44
Views
105
CrossRef citations to date
0
Altmetric
Cell and Organelle Structure and Assembly

Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences

, , , &
Pages 4413-4424 | Received 10 Jan 2001, Accepted 10 Apr 2001, Published online: 28 Mar 2023

REFERENCES

  • Amery, L., M. Fransen, K. De Nys, G. P. Mannaerts, and P. P. Van Veldhoven. 2000. Mitochondrial and peroxisomal targeting of 2-methylacyl-CoA racemase in human. J. Lipid Res. 41:1752–1759.
  • Baerends, R. J. S., K. N. Faber, A. M. Kram, J. A. Kiel, I. J. van der Klei, and M. Veenhuis. 2000. A stretch of positively charged amino acids at the N-terminus of Hansenula polymorpha Pex3p is involved in incorporation of the protein into the peroxisomal membrane. J. Biol. Chem. 275:9986–9995.
  • Boussif, O., F. Lezoualc'h, M. A. Zanta, M. D. Mergny, D. Scherman, B. Demeneix, and J. P. Behr. 1995. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl. Acad. Sci. USA 92:7297–7301.
  • Cadwell, R. C., and G. F. Joyce. 1995. Mutagenic PCR. PCR primer: a laboratory manual.. C. W. Dieffenbach, and G. S. Dveksler. 583–585. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y
  • Chang, C. C., D. S. Warren, K. A. Sacksteder, and S. J. Gould. 1999. PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import. J. Cell Biol. 147:761–773.
  • Collins, C. S., J. E. Kalish, J. C. Morrell, J. M. McCaffery, and S. J. Gould. 2000. The peroxisome biogenesis factors Pex4p, Pex22p, Pex1p, and Pex6p act in the terminal steps of peroxisomal matrix protein import. Mol. Cell. Biol. 20:7516–7526.
  • Dyer, J. M., J. A. McNew, and J. M. Goodman. 1996. The sorting sequence of the peroxisomal integral membrane protein PMP47 is contained within a short hydrophilic loop. J. Cell Biol. 133:269–280.
  • Elgersma, Y., L. Kwast, M. van den Berg, W. B. Snyder, B. Distel, S. Subramani, and H. F. Tabak. 1997. Overexpression of Pex15p, a phosphorylated peroxisomal integral membrane protein required for peroxisome assembly in S. cerevisiae, causes proliferation of the endoplasmic reticulum membrane. EMBO J. 16:7326–7341.
  • Fransen, M., C. Brees, P. P. Van Veldhoven, and G. P. Mannaerts. 1996. The visualization of peroxisomal proteins containing a C-terminal targeting sequence on Western blot by using the biotinylated PTS1-receptor. Anal. Biochem. 242:26–30.
  • Fransen, M., P. P. Van Veldhoven, and S. Subramani. 1999. Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. Biochem. J. 340:561–568.
  • Fransen, M., S. R. Terlecky, and S. Subramani. 1998. Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import. Proc. Natl. Acad. Sci. USA 95:8087–8092.
  • Fujiki, Y.. 2000. Peroxisome biogenesis and peroxisome biogenesis disorders. FEBS Lett. 476:42–46.
  • Fujiki, Y., A. L. Hubbard, S. Fowler, and P. B. Lazarow. 1982. Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum. J. Cell Biol. 93:97–102.
  • Ghaedi, K., S. Tamura, K. Okumoto, Y. Matsuzono, and Y. Fujiki. 2000. The peroxin Pex3p initiates membrane assembly in peroxisome biogenesis. Mol. Biol. Cell 11:2085–2102.
  • Gloeckner, C. J., P. U. Mayerhofer, P. Landgraf, A. C. Muntau, A. Holzinger, J. K. Gerber, S. Kammerer, J. Adamski, and A. A. Roscher. 2000. Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein Pex19p. Biochem. Biophys. Res. Commun. 271:144–150.
  • Götte, K., W. Girzalsky, M. Linkert, E. Baumgart, S. Kammerer, W. H. Kunau, and R. Erdmann. 1998. Pex19p, a farnesylated protein essential for peroxisome biogenesis. Mol. Cell. Biol. 18:616–628.
