49
Views
45
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Gene Expression Analysis of Tumor Spheroids Reveals a Role for Suppressed DNA Mismatch Repair in Multicellular Resistance to Alkylating Agents

, , , &
Pages 6837-6849 | Received 10 Mar 2004, Accepted 12 Apr 2004, Published online: 27 Mar 2023

REFERENCES

  • Borst, P. 1991. Genetic mechanisms of drug resistance. Rev. Oncol. 4:87–105.
  • Bradley, G., Juranka P. F., and Ling V.. 1988. Mechanisms of multidrug resistance. Biochem. Biophys. Acta 948:87–128.
  • Branch, P., Aquilina G., Bignami M., and Karran P.. 1993. Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage. Nature 362:652–654.
  • Desoize, B., and Jardillier J.. 2000. Multicellular resistance: a paradigm for clinical resistance? Crit. Rev. Oncol. Hematol. 36:193–207.
  • Drummond, J. T., Anthoney A., Brown R., and Modrich P.. 1996. Cisplatin and adriamycin resistance are associated with MutLα and mismatch repair deficiency in an ovarian tumor cell line. J. Biol. Chem. 271:19645–19648.
  • Fan, D. 1994. Reversal of multidrug resistance, p. 93–125. In Kellen J. A. (ed.), Reversal of multidrug resistance in cancer. CRC Press, Boca Raton, Fla.
  • Francia, G., Mitchell S. D., Moss S. E., Hanby A. M., Marshall J. F., and Hart I. R.. 1996. Identification by differential display of annexin-VI, a gene differentially expressed during melanoma progression. Cancer Res. 56:3855–3858.
  • Frankel, A., Man S., Elliott P., Adams J., and Kerbel R. S.. 2000. Lack of multicellular drug resistance observed in human ovarian and prostate carcinoma treated with the proteasome inhibitor PS-341. Clin. Cancer Res. 6:3719–3728.
  • Fritzell, J. A., Narayanan L., Baker S. M., Bronner C. E., Andrew S. E., Prolla T. A., Bradley A., Jirik F. R., Liskay R. M., and Glazer P. M.. 1997. Role of DNA mismatch repair in the cytotoxicity of ionizing radiation. Cancer Res. 57:5143–5147.
  • Graham, C. H., Kobayashi H., Stankiewicz K. S., Man S., Kapitain S. J., and Kerbel R. S.. 1994. Rapid acquisition of multicellular drug resistance after a single transient exposure of mammary tumor cells to alkylating agents. J. Natl. Cancer Inst. 86:975–982.
  • Green, S. K., Francia G., Isidoro C., and Kerbel R. S.. 2004. Anti-adhesive antibodies targeting e-cadherin sensitize multicellular tumor spheroids to chemotherapy in vitro. Mol. Cancer Ther. 3:149–159.
  • Green, S. K., Frankel A., and Kerbel R. S.. 1999. Adhesion-dependent multicellular drug resistance. Anti-Cancer Drug Design 14:153–168.
  • Houghton, P. J., and Kaye S. B.. 1994. Multidrug resistance is not an important factor in therapeutic outcome in human malignancies. J. NIH Res. 6:55.
  • Jain, R. K. 1989. Delivery of novel therapeutic agents in tumors: physiological barriers and strategies. J. Natl. Cancer Inst. 81:570–576.
  • Jeltsch, M., Kaipainen a., Joukov V., Meng X., Lakso M., Rauvala H., Swartz M., Fukumura D., Jain R. K., and Alitalo K.. 1997. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science 276:1423–1425.
  • Kartner, N., Riordan J. R., and Ling V.. 1983. Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines. Science 221:1285–1288.
  • Kerbel, R. S., Rak J., Kobayashi H., Man M. S., St. Croix B., and Graham C. H.. 1994. Multicellular resistance: a new paradigm to explain aspects of acquired drug resistance of solid tumors. Cold Spring Harbor Symp. Quant. Biol. 59:661–672.
  • Kobayashi, H., Man S., Kapitain S. J., Teicher B. A., and Kerbel R. S.. 1993. Acquired multicellular-mediated resistance to alkylating agents in cancer. Proc. Natl. Acad. Sci. USA 90:3294–3298.
  • Lal, A., Peters H., St Croix B., Harpoon Z. A., Dewhirst M. W., Strausberg R. L., Kaanders J. H., van der Kogel A. J., and Riggins G. J.. 2001. Transcriptional response to hypoxia in human tumors. J. Natl. Cancer Inst. 93:1337–1343.
  • Liang, P., and Pardee A. B.. 1992. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 257:967–971.
  • Mansbridge, J. N., Ausserer W. A., Knapp M. A., and Sutherland R. M.. 1994. Adaptation of EGF receptor signal transduction to three-dimensional culture conditions: changes in surface receptor expression and protein tyrosine phosphorylation. J. Cell Physiol. 161:374–382.
  • Martin, S. J., and Green D. R.. 1994. Apoptosis as a goal of cancer therapy. Curr. Opin. Cell Biol. 6:616–621.
  • Mihaylova, V. T., Bindra R. S., Yuan J., Campisi D., Narayanan L., Jensen R., Giordano F., Johnson R. S., Rockwell S., and Glazer P. M.. 2003. Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. Mol. Cell. Biol. 23:3265–3273.
  • Morin, P. J., Downs J. A., Snodgrass A. M., and Gilmore T. D.. 1995. Genetic analysis of growth inhibition by GAL4-L κ B-α in Saccharomyces cerevisiae. Cell Growth Differ. 6:789–798.
  • Murphy, B. J., Laderoute K. R., Vreman H. J., Grant T. D., Gill N. S., Stevenson D. K., and Sutherland R. M.. 1993. Enhancement of heme oxygenase expression and activity in A431 squamous carcinoma multicellular tumor spheroids. Cancer Res. 53:2700–2703.
  • Nicolaides, N. C., Kinzler K. W., and Vogelstein B.. 1995. Analysis of the 5′ region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene. Genomics 29:329–334.
  • Nicolaides, N. C., Littman S. J., Modrich P., Kinzler K. W., and Vogelstein B.. 1998. A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype. Mol. Cell. Biol. 18:1635–1641.
  • Nicolaides, N. C., Papadopoulos N., Liu B., Wei Y. F., Carter K. C., Ruben S. M., Rosen C. A., Haseltine W. A., Fleischmann R. D., and Fraser C. M.. 1994. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature 371:75–80.
  • Olive, P. L., and Durand R. E.. 1994. Drug and radiation resistance in spheroids: cell contact and kinetics. Cancer Metastasis Rev. 13:121–138.
  • Phillips, R. M., de la Cruz A., Traver R. D., and Gibson N. W.. 1994. Increased activity and expression of NAD(P)H: quinone acceptor oxidoreductase in confluent cell cultures and within multicellular spheroids. Cancer Res. 54:3766–3771.
  • Prolla, T. A., Baker S. M., Harris A. C., Tsao J. L., Yao X., Bronner C. E., Zheng B., Gordon M., Reneker J., Arnheim N., Shibata D., Bradley A., and Liskay R. M.. 1998. Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Nat. Genet. 18:276–279.
  • Sakata, K., Kwok T. T., Gordon G. R., Waleh N. S., and Sutherland R. M.. 1994. Resistance to verapamil sensitization of multidrug resistant cells grown as multicellular spheroids. Int. J. Cancer 59:282–286.
  • St. Croix, B., Florenes V. A., Rak J. W., Flanagan M., Bhattacharya N., Slingerland J. M., and Kerbel R. S.. 1996. Impact of the cyclin dependent kinase inhibitor p27Kip1 on adhesion-dependent resistance of tumor cells to anticancer agents. Nat. Med. 2:1204–1210.
  • St. Croix, B., and Kerbel R. S.. 1997. Cell adhesion and drug resistance in cancer. Curr. Opin. Cell Biol. 9:549–556.
  • St. Croix, B., Rak J. W., Kapitain S., Sheehan C., Graham C. H., and Kerbel R. S.. 1996. Reversal by hyaluronidase of adhesion-dependent multicellular drug resistance in mammary carcinoma cells. J. Natl. Cancer Inst. 88:1285–1296.
  • St. Croix, B., Sheehan C., Rak J. W., Florenes V. A., Slingerland J. M., and Kerbel R. S.. 1998. E-cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27KIP1. J. Cell Biol. 142:557–571.
  • Sutherland, R. M. 1988. Cell and environment interactions in tumor microregions: the multicell spheroid model. Science 240:177–184.
  • Teicher, B. A., Herman T. S., Holden S. A., Wang Y., Pfeffer M. R., Crawford J. W., and Frei III E.. 1990. Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo. Science 247:1457–1461.
  • Tunggal, J. K., Melo T., Ballinger J. R., and Tannock I. F.. 2000. The influence of expression of P-glycoprotein on the penetration of anticancer drugs through multicellular layers. Int. J. Cancer 86:101–107.
  • Waleh, N. S., Gallo J., Grant T. D., Murphy B. J., Kramer R. H., and Sutherland R. M.. 1994. Selective down-regulation of integrin receptors in spheroids of squamous cell carcinoma. Cancer Res. 54:838–843.
  • Wartenberg, M., Fischer K., Hescheler J., and Sauer H.. 2000. Redox regulation of P-glycoprotein-mediated multidrug resistance in multicellular prostate tumor spheroids. Int. J. Cancer 85:267–274.
  • Wood, R. D., Mitchell M., Sgouros J., and Lindahl T.. 2001. Human DNA repair genes. Science 291:1284–1289.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.