Critical Residues within the BTB Domain of PLZF and Bcl-6 Modulate Interaction with Corepressors

REFERENCES

• Ahmad, K. F., C. K. Engel, and G. G. Prive. 1998. Crystal structure of the BTB domain from PLZF. Proc. Natl. Acad. Sci. USA 95: 12123–12128.
   PubMed Web of Science ®Google Scholar
• Ball, H. J., A. Melnick, R. Shaknovich, R. A. Kohanski, and J. D. Licht. 1999. The promyelocytic leukemia zinc finger (PLZF) protein binds DNA in a high molecular weight complex associated with cdc2 kinase. Nucleic Acids Res. 27: 4106–4113.
   PubMedGoogle Scholar
• Barna, M., N. Hawe, L. Niswander, and P. P. Pandolfi. 2000. Plzf regulates limb and axial skeletal patterning. Nat. Genet. 25: 166–172.
   PubMed Web of Science ®Google Scholar
• Cattoretti, G., C. C. Chang, K. Cechova, J. Zhang, B. H. Ye, B. Falini, D. C. Louie, K. Offit, R. S. Chaganti, and R. Dalla-Favera. 1995. BCL-6 protein is expressed in germinal-center B cells. Blood 86: 45–53.
   PubMed Web of Science ®Google Scholar
• Chang, C. C., B. H. Ye, R. S. Chaganti, and R. Dalla-Favera. 1996. BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. Proc. Natl. Acad. Sci. USA 93: 6947–6952.
   PubMed Web of Science ®Google Scholar
• Chen, Z., N. J. Brand, A. Chen, S. J. Chen, J. H. Tong, Z. Y. Wang, S. Waxman, and A. Zelent. 1993. Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. EMBO J. 12: 1161–1167.
   PubMed Web of Science ®Google Scholar
• David, G., L. Alland, S. H. Hong, C. W. Wong, R. A. DePinho, and A. Dejean. 1998. Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein. Oncogene 16: 2549–2556.
   PubMed Web of Science ®Google Scholar
• Deltour, S., C. Guerardel, and D. Leprince. 1999. Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B. Proc. Natl. Acad. Sci. USA 96: 14831–14836.
   PubMedGoogle Scholar
• Dent, A. L., A. L. Shaffer, X. Yu, D. Allman, and L. M. Staudt. 1997. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276: 589–592.
   PubMed Web of Science ®Google Scholar
• Dhordain, P., O. Albagli, S. Ansieau, M. H. Koken, C. Deweindt, S. Quief, D. Lantoine, A. Leutz, J. P. Kerckaert, and D. Leprince. 1995. The BTB/POZ domain targets the LAZ3/BCL6 oncoprotein to nuclear dots and mediates homomerisation in vivo. Oncogene 11: 2689–2697.
   PubMed Web of Science ®Google Scholar
• Dhordain, P., O. Albagli, R. J. Lin, S. Ansieau, S. Quief, A. Leutz, J. P. Kerckaert, R. M. Evans, and D. Leprince. 1997. Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein. Proc. Natl. Acad. Sci. USA 94: 10762–10767.
   PubMed Web of Science ®Google Scholar
• Dhordain, P., R. J. Lin, S. Quief, D. Lantoine, J. P. Kerckaert, R. M. Evans, and O. Albagli. 1998. The LAZ3(BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression. Nucleic Acids Res. 26: 4645–4651.
   PubMed Web of Science ®Google Scholar
• Dong, S., J. Zhu, A. Reid, P. Strutt, F. Guidez, H. J. Zhong, Z. Y. Wang, J. Licht, S. Waxman, C. Chomienne et al. 1996. Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein. Proc. Natl. Acad. Sci. USA 93: 3624–3629.
   PubMed Web of Science ®Google Scholar
• Gaidano, G., F. Lo Coco, B. H. Ye, D. Shibata, A. M. Levine, D. M. Knowles, and R. Dalla-Favera. 1994. Rearrangements of the BCL-6 gene in acquired immunodeficiency syndrome-associated non-Hodgkin's lymphoma: association with diffuse large-cell subtype. Blood 84: 397–402.
   PubMed Web of Science ®Google Scholar
• Glass, C. K., and M. G. Rosenfeld. 2000. The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev. 14: 121–141.