  • Gould, S. J., and D. Valle. 2000. Peroxisome biogenesis disorders: genetics and cell biology. Trends Genet. 16:340–345.
  • Hettema, E. H., W. Girzalsky, M. van Den Berg, R. Erdmann, and B. Distel. 2000. Saccharomyces cerevisiae Pex3p and Pex19p are required for proper localization and stability of peroxisomal membrane proteins. EMBO J. 19:223–233.
  • Honsho, M., and Y. Fujiki. 2001. Topogenesis of peroxisomal membrane protein requires a short positively charged intervening-loop sequence and flanking hydrophobic segments: study using human membrane protein PMP34. J. Biol. Chem. 276:9375–9382.
  • Just, W. W., and P. Diestelkötter. 1996. Protein insertion into the peroxisomal membrane. Ann. N. Y. Acad. Sci. 804:60–75.
  • Kammerer, S., A. Holzinger, U. Welsch, and A. A. Roscher. 1998. Cloning and characterization of the gene encoding the human peroxisomal assembly protein Pex3p. FEBS Lett. 429:53–60.
  • Lazarow, P. B., and Y. Fujiki. 1985. Biogenesis of peroxisomes. Annu. Rev. Cell Biol. 1:489–530.
  • Marshall, C. J.. 1993. Protein prenylation: a mediator of protein-protein interactions. Science 259:1865–1866.
  • Matsuzono, Y., N. Kinoshita, S. Tamura, N. Shimozawa, M. Hamasaki, K. Ghaedi, R. J. A. Wanders, Y. Suzuki, N. Kondo, and Y. Fujiki. 1999. Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger Syndrome, and potential role in peroxisomal membrane assembly. Proc. Natl. Acad. Sci. USA 96:2116–2121.
  • Okumoto, K., I. Abe, and Y. Fujiki. 2000. Molecular anatomy of the peroxin Pex12p. Ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p. J. Biol. Chem. 275:25700–25710.
  • Pause, B., P. Diestelkötter, H. Heid, and W. W. Just. 1997. Cytosolic factors mediate protein insertion into the peroxisomal membrane. FEBS Lett. 414:95–98.
  • Pause, B., R. Saffrich, A. Hunziker, W. Ansorge, and W. W. Just. 2000. Targeting of the 22 kDa integral peroxisomal membrane protein. FEBS Lett. 471:23–28.
  • Sacksteder, K. A., J. M. Jones, S. T. South, X. Li, Y. Liu, and S. J. Gould. 2000. PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. J. Cell Biol. 148:931–944.
  • Snyder, W. B., A. Koller, A. J. Choy, and S. Subramani. 2000. The peroxin Pex19p interacts with multiple, integral membrane proteins at the peroxisomal membrane. J. Cell Biol. 149:1171–1177.
  • Snyder, W. B., K. N. Faber, T. J. Wenzel, A. Koller, G. H. Lüers, L. Rangell, G. A. Keller, and S. Subramani. 1999. Pex19p interacts with Pex3p and Pex10p and is essential for peroxisome biogenesis in Pichia pastoris. Mol. Biol. Cell 10:1745–1761.
  • Soukupova, M., C. Sprenger, K. Gorgas, W. H. Kunau, and G. Dodt. 1999. Identification and characterization of the human peroxin PEX3. Eur. J. Cell Biol. 78:357–374.
  • Subramani, S., A. Koller, and W. B. Snyder. 2000. Import of peroxisomal matrix and membrane proteins. Annu. Rev. Biochem. 69:399–418.
  • Terlecky, S. R., and M. Fransen. 2000. How peroxisomes arise. Traffic 1:465–473.
  • Wang, X., M. J. Unruh, and J. M. Goodman. 2001. Discrete targeting signals direct PMP47 to oleate-induced peroxisomes in Saccharomyces cerevisiae. J. Biol. Chem. 276:10897–10905.
  • Wiemer, E. A. C., G. H. Lüers, K. N. Faber, T. Wenzel, M. Veenhuis, and S. Subramani. 1996. Isolation and characterization of Pas2p, a peroxisomal membrane protein essential for peroxisome biogenesis in the methylotrophic yeast Pichia pastoris. J. Biol. Chem. 271:18973–18980.
  • Zhang, F. L., and P. J. Casey. 1996. Protein prenylation: molecular mechanisms and functional consequences. Annu. Rev. Biochem. 65:241–269.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.