Two Distinct Domains within CIITA Mediate Self-Association: Involvement of the GTP-Binding and Leucine-Rich Repeat Domains

REFERENCES

• Accolla, R. S., M. Jotterand-Bellomo, L. Scarpellino, A. Maffei, G. Carra, and J. Guardiola. 1986. aIr-1, a newly found locus on mouse chromosome 16 encoding a trans-acting activator factor for MHC class II gene expression. J. Exp. Med. 164:369–374.
   PubMed Web of Science ®Google Scholar
• Adrain, C., E. A. Slee, M. T. Harte, and S. J. Martin. 1999. Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region. J. Biol. Chem. 274:20855–20860.
   PubMed Web of Science ®Google Scholar
• Baker, B., P. Zambryski, B. Staskawicz, and S. P. Dinesh-Kumar. 1997. Signaling in plant-microbe interactions. Science 276:726–733.
   PubMed Web of Science ®Google Scholar
• Bertin, J., W. J. Nir, C. M. Fischer, O. V. Tayber, P. R. Errada, J. R. Grant, J. J. Keilty, M. L. Gosselin, K. E. Robison, G. H. Wong, M. A. Glucksmann, and P. S. DiStefano. 1999. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB. J. Biol. Chem. 274:12955–12958.
   PubMed Web of Science ®Google Scholar
• Bontron, S., V. Steimle, C. Ucla, M. M. Eibl, and B. Mach. 1997. Two novel mutations in the MHC class II transactivator CIITA in a second patient from MHC class II deficiency complementation group A. Hum. Genet. 99:541–546.
   PubMedGoogle Scholar
• Boss, J. M.. 1997. Regulation of transcription of MHC class II genes. Curr. Opin. Immunol. 9:107–113.
   PubMedGoogle Scholar
• Boyes, D. C., J. Nam, and J. L. Dangl. 1998. The Arabidopsis thaliana RPM1 disease resistance gene product is a peripheral plasma membrane protein that is degraded coincident with the hypersensitive response. Proc. Natl. Acad. Sci. USA 95:15849–15854.
   PubMed Web of Science ®Google Scholar
• Buchanan, S. G., and N. J. Gay. 1996. Structural and functional diversity in the leucine-rich repeat family of proteins. Prog. Biophys. Mol. Biol. 65:1–44.
   PubMedGoogle Scholar
• Bucher, P.. 1990. Weight matrix descriptions of four eukaryotic RNA polymerase II promoter elements derived from 502 unrelated promoter sequences. J. Mol. Biol. 212:563–578.
   PubMed Web of Science ®Google Scholar
• Chang, C. H., J. D. Fontes, B. M. Peterlin, and R. A. Flavell. 1994. Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes. J. Exp. Med. 180:1367–1374.
   PubMedGoogle Scholar
• Chapman, H. A.. 1998. Endosomal proteolysis and MHC class II function. Curr. Opin. Immunol. 10:93–102.
   PubMed Web of Science ®Google Scholar
• Chin, K. C., G. Li, and J. P.-Y. Ting. 1997. Activation and transdominant suppression of MHC class II and HLA-DMB promoters by a series of C-terminal class II transactivator deletion mutants. J. Immunol. 159:2789–2794.
   PubMedGoogle Scholar
• Chin, K. C., G. G. Li, and J. P.-Y. Ting. 1997. Importance of acidic, proline/serine/threonine-rich, and GTP-binding regions in the major histocompatibility complex class II transactivator: generation of transdominant-negative mutants. Proc. Natl. Acad. Sci. USA 94:2501–2506.
   PubMedGoogle Scholar
• Chin, K. C., C. Mao, C. Skinner, J. L. Riley, K. L. Wright, C. S. Moreno, G. R. Stark, J. M. Boss, and J. P.-Y. Ting. 1994. Molecular analysis of G1B and G3A IFN gamma mutants reveals that defects in CIITA or RFX result in defective class II MHC and Ii gene induction. Immunity 1:687–697.
   PubMedGoogle Scholar
• Cressman, D. E., K. C. Chin, D. J. Taxman, and J. P.-Y. Ting. 1999. A defect in the nuclear translocation of CIITA causes a form of type II bare lymphocyte syndrome. Immunity 10:163–171.
