Ribosomal Protein L12 Uses a Distinct Nuclear Import Pathway Mediated by Importin 11

REFERENCES

• Adam, S. A., and L. Gerace. 1991. Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import. Cell 66: 837–847.
   PubMed Web of Science ®Google Scholar
• Adam, S. A., T. J. Lobl, M. A. Mitchell, and L. Gerace. 1989. Identification of specific binding proteins for a nuclear location sequence. Nature 337: 276–279.
   PubMedGoogle Scholar
• Bischoff, F. R., C. Klebe, J. Kretschmer, A. Wittinghofer, and H. Ponstingl. 1994. RanGAP1 induces GTPase activity of nuclear Ras-related Ran. Proc. Natl. Acad. Sci. USA 91: 2587–2591.
   PubMed Web of Science ®Google Scholar
• Bonner, W. M. 1978. Protein migration and accumulation in nuclei, p. 97–148. In H. Busch (ed.), The cell nucleus, vol. 6, part C. Academic Press, New York, N.Y.
   Google Scholar
• Corbett, A. H., and P. A. Silver. 1997. Nucleocytoplasmic transport of macromolecules. Microbiol. Mol. Biol. Rev. 61: 193–211.
   PubMedGoogle Scholar
• Enenkel, C., G. Blobel, and M. Rexach. 1995. Identification of a yeast karyopherin heterodimer that targets import substrate to mammalian nuclear pore complexes. J. Biol. Chem. 270: 16499–16502.
   PubMed Web of Science ®Google Scholar
• Gadal, O., D. Strauss, J. Kessl, B. Trumpower, D. Tollervey, and E. Hurt. 2001. Nuclear export of 60s ribosomal subunits depends on Xpo1p and requires a nuclear export sequence-containing factor, Nmd3p, that associates with the large subunit protein Rpl10p. Mol. Cell. Biol. 21: 3405–3415.
   PubMed Web of Science ®Google Scholar
• Gorlich, D., M. Dabrowski, F. R. Bischoff, U. Kutay, P. Bork, E. Hartmann, S. Prehn, and E. Izaurralde. 1997. A novel class of RanGTP binding proteins. J. Cell Biol. 138: 65–80.
   PubMed Web of Science ®Google Scholar
• Gorlich, D., S. Kostka, R. Kraft, C. Dingwall, R. A. Laskey, E. Hartmann, and S. Prehn. 1995. Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope. Curr. Biol. 5: 383–392.
   PubMedGoogle Scholar
• Gorlich, D., and U. Kutay. 1999. Transport between the cell nucleus and the cytoplasm. Annu. Rev. Cell Dev. Biol. 15: 607–660.
   PubMed Web of Science ®Google Scholar
• Gorlich, D., F. Vogel, A. D. Mills, E. Hartmann, and R. A. Laskey. 1995. Distinct functions for the two importin subunits in nuclear protein import. Nature 377: 246–248.
   PubMedGoogle Scholar
• Grosshans, H., K. Deinert, E. Hurt, and G. Simos. 2001. Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export. J. Cell Biol. 153: 745–762.
   PubMed Web of Science ®Google Scholar
• Ho, J. H., G. Kallstrom, and A. W. Johnson. 2000. Nmd3p is a Crm1p-dependent adapter protein for nuclear export of the large ribosomal subunit. J. Cell Biol. 151: 1057–1066.
   PubMed Web of Science ®Google Scholar
• Imamoto, N., T. Tachibana, M. Matsubae, and Y. Yoneda. 1995. A karyophilic protein forms a stable complex with cytoplasmic components prior to nuclear pore binding. J. Biol. Chem. 270: 8559–8565.
   PubMedGoogle Scholar
• Jakel, S., and D. Gorlich. 1998. Importin β, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. EMBO J. 17: 4491–4502.
   PubMed Web of Science ®Google Scholar
• Jeeninga, R. E., J. Venema, and H. A. Raue. 1996. Rat RL23a ribosomal protein efficiently competes with its Saccharomyces cerevisiae L25 homologue for assembly into 60 S subunits. J. Mol. Biol. 263: 648–656.
   PubMedGoogle Scholar
• Klebe, C., F. R. Bischoff, H. Ponstingl, and A. Wittinghofer. 1995. Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1. Biochemistry 34: 639–647.
   PubMedGoogle Scholar
• Kruiswijk, T., R. J. Planta, and J. M. Krop. 1978. The course of the assembly of ribosomal subunits in yeast. Biochim. Biophys. Acta 517: 378–389.
   PubMedGoogle Scholar
• Lounsbury, K. M., and I. G. Macara. 1997. Ran-binding protein 1 (RanBP1) forms a ternary complex with Ran and karyopherin beta and reduces Ran Gtpase-activating protein (RanGAP) inhibition by karyopherin beta. J. Biol. Chem. 272: 551–555.
   PubMed Web of Science ®Google Scholar
• Mattaj, I. W., and L. Englmeier. 1998. Nucleocytoplasmic transport: the soluble phase. Annu. Rev. Biochem. 67: 265–306.
