154
Views
102
CrossRef citations to date
0
Altmetric
Cell Growth and Development

NAD+-Dependent Deacetylase Hst1p Controls Biosynthesis and Cellular NAD+ Levels in Saccharomyces cerevisiae

, , , &
Pages 7044-7054 | Received 16 May 2003, Accepted 07 Jul 2003, Published online: 27 Mar 2023

REFERENCES

  • Anderson, R. M., K. J. Bitterman, J. G. Wood, O. Medvedik, H. Cohen, S. S. Lin, J. K. Manchester, J. I. Gordon, and D. A. Sinclair. 2002. Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. J. Biol. Chem. 277: 18881–18890.
  • Anderson, R. M., K. J. Bitterman, J. G. Wood, O. Medvedik, and D. A. Sinclair. 2003. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 423: 181–185.
  • Bedalov, A., T. Gatbonton, W. P. Irvine, D. E. Gottschling, and J. A. Simon. 2001. Identification of a small molecule inhibitor of Sir2p. Proc. Natl. Acad. Sci. USA 98: 15113–15118.
  • Bernstein, B. E., J. K. Tong, and S. L. Schreiber. 2000. Genomewide studies of histone deacetylase function in yeast. Proc. Natl. Acad. Sci. USA 97: 13708–13713.
  • Bitterman, K. J., R. M. Anderson, H. Y. Cohen, M. Latorre-Esteves, and D. A. Sinclair. 2002. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J. Biol. Chem. 277: 45099–45107.
  • Brachmann, C. B., A. Davies, G. J. Cost, E. Caputo, J. Li, P. Hieter, and J. D. Boeke. 1998. Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 14: 115–132.
  • Carson, D. A., S. Seto, and D. B. Wasson. 1987. Pyridine nucleotide cycling and poly(ADP-ribose) synthesis in resting human lymphocytes. J. Immunol. 138: 1904–1907.
  • Chinnadurai, G. 2002. CtBP, an unconventional transcriptional corepressor in development and oncogenesis. Mol. Cell 9: 213–224.
  • Dudley, A. M., C. Rougeulle, F. Winston, and A. T. Dudley. 1999. The Spt components of SAGA facilitate TBP binding to a promoter at a post-activator-binding step in vivo. Genes Dev. 13: 2940–2945.
  • Gottlieb, S., and R. E. Esposito. 1989. A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA. Cell 56: 771–776.
  • Ha, H. C., and S. H. Snyder. 1999. Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proc. Natl. Acad. Sci. USA 96: 13978–13982.
  • Hageman, G. J., and R. H. Stierum. 2001. Niacin, poly(ADP-ribose) polymerase-1 and genomic stability. Mutat. Res. 475: 45–56.
  • Henderson, L. M. 1983. Niacin. Annu. Rev. Nutrit. 3: 289–307.
  • Herceg, Z., and Z. Q. Wang. 1999. Failure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis. Mol. Cell. Biol. 19: 5124–5133.
  • Herceg, Z., and Z. Q. Wang. 2001. Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death. Mutat. Res. 477: 97–110.
  • Imai, S., C. M. Armstrong, M. Kaeberlein, and L. Guarente. 2000. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403: 795–800.
  • Jacobson, E. L., and M. K. Jacobson. 1997. Tissue NAD as a biochemical measure of niacin status in humans. Methods Enzymol. 280: 221–230.
  • Koubova, J., and L. Guarente. 2003. How does calorie restriction work? Genes Dev. 17: 313–321.
  • Kumar, V., J. E. Carlson, K. A. Ohgi, T. A. Edwards, D. W. Rose, C. R. Escalante, M. G. Rosenfeld, and A. K. Aggarwal. 2002. Transcription corepressor CtBP is an NAD+-regulated dehydrogenase. Mol. Cell 10: 857–869.
  • Landry, J., A. Sutton, S. T. Tafrov, R. C. Heller, J. Stebbins, L. Pillus, and R. Sternglanz. 2000. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc. Natl. Acad. Sci. USA 97: 5807–5811.
  • Lin, S. J., P. A. Defossez, and L. Guarente. 2000. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289: 2126–2128.
  • Lin, S. J., and L. Guarente. 2003. Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. Curr. Opin. Cell Biol. 15: 241–246.
  • Llorente, B. 2000. Transcriptional regulation of the Saccharomyces cerevisiae DAL5 gene family and identification of the high affinity nicotinic acid permease TNA1. FEBS Lett. 475: 237–241.
  • Luo, J., A. Y. Nikolaev, S. Imai, D. Chen, F. Su, A. Shiloh, L. Guarente, and W. Gu. 2001. Negative control of p53 by Sir2α promotes cell survival under stress. Cell 107: 137–148.
