Defective Neural Tube Closure and Anteroposterior Patterning in Mice Lacking the LIM Protein LMO4 or Its Interacting Partner Deaf-1

REFERENCES

• Agulnick, A. D., Taira M., Breen J. J., Tanaka T., Dawid I. B., and Westphal H.. 1996. Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature 384:270–272.
   PubMed Web of Science ®Google Scholar
• Bach, I. 2000. The LIM domain: regulation by association. Mech. Dev. 91:5–17.
   PubMed Web of Science ®Google Scholar
• Bach, I., Carriere C., Ostendorff H. P., Andersen B., and Rosenfeld M. G.. 1997. A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins. Genes Dev. 11:1370–1380.
   PubMedGoogle Scholar
• Bottomley, M. J., Collard M. W., Huggenvik J. I., Liu Z., Gibson T. J., and Sattler M.. 2001. The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation. Nat. Struct. Biol. 8:626–633.
   PubMedGoogle Scholar
• Chai, Y., Jiang X., Ito Y., Bringas P., Jr., Han J., Rowitch D. H., Soriano P., McMahon A. P., and Sucov H. M.. 2000. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development 127:1671–1679.
   PubMed Web of Science ®Google Scholar
• Chen, H. H., Yip J. W., Stewart A. F., and Frank E.. 2002. Differential expression of a transcription regulatory factor, the LIM domain only 4 protein Lmo4, in muscle sensory neurons. Development 129:4879–4889.
   PubMedGoogle Scholar
• Danielian, P. S., Muccino D., Rowitch D. H., Michael S. K., and McMahon A. P.. 1998. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr. Biol. 8:1323–1326.
   PubMed Web of Science ®Google Scholar
• Dawid, I. B., Breen J. J., and Toyama R.. 1998. LIM domains: multiple roles as adapters and functional modifiers in protein interactions. Trends Genet. 14:156–162.
   PubMed Web of Science ®Google Scholar
• Echelard, Y., Vassileva G., and McMahon A. P.. 1994. Cis-acting regulatory sequences governing Wnt-1 expression in the developing mouse CNS. Development 120:2213–2224.
   PubMedGoogle Scholar
• Gavalas, A., Davenne M., Lumsden A., Chambon P., and Rijli F. M.. 1997. Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning. Development 124:3693–3702.
   PubMedGoogle Scholar
• Gibson, T. J., Ramu C., Gemund C., and Aasland R.. 1998. The APECED polyglandular autoimmune syndrome protein, AIRE-1, contains the SAND domain and is probably a transcription factor. Trends Biochem. Sci. 23:242–244.
   PubMed Web of Science ®Google Scholar
• Gross, C. T., and McGinnis W.. 1996. DEAF-1, a novel protein that binds an essential region in a Deformed response element. EMBO J. 15:1961–1970.
   PubMed Web of Science ®Google Scholar
• Grutz, G., Forster A., and Rabbitts T. H.. 1998. Identification of the LMO4 gene encoding an interaction partner of the LIM-binding protein LDB1/NLI1: a candidate for displacement by LMO proteins in T cell acute leukaemia. Oncogene 17:2799–2803.
   PubMedGoogle Scholar
• Hobert, O., and Westphal H.. 2000. Functions of LIM-homeobox genes. Trends Genet. 16:75–83.
   PubMed Web of Science ®Google Scholar
• Hogan, B., Beddington R., Costantini F., and Lucy E.. 1994. Manipulating the mouse embryo. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
   Google Scholar
• Horan, G. S., Ramirez-Solis R., Featherstone M. S., Wolgemuth D. J., Bradley A., and Behringer R. R.. 1995. Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed. Genes Dev. 9:1667–1677.
   PubMed Web of Science ®Google Scholar
• Huggenvik, J. I., Michelson R. J., Collard M. W., Ziemba A. J., Gurley P., and Mowen K. A.. 1998. Characterization of a nuclear deformed epidermal autoregulatory factor-1 (DEAF-1)-related (NUDR) transcriptional regulator protein. Mol. Endocrinol. 12:1619–1639.
   PubMedGoogle Scholar
• Jasinski, M., Keller P., Fujiwara Y., Orkin S. H., and Bessler M.. 2001. GATA1-Cre mediates Piga gene inactivation in the erythroid/megakaryocytic lineage and leads to circulating red cells with a partial deficiency in glycosyl phosphatidylinositol-linked proteins (paroxysmal nocturnal hemoglobinuria type II cells). Blood 98:2248–2255.
   PubMed Web of Science ®Google Scholar
• Jurata, L. W., and Gill G. N.. 1997. Functional analysis of the nuclear LIM domain interactor NLI. Mol. Cell. Biol. 17:5688–5698.
   PubMedGoogle Scholar
• Jurata, L. W., and Gill G. N.. 1998. Structure and function of LIM domains. Curr. Top. Microbiol. Immunol. 228:75–113.
   PubMedGoogle Scholar
• Kenny, D. A., Jurata L. W., Saga Y., and Gill G. N.. 1998. Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis. Proc. Natl. Acad. Sci. USA 95:11257–11262.
   PubMedGoogle Scholar
• Kudryavtseva, E. I., Sugihara T. M., Wang N., Lasso R. J., Gudnason J. F., Lipkin S. M., and Andersen B.. 2003. Identification and characterization of Grainyhead-like epithelial transactivator (GET-1), a novel mammalian Grainyhead-like factor. Dev. Dyn. 226:604–617.
   PubMedGoogle Scholar
• LeBoeuf, R. D., Ban E. M., Green M. M., Stone A. S., Propst S. M., Blalock J. E., and Tauber J. D.. 1998. Molecular cloning, sequence analysis, expression, and tissue distribution of suppressin, a novel suppressor of cell cycle entry. J. Biol. Chem. 273:361–368.