   PubMed Web of Science ®Google Scholar
• DeSandro, A. M., U. M. Nagarajan, and J. M. Boss. 2000. Associations and interactions between bare lymphocyte syndrome factors. Mol. Cell. Biol. 20:6587–6599.
   PubMedGoogle Scholar
• Durand, B., P. Sperisen, P. Emery, E. Barras, M. Zufferey, B. Mach, and W. Reith. 1997. RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency. EMBO J. 16:1045–1055.
   PubMedGoogle Scholar
• Fontes, J. D., B. Jiang, and B. M. Peterlin. 1997. The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32. Nucleic Acids Res 25:2522–2528.
   PubMed Web of Science ®Google Scholar
• Fontes, J. D., S. Kanazawa, D. Jean, and B. M. Peterlin. 1999. Interactions between the class II transactivator and CREB binding protein increase transcription of major histocompatibility complex class II genes. Mol. Cell. Biol. 19:941–947.
   PubMedGoogle Scholar
• Glimcher, L. H., and C. J. Kara. 1992. Sequences and factors: a guide to MHC class-II transcription. Annu. Rev. Immunol. 10:13–49.
   PubMed Web of Science ®Google Scholar
• Gobin, S. J., A. Peijnenburg, V. Keijsers, and P. J. van den Elsen. 1997. Site alpha is crucial for two routes of IFN gamma-induced MHC class I transactivation: the ISRE-mediated route and a novel pathway involving CIITA. Immunity 6:601–611.
   PubMed Web of Science ®Google Scholar
• Hake, S. B., K. Masternak, C. Kammerbauer, C. Janzen, W. Reith, and V. Steimle. 2000. CIITA leucine-rich repeats control nuclear localization, In vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation. Mol. Cell. Biol. 20:7716–7725.
   PubMedGoogle Scholar
• Harton, J. A., D. E. Cressman, K. C. Chin, C. J. Der, and J. P.-Y. Ting. 1999. GTP binding by class II transactivator: role in nuclear import. Science 285:1402–1405.
   PubMedGoogle Scholar
• Harton, J. A., and J. P. Ting. 2000. Class II transactivator: mastering the art of major histocompatibility complex expression. Mol. Cell. Biol. 20:6185–6194.
   PubMedGoogle Scholar
• Hillig, R. C., L. Renault, I. R. Vetter, T. Drell, A. Wittinghofer, and J. Becker. 1999. The crystal structure of rna1p: a new fold for a GTPase-activating protein. Mol. Cell 3:781–791.
   PubMed Web of Science ®Google Scholar
• Hlaing, T., R. F. Guo, K. A. Dilley, J. M. Loussia, T. A. Morrish, M. M. Shi, C. Vincenz, and P. A. Ward. Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins. J. Biol. Chem., in press.
   Google Scholar
• Hu, Y., L. Ding, D. M. Spencer, and G. Nunez. 1998. WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation. J. Biol. Chem. 273:33489–33494.
   PubMedGoogle Scholar
• Inohara, N., T. Koseki, L. del Peso, Y. Hu, C. Yee, S. Chen, R. Carrio, J. Merino, D. Liu, J. Ni, and G. Nunez. 1999. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. J. Biol. Chem. 274:14560–14567.
   PubMed Web of Science ®Google Scholar
• Inohara, N., T. Koseki, J. Lin, L. del Peso, P. C. Lucas, F. F. Chen, Y. Ogura, and G. Nunez. 2000. An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. J. Biol. Chem. 275:27823–27831.
   PubMed Web of Science ®Google Scholar
• Inohara, N., Y. Ogura, F. F. Chen, A. Muto, and G. Nunez. 2000. Human Nod1 confers responsiveness to bacterial lipopolysaccharides. J. Biol. Chem. 276:2551–2554.
   PubMedGoogle Scholar
• Kanazawa, S., T. Okamoto, and B. M. Peterlin. 2000. Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection. Immunity 12:61–70.