   PubMed Web of Science ®Google Scholar
• Melchior, F., and L. Gerace. 1998. Two-way trafficking with Ran. Trends Cell Biol. 8: 175–179.
   PubMedGoogle Scholar
• Moroianu, J., G. Blobel, and A. Radu. 1996. Nuclear protein import: Ran-GTP dissociates the karyopherin alphabeta heterodimer by displacing alpha from an overlapping binding site on beta. Proc. Natl. Acad. Sci. USA 93: 7059–7062.
   PubMed Web of Science ®Google Scholar
• Moroianu, J., G. Blobel, and A. Radu. 1995. Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes. Proc. Natl. Acad. Sci. USA 92: 2008–2011.
   PubMed Web of Science ®Google Scholar
• Nakielny, S., and G. Dreyfuss. 1999. Transport of proteins and RNAs in and out of the nucleus. Cell 99: 677–690.
   PubMed Web of Science ®Google Scholar
• Neudauer, C. L., G. Joberty, N. Tatsis, and I. G. Macara. 1998. Distinct cellular effects and interactions of the Rho-family GTPase TC10. Curr. Biol. 8: 1151–1160.
   PubMedGoogle Scholar
• Pemberton, L. F., G. Blobel, and J. S. Rosenblum. 1998. Transport routes through the nuclear pore complex. Curr. Opin. Cell Biol. 10: 392–399.
   PubMedGoogle Scholar
• Plafker, K., and I. G. Macara. 2000. Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1. Mol. Cell. Biol. 20: 3510–3521.
   PubMed Web of Science ®Google Scholar
• Plafker, S. M., and I. G. Macara. 2000. Importin-11, a nuclear import receptor for the ubiquitin-conjugating enzyme, UbcM2. EMBO J. 19: 5502–5513.
   PubMedGoogle Scholar
• Pollard, V. W., W. M. Michael, S. Nakielny, M. C. Siomi, F. Wang, and G. Dreyfuss. 1996. A novel receptor-mediated nuclear protein import pathway. Cell 86: 985–994.
   PubMed Web of Science ®Google Scholar
• Radu, A., G. Blobel, and M. S. Moore. 1995. Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Proc. Natl. Acad. Sci. USA 92: 1769–1773.
   PubMedGoogle Scholar
• Rexach, M., and G. Blobel. 1995. Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins. Cell 83: 683–692.
   PubMed Web of Science ®Google Scholar
• Rout, M. P., G. Blobel, and J. D. Aitchison. 1997. A distinct nuclear import pathway used by ribosomal proteins. Cell 89: 715–725.
   PubMed Web of Science ®Google Scholar
• Schlenstedt, G., E. Smirnova, R. Deane, J. Solsbacher, U. Kutay, D. Gorlich, H. Ponstingl, and F. R. Bischoff. 1997. Yrb4p, a yeast Ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus. EMBO J. 16: 6237–6249.
   PubMed Web of Science ®Google Scholar
• Siomi, H., and G. Dreyfuss. 1995. A nuclear localization domain in the hnRNP A1 protein. J. Cell Biol. 129: 551–560.
   PubMed Web of Science ®Google Scholar
• Siomi, M. C., P. S. Eder, N. Kataoka, L. L. Wan, Q. Liu, and G. Dreyfuss. 1997. Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. J. Cell Biol. 138: 1181–1192.
   PubMed Web of Science ®Google Scholar
• Stage-Zimmermann, T., U. Schmidt, and P. A. Silver. 2000. Factors affecting nuclear export of the 60S ribosomal subunit in vivo. Mol. Biol. Cell 11: 3777–3789.
   PubMedGoogle Scholar
• Suzuki, K., and I. G. Wool. 1993. The primary structure of rat ribosomal protein L23a. J. Biol. Chem. 268: 2755–2761.
   PubMedGoogle Scholar
• Warner, J. R. 1989. Synthesis of ribosomes in Saccharomyces cerevisiae. Microbiol. Rev. 53: 256–271.
   PubMedGoogle Scholar
• Warner, J. R., G. Mitra, W. F. Schwindinger, M. Studeny, and H. M. Fried. 1985. Saccharomyces cerevisiae coordinates the accumulation of yeast ribosomal proteins by modulating mRNA splicing, translational initiation, and protein turnover. Mol. Cell. Biol. 5: 1512–1521.
   PubMed Web of Science ®Google Scholar
• Weis, K., I. W. Mattaj, and A. I. Lamond. 1995. Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences. Science 268: 1049–1053.
   PubMedGoogle Scholar
• Wente, S. R. 2000. Gatekeepers of the nucleus. Science 288: 1374–1377.
   PubMed Web of Science ®Google Scholar
• Wozniak, R. W., M. P. Rout, and J. D. Aitchison. 1998. Karyopherins and kissing cousins. Trends Cell Biol. 8: 184–188.
   PubMedGoogle Scholar