   PubMedGoogle Scholar
• Manetopoulos, C., Hansson A., Karlsson J., Jonsson J. I., and Axelson H.. 2003. The LIM-only protein LMO4 modulates the transcriptional activity of HEN1. Biochem. Biophys. Res. Commun. 307:891–899.
   PubMedGoogle Scholar
• Mao, X., Fujiwara Y., and Orkin S. H.. 1999. Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice. Proc. Natl. Acad. Sci. USA 96:5037–5042.
   PubMed Web of Science ®Google Scholar
• Medina-Martinez, O., Bradley A., and Ramirez-Solis R.. 2000. A large targeted deletion of Hoxb1-Hoxb9 produces a series of single-segment anterior homeotic transformations. Dev. Biol. 222:71–83.
   PubMedGoogle Scholar
• Merrill, V. K., Turner F. R., and Kaufman T. C.. 1987. A genetic and developmental analysis of mutations in the Deformed locus in Drosophila melanogaster. Dev. Biol. 122:379–395.
   PubMedGoogle Scholar
• Mochizuki, T., Karavanov A. A., Curtiss P. E., Ault K. T., Sugimoto N., Watabe T., Shiokawa K., Jamrich M., Cho K. W., Dawid I. B., and Taira M.. 2000. Xlim-1 and LIM domain binding protein 1 cooperate with various transcription factors in the regulation of the goosecoid promoter. Dev. Biol. 224:470–485.
   PubMedGoogle Scholar
• Mukhopadhyay, M., Teufel A., Yamashita T., Agulnick A. D., Chen L., Downs K. M., Schindler A., Grinberg A., Huang S. P., Dorward D., and Westphal H.. 2003. Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation. Development 130:495–505.
   PubMedGoogle Scholar
• Rabbitts, T. H. 1998. LMO T-cell translocation oncogenes typify genes activated by chromosomal translocations that alter transcription and developmental processes. Genes Dev. 12:2651–2657.
   PubMed Web of Science ®Google Scholar
• Racevskis, J., Dill A., Sparano J. A., and Ruan H.. 1999. Molecular cloning of LMO4, a new human LIM domain gene. Biochim. Biophys. Acta 1445:148–153.
   PubMedGoogle Scholar
• Sah, V. P., Attardi L. D., Mulligan G. J., Williams B. O., Bronson R. T., and Jacks T.. 1995. A subset of p53-deficient embryos exhibit exencephaly. Nat. Genet. 10:175–180.
   PubMed Web of Science ®Google Scholar
• Sugihara, T. M., Bach I., Kioussi C., Rosenfeld M. G., and Andersen B.. 1998. Mouse deformed epidermal autoregulatory factor 1 recruits a LIM domain factor, LMO-4, and CLIM coregulators. Proc. Natl. Acad. Sci. USA 95:15418–15423.
   PubMedGoogle Scholar
• Sum, E. Y., Peng B., Yu X., Chen J., Byrne J., Lindeman G. J., and Visvader J. E.. 2002. The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. J. Biol. Chem. 277:7849–7856.
   PubMedGoogle Scholar
• Swiatek, P. J., and Gridley T.. 1993. Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20. Genes Dev. 7:2071–2084.
   PubMed Web of Science ®Google Scholar
• Trainor, P. A., and Krumlauf R.. 2000. Patterning the cranial neural crest: hindbrain segmentation and Hox gene plasticity. Nat. Rev. Neurosci. 1:116–124.
   PubMed Web of Science ®Google Scholar
• Tsang, A. P., Fujiwara Y., Hom D. B., and Orkin S. H.. 1998. Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. Genes Dev. 12:1176–1188.
   PubMedGoogle Scholar
• Tse, E., Grutz G., Garner A. A., Ramsey Y., Carter N. P., Copeland N., Gilbert D. J., Jenkins N. A., Agulnick A., Forster A., and Rabbitts T. H.. 1999. Characterization of the Lmo4 gene encoding a LIM-only protein: genomic organization and comparative chromosomal mapping. Mamm. Genome 10:1089–1094.
   PubMed Web of Science ®Google Scholar
• Veraksa, A., Kennison J., and McGinnis W.. 2002. DEAF-1 function is essential for the early embryonic development of Drosophila. Genesis 33:67–76.
   PubMedGoogle Scholar
• Visvader, J. E., Mao X., Fujiwara Y., Hahm K., and Orkin S. H.. 1997. The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proc. Natl. Acad. Sci. USA 94:13707–13712.
   PubMedGoogle Scholar
• Visvader, J. E., Venter D., Hahm K., Santamaria M., Sum E. Y., O'Reilly L., White D., Williams R., Armes J., and Lindeman G. J.. 2001. The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer. Proc. Natl. Acad. Sci. USA 98:14452–14457.
   PubMedGoogle Scholar
• Wadman, I. A., Osada H., Grutz G. G., Agulnick A. D., Westphal H., Forster A., and Rabbitts T. H.. 1997. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J. 16:3145–3157.
   PubMed Web of Science ®Google Scholar
• Yamada, Y., Pannell R., Forster A., and Rabbitts T. H.. 2000. The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in mice. Proc. Natl. Acad. Sci. USA 97:320–324.
   PubMed Web of Science ®Google Scholar
• Yamada, Y., Warren A. J., Dobson C., Forster A., Pannell R., and Rabbitts T. H.. 1998. The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis. Proc. Natl. Acad. Sci. USA 95:3890–3895.
   PubMed Web of Science ®Google Scholar