Astrocyte-Specific Inactivation of the Neurofibromatosis 1 Gene (NF1) Is Insufficient for Astrocytoma Formation

REFERENCES

• Amundson, R. H., S. K. Goderlie, and H. K. Kimelberg. 1992. Uptake of 3H-serotonin and 3H-glutamate by primary astrocyte cultures. II. Differences in cultures prepared from different brain regions. Glia 6: 9–18.
   PubMedGoogle Scholar
• Anton, M., and F. L. Graham. 1995. Site-specific recombination mediated by an adenovirus vector expressing the cre recombinase protein: a molecular switch for control of gene expression. J. Virol. 69: 4600–4606.
   PubMed Web of Science ®Google Scholar
• Bajenaru, M. L., J. Donahoe, T. Corral, K. M. Reilly, S. Brophy, A. Pellicer, and D. H. Gutmann. 2001. Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes. Glia 33: 314–323.
   PubMedGoogle Scholar
• Ballester, R., D. A. Marchuk, M. Boguski, A. M. Saulino, R. Letcher, M. Wigler, and F. S. Collins. 1990. The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell 63: 851–859.
   PubMed Web of Science ®Google Scholar
• Basu, T. N., D. H. Gutmann, J. A. Fletcher, T. W. Glover, F. S. Collins, and J. Downward. 1992. Aberrant regulation of ras proteins in tumour cells from type 1 neurofibromatosis patients. Nature 356: 713–715.
   PubMed Web of Science ®Google Scholar
• Bollag, G., and F. McCormick. 1991. Regulators and effectors of ras proteins. Annu. Rev. Cell Biol. 7: 601–632.
   PubMedGoogle Scholar
• Bollag, G., D. W. Clapp, S. Shih, F. Adler, Y. Y. Zhang, P. Thompson, B. J. Lange, M. H. Freedman, F. McCormick, T. Jacks, and K. Shannon. 1996. Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells. Nat. Genet. 12: 144–148.
   PubMed Web of Science ®Google Scholar
• Brannan, C. I., A. S. Perkins, K. S. Vogel, N. Ratner, M. L. Nordlund, S. W. Reid, A. M. Buchberg, N. A. Jenkins, L. F. Parada, and N. G. Copeland. 1994. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev. 8: 1019–1029.
   PubMed Web of Science ®Google Scholar
• Brenner, M., and A. Messing. 1996. GFAP transgenic mice. Methods 10: 351–364.
   PubMedGoogle Scholar
• Cawthon, R. M., M. Weiss, G. Xu, D. Viskochil, M. Culver, J. Stevens, M. Robertson, D. Dunn, R. Gesteland, P. O'Connell, and R. White. 1990. A major segment of the neurofibromatosis 1 gene: cDNA sequence, genomic structure and point mutations. Cell 62: 193–201.
   PubMed Web of Science ®Google Scholar
• Cheng, Y., J. C. S. Pang, H.-K. Ng, M. Ding, S. F. Zhang, J. Zheng, D. G. Liu, and W. S. Poon. 2000. Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas. Histopathology 37: 437–444.
   PubMedGoogle Scholar
• DeClue, J. E., A. G. Papageorge, J. A. Fletcher, S. R. Diehl, N. Ratner, W. C. Vass, and D. R. Lowy. 1992. Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis. Cell 69: 265–273.
   PubMedGoogle Scholar
• Ding, H., L. Roncari, P. Shannon, S. MacMaster, X. Wu, N. Lau, J. Karaskova, D. H. Gutmann, J. A. Squire, A. Nagy, and A. Guha. 2001. Astrocyte-specific expression of activated Ras results in malignant astrocytomas in a transgenic mouse model of human gliomas. Cancer Res. 61: 3826–3836.
   PubMed Web of Science ®Google Scholar
• Escalona-Zapara, J., and M. D. Diez-Nau. 1981. Distinctive growth patterns between cerebral and cerebellar astrocytomas—a tissue culture study. Histopathology 5: 639–650.
   PubMedGoogle Scholar
• Figarella-Branger, D., L. Daniel, P. Andre, S. Guia, W. Renaud, G. Monti, E. Vivier, and G. Rougon. 1999. The PEN5 epitope identifies an oligodendrocyte precursor cell population and pilocytic astrocytomas. Am. J. Pathol. 155: 1261–1269.
   PubMedGoogle Scholar
• Friedman, J. M., D. H. Gutmann, M. M. MacCollin, and V. M. Riccardi (ed.). 1999. Neurofibromatosis, 3rd ed. Johns Hopkins Press, Baltimore, Md.
   Google Scholar
• Gutmann, D. H., D. L. Wood, and F. S. Collins. 1991. Identification of the neurofibromatosis type 1 gene product. Proc. Natl. Acad. Sci. USA 21: 9658–9662.
