Nuclear Speckle-Associated Protein Pnn/DRS Binds to the Transcriptional Corepressor CtBP and Relieves CtBP- Mediated Repression of the E-Cadherin Gene

REFERENCES

• Barnes, C. J., Vadlamudi R. K., Mishra S. K., Jacobson R. H., Li F., and Kumar R.. 2003. Functional inactivation of a transcriptional corepressor by a signaling kinase. Nat. Struct. Biol. 10:622–628.
   PubMedGoogle Scholar
• Bellavite, P., Bazzoni F., Cassatella M. A., Hunter K. J., and Bannister J. V.. 1990. Isolation and characterization of a cDNA clone for a novel serine-rich neutrophil protein. Biochem. Biophys. Res. Commun. 170:915–922.
   PubMedGoogle Scholar
• Boyd, J. M., Subramanian T., Schaeper U., La Regina M., Bayley S., and Chinnadurai G.. 1993. A region in the C terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis, and metastasis. EMBO J. 12:469–478.
   PubMed Web of Science ®Google Scholar
• Brandner, J. M., Reidenbach S., and Franke W. W.. 1997. Evidence that “pinin,” reportedly a differentiation-specific desmosomal protein, is actually a widespread nuclear protein. Differentiation 62:119–127.
   PubMedGoogle Scholar
• Burke, L. J., and Bahianmad A.. 2000. Corepressors 2000. FASEB J. 14:1876–1888.
   PubMed Web of Science ®Google Scholar
• Caceres, J. F., Misteli T., Screaton G. R., Spector D. L., and Krainer A. R.. 1997. Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity. J. Cell Biol. 138:225–238.
   PubMed Web of Science ®Google Scholar
• Chinnadurai, G. 2002. CtBP, an unconventional transcriptional corepressor in development and oncogenesis. Mol. Cell 9:213–224.
   PubMed Web of Science ®Google Scholar
• Comijn, J., Berx G., Vermassen P., Verschueren K., van Grunsven L., Bruyneel E., Mareel M., Huylebroeck D., and van Roy F.. 2001. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol. Cell 7:1267–1278.
   PubMed Web of Science ®Google Scholar
• Dellaire, G., Makarov E. M., Cowger J. J., Longman D., Sutherland H. G., Luhrmann R., Torchia J., and Bickmore W. A.. 2002. Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes. Mol. Cell. Biol. 22:5141–5156.
   PubMed Web of Science ®Google Scholar
• Frisch, S. M. 1994. E1a induces the expression of epithelial characteristics. J. Cell Biol. 127:1085–1096.
   PubMedGoogle Scholar
• Giroldi, L. A., Bringuier P. P., de Weijert M., Jansen C., van Bokhoven A., and Schalken J. A.. 1997. Role of E boxes in the repression of E-cadherin expression. Biochem. Biophys. Res. Commun. 241:453–458.
   PubMed Web of Science ®Google Scholar
• Goldstrohm, A. C., Albrecht T. R., Sune C., Bedford M. T., and Garcia-Blanco M. A.. 2001. The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1. Mol. Cell. Biol. 21:7617–7628.
   PubMed Web of Science ®Google Scholar
• Goldstrohm, A. C., Greenleaf A. L., and Garcia-Blanco M. A.. 2001. Co-transcriptional splicing of pre-messenger RNAs: considerations for the mechanism of alternative splicing. Gene 277:31–47.
   PubMed Web of Science ®Google Scholar
• Graff, J. R., Gabrielson E., Fujii H., Baylin S. B., and Herman J. G.. 2000. Methylation patterns of the E-cadherin 5′ CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression. J. Biol. Chem. 275:2727–2732.
   PubMed Web of Science ®Google Scholar
• Grooteclaes, M., Deveraux Q., Hildebrand J., Zhang Q., Goodman R. H., and Frisch S. M.. 2003. C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs. Proc. Natl. Acad. Sci. USA 100:4568–4573.
