Caveolin-1 Is Not Essential for Biosynthetic Apical Membrane Transport

REFERENCES

• Alfieri, J. A., A. D. Martin, J. Takeda, G. Kondoh, D. G. Myles, and P. Primakoff. 2003. Infertility in female mice with an oocyte-specific knockout of GPI-anchored proteins. J. Cell Sci. 116:2149–2155.
   PubMed Web of Science ®Google Scholar
• Balcarova-Stander, J., S. E. Pfeiffer, S. D. Fuller, and K. Simons. 1984. Development of cell surface polarity in the epithelial Madin-Darby canine kidney (MDCK) cell line. EMBO J. 3:2687–2694.
   PubMedGoogle Scholar
• Brazer, S. C., B. B. Singh, X. Liu, W. Swaim, and I. S. Ambudkar. 2003. Caveolin-1 contributes to assembly of store-operated Ca2+ influx channels by regulating plasma membrane localization of TRPC1. J. Biol. Chem. 278:27208–27215.
   PubMed Web of Science ®Google Scholar
• Brown, D. A., B. Crise, and J. K. Rose. 1989. Mechanism of membrane anchoring affects polarized expression of two proteins in MDCK cells. Science 245:1499–1501.
   PubMedGoogle Scholar
• Cheong, K. H., D. Zacchetti, E. E. Schneeberger, and K. Simons. 1999. VIP17/MAL, a lipid raft-associated protein, is involved in apical transport in MDCK cells. Proc. Natl. Acad. Sci. USA 96:6241–6248.
   PubMed Web of Science ®Google Scholar
• Cohen, A. W., R. Hnasko, W. Schubert, and M. P. Lisanti. 2004. Role of caveolae and caveolins in health and disease. Physiol. Rev. 84:1341–1379.
   PubMed Web of Science ®Google Scholar
• Delacour, D., V. Gouyer, J. P. Zanetta, H. Drobecq, E. Leteurtre, G. Grard, O. Moreau-Hannedouche, E. Maes, A. Pons, S. Andre, A. Le Bivic, H. J. Gabius, A. Manninen, K. Simons, and G. Huet. 2005. Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells. J. Cell Biol. 169:491–501.
   PubMed Web of Science ®Google Scholar
• de Marco, M. C., F. Martin-Belmonte, L. Kremer, J. P. Albar, I. Correas, J. P. Vaerman, M. Marazuela, J. A. Byrne, and M. A. Alonso. 2002. MAL2, a novel raft protein of the MAL family, is an essential component of the machinery for transcytosis in hepatoma HepG2 cells. J. Cell Biol. 159:37–44.
   PubMed Web of Science ®Google Scholar
• Diep, D. B., K. L. Nelson, S. M. Raja, E. N. Pleshak, and J. T. Buckley. 1998. Glycosylphosphatidylinositol anchors of membrane glycoproteins are binding determinants for the channel-forming toxin aerolysin. J. Biol. Chem. 273:2355–2360.
   PubMed Web of Science ®Google Scholar
• Drab, M., P. Verkade, M. Elger, M. Kasper, M. Lohn, B. Lauterbach, J. Menne, C. Lindschau, F. Mende, F. C. Luft, A. Schedl, H. Haller, and T. V. Kurzchalia. 2001. Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice. Science 293:2449–2452.
   PubMed Web of Science ®Google Scholar
• Etienne-Manneville, S., and A. Hall. 2003. Cell polarity: Par6, aPKC and cytoskeletal crosstalk. Curr. Opin. Cell Biol. 15:67–72.
   PubMedGoogle Scholar
• Fiedler, K., F. Lafont, R. G. Parton, and K. Simons. 1995. Annexin XIIIb: a novel epithelial specific annexin is implicated in vesicular traffic to the apical plasma membrane. J. Cell Biol. 128:1043–1053.
   PubMedGoogle Scholar
• Fielding, C. J., and P. E. Fielding. 2000. Cholesterol and caveolae: structural and functional relationships. Biochim. Biophys. Acta 1529:210–222.
   PubMed Web of Science ®Google Scholar
• Fivaz, M., F. Vilbois, S. Thurnheer, C. Pasquali, L. Abrami, P. E. Bickel, R. G. Parton, and F. G. Van Der Goot. 2002. Differential sorting and fate of endocytosed GPI-anchored proteins. EMBO J. 21:3989–4000.
   PubMed Web of Science ®Google Scholar
• Fra, A. M., E. Williamson, K. Simons, and R. G. Parton. 1995. De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin. Proc. Natl. Acad. Sci. USA 92:8655–8659.
