Hagan, J. Garbern, and J. Kamholz. 1997. Evidence that the homeodomain protein Gtx is involved in the regulation of oligodendrocytes myelination. J. Neurosci. 17:6657–6668.
   PubMedGoogle Scholar
• Awatramani, R., J. Beesley, H. Yang, H. Jiang, F. Cambi, J. Grinspan, J. Garbern, and J. Kamholz. 2000. Gtx, an oligodendrocyte-specific homeodomain protein, has repressor activity. J. Neurosci. Res. 61:376–387.
   PubMed Web of Science ®Google Scholar
• Briscoe, J., L. Sussel, P. Serup, D. Hartigan-O'Conner, T. M. Jessell, J. L. Rubenstein, and J. Ericson. 1999. Homeobox gene Nkx-2.2 and specification of neuronal identity by graded sonic hedgehog signaling. Nature 398:622–627.
   PubMed Web of Science ®Google Scholar
• Cai, J., T. St Amand, H. Yin, H. Guo, G. Li, Y. Zhang, Y. Chen, and M. Qiu. 1999. Expression and regulation of the chicken Nkx6.2 homeobox gene suggest its possible involvement in the ventral neural patterning and cell fate specification. Dev. Dyn. 216:459–468.
   PubMed Web of Science ®Google Scholar
• Ericson, J., P. Rashbass, A. Schedl, S. Brenner-Morton, A. Kawakami, V. van Heyningen, T. Jessell, and J. Briscoe. 1997. Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. Cell 90:169–180.
   PubMedGoogle Scholar
• Hynes, M., K. Poulsen, M. Tessier-Lavigne, and A. Rosenthal. 1995. Control of neuronal diversity by the floor plate: contact-mediated induction of midbrain dopaminergic neurons. Cell 80:95–101.
   PubMed Web of Science ®Google Scholar
• Hynes, M., and A. Rosenthal. 1999. Specification of dopaminergic and serotonergic neurons in the vertebrate CNS. Curr. Opin. Neurobiol. 9:26–36.
   PubMed Web of Science ®Google Scholar
• Komuro, I., M. Schalling, L. Jahn, R. Bodmer, N. Jenkins, N. Copeland, and S. Izumo. 1993. Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter. EMBO J. 12:1387–1401.
   PubMedGoogle Scholar
• Pabst, O., H. Herbrand, and H.-H. Arnold. 1998. Nkx-2.9 is a novel homeobox transcription factor which demarcates ventral domains in the developing mouse CNS. Mech. Dev. 73:85–93.
   PubMedGoogle Scholar
• Qiu, M., A. Bulfone, S. Martinez, J. Meneses, K. Shimamura, R. Pedersen, and J. Rubenstein. 1995. Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain. Genes Dev. 9:2523–2538.
   PubMed Web of Science ®Google Scholar
• Qiu, M., K. Shimamura, L. Sussel, S. Chen, and J. L. Rubenstein. 1998. Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development. Mech. Dev. 72:77–88.
   PubMedGoogle Scholar
• Rinkwitz-Brandt, S., M. Justus, I. Oldenettel, H. H. Arnold, and E. Bober. 1995. Distinct temporal expression of mouse Nkx-5.1 and Nkx-5.2 homeobox genes during brain and ear development. Mech. Dev. 52:371–381.
   PubMedGoogle Scholar
• Schaeren-Wiemers, N., and A. Gerfin-Moser. 1993. A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labeled cRNA probes. Histochemistry 100:431–440.
   PubMedGoogle Scholar
• Shimamura, K., D. J. Hartigan, S. Martinez, L. Puelles, and J. Rubenstein. 1995. Longitudinal organization of the anterior neural plate and neural tube. Development 121:3923–3933.
   PubMed Web of Science ®Google Scholar
• Sim, F., G. Hinks, and R. J. Franklin. 2000. The re-expression of the homeodomain transcription factor gtx during remyelination of experimentally induced demyelinating lesions in young and old rat brain. Neuroscience 100:131–139.
   PubMed Web of Science ®Google Scholar
• Tanabe, Y., C. William, and T. Jessell. 1998. Specification of motor neuron identity by the MNR2 homeodomain protein. Cell 95:67–80.
   PubMedGoogle Scholar
• Xu, X., J. Cai, F. Hui, Y. Qi, G. Modderman, R. Liu, and M. Qiu. 2000. Selective expression of Nkx-2.2 transcription factor in the migratory chicken oligodendrocyte progenitor cells and implications for the embryonic origin of oligodendrocytes. Mol. Cell. Neurosci. 16:740–753.
   PubMedGoogle Scholar
• Ye, W., K. Shimamura, J. Rubenstein, M. Hynes, and A. Rosenthal. 1998. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell 93:755–766.
   PubMed Web of Science ®Google Scholar