   PubMedGoogle Scholar
• Klemm, J. D., S. L. Schreiber, and G. R. Crabtree. 1998. Dimerization as a regulatory mechanism in signal transduction. Annu. Rev. Immunol. 16:569–592.
   PubMed Web of Science ®Google Scholar
• Kobe, B., and J. Deisenhofer. 1993. Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. Nature 366:751–756.
   PubMed Web of Science ®Google Scholar
• Kobe, B., and J. Deisenhofer. 1994. The leucine-rich repeat: a versatile binding motif. Trends Biochem. Sci. 19:415–421.
   PubMed Web of Science ®Google Scholar
• Kobe, B., and J. Deisenhofer. 1995. Proteins with leucine-rich repeats. Curr. Opin. Struct. Biol. 5:409–416.
   PubMed Web of Science ®Google Scholar
• Kretsovali, A., T. Agalioti, C. Spilianakis, E. Tzortzakaki, M. Merika, and J. Papamatheakis. 1998. Involvement of CREB binding protein in expression of major histocompatibility complex class II genes via interaction with the class II transactivator. Mol. Cell. Biol. 18:6777–6783.
   PubMed Web of Science ®Google Scholar
• Li, P., D. Nijhawan, I. Budihardjo, S. M. Srinivasula, M. Ahmad, E. S. Alnemri, and X. Wang. 1997. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479–489.
   PubMed Web of Science ®Google Scholar
• Mach, B., V. Steimle, E. Martinez-Soria, and W. Reith. 1996. Regulation of MHC class II genes: lessons from a disease. Annu. Rev. Immunol. 14:301–331.
   PubMed Web of Science ®Google Scholar
• Mahanta, S. K., T. Scholl, F. C. Yang, and J. L. Strominger. 1997. Transactivation by CIITA, the type II bare lymphocyte syndrome- associated factor, requires participation of multiple regions of the TATA box binding protein. Proc. Natl. Acad. Sci. USA 94:6324–6329.
   PubMedGoogle Scholar
• Mantovani, R.. 1999. The molecular biology of the CCAAT-binding factor NF-Y. Gene 239:15–27.
   PubMed Web of Science ®Google Scholar
• Mantovani, R.. 1998. A survey of 178 NF-Y binding CCAAT boxes. Nucleic Acids Res. 26:1135–1143.
   PubMed Web of Science ®Google Scholar
• Martin, B. K., K. C. Chin, J. C. Olsen, C. A. Skinner, A. Dey, K. Ozato, and J. P. Ting. 1997. Induction of MHC class I expression by the MHC class II transactivator CIITA. Immunity 6:591–600.
   PubMedGoogle Scholar
• Masternak, K., E. Barras, M. Zufferey, B. Conrad, G. Corthals, R. Aebersold, J. C. Sanchez, D. F. Hochstrasser, B. Mach, and W. Reith. 1998. A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients. Nat. Genet. 20:273–277.
   PubMedGoogle Scholar
• Masternak, K., A. Muhlethaler-Mottet, J. Villard, M. Zufferey, V. Steimle, and W. Reith. 2000. CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex. Genes Dev. 14:1156–1166.
   PubMed Web of Science ®Google Scholar
• Moreno, C. S., G. W. Beresford, P. Louis-Plence, A. C. Morris, and J. M. Boss. 1999. CREB regulates MHC class II expression in a CIITA-dependent manner. Immunity 10:143–151.
   PubMedGoogle Scholar
• Nagarajan, U. M., P. Louis-Plence, A. DeSandro, R. Nilsen, A. Bushey, and J. M. Boss. 1999. RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency. Immunity 10:153–162.
   PubMedGoogle Scholar
• Ogura, Y., N. Inohara, A. Benito, F. F. Chen, S. Yamaoka, and G. Nunez. 2000. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NFκB. J. Biol. Chem. 276:4812–4818.
   PubMedGoogle Scholar
• Pieters, J.. 1997. MHC class II-restricted antigen presentation. Curr. Opin. Immunol. 9:89–96.
   PubMedGoogle Scholar
• Quan, V., M. Towey, S. Sacks, and A. P. Kelly. 1999. Absence of MHC class II gene expression in a patient with a single amino acid substitution in the class II transactivator protein CIITA. Immunogenetics 49:957–963.