   PubMed Web of Science ®Google Scholar
• Fujimoto, T., H. Kogo, K. Ishiguro, K. Tauchi, and R. Nomura. 2001. Caveolin-2 is targeted to lipid droplets, a new “membrane domain” in the cell. J. Cell Biol. 152:1079–1085.
   PubMedGoogle Scholar
• Fujimoto, T., H. Kogo, R. Nomura, and T. Une. 2000. Isoforms of caveolin-1 and caveolar structure. J. Cell Sci. 113:3509–3517.
   PubMed Web of Science ®Google Scholar
• Fullekrug, J., P. Scheiffele, and K. Simons. 1999. VIP36 localisation to the early secretory pathway. J. Cell Sci. 112:2813–2821.
   PubMedGoogle Scholar
• Fullekrug, J., and K. Simons. 2004. Lipid rafts and apical membrane traffic. Ann. N. Y. Acad. Sci. 1014:164–169.
   PubMed Web of Science ®Google Scholar
• Gilbert, T., A. Le Bivic, A. Quaroni, and E. Rodriguez-Boulan. 1991. Microtubular organization and its involvement in the biogenetic pathways of plasma membrane proteins in Caco-2 intestinal epithelial cells. J. Cell Biol. 113:275–288.
   PubMed Web of Science ®Google Scholar
• Gumbiner, B., and K. Simons. 1986. A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide. J. Cell Biol. 102:457–468.
   PubMed Web of Science ®Google Scholar
• Hara-Kuge, S., A. Seko, O. Shimada, H. Tosaka-Shimada, and K. Yamashita. 2004. The binding of VIP36 and alpha-amylase in the secretory vesicles via high-mannose type glycans. Glycobiology 14:739–744.
   PubMedGoogle Scholar
• Kawagoe, K., D. Kitamura, M. Okabe, I. Taniuchi, M. Ikawa, T. Watanabe, T. Kinoshita, and J. Takeda. 1996. Glycosylphosphatidylinositol-anchor-deficient mice: implications for clonal dominance of mutant cells in paroxysmal nocturnal hemoglobinuria. Blood 87:3600–3606.
   PubMed Web of Science ®Google Scholar
• Keller, P., D. Toomre, E. Diaz, J. White, and K. Simons. 2001. Multicolour imaging of post-Golgi sorting and trafficking in live cells. Nat. Cell Biol. 3:140–149.
   PubMed Web of Science ®Google Scholar
• Kurzchalia, T. V., P. Dupree, R. G. Parton, R. Kellner, H. Virta, M. Lehnert, and K. Simons. 1992. VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles. J. Cell Biol. 118:1003–1014.
   PubMed Web of Science ®Google Scholar
• Lafont, F., J. K. Burkhardt, and K. Simons. 1994. Involvement of microtubule motors in basolateral and apical transport in kidney cells. Nature 372:801–803.
   PubMedGoogle Scholar
• Lafont, F., S. Lecat, P. Verkade, and K. Simons. 1998. Annexin XIIIb associates with lipid microdomains to function in apical delivery. J. Cell Biol. 142:1413–1427.
   PubMedGoogle Scholar
• Lahtinen, U., M. Honsho, R. G. Parton, K. Simons, and P. Verkade. 2003. Involvement of caveolin-2 in caveolar biogenesis in MDCK cells. FEBS Lett. 538:85–88.
   PubMedGoogle Scholar
• Linstedt, A. D., and H. P. Hauri. 1993. Giantin, a novel conserved Golgi membrane protein containing a cytoplasmic domain of at least 350 kDa. Mol. Biol. Cell 4:679–693.
   PubMedGoogle Scholar
• Lipardi, C., R. Mora, V. Colomer, S. Paladino, L. Nitsch, E. Rodriguez-Boulan, and C. Zurzolo. 1998. Caveolin transfection results in caveolae formation but not apical sorting of glycosylphosphatidylinositol (GPI)-anchored proteins in epithelial cells. J. Cell Biol. 140:617–626.
   PubMedGoogle Scholar
• Liu, P., M. Rudick, and R. G. Anderson. 2002. Multiple functions of caveolin-1. J. Biol. Chem. 277:41295–41298.
   PubMed Web of Science ®Google Scholar
• Matlin, K. S., and K. Simons. 1983. Reduced temperature prevents transfer of a membrane glycoprotein to the cell surface but does not prevent terminal glycosylation. Cell 34:233–243.
   PubMed Web of Science ®Google Scholar
• Meder, D., A. Shevchenko, K. Simons, and J. Fullekrug. 2005. Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells. J. Cell Biol. 168:303–313.
   PubMedGoogle Scholar
• Monier, S., R. G. Parton, F. Vogel, J. Behlke, A. Henske, and T. V. Kurzchalia. 1995. VIP21-caveolin, a membrane protein constituent of the caveolar coat, oligomerizes in vivo and in vitro. Mol. Biol. Cell. 6:911–927.
