The Novel ATP-Binding Cassette Protein ARB1 Is a Shuttling Factor That Stimulates 40S and 60S Ribosome Biogenesis

REFERENCES

• Anderson, J. T., M. R. Paddy, and M. S. Swanson. 1993. PUB1 is a major nuclear and cytoplasmic polyadenylated RNA-binding protein in Saccharomyces cerevisiae. Mol. Cell. Biol. 13:6102–6113.
   PubMedGoogle Scholar
• Basu, U., K. Si, J. R. Warner, and U. Maitra. 2001. The Saccharomyces cerevisiae TIF6 gene encoding translation initiation factor 6 is required for 60S ribosomal subunit biogenesis. Mol. Cell. Biol. 21:1453–1462.
   PubMed Web of Science ®Google Scholar
• Brown, C. R., J. A. McCann, and H. L. Chiang. 2000. The heat shock protein Ssa2p is required for import of fructose-1, 6-bisphosphatase into Vid vesicles. J. Cell Biol. 150:65–76.
   PubMed Web of Science ®Google Scholar
• Cesareni, G., and J. A. H. Murray. 1987. Plasmid vectors carrying the replication origin of filamentous single-stranded phages, p. 135–154. In J. K. Setlow and A. Hollaender (ed.), Genetic engineering: principals and methods, vol. 9. Plenum Press, New York, N.Y.
   Google Scholar
• Chakraburtty, K. 1992. Elongation factor 3: a unique fungal protein, p. 114–142. In P. B. Fernandes (ed.), New approaches for antifungal drugs. Birkhauser, Basel, Switzerland.
   Google Scholar
• Chen, J., G. Lu, J. Lin, A. L. Davidson, and F. A. Quiocho. 2003. A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle. Mol. Cell 12:651–661.
   PubMed Web of Science ®Google Scholar
• Chen, W., J. Bucaria, D. A. Band, A. Sutton, and R. Sternglanz. 2003. Enp1, a yeast protein associated with U3 and U14 snoRNAs, is required for pre-rRNA processing and 40S subunit synthesis. Nucleic Acids Res. 31:690–699.
   PubMed Web of Science ®Google Scholar
• Davidson, A. L. 2002. Mechanism of coupling of transport to hydrolysis in bacterial ATP-binding cassette transporters. J. Bacteriol. 184:1225–1233.
   PubMedGoogle Scholar
• de la Cruz, J., I. Iost, D. Kressler, and P. Linder. 1997. The p20 and Ded1 proteins have antagonistic roles in eIF4E-dependent translation in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 94:5201–5206.
   PubMed Web of Science ®Google Scholar
• Dez, C., C. Froment, J. Noaillac-Depeyre, B. Monsarrat, M. Caizergues-Ferrer, and Y. Henry. 2004. Npa1p, a component of very early pre-60S ribosomal particles, associates with a subset of small nucleolar RNPs required for peptidyl transferase center modification. Mol. Cell. Biol. 24:6324–6337.
   PubMed Web of Science ®Google Scholar
• Dong, J., R. Lai, K. Nielsen, C. A. Fekete, H. Qiu, and A. G. Hinnebusch. 2004. The essential ATP-binding cassette protein RLI1 functions in translation by promoting preinitiation complex assembly. J. Biol. Chem. 279:42157–42168.
   PubMedGoogle Scholar
• Dong, J., H. Qiu, M. Garcia-Barrio, J. Anderson, and A. G. Hinnebusch. 2000. Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain. Mol. Cell 6:269–279.
   PubMed Web of Science ®Google Scholar
• Dragon, F., J. E. Gallagher, P. A. Compagnone-Post, B. M. Mitchell, K. A. Porwancher, K. A. Wehner, S. Wormsley, R. E. Settlage, J. Shabanowitz, Y. Osheim, A. L. Beyer, D. F. Hunt, and S. J. Baserga. 2002. A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. Nature 417:967–970.
   PubMed Web of Science ®Google Scholar
• Eng, J. K., A. L. McCormack, and J. R. Yates Spaceiiiqq. 1994. An approach to correlate tandem mass spectral data of peptides with amino acid sequences. J. Am. Soc. Mass Spectrom. 5:976–989.
   PubMed Web of Science ®Google Scholar
• Fatica, A., and D. Tollervey. 2002. Making ribosomes. Curr. Opin. Cell Biol. 14:313–318.
   PubMed Web of Science ®Google Scholar
• Gadal, O., D. Strauss, J. Kessl, B. Trumpower, D. Tollervey, and E. Hurt. 2001. Nuclear export of 60s ribosomal subunits depends on Xpo1p and requires a nuclear export sequence-containing factor, Nmd3p, that associates with the large subunit protein Rpl10p. Mol. Cell. Biol. 21:3405–3415.
   PubMed Web of Science ®Google Scholar
• Garcia-Barrio, M., J. Dong, S. Ufano, and A. G. Hinnebusch. 2000. Association of GCN1/GCN20 regulatory complex with the conserved N-terminal domain of eIF2α kinase GCN2 is required for GCN2 activation in vivo. EMBO J. 19:1887–1899.