   Google Scholar
• Gutmann, D. H., A. Loehr, Y. Zhang, J. Kim, M. Henkemeyer, and A. Cashen. 1999. Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation. Oncogene 18: 4450–4459.
   PubMedGoogle Scholar
• Gutmann, D. H., J. Donahoe, T. Brown, C. D. James, and A. Perry. 2000. Loss of neurofibromatosis 1 (NF1) gene expression in NF1-associated pilocytic astrocytomas. Neuropathol. Exp. Neurobiol. 26: 361–367.
   PubMed Web of Science ®Google Scholar
• Gutmann, D. H., N. M. Hedrick, J. Li, R. Nagarajan, A. Perry, and M. A. Watson. 2002. Comparative gene expression profile analysis of neurofibromatosis 1 (NF1)-associated and sporadic pilocytic astrocytomas. Cancer Res. 62: 2085–2091.
   PubMed Web of Science ®Google Scholar
• Hewett, S. J., D. W. Choi, and D. H. Gutmann. 1995. Increased expression of the neurofibromatosis 1 (NF1) tumor suppressor gene protein, neurofibromin, in reactive astrocytes in vitro. Neuroreport 6: 1505–1508.
   PubMedGoogle Scholar
• Huynh, D. P., T. Nechiporuk, and S. M. Pulst. 1994. Differential expression and tissue distribution of type I and type II neurofibromins during mouse fetal development. Dev. Biol. 161: 538–551.
   PubMedGoogle Scholar
• Ishii, N., Y. Sawamura, M. Tada, D. M. Daub, R. C. Janzer, M. Meagher-Villemure, N. de Tribolet, and E. G. Van Meir. 1998. Absence of p53 gene mutations in a tumor panel representative of pilocytic astrocytoma diversity by using a p53 functional assay. Int. J. Cancer 76: 797–800.
   PubMedGoogle Scholar
• Jacks, T., T. S. Shih, E. M. Schmitt, R. T. Bronson, A. Bernards, and R. A. Weinberg. 1994. Tumor predisposition in mice heterozygous for a targeted mutation in NF1. Nat. Genet. 7: 353–361.
   PubMed Web of Science ®Google Scholar
• Kluwe, L., C. Hagel, M. Tatagiba, S. Thomas, D. Stavrou, H. Ostertag, A. von Deimling, and V. F. Mautner. 2001. Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas. J. Neuropathol. Exp. Neurol. 60: 917–920.
   PubMed Web of Science ®Google Scholar
• Kolb, A. F., and S. G. Siddell. 1996. Genomic targeting with an MBP-Cre fusion protein. Gene 183: 53–60.
   PubMedGoogle Scholar
• Kwon, C. H., X. Zhu, J. Zhang, L. L. Knoop, R. Tharp, R. J. Smeyne, C. G. Eberhart, P. C. Burger, and S. J. Baker. 2001. Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease. Nat. Genet. 29: 404–411.
   PubMed Web of Science ®Google Scholar
• Lau, N., M. M. Feldkamp, L. Roncari, A. H. Loehr, P. Shannon, D. H. Gutmann, and A. Guha. 2000. Loss of neurofibromin is associated with activation of the RAS/MAPK and PI3-K/AKT signaling in neurofibromatosis 1 astrocytoma. J. Neuropathol. Exp. Neurol. 59: 759–767.
   PubMed Web of Science ®Google Scholar
• Lee, S. H., W. T. Kim, A. H. Cornell-Bell, and H. Sontheimer. 1994. Astrocytes exhibit regional specificity in gap-junction coupling. Glia 11: 315–325.
   PubMed Web of Science ®Google Scholar
• Li, J., A. Perry, C. D. James, and D. H. Gutmann. 2001. Cancer related gene expression in neurofibromatosis 1 (NF1)-associated pilocytic astrocytomas. Neurology 56: 885–890.
   PubMed Web of Science ®Google Scholar
• Listernick, R., D. N. Louis, R. J. Packer, and D. H. Gutmann. 1997. Optic pathway gliomas in children with neurofibromatosis 1: consensus statement from the NF1 optic pathway glioma task force. Ann. Neurol. 41: 143–149.
   PubMed Web of Science ®Google Scholar
• Lobe, C. G., K. E. Koop, W. Kreppner, H. Lomeli, M. Gertsenstein, and A. Nagy. 1999. Z/AP, a double reporter for cre-mediated recombination. Dev. Biol. 208: 281–292.
   PubMed Web of Science ®Google Scholar
• Marino, S., M. Vooijs, H. van der Gulden, J. Jonkers, and A. Berns. 2000. Induction of medulloblastomas in p53-null mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 14: 994–1004.