   PubMed Web of Science ®Google Scholar
• Mora, R., V. L. Bonilha, A. Marmorstein, P. E. Scherer, D. Brown, M. P. Lisanti, and E. Rodriguez-Boulan. 1999. Caveolin-2 localizes to the golgi complex but redistributes to plasma membrane, caveolae, and rafts when co-expressed with caveolin-1. J. Biol. Chem. 274:25708–25717.
   PubMed Web of Science ®Google Scholar
• Mostov, K., T. Su, and M. ter Beest. 2003. Polarized epithelial membrane traffic: conservation and plasticity. Nat. Cell Biol. 5:287–293.
   PubMed Web of Science ®Google Scholar
• Murata, M., J. Peranen, R. Schreiner, F. Wieland, T. V. Kurzchalia, and K. Simons. 1995. VIP21/caveolin is a cholesterol-binding protein. Proc. Natl. Acad. Sci. USA 92:10339–10343.
   PubMed Web of Science ®Google Scholar
• Nakatsu, F., and H. Ohno. 2003. Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network. Cell Struct. Funct. 28:419–429.
   PubMed Web of Science ®Google Scholar
• Nelson, W. J. 2003. Adaptation of core mechanisms to generate cell polarity. Nature 422:766–774.
   PubMed Web of Science ®Google Scholar
• Nozaki, M., K. Ohishi, N. Yamada, T. Kinoshita, A. Nagy, and J. Takeda. 1999. Developmental abnormalities of glycosylphosphatidylinositol-anchor-deficient embryos revealed by Cre/loxP system. Lab. Investig. 79:293–299.
   PubMedGoogle Scholar
• Ojakian, G. K., and R. Schwimmer. 1988. The polarized distribution of an apical cell surface glycoprotein is maintained by interactions with the cytoskeleton of Madin-Darby canine kidney cells. J. Cell Biol. 107:2377–2387.
   PubMed Web of Science ®Google Scholar
• Ostermeyer, A. G., J. M. Paci, Y. Zeng, D. M. Lublin, S. Munro, and D. A. Brown. 2001. Accumulation of caveolin in the endoplasmic reticulum redirects the protein to lipid storage droplets. J. Cell Biol. 152:1071–1078.
   PubMed Web of Science ®Google Scholar
• Parolini, I., M. Sargiacomo, F. Galbiati, G. Rizzo, F. Grignani, J. A. Engelman, T. Okamoto, T. Ikezu, P. E. Scherer, R. Mora, E. Rodriguez-Boulan, C. Peschle, and M. P. Lisanti. 1999. Expression of caveolin-1 is required for the transport of caveolin-2 to the plasma membrane. Retention of caveolin-2 at the level of the golgi complex. J. Biol. Chem. 274:25718–25725.
   PubMed Web of Science ®Google Scholar
• Pelkmans, L., T. Burli, M. Zerial, and A. Helenius. 2004. Caveolin-stabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane traffic. Cell 118:767–780.
   PubMed Web of Science ®Google Scholar
• Pelkmans, L., and A. Helenius. 2002. Endocytosis via caveolae. Traffic 3:311–320.
   PubMed Web of Science ®Google Scholar
• Pelkmans, L., D. Puntener, and A. Helenius. 2002. Local actin polymerization and dynamin recruitment in SV40-induced internalization of caveolae. Science 296:535–539.
   PubMed Web of Science ®Google Scholar
• Pol, A., R. Luetterforst, M. Lindsay, S. Heino, E. Ikonen, and R. G. Parton. 2001. A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance. J. Cell Biol. 152:1057–1070.
   PubMed Web of Science ®Google Scholar
• Pol, A., S. Martin, M. A. Fernandez, C. Ferguson, A. Carozzi, R. Luetterforst, C. Enrich, and R. G. Parton. 2004. Dynamic and regulated association of caveolin with lipid bodies: modulation of lipid body motility and function by a dominant negative mutant. Mol. Biol. Cell. 15:99–110.
   PubMed Web of Science ®Google Scholar
• Pol, A., S. Martin, M. A. Fernandez, M. Ingelmo-Torres, C. Ferguson, C. Enrich, and R. G. Parton. 2005. Cholesterol and fatty acids regulate dynamic caveolin trafficking through the golgi complex and between the cell surface and lipid bodies. Mol. Biol. Cell 16:2091–2105.
   PubMedGoogle Scholar
• Puertollano, R., F. Martin-Belmonte, J. Millan, M. C. de Marco, J. P. Albar, L. Kremer, and M. A. Alonso. 1999. The MAL proteolipid is necessary for normal apical transport and accurate sorting of the influenza virus hemagglutinin in Madin-Darby canine kidney cells. J. Cell Biol. 145:141–151.