   PubMedGoogle Scholar
• Gautier, T., T. Berges, D. Tollervey, and E. Hurt. 1997. Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis. Mol. Cell. Biol. 17:7088–7098.
   PubMedGoogle Scholar
• Gavin, A. C., M. Bosche, R. Krause, P. Grandi, M. Marzioch, A. Bauer, J. Schultz, J. M. Rick, A. M. Michon, C. M. Cruciat, M. Remor, C. Hofert, M. Schelder, M. Brajenovic, H. Ruffner, A. Merino, K. Klein, M. Hudak, D. Dickson, T. Rudi, V. Gnau, A. Bauch, S. Bastuck, B. Huhse, C. Leutwein, M. A. Heurtier, R. R. Copley, A. Edelmann, E. Querfurth, V. Rybin, G. Drewes, M. Raida, T. Bouwmeester, P. Bork, B. Seraphin, B. Kuster, G. Neubauer, and G. Superti-Furga. 2002. Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature 415:141–147.
   PubMed Web of Science ®Google Scholar
• Gelperin, D., L. Horton, J. Beckman, J. Hensold, and S. K. Lemmon. 2001. Bms1p, a novel GTP-binding protein, and the related Tsr1p are required for distinct steps of 40S ribosome biogenesis in yeast. RNA 7:1268–1283.
   PubMed Web of Science ®Google Scholar
• Giaever, G., A. M. Chu, L. Ni, C. Connelly, L. Riles, S. Veronneau, S. Dow, A. Lucau-Danila, K. Anderson, B. Andre, A. P. Arkin, A. Astromoff, M. El-Bakkoury, R. Bangham, R. Benito, S. Brachat, S. Campanaro, M. Curtiss, K. Davis, A. Deutschbauer, K. D. Entian, P. Flaherty, F. Foury, D. J. Garfinkel, M. Gerstein, D. Gotte, U. Guldener, J. H. Hegemann, S. Hempel, Z. Herman, D. F. Jaramillo, D. E. Kelly, S. L. Kelly, P. Kotter, D. LaBonte, D. C. Lamb, N. Lan, H. Liang, H. Liao, L. Liu, C. Luo, M. Lussier, R. Mao, P. Menard, S. L. Ooi, J. L. Revuelta, C. J. Roberts, M. Rose, P. Ross-Macdonald, B. Scherens, G. Schimmack, B. Shafer, D. D. Shoemaker, S. Sookhai-Mahadeo, R. K. Storms, J. N. Strathern, G. Valle, M. Voet, G. Volckaert, C. Y. Wang, T. R. Ward, J. Wilhelmy, E. A. Winzeler, Y. Yang, G. Yen, E. Youngman, K. Yu, H. Bussey, J. D. Boeke, M. Snyder, P. Philippsen, R. W. Davis, and M. Johnston. 2002. Functional profiling of the Saccharomyces cerevisiae genome. Nature 418:387–391.
   PubMed Web of Science ®Google Scholar
• Gietz, R. D., and A. Sugino. 1988. New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74:527–534.
   PubMed Web of Science ®Google Scholar
• Graack, H. R., and B. Wittmann-Liebold. 1998. Mitochondrial ribosomal proteins (MRPs) of yeast. Biochem. J. 329:433–448.
   PubMedGoogle Scholar
• Grandi, P., V. Rybin, J. Bassler, E. Petfalski, D. Strauss, M. Marzioch, T. Schafer, B. Kuster, H. Tschochner, D. Tollervey, A. C. Gavin, and E. Hurt. 2002. 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol. Cell 10:105–115.
   PubMed Web of Science ®Google Scholar
• Granneman, S., and S. J. Baserga. 2004. Ribosome biogenesis: of knobs and RNA processing. Exp. Cell Res. 296:43–50.
   PubMedGoogle Scholar
• Harnpicharnchai, P., J. Jakovljevic, E. Horsey, T. Miles, J. Roman, M. Rout, D. Meagher, B. Imai, Y. Guo, C. J. Brame, J. Shabanowitz, D. F. Hunt, and J. L. Woolford, Jr. 2001. Composition and functional characterization of yeast 66S ribosome assembly intermediates. Mol. Cell 8:505–515.
   PubMed Web of Science ®Google Scholar
• Haselbeck, R. J., and L. McAlister-Henn. 1993. Function and expression of yeast mitochondrial NAD- and NADP-specific isocitrate dehydrogenases. J. Biol. Chem. 268:12116–12122.
   PubMed Web of Science ®Google Scholar
• Hayano, T., M. Yanagida, Y. Yamauchi, T. Shinkawa, T. Isobe, and N. Takahashi. 2003. Proteomic analysis of human Nop56p-associated pre-ribosomal ribonucleoprotein complexes. Possible link between Nop56p and the nucleolar protein treacle responsible for Treacher Collins syndrome. J. Biol. Chem. 278:34309–34319.