   PubMed Web of Science ®Google Scholar
• Grignani, F., S. De Matteis, C. Nervi, L. Tomassoni, V. Gelmetti, M. Cioce, M. Fanelli, M. Ruthardt, F. F. Ferrara, I. Zamir, C. Seiser, M. A. Lazar, S. Minucci, and P. G. Pelicci. 1998. Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia. Nature 391: 815–818.
   PubMed Web of Science ®Google Scholar
• Guerardel, C., S. Deltour, and D. Leprince. 1999. Evolutionary divergence in the broad complex, tramtrack and bric a brac/poxviruses and zinc finger domain from the candidate tumor suppressor gene hypermethylated in cancer. FEBS Lett. 451: 253–256.
   PubMedGoogle Scholar
• Guidez, F., S. Ivins, J. Zhu, M. Soderstrom, S. Waxman, and A. Zelent. 1998. Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia. Blood 91: 2634–2642.
   PubMed Web of Science ®Google Scholar
• He, L. Z., F. Guidez, C. Tribioli, D. Peruzzi, M. Ruthardt, A. Zelent, and P. P. Pandolfi. 1998. Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL. Nat. Genet. 18: 126–135.
   PubMed Web of Science ®Google Scholar
• Hoatlin, M. E., Y. Zhi, H. Ball, K. Silvey, A. Melnick, S. Stone, S. Arai, N. Hawe, G. Owen, A. Zelent, and J. D. Licht. 1999. A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. Blood 94: 3737–3747.
   PubMedGoogle Scholar
• Hong, S. H., G. David, C. W. Wong, A. Dejean, and M. L. Privalsky. 1997. SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia. Proc. Natl. Acad. Sci. USA 94: 9028–9033.
   PubMed Web of Science ®Google Scholar
• Horowitz, H., and C. A. Berg. 1996. The Drosophila pipsqueak gene encodes a nuclear BTB-domain-containing protein required early in oogenesis. Development 122: 1859–1871.
   PubMedGoogle Scholar
• Huynh, K. D., and V. J. Bardwell. 1998. The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT. Oncogene 17: 2473–2484.
   PubMed Web of Science ®Google Scholar
• Huynh, K. D., W. Fischle, E. Verdin, and V. J. Bardwell. 2000. BCoR, a novel corepressor involved in BCL-6 repression. Genes Dev. 14: 1810–1823.
   PubMed Web of Science ®Google Scholar
• Katsani, K. R., M. A. Hajibagheri, and C. P. Verrijzer. 1999. Co-operative DNA binding by GAGA transcription factor requires the conserved BTB/POZ domain and reorganizes promoter topology. EMBO J. 18: 698–708.
   PubMedGoogle Scholar
• Kobayashi, A., H. Yamagiwa, H. Hoshino, A. Muto, K. Sato, M. Morita, N. Hayashi, M. Yamamoto, and K. Igarashi. 2000. A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain. Mol. Cell. Biol. 20: 1733–1746.
   PubMedGoogle Scholar
• Koken, M. H., A. Reid, F. Quignon, M. K. Chelbi-Alix, J. M. Davies, J. H. Kabarowski, J. Zhu, S. Dong, S. Chen, Z. Chen, C. C. Tan, J. Licht, S. Waxman, H. de The, and A. Zelent. 1997. Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies. Proc. Natl. Acad. Sci. USA 94: 10255–10260.
   PubMed Web of Science ®Google Scholar
• Lai, Z. C., and Y. Li. 1999. Tramtrack69 is positively and autonomously required for Drosophila photoreceptor development. Genetics 152: 299–305.