   PubMed Web of Science ®Google Scholar
• Grooteclaes, M. L., and Frisch S. M.. 2000. Evidence for a function of CtBP in epithelial gene regulation and anoikis. Oncogene 19:3823–3828.
   PubMed Web of Science ®Google Scholar
• Hateboer, G., Gennissen A., Ramos Y. F., Kerkhoven R. M., Sonntag-Buck V., Stunnenberg H. G., and Bernards R.. 1995. BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation. EMBO J. 14:3159–3169.
   PubMed Web of Science ®Google Scholar
• Hennig, G., Behrens J., Truss M., Frisch S., Reichmann E., and Birchmeier W.. 1995. Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo. Oncogene 11:475–484.
   PubMed Web of Science ®Google Scholar
• Hennig, G., Lowrick O., Birchmeier W., and Behrens J.. 1996. Mechanisms identified in the transcriptional control of epithelial gene expression. J. Biol. Chem. 271:595–602.
   PubMed Web of Science ®Google Scholar
• Hildebrand, J. D., and Soriano P.. 2002. Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development. Mol. Cell. Biol. 22:5296–5307.
   PubMed Web of Science ®Google Scholar
• Hosono, S., Gross I., English M. A., Hajra K. M., Fearon E. R., and Licht J. D.. 2000. E-cadherin is a WT1 target gene. J. Biol. Chem. 275:10943–10953.
   PubMed Web of Science ®Google Scholar
• Izutsu, K., Kurokawa M., Imai Y., Maki K., Mitani K., and Hirai H.. 2001. The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling. Blood 97:2815–2822.
   PubMed Web of Science ®Google Scholar
• Kagey, M. H., Melhuish T. A., and Wotton D.. 2003. The polycomb protein Pc2 is a SUMO E3. Cell 113:127–137.
   PubMed Web of Science ®Google Scholar
• Koipally, J., and Georgopoulos K.. 2000. Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity. J. Biol. Chem. 275:19594–19602.
   PubMedGoogle Scholar
• Kumar, V., Carlson J. E., Ohgi K. A., Edwards T. A., Rose D. W., Escalante C. R., Rosenfeld M. G., and Aggarwal A. K.. 2002. Transcription corepressor CtBP is an NAD+-regulated dehydrogenase. Mol. Cell 10:857–869.
   PubMed Web of Science ®Google Scholar
• Ladendorff, N. E., Wu S., and Lipsick J. S.. 2001. BS69, an adenovirus E1A-associated protein, inhibits the transcriptional activity of c-Myb. Oncogene 20:125–132.
   PubMed Web of Science ®Google Scholar
• Li, C., Lin R. I., Lai M. C., Ouyang P., and Tarn W. Y.. 2003. Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1. Mol. Cell. Biol. 23:7363–7376.
   PubMedGoogle Scholar
• Lin, X., Liang Y. Y., Sun B., Liang M., Shi Y., Brunicardi F. C., and Feng X. H.. 2003. Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription. Mol. Cell. Biol. 23:9081–9093.
   PubMedGoogle Scholar
• Lin, X., Sun B., Liang M., Liang Y. Y., Gast A., Hildebrand J., Brunicardi F. C., Melchior F., and Feng X. H.. 2003. Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding. Mol. Cell 11:1389–1396.
   PubMedGoogle Scholar
• Longman, D., Johnstone I. L., and Caceres J. F.. 2000. Functional characterization of SR and SR-related genes in Caenorhabditis elegans. EMBO J. 19:1625–1637.
   PubMedGoogle Scholar
• Marmorstein, R. 2002. Dehydrogenases, NAD, and transcription: what's the connection? Structure 10:1465–1466.
   PubMedGoogle Scholar
• Martinez, E., Palhan V. B., Tjernberg A., Lymar E. S., Gamper A. M., Kundu T. K., Chait B. T., and Roeder R. G.. 2001. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. Mol. Cell. Biol. 21:6782–6795.