  • Moazed, D. 2001. Enzymatic activities of Sir2 and chromatin silencing. Curr. Opin. Cell Biol. 13: 232–238.
  • Natarajan, K., M. R. Meyer, B. M. Jackson, D. Slade, C. Roberts, A. G. Hinnebusch, and M. J. Marton. 2001. Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast. Mol. Cell. Biol. 21: 4347–4368.
  • Panozzo, C., M. Nawara, C. Suski, R. Kucharczyka, M. Skoneczny, A. M. Becam, J. Rytka, and C. J. Herbert. 2002. Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae. FEBS Lett. 517: 97–102.
  • Passador, L., and W. Iglewski. 1994. ADP-ribosylating toxins. Methods Enzymol. 235: 617–631.
  • Rosenberg, M. I., and S. M. Parkhurst. 2002. Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination. Cell 109: 447–458.
  • Rusche, L. N., and J. Rine. 2001. Conversion of a gene-specific repressor to a regional silencer. Genes Dev. 15: 955–967.
  • Rutter, J., M. Reick, L. C. Wu, and S. L. McKnight. 2001. Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. Science 293: 510–514.
  • Sandmeier, J. J., I. Celic, J. D. Boeke, and J. S. Smith. 2002. Telomeric and rDNA silencing in Saccharomyces cerevisiae are dependent on a nuclear NAD+ salvage pathway. Genetics 160: 877–889.
  • Sauve, A. A., I. Celic, J. Avalos, H. Deng, J. D. Boeke, and V. L. Schramm. 2001. Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions. Biochemistry 40: 15456–15463.
  • Sherman, F. 1991. Getting started with yeast. Methods Enzymol. 194: 3–21.
  • Sies, H. 1982. Metabolic compartmentation. Academic Press, London, England.
  • Sinclair, D. A., and L. Guarente. 1997. Extrachromosomal rDNA circles—a cause of aging in yeast. Cell 91: 1033–1042.
  • Smith, J. S., J. Avalos, I. Celic, S. Muhammad, C. Wolberger, and J. D. Boeke. 2002. SIR2 family of NAD+-dependent protein deacetylases. Methods Enzymol. 353: 282–300.
  • Smith, J. S., and J. D. Boeke. 1997. An unusual form of transcriptional silencing in yeast ribosomal DNA. Genes Dev. 11: 241–254.
  • Smith, J. S., C. B. Brachmann, I. Celic, M. A. Kenna, S. Muhammad, V. J. Starai, J. L. Avalos, J. C. Escalante-Semerena, C. Grubmeyer, C. Wolberger, and J. D. Boeke. 2000. A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc. Natl. Acad. Sci. USA 97: 6658–6663.
  • Sutton, A., R. C. Heller, J. Landry, J. S. Choy, A. Sirko, and R. Sternglanz. 2001. A novel form of transcriptional silencing by Sum1-1 requires Hst1 and the origin recognition complex. Mol. Cell. Biol. 21: 3514–3522.
  • Tanner, K. G., J. Landry, R. Sternglanz, and J. M. Denu. 2000. Silent information regulator 2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose. Proc. Natl. Acad. Sci. USA 97: 14178–14182.
  • Tanny, J. C., and D. Moazed. 2001. Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: evidence for acetyl transfer from substrate to an NAD breakdown product. Proc. Natl. Acad. Sci. USA 98: 415–420.
  • Tissenbaum, H. A., and L. Guarente. 2001. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410: 227–230.
  • Vaziri, H., S. K. Dessain, E. Ng Eaton, S. I. Imai, R. A. Frye, T. K. Pandita, L. Guarente, and R. A. Weinberg. 2001. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107: 149–159.
  • Vershon, A. K., and M. Pierce. 2000. Transcriptional regulation of meiosis in yeast. Curr. Opin. Cell Biol. 12: 334–339.
  • Voet, D., and J. G. Voet. 1995. Biochemistry, p. 334–337. John Wiley & Sons, New York, N.Y.
  • Vogelauer, M., J. Wu, N. Suka, and M. Grunstein. 2000. Global histone acetylation and deacetylation in yeast. Nature 408: 495–498.
  • Wilson, W. A., and P. J. Roach. 2002. Nutrient-regulated protein kinases in budding yeast. Cell 111: 155–158.
  • Xie, J., M. Pierce, V. Gailus-Durner, M. Wagner, E. Winter, and A. K. Vershon. 1999. Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. EMBO J. 18: 6448–6454.
  • Zhang, Q., D. W. Piston, and R. H. Goodman. 2002. Regulation of corepressor function by nuclear NADH. Science 295: 1895–1897.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.