   PubMedGoogle Scholar
• Lander, E. S., L. M. Linton, B. Birren, C. Nusbaum, M. C. Zody, J. Baldwin, K. Devon, K. Dewar, M. Doyle, W. FitzHugh, R. Funke, D. Gage, K. Harris, A. Heaford, J. Howland, L. Kann, J. Lehoczky, R. LeVine, P. McEwan, K. McKernan, J. Meldrim, J. P. Mesirov, C. Miranda, W. Morris, J. Naylor, C. Raymond, M. Rosetti, R. Santos, A. Sheridan, C. Sougnez, N. Stange-Thomann, N. Stojanovic, A. Subramanian, D. Wyman, J. Rogers, J. Sulston, R. Ainscough, S. Beck, D. Bentley, J. Burton, C. Clee, N. Carter, A. Coulson, R. Deadman, P. Deloukas, A. Dunham, I. Dunham, R. Durbin, L. French, D. Grafham, S. Gregory, T. Hubbard, S. Humphray, A. Hunt, M. Jones, C. Lloyd, A. McMurray, L. Matthews, S. Mercer, S. Milne, J. C. Mullikin, A. Mungall, R. Plumb, M. Ross, R. Shownkeen, S. Sims, R. H. Waterston, R. K. Wilson, L. W. Hillier, J. D. McPherson, M. A. Marra, E. R. Mardis, L. A. Fulton, A. T. Chinwalla, K. H. Pepin, W. R. Gish, S. L. Chissoe, M. C. Wendl, K. D. Delehaunty, T. L. Miner, A. Delehaunty, J. B. Kramer, L. L. Cook, R. S. Fulton, D. L. Johnson, P. J. Minx, S. W. Clifton, T. Hawkins, E. Branscomb, P. Predki, P. Richardson, S. Wenning, T. Slezak, N. Doggett, J. F. Cheng, A. Olsen, S. Lucas, C. Elkin, E. Uberbacher, M. Frazier et al. 2001. Initial sequencing and analysis of the human genome. Nature 409: 860–921.
   PubMed Web of Science ®Google Scholar
• Li, J. Y., M. A. English, H. J. Ball, P. L. Yeyati, S. Waxman, and J. D. Licht. 1997. Sequence-specific DNA binding and transcriptional regulation by the promyelocytic leukemia zinc finger protein. J. Biol. Chem. 272: 22447–22455.
   PubMedGoogle Scholar
• Li, X., H. Peng, D. C. Schultz, J. M. Lopez-Guisa, F. J. Rauscher III, and R. Marmorstein. 1999. Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein. Cancer Res. 59: 5275–5282.
   PubMedGoogle Scholar
• Licht, J. D., C. Chomienne, A. Goy, A. Chen, A. A. Scott, D. R. Head, J. L. Michaux, Y. Wu, A. DeBlasio, W. H. Miller, Jr., et al. 1995. Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17). Blood 85: 1083–1094.
   PubMed Web of Science ®Google Scholar
• Licht, J. D., R. Shaknovich, M. A. English, A. Melnick, J. Y. Li, J. C. Reddy, S. Dong, S. J. Chen, A. Zelent, and S. Waxman. 1996. Reduced and altered DNA-binding and transcriptional properties of the PLZF-retinoic acid receptor-alpha chimera generated in t(11;17)-associated acute promyelocytic leukemia. Oncogene 12: 323–336.
   PubMed Web of Science ®Google Scholar
• Lin, R. J., L. Nagy, S. Inoue, W. Shao, W. H. Miller, Jr., and R. M. Evans. 1998. Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature 391: 811–814.
   PubMed Web of Science ®Google Scholar
• Lo Coco, F., B. H. Ye, F. Lista, P. Corradini, K. Offit, D. M. Knowles, R. S. Chaganti, and R. Dalla-Favera. 1994. Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma. Blood 83: 1757–1759.
   PubMed Web of Science ®Google Scholar
• Melnick, A., K. F. Ahmad, S. Arai, A. Polinger, H. Ball, K. L. Borden, G. W. Carlile, G. G. Prive, and J. D. Licht. 2000. In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions. Mol. Cell. Biol. 20: 6550–6567.
   PubMedGoogle Scholar
• Melnick, A. M., J. J. Westendorf, A. Polinger, G. W. Carlile, S. Arai, H. J. Ball, B. Lutterbach, S. W. Hiebert, and J. D. Licht. 2000. The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein. Mol. Cell. Biol. 20: 2075–2086.
   PubMed Web of Science ®Google Scholar
• Muto, A., H. Hoshino, L. Madisen, N. Yanai, M. Obinata, H. Karasuyama, N. Hayashi, H. Nakauchi, M. Yamamoto, M. Groudine, and K. Igarashi. 1998. Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3′ enhancer. EMBO J. 17: 5734–5743.
   PubMed Web of Science ®Google Scholar
• Okabe, S., T. Fukuda, K. Ishibashi, S. Kojima, S. Okada, M. Hatano, M. Ebara, H. Saisho, and T. Tokuhisa. 1998. BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor. Mol. Cell. Biol. 18: 4235–4244.