   PubMed Web of Science ®Google Scholar
• Masselink, H., and Bernards R.. 2000. The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR. Oncogene 19:1538–1546.
   PubMed Web of Science ®Google Scholar
• Melhuish, T. A., and Wotton D.. 2000. The interaction of C-terminal binding protein with the Smad corepressor TG-interacting factor is disrupted by a holoprosencephaly mutation in TGIF. J. Biol. Chem. 275:39762–39766.
   PubMed Web of Science ®Google Scholar
• Meloni, A. R., Smith E. J., and Nevins J. R.. 1999. A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor. Proc. Natl. Acad. Sci. USA 96:9574–9579.
   PubMedGoogle Scholar
• Mintz, P. J., and Spector D. L.. 2000. Compartmentalization of RNA processing factors within nuclear speckles. J. Struct. Biol. 129:241–251.
   PubMedGoogle Scholar
• Misteli, T., Caceres J. F., and Spector D. L.. 1997. The dynamics of a pre-mRNA splicing factor in living cells. Nature 387:523–527.
   PubMed Web of Science ®Google Scholar
• Nardini, M., Spano S., Cericola C., Pesce A., Massaro A., Millo E., Luini A., Corda D., and Bolognesi M.. 2003. CtBP/BARS: a dual-function protein involved in transcription co-repression and Golgi membrane fission. EMBO J. 22:3122–3130.
   PubMed Web of Science ®Google Scholar
• Ogawa, H., Ishiguro K., Gaubatz S., Livingston D. M., and Nakatani Y.. 2002. A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science 296:1132–1136.
   PubMed Web of Science ®Google Scholar
• Ouyang, P. 1999. Antibodies differentiate desmosome-form and nucleus-form pinin: evidence that pinin is a moonlighting protein with dual location at the desmosome and within the nucleus. Biochem. Biophys. Res. Commun. 263:192–200.
   PubMedGoogle Scholar
• Ouyang, P., and Sugrue S. P.. 1996. Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex. J. Cell Biol. 135:1027–1042.
   PubMedGoogle Scholar
• Ouyang, P., and Sugrue S. P.. 1992. Identification of an epithelial protein related to the desmosome and intermediate filament network. J. Cell Biol. 118:1477–1488.
   PubMedGoogle Scholar
• Phippen, T. M., Sweigart A. L., Moniwa M., Krumm A., Davie J. R., and Parkhurst S. M.. 2000. Drosophila C-terminal binding protein functions as a context-dependent transcriptional cofactor and interferes with both mad and groucho transcriptional repression. J. Biol. Chem. 275:37628–37637.
   PubMedGoogle Scholar
• Postigo, A. A., and Dean D. C.. 2000. Differential expression and function of members of the zfh-1 family of zinc finger/homeodomain repressors. Proc. Natl. Acad. Sci. USA 97:6391–6396.
   PubMed Web of Science ®Google Scholar
• Postigo, A. A., and Dean D. C.. 1999. ZEB represses transcription through interaction with the corepressor CtBP. Proc. Natl. Acad. Sci. USA 96:6683–6688.
   PubMedGoogle Scholar
• Reed, R. 2003. Coupling transcription, splicing and mRNA export. Curr. Opin. Cell Biol. 15:326–331.
   PubMedGoogle Scholar
• Sacco-Bubulya, P., and Spector D. L.. 2002. Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing. J. Cell Biol. 156:425–436.
   PubMedGoogle Scholar
• Sakashita, E., Tatsumi S., Werner D., Endo H., and Mayeda A.. 2004. Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo. Mol. Cell. Biol. 24:1174–1187.
   PubMed Web of Science ®Google Scholar
• Schaeper, U., Boyd J. M., Verma S., Uhlmann E., Subramanian T., and Chinnadurai G.. 1995. Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. Proc. Natl. Acad. Sci. USA 92:10467–10471.