   PubMed Web of Science ®Google Scholar
• Hazbun, T. R., L. Malmstrom, S. Anderson, B. J. Graczyk, B. Fox, M. Riffle, B. A. Sundin, J. D. Aranda, W. H. McDonald, C. H. Chiu, B. E. Snydsman, P. Bradley, E. G. Muller, S. Fields, D. Baker, J. R. Yates III, and T. N. Davis. 2003. Assigning function to yeast proteins by integration of technologies. Mol. Cell 12:1353–1365.
   PubMed Web of Science ®Google Scholar
• Hedges, J., M. West, and A. W. Johnson. 2005. Release of the export adapter, Nmd3p, from the 60S ribosomal subunit requires Rpl10p and the cytoplasmic GTPase Lsg1p. EMBO J. 24:567–579.
   PubMed Web of Science ®Google Scholar
• Ho, J. H., G. Kallstrom, and A. W. Johnson. 2000. Nmd3p is a Crm1p-dependent adapter protein for nuclear export of the large ribosomal subunit. J. Cell Biol. 151:1057–1066.
   PubMed Web of Science ®Google Scholar
• Hopfner, K. P., A. Karcher, D. S. Shin, L. Craig, L. M. Arthur, J. P. Carney, and J. A. Tainer. 2000. Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily. Cell 101:789–800.
   PubMed Web of Science ®Google Scholar
• Johnson, A. W., E. Lund, and J. Dahlberg. 2002. Nuclear export of ribosomal subunits. Trends Biochem. Sci. 27:580–585.
   PubMedGoogle Scholar
• Kallstrom, G., J. Hedges, and A. Johnson. 2003. The putative GTPases Nog1p and Lsg1p are required for 60S ribosomal subunit biogenesis and are localized to the nucleus and cytoplasm, respectively. Mol. Cell. Biol. 23:4344–4355.
   PubMed Web of Science ®Google Scholar
• Karcher, A., K. Buttner, B. Martens, R. P. Jansen, and K. P. Hopfner. 2005. X-ray structure of RLI, an essential twin cassette ABC ATPase involved in ribosome biogenesis and HIV capsid assembly. Structure 13:649–659.
   PubMedGoogle Scholar
• Kettner, C., G. Obermeyer, and A. Bertl. 2003. Inhibition of the yeast V-type ATPase by cytosolic ADP. FEBS Lett. 535:119–124.
   PubMed Web of Science ®Google Scholar
• Kispal, G., K. Sipos, H. Lange, Z. Fekete, T. Bedekovics, T. Janaky, J. Bassler, D. J. Aguilar Netz, J. Balk, C. Rotte, and R. Lill. 2005. Biogenesis of cytosolic ribosomes requires the essential iron-sulphur protein Rli1p and mitochondria. EMBO J. 24:589–598.
   PubMedGoogle Scholar
• Koronakis, E., C. Hughes, I. Milisav, and V. Koronakis. 1995. Protein exporter function and in vitro ATPase activity are correlated in ABC-domain mutants of HlyB. Mol. Microbiol. 16:87–96.
   PubMedGoogle Scholar
• Kressler, D., J. de la Cruz, M. Rojo, and P. Linder. 1997. Fal1p is an essential DEAD-box protein involved in 40S-ribosomal-subunit biogenesis in Saccharomyces cerevisiae. Mol. Cell. Biol. 17:7283–7294.
   PubMed Web of Science ®Google Scholar
• Kressler, D., P. Linder, and J. de La Cruz. 1999. Protein trans-acting factors involved in ribosome biogenesis in Saccharomyces cerevisiae. Mol. Cell. Biol. 19:7897–7912.
   PubMed Web of Science ®Google Scholar
• Krogan, N. J., W. T. Peng, G. Cagney, M. D. Robinson, R. Haw, G. Zhong, X. Guo, X. Zhang, V. Canadien, D. P. Richards, B. K. Beattie, A. Lalev, W. Zhang, A. P. Davierwala, S. Mnaimneh, A. Starostine, A. P. Tikuisis, J. Grigull, N. Datta, J. E. Bray, T. R. Hughes, A. Emili, and J. F. Greenblatt. 2004. High-definition macromolecular composition of yeast RNA-processing complexes. Mol. Cell 13:225–239.
   PubMed Web of Science ®Google Scholar
• Lee, S. J., and S. J. Baserga. 1999. Imp3p and Imp4p, two specific components of the U3 small nucleolar ribonucleoprotein that are essential for pre-18S rRNA processing. Mol. Cell. Biol. 19:5441–5452.
   PubMedGoogle Scholar
• Link, A. J., J. Eng, D. M. Schieltz, E. Carmack, G. J. Mize, D. R. Morris, B. M. Garvik, and J. R. Yates III. 1999. Direct analysis of protein complexes using mass spectrometry. Nat. Biotechnol. 17:676–682.
   