   PubMedGoogle Scholar
• Peukert, K., P. Staller, A. Schneider, G. Carmichael, F. Hanel, and M. Eilers. 1997. An alternative pathway for gene regulation by Myc. EMBO J. 16: 5672–5686.
   PubMed Web of Science ®Google Scholar
• Prokhortchouk, A., B. Hendrich, H. Jorgensen, A. Ruzov, M. Wilm, G. Georgiev, A. Bird, and E. Prokhortchouk. 2001. The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor. Genes Dev. 15: 1613–1618.
   PubMed Web of Science ®Google Scholar
• Read, D., M. J. Butte, A. F. Dernburg, M. Frasch, and T. B. Kornberg. 2000. Functional studies of the BTB domain in the Drosophila GAGA and Mod(mdg4) proteins. Nucleic Acids Res. 28: 3864–3870.
   PubMedGoogle Scholar
• Rietveld, L. E., E. Caldenhoven, and H. G. Stunnenberg. 2001. Avian erythroleukemia: a model for corepressor function in cancer. Oncogene 20: 3100–3109.
   PubMedGoogle Scholar
• Seyfert, V. L., D. Allman, Y. He, and L. M. Staudt. 1996. Transcriptional repression by the proto-oncogene BCL-6. Oncogene 12: 2331–2342.
   PubMed Web of Science ®Google Scholar
• Shaffer, A. L., X. Yu, Y. He, J. Boldrick, E. P. Chan, and L. M. Staudt. 2000. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity 13: 199–212.
   PubMed Web of Science ®Google Scholar
• Shaknovich, R., P. L. Yeyati, S. Ivins, A. Melnick, C. Lempert, S. Waxman, A. Zelent, and J. D. Licht. 1998. The promyelocytic leukemia zinc finger protein affects myeloid cell growth, differentiation, and apoptosis. Mol. Cell. Biol. 18: 5533–5545.
   PubMedGoogle Scholar
• Staudt, L. M., A. L. Dent, A. L. Shaffer, and X. Yu. 1999. Regulation of lymphocyte cell fate decisions and lymphomagenesis by BCL-6. Int. Rev. Immunol. 18: 381–403.
   PubMedGoogle Scholar
• Usui-Aoki, K., H. Ito, K. Ui-Tei, K. Takahashi, T. Lukacsovich, W. Awano, H. Nakata, Z. F. Piao, E. E. Nilsson, J. Tomida, and D. Yamamoto. 2000. Formation of the male-specific muscle in female Drosophila by ectopic fruitless expression. Nat. Cell Biol. 2: 500–506.
   PubMedGoogle Scholar
• Wen, Y., D. Nguyen, Y. Li, and Z. C. Lai. 2000. The N-terminal BTB/POZ domain and C-terminal sequences are essential for Tramtrack69 to specify cell fate in the developing Drosophila eye. Genetics 156: 195–203.
   PubMedGoogle Scholar
• Wong, C. W., and M. L. Privalsky. 1998. Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6. J. Biol. Chem. 273: 27695–27702.
   PubMed Web of Science ®Google Scholar
• Ye, B. H., F. Lista, F. Lo Coco, D. M. Knowles, K. Offit, R. S. Chaganti, and R. Dalla-Favera. 1993. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. Science 262: 747–750.
   PubMed Web of Science ®Google Scholar
• Yeyati, P. L., R. Shaknovich, S. Boterashvili, J. Li, H. J. Ball, S. Waxman, K. Nason-Burchenal, E. Dmitrovsky, A. Zelent, and J. D. Licht. 1999. Leukemia translocation protein PLZF inhibits cell growth and expressionof cyclin A. Oncogene 18: 925–934.
   PubMed Web of Science ®Google Scholar
• Yoshida, C., F. Tokumasu, K. I. Hohmura, J. Bungert, N. Hayashi, T. Nagasawa, J. D. Engel, M. Yamamoto, K. Takeyasu, and K. Igarashi. 1999. Long range interaction of cis-DNA elements mediated by architectural transcription factor Bach1. Genes Cells 4: 643–655.
   PubMed Web of Science ®Google Scholar
• Zollman, S., D. Godt, G. G. Prive, J. L. Couderc, and F. A. Laski. 1994. The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. Proc. Natl. Acad. Sci. USA 91: 10717–10721.
   PubMed Web of Science ®Google Scholar