   PubMedGoogle Scholar
• Reith, W., S. Satola, C. H. Sanchez, I. Amaldi, B. Lisowska-Grospierre, C. Griscelli, M. R. Hadam, and B. Mach. 1988. Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X. Cell 53:897–906.
   PubMed Web of Science ®Google Scholar
• Riley, J. L., S. D. Westerheide, J. A. Price, J. A. Brown, and J. M. Boss. 1995. Activation of class II MHC genes requires both the X box region and the class II transactivator (CIITA). Immunity 2:533–543.
   PubMedGoogle Scholar
• Sinha, S., S. N. Maity, J. Lu, and B. de Crombrugghe. 1995. Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3. Proc. Natl. Acad. Sci. USA 92:1624–1628.
   PubMed Web of Science ®Google Scholar
• Sisk, T. J., T. Gourley, S. Roys, and C. H. Chang. 2000. MHC class II transactivator inhibits IL-4 gene transcription by competing with NF-AT to bind the coactivator CREB binding protein (CBP)/p300. J. Immunol. 165:2511–2517.
   PubMed Web of Science ®Google Scholar
• Spilianakis, C., J. Papamatheakis, and A. Kretsovali. 2000. Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes. Mol. Cell. Biol. 20:8489–8498.
   PubMed Web of Science ®Google Scholar
• Srinivasula, S. M., M. Ahmad, T. Fernandes-Alnemri, and E. S. Alnemri. 1998. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol. Cell. 1:949–957.
   PubMed Web of Science ®Google Scholar
• Steimle, V., B. Durand, E. Barras, M. Zufferey, M. R. Hadam, B. Mach, and W. Reith. 1995. A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome). Genes Dev 9:1021–1032.
   PubMedGoogle Scholar
• Steimle, V., L. A. Otten, M. Zufferey, and B. Mach. 1993. Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome). Cell 75:135–146.
   PubMed Web of Science ®Google Scholar
• Steimle, V., C. A. Siegrist, A. Mottet, B. Lisowska-Grospierre, and B. Mach. 1994. Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA. Science 265:106–109.
   PubMed Web of Science ®Google Scholar
• Tong, Z. B., L. Gold, K. E. Pfeifer, H. Dorward, E. Lee, C. A. Bondy, J. Dean, and L. M. Nelson. 2000. Mater, a maternal effect gene required for early embryonic development in mice. Nat. Genet 26:267–268.
   PubMed Web of Science ®Google Scholar
• Tong, Z. B., and L. M. Nelson. 1999. A mouse gene encoding an oocyte antigen associated with autoimmune premature ovarian failure. Endocrinology 140:3720–3726.
   PubMed Web of Science ®Google Scholar
• Tong, Z. B., L. M. Nelson, and J. Dean. 2000. Mater encodes a maternal protein in mice with a leucine-rich repeat domain homologous to porcine ribonuclease inhibitor. Mamm. Genome 11:281–287.
   PubMed Web of Science ®Google Scholar
• Yang, X., H. Y. Chang, and D. Baltimore. 1998. Autoproteolytic activation of pro-caspases by oligomerization. Mol. Cell 1:319–325.
   PubMed Web of Science ®Google Scholar
• Yang, X., H. Y. Chang, and D. Baltimore. 1998. Essential role of CED-4 oligomerization in CED-3 activation and apoptosis. Science 281:1355–1357.
   PubMedGoogle Scholar
• Zhou, H., and L. H. Glimcher. 1995. Human MHC class II gene transcription directed by the carboxyl terminus of CIITA, one of the defective genes in type II MHC combined immune deficiency. Immunity 2:545–553.
   PubMedGoogle Scholar
• Zhu, X. S., M. W. Linhoff, G. Li, K. C. Chin, S. N. Maity, and J. P. Ting. 2000. Transcriptional scaffold: CIITA interacts with NF-Y, RFX, and CREB to cause stereospecific regulation of the class II major histocompatibility complex promoter. Mol. Cell. Biol. 20:6051–6061.
   PubMed Web of Science ®Google Scholar