   PubMed Web of Science ®Google Scholar
• Martin, G. A., D. Viskochil, G. Bollag, P. C. McCabe, W. J. Crosier, H. Haubruck, L. Conroy, R. Clark, P. O'Connell, R. M. Cawthon, M. A. Innis, and F. McCormick. 1990. The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21. Cell 63: 843–849.
   PubMed Web of Science ®Google Scholar
• Nordlund, M. L., T. A. Rizvi, C. I. Brannan, and N. Ratner. 1995. Neurofibromin expression and astrogliosis in neurofibromatosis (type 1) brains. J. Neuropathol. Exp. Neurol. 54: 588–600.
   PubMedGoogle Scholar
• Norton, K. K., R. T. Geist, D. K. Mahadeo, and D. H. Gutmann. 1996. Expression of the neurofibromatosis 1 (NF1) tumor suppressor gene product, neurofibromin, during growth arrest in fibroblasts. Neuroreport 7: 601–604.
   PubMedGoogle Scholar
• Paxinos, G., and C. Watson. 1986. The rat brain in stereotaxic coordinates, 2nd ed. Academic Press, New York, N.Y.
   Google Scholar
• Platten, M., M. J. Giordano, C. M. F. Dirvem, D. H. Gutmann, and D. N. Louis. 1996. Upregulation of specific NF1 gene transcripts in sporadic pilocytic astrocytomas. Am. J. Pathol. 149: 621–627.
   PubMed Web of Science ®Google Scholar
• Reilly, K. M., D. A. Loisel, R. T. Bronson, M. E. McLaughlin, and T. Jacks. 2000. Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nat. Genet. 26: 109–113.
   PubMed Web of Science ®Google Scholar
• Sanoudou, D., O. Tingby, M. A. Ferguson-Smith, V. P. Collins, and N. Coleman. 2000. Analysis of pilocytic astrocytomas by comparative genomic hybridization. Br. J. Cancer 82: 1218–1222.
   PubMed Web of Science ®Google Scholar
• Stec, D. E., R. L. Davisson, R. E. Haskell, B. L. Davidson, and C. D. Sigmund. 1999. Efficient liver-specific deletion of a floxed human angiotensin transgene by adenoviral delivery of Cre recombinase in vivo. J. Biol. Chem. 274: 21285–21290.
   PubMedGoogle Scholar
• Viskochil, D., A. M. Buchberg, G. Xu, R. M. Cawthon, J. Stevens, R. K. Wolff, M. Culver, J. C. Carey, N. G. Copeland, N. A. Jenkins, and R. White. 1990. Deletions and translocation interrupt a cloned gene at the neurofibromatosis 1 locus. Cell 62: 187–192.
   PubMed Web of Science ®Google Scholar
• Wallace, M. R., D. A. Marchuk, L. B. Andersen, R. Letcher, H. M. Odeh, A. M. Saulino, J. W. Fountain, A. Brereton, J. Nicholson, A. L. Mitchell, and F. S. Collins. 1990. Type 1 neurofibromatosis gene: identification of a large transcript disrupted in NF1 patients. Science 249: 181–186.
   PubMed Web of Science ®Google Scholar
• White, F. V., D. C. Anthony, E. J. Yunis, N. J. Tarbell, R. M. Scott, and D. E. Schofield. 1995. Nonrandom chromosomal gains in pilocytic astrocytomas of childhood. Hum. Pathol. 26: 979–986.
   PubMed Web of Science ®Google Scholar
• Xu, G., B. Lin, K. Tanaka, D. Dunn, D. Wood, R. Gesteland, R. White, R. Weiss, and F. Tamanoi. 1990. The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae. Cell 63: 835–841.
   PubMed Web of Science ®Google Scholar
• Zaidi, A. U., H. Enomoto, J. Milbrandt, and K. A. Roth. 2000. Dual fluorescent in situ hybridization and immunohistochemical detection with tyramide signal amplification. J. Histochem. Cytochem. 48: 1369–1375.
   PubMedGoogle Scholar
• Zattara-Cannoni, H., D. Gambarelli, G. Lena, H. Dufour, M. Choux, F. Grisoli, and A. M. Vagner-Capodano. 1998. Are juvenile pilocytic astrocytomas benign tumors? A cytogenetic study in 24 cases. Cancer Genet. Cytogenet. 104: 157–160.
   PubMedGoogle Scholar
• Zhu, Y., M. I. Romero, P. Ghosh, Z. Ye, P. Charnay, E. J. Rushing, J. D. Marth, and L. Parada. 2001. Ablation of NF1 function in neurons induces abnormal development of the cerebral cortex and reactive gliosis in the brain. Genes Dev. 15: 859–876.
   PubMedGoogle Scholar