   PubMedGoogle Scholar
• Razani, B., T. P. Combs, X. B. Wang, P. G. Frank, D. S. Park, R. G. Russell, M. Li, B. Tang, L. A. Jelicks, P. E. Scherer, and M. P. Lisanti. 2002. Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities. J. Biol. Chem. 277:8635–8647.
   PubMed Web of Science ®Google Scholar
• Razani, B., J. A. Engelman, X. B. Wang, W. Schubert, X. L. Zhang, C. B. Marks, F. Macaluso, R. G. Russell, M. Li, R. G. Pestell, D. Di Vizio, H. Hou, Jr., B. Kneitz, G. Lagaud, G. J. Christ, W. Edelmann, and M. P. Lisanti. 2001. Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J. Biol. Chem. 276:38121–38138.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Boulan, E., G. Kreitzer, and A. Musch. 2005. Organization of vesicular trafficking in epithelia. Nat. Rev. Mol. Cell. Biol. 6:233–247.
   PubMed Web of Science ®Google Scholar
• Rothberg, K. G., J. E. Heuser, W. C. Donzell, Y. S. Ying, J. R. Glenney, and R. G. Anderson. 1992. Caveolin, a protein component of caveolae membrane coats. Cell 68:673–682.
   PubMed Web of Science ®Google Scholar
• Saemann, M. D., T. Weichhart, W. H. Horl, and G. J. Zlabinger. 2005. Tamm-Horsfall protein: a multilayered defence molecule against urinary tract infection. Eur. J. Clin. Investig. 35:227–235.
   PubMedGoogle Scholar
• Scheiffele, P., P. Verkade, A. M. Fra, H. Virta, K. Simons, and E. Ikonen. 1998. Caveolin-1 and -2 in the exocytic pathway of MDCK cells. J. Cell Biol. 140:795–806.
   PubMed Web of Science ®Google Scholar
• Schuck, S., A. Manninen, M. Honsho, J. Fullekrug, and K. Simons. 2004. Generation of single and double knockdowns in polarized epithelial cells by retrovirus-mediated RNA interference. Proc. Natl. Acad. Sci. USA 101:4912–4917.
   PubMedGoogle Scholar
• Schuck, S., and K. Simons. 2004. Polarized sorting in epithelial cells: raft clustering and the biogenesis of the apical membrane. J. Cell Sci. 117:5955–5964.
   PubMed Web of Science ®Google Scholar
• Simons, K., and W. L. Vaz. 2004. Model systems, lipid rafts, and cell membranes. Annu. Rev. Biophys. Biomol. Struct. 33:269–295.
   PubMedGoogle Scholar
• Sotgia, F., B. Razani, G. Bonuccelli, W. Schubert, M. Battista, H. Lee, F. Capozza, A. L. Schubert, C. Minetti, J. T. Buckley, and M. P. Lisanti. 2002. Intracellular retention of glycosylphosphatidyl inositol-linked proteins in caveolin-deficient cells. Mol. Cell. Biol. 22:3905–3926.
   PubMed Web of Science ®Google Scholar
• Tarutani, M., S. Itami, M. Okabe, M. Ikawa, T. Tezuka, K. Yoshikawa, T. Kinoshita, and J. Takeda. 1997. Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development. Proc. Natl. Acad. Sci. USA 94:7400–7405.
   PubMed Web of Science ®Google Scholar
• Verkade, P., T. Harder, F. Lafont, and K. Simons. 2000. Induction of caveolae in the apical plasma membrane of Madin-Darby canine kidney cells. J. Cell Biol. 148:727–739.
   PubMed Web of Science ®Google Scholar
• Wyse, B. D., I. A. Prior, H. Qian, I. C. Morrow, S. Nixon, C. Muncke, T. V. Kurzchalia, W. G. Thomas, R. G. Parton, and J. F. Hancock. 2003. Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane. J. Biol. Chem. 278:23738–23746.
   PubMedGoogle Scholar
• Yoshimori, T., P. Keller, M. G. Roth, and K. Simons. 1996. Different biosynthetic transport routes to the plasma membrane in BHK and CHO cells. J. Cell Biol. 133:247–256.
   PubMedGoogle Scholar
• Zhao, Y. Y., Y. Liu, R. V. Stan, L. Fan, Y. Gu, N. Dalton, P. H. Chu, K. Peterson, J. Ross, Jr., and K. R. Chien. 2002. Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice. Proc. Natl. Acad. Sci. USA 99:11375–11380.
   PubMed Web of Science ®Google Scholar