   PubMed Web of Science ®Google Scholar
• Schaeper, U., Subramanian T., Lim L., Boyd J. M., and Chinnadurai G.. 1998. Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif. J. Biol. Chem. 273:8549–8552.
   PubMed Web of Science ®Google Scholar
• Sewalt, R. G., Gunster M. J., van der Vlag J., Satijn D. P., and Otte A. P.. 1999. C-Terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins. Mol. Cell. Biol. 19:777–787.
   PubMed Web of Science ®Google Scholar
• Shi, J., and Sugrue S. P.. 2000. Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus. J. Biol. Chem. 275:14910–14915.
   PubMedGoogle Scholar
• Shi, Y., Ouyang P., and Sugrue S. P.. 2000. Characterization of the gene encoding pinin/DRS/memA and evidence for its potential tumor suppressor function. Oncogene 19:289–297.
   PubMedGoogle Scholar
• Shi, Y., Sawada J., Sui G., Affar el B., Whetstine J. R., Lan F., Ogawa H., Luke M. P., and Nakatani Y.. 2003. Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature 422:735–738.
   PubMed Web of Science ®Google Scholar
• Shi, Y., Simmons M. N., Seki T., Oh S. P., and Sugrue S. P.. 2001. Change in gene expression subsequent to induction of Pnn/DRS/memA: increase in p21cip1/waf1. Oncogene 20:4007–4018.
   PubMedGoogle Scholar
• Shi, Y., Tabesh M., and Sugrue S. P.. 2000. Role of cell adhesion-associated protein, pinin (DRS/memA), in corneal epithelial migration. Investig. Ophthalmol. Vis. Sci. 41:1337–1345.
   PubMedGoogle Scholar
• Shin, C., and Manley J. L.. 2002. The SR protein SRp38 represses splicing in M phase cells. Cell 111:407–417.
   PubMed Web of Science ®Google Scholar
• Spector, D. L. 2001. Nuclear domains. J. Cell Sci. 114:2891–2893.
   PubMed Web of Science ®Google Scholar
• Sui, G., Soohoo C., Affar el B., Gay F., Shi Y., and Forrester W. C.. 2002. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc. Natl. Acad. Sci. USA 99:5515–5520.
   PubMed Web of Science ®Google Scholar
• Sundqvist, A., Bajak E., Kurup S. D., Sollerbrant K., and Svensson C.. 2001. Functional knockout of the corepressor CtBP by the second exon of adenovirus E1a relieves repression of transcription. Exp. Cell Res. 268:284–293.
   PubMedGoogle Scholar
• Wang, D., Miller R., Shaw R., and S. G. 1996. The Pleckstrin homology Domain of Human βIΣII Spectrin is targeted to the plasma membrane in vivo. Biochem. Biophys. Res. Commun. 225:420–426.
   PubMedGoogle Scholar
• Wang, P., Lou P. J., Leu S., and Ouyang P.. 2002. Modulation of alternative pre-mRNA splicing in vivo by pinin. Biochem. Biophys. Res. Commun. 294:448–455.
   PubMed Web of Science ®Google Scholar
• Zhang, Q., Piston D. W., and Goodman R. H.. 2002. Regulation of corepressor function by nuclear NADH. Science 295:1895–1897.
   PubMed Web of Science ®Google Scholar
• Zhang, Q., Yao H., Vo N., and Goodman R. H.. 2000. Acetylation of adenovirus E1A regulates binding of the transcriptional corepressor CtBP. Proc. Natl. Acad. Sci. USA 97:14323–14328.
   PubMed Web of Science ®Google Scholar
• Zimowska, G., Shi J., Munguba G., Jackson M. R., Alpatov R., Simmons M. N., Shi Y., and Sugrue S. P.. 2003. Pinin/DRS/memA interacts with SRp75, SRm300, and SRrp130 in corneal epithelial cells. Investig. Ophthalmol. Vis. Sci. 44:4715–4723.
   PubMedGoogle Scholar