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Mammalian Genetic Models with Minimal or Complex Phenotypes

Purα Is Essential for Postnatal Brain Development and Developmentally Coupled Cellular Proliferation As Revealed by Genetic Inactivation in the Mouse

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Pages 6857-6875 | Received 23 Jul 2002, Accepted 10 Apr 2003, Published online: 27 Mar 2023

REFERENCES

  • Barr, S. M., and E. M. Johnson. 2001. Ras-induced colony formation and anchorage-independent growth inhibited by elevated expression of Puralpha in NIH3T3 cells. J. Cell. Biochem. 81: 621–638.
  • Bergemann, A. D., and E. M. Johnson. 1992. The HeLa Pur factor binds single-stranded DNA at a specific element conserved in gene flanking regions and origins of DNA replication. Mol. Cell. Biol. 12: 1257–1265.
  • Bergemann, A. D., Z. W. Ma, and E. M. Johnson. 1992. Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein. Mol. Cell. Biol. 12: 5673–5682.
  • Blow, J. J., and B. Hodgson. 2002. Replication licensing-origin licensing: defining the proliferative state? Trends Cell Biol. 12: 72–78.
  • Chang, C.-F., G. Gallia, V. Muralidharan, N. N. Chen, P. Zoltick, E. Johnson, and K. Khalili. 1996. Evidence that replication of human neurotropic JC virus DNA in glial cells is regulated by the sequence-specific single-stranded DNA-binding protein Pur α. J. Virol. 70: 4150–4156.
  • Chen, N. N., and K. Khalili. 1995. Transcriptional regulation of human JC polyomavirus promoters by cellular proteins YB-1 and Pur α in glial cells. J. Virol. 69: 5843–5848.
  • Chen, N. N., C.-F. Chang, G. L. Gallia, D. A Kerr, E. M. Johnson, C. P. Krachmarov, S. M. Barr, R. J. Frisque, B. Bollag, and K. Khalili. 1995. Cooperative action of cellular proteins YB-1 and Purα with the tumor antigen of the human JC polymovirus determines their interaction with the viral lytic control element. Proc. Natl. Acad. Sci. USA 92: 1087–1091.
  • Chepenik, L. G., A. P. Tretiakova, C. P. Krachmarov, E. M. Johnson, and K. Khalili. 1998. The single-stranded DNA binding protein, Pur-alpha, binds HIV-1 TAR RNA and activates HIV-1 transcription. Gene 210: 37–44.
  • Daniel, D. C., M. J. Wortman, R. J. Schiller, H. Liu, L. Gan, J. S. Mellen, C. F. Chang, G. L. Gallia, J. Rappaport, K. Khalili, and E. M. Johnson. 2001. Coordinate effects of human immunodeficiency virus type 1 protein Tat and cellular protein Puralpha on DNA replication initiated at the JC virus origin. J. Gen. Virol. 82: 1543–1553.
  • Darbinian, N., G. L. Gallia, M. Kundu, N. Shcherbik, A. Tretiakova, A. Giordano, and K. Khalili. 1999. Association of Purα and E2F-1 suppresses transcriptional activity of E2F-1. Oncogene 18: 6398–6402.
  • Darbinian, N., G. L. Gallia, J. King, L. Del Valle, E. M. Johnson, and K. Khalili. 2001. Growth inhibition of glioblastoma cells by human Pur(alpha). J. Cell. Physiol. 189: 334–340.
  • Du, Q., A. E. Tomkinson, and P. D. Gardner. 1997. Transcriptional regulation of neuronal nicotinic acetylcholine receptor genes. A possible role for the DNA-binding protein, Purα. J. Biol. Chem. 272: 14990–14995.
  • Edwards, M. C., A. V. Tutter, C. Cvetic, C. H. Gilbert, T. A. Prokhorova, and J. C. Walter. 2002. MCM2-7 complexes bind chromatin in a distributed pattern surrounding the origin recognition complex in Xenopus egg extracts. J. Biol. Chem. 277: 33049–33057.
  • Freeman, A., L. S. Morris, A. D. Mills, K. Stoeber, R. A. Laskey, G. H. Williams, and N. Coleman. 1999. Minichromosome maintenance proteins as biological markers of dysplasia and malignancy. Clin. Cancer Res. 5: 2121–2132.
  • Gallia, G. L., M. Safak, and K. Khalili. 1998. Interaction of the single-stranded DNA-binding protein Purα with human polyomavirus JC virus early protein T-antigen. J. Biol. Chem. 273: 32662–32669.
  • Gallia, G. L., N. Darbinian, A. Tretiakova, S. A. Ansari, J. Rappaport, J. Brady, M. J. Wortman, E. M. Johnson, and K. Khalili. 1999. RNA-dependent interaction between the cellular protein Purα and the HIV-1 Tat protein. Proc. Natl. Acad. Sci. USA 96: 11572–11577.
  • Gallia, G. L., E. M. Johnson, and K. Khalili. 2000. Purα: a multifunctional single-stranded DNA and RNA-binding protein. Nucleic Acids Res. 28: 3197–3205.
  • Gallia, G. L., N. Darbinian, N. Jaffe, and K. Khalili. 2001. Single-stranded nucleic acid-binding protein, Pur alpha, interacts with RNA homologous to 18S ribosomal RNA and inhibits translation in vitro J. Cell. Biochem. 83: 355–363.
  • Gilmore, E. C., T. Ohshima, A. M. Goffinet, A. B. Kulkarni, and K. Herrup. 1998. Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex. J. Neurosci. 18: 6370–6377.
  • Goldowitz, D., and K. Hamre. 1998. The cells and molecules that make a cerebellum. Trends Neurosci. 21: 375–382.
  • Haas, S., J. Gordon, and K. Khalili. 1993. A developmentally regulated DNA-binding protein from mouse brain stimulates myelin basic protein gene expression. Mol. Cell. Biol. 13: 3103–3112.
  • Haas, S., P. Thatikunta, A. Steplewski, E. Johnson, K. Khalili, and S. Amini. 1995. A 39 kD DNA-binding protein from mouse brain stimulates transcription of myelin basic protein gene in oligodendrocytic cells. J. Cell Biol. 130: 1171–1179.
  • Itoh, H., M. J. Wortman, M. Kanovsky, R. R. Uson, R. E. Gordon, N. Alfano, and E. M. Johnson. 1998. Alterations in Pura levels and intracellular localization in the CV-1 cell cycle. Cell Growth Differ. 9: 651–665.
  • Johnson, E. M. 2003. The Pur protein family: clues to function from recent studies on cancer and AIDS. Anticancer Res. 23: 2093–2100.
  • Johnson, E. M., P.-L. Chen., C. P. Krachmarov, S. Barr, Z. W. Ma, and W.-H. Lee. 1995. Association of human Purα with the retinoblastoma protein, Rb, regulates binding to the Purα single-stranded DNA recognition element. J. Biol. Chem. 270: 24352–24360.
  • Johnson, E. M., M. J. Wortman, K. Khalili, and D. C. Daniel. 2002. Mechanisms of regulation of replication of HIV-1 and JC virus in the CNS provide a model for regulation of cellular gene expression by sequence-specific single-stranded DNA- and RNA-binding protein Pur-alpha. J. Neurovirol. 8(Suppl. 1): 26. (Abstract.)
  • Kelm, R. J., Jr., P. K. Elder, A. R. Strauch, and M. J. Getz. 1997. Sequence of cDNAs encoding components of vascular actin single-stranded DNA-binding factor 2 establish identity to Purα and Purβ. J. Biol. Chem. 272: 26727–26733.
  • Kelm, R. J., Jr., J. G. Cogan, P. K. Elder, A. R. Strauch, and M. J. Getz. 1999. Molecular interactions between single-stranded DNA-binding proteins associated with an essential MCAT element in the mouse smooth muscle alpha-actin promoter. J. Biol. Chem. 274: 14238–14245.
  • Kobayashi, S., K. Agui, S. Kamo, Y. Li, and K. Anzai. 2000. Neural BC1 RNA associates with Purα, a single-stranded DNA and RNA binding protein, which is involved in the transcription of the BC1 RNA gene. Biochem. Biophys. Res. Commun. 277: 341–347.
  • Krachmarov, C. P., L. G. Chepenik, S. M. Barr-Vagell, K. Khalili, and E. M. Johnson. 1996. Activation of the JC virus Tat-responsive transcriptional control element by association of the Tat protein of human immunodeficiency virus 1 with cellular protein, Purα. Proc. Natl. Acad. Sci. USA 93: 14112–14117.
  • Lezon-Geyda, K., V. Najfeld, and E. M. Johnson. 2001. Deletions of PURA, at 5q31, and PURB, at 7p13, in myelodysplastic syndrome and progression to acute myelogenous leukemia. Leukemia 15: 954–962.
  • Liu, H., and E. M. Johnson. 2002. Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation. Nucleic Acids Res. 30: 2417–2426.
  • Ma, Z. W., A. D. Bergemann, and E. M. Johnson. 1994. Conservation in human and mouse Purα of a motif common to several proteins involved in initiation of DNA replication. Gene 149: 311–314.
  • Ma, Z. W., T. Pejovic, N. Najfeld, D. C. Ward, and E. M. Johnson. 1995. Localization of PURA, the gene encoding the sequence-specific single-stranded-DNA-binding protein Pur alpha, to chromosome band 5q31. Cytogenet. Cell Genet. 71: 64–67.
  • Mallardo, M., A. Deitinghoff, J. Muller, B. Goetze, P. Macchi, C. Peters, and M. A. Kiebler. 2003. Isolation and characterization of Staufen-containing ribonucleoprotein particles from rat brain. Proc. Natl. Acad. Sci. USA 100: 2100–2105.
  • Ohashi, S., K. Koike, A. Omori, S. Ichinose, S. Ohara, S., Kobayashi, T. A. Sato, and K. Anzai. 2002. Identification of mRNP complexes containing pur alpha, mStaufen, fragile X protein and myosin Va, and their association with rough endoplasmic reticulum equipped with a kinesin motor. J. Biol. Chem. 277: 37804–37810.
  • Qi, Z., D. Tang, X. Zhu, D. J. Fujita, and J. H. Wang. 1998. Association of neurofilament proteins with neuronal Cdk5 activator. J. Biol. Chem. 273: 2329–2335.
  • Qin, L., G. S. Marrs, R. McKim, and M. E. Dailey. 2001. Hippocampal mossy fibers induce assembly and clustering of PSD95-containing postsynaptic densities independent of glutamate receptor activation. J. Comp. Neurol. 440: 284–298.
  • Romanowski, P., M. A. Madine, and R. A. Laskey. 1996. XMCM7, a novel member of the Xenopus MCM family, interacts with XMCM3 and colocalizes with it throughout replication. Proc. Natl. Acad. Sci. USA 93: 10189–10194.
  • Ruppert, C., D. Goldowitz, and W. Wille. 1986. Proto-oncogene c-myc is expressed in cerebellar neurons at different developmental stages. EMBO J. 5: 1897–1901.
  • Sadakata, T., C. Kuo, H. Ichikawa, E. Nishikawa, S. Y. Niu, E. Kumamaru, and N. Miki. 2000. Puralpha, a single-stranded DNA binding protein, suppresses the enhancer activity of cAMP response element. Brain Res. Mol. Brain Res. 77: 47–54.
  • Safak, M., G. Gallia, and K. Khalili. 1999. Reciprocal interaction between two cellular proteins, Purα and YB-1, modulates transcriptional activity of human JCVCY in glial cells. Mol. Cell. Biol. 19: 2712–2723.
  • Schaarschmidt, D., E. M. Ladenburger, C. Keller, and R. Knippers. 2002. Human MCM proteins at a replication origin during the G1 to S phase transition. Nucleic Acids Res. 30: 4176–4185.
  • Stacey, D. W., M. Hitomi, M. Kanovsky, L. Gan, and E. M. Johnson. 1999. Cell cycle arrest and morphological alterations following microinjection of NIH3T3 cells with Pur alpha. Oncogene 18: 4254–4261.
  • Sun, D., C. L. Leung, and R. K. H. Leim. 1996. Phosphorylation of the high molecular weight neurofilament protein (NF-H) by Cdk5 and p35. J. Biol. Chem. 271: 14245–14251.
  • Tretiakova, A., G. L. Gallia, N. Shcherbik, B. A. Jameson, E. M. Johnson, S. Amini, and K. Khalili. 1998. Association of Purα with RNAs homologous to 7 SL determines its binding ability to the MBP promoter DNA sequence. J. Biol. Chem. 273: 22241–22247.
  • Tretiakova, A., A. Steplewski, E. M. Johnson, K. Khalili, and S. Amini. 1999. Regulation of myelin basic protein gene transcription by Sp1 and Purα; evidence for association of Sp1 and Purα in brain. J. Cell. Physiol. 181: 160–168.
  • Tretiakova, A., J. Otte, S. E. Croul, J. H. Kim, E. M. Johnson, S. Amini, and K. Khalili. 1999. Association of JC virus large T antigen with myelin basic protein transcription factor (MEF-1/Purα in hypomyelinated brains of mice transgenically expressing T antigen. J. Virol. 73: 6076–6084.
  • Tye, B. K. 1999. MCM proteins in DNA replication. Annu. Rev. Biochem. 68: 649–686.
  • Wenzel, H. J., C. A. Robbins, L. H. Tsai, and P. A. Schwartzkroin. 2001. Abnormal morphological and functional organization of the hippocampus in a p35 mutant model of cortical dysplasia associated with spontaneous seizures. J. Neurosci. 21: 983–998.
  • Zambrano, N., S. De Renzis, G. Minopoli, R. Faraonio, V. Donini, A. Scaloni, F. Cimino, and T. Russo. 1997. DNA-binding protein Purα and transcription factor YY1 function as transcription activators of the neuron-specific FE65 gene promoter. Biochem. J. 328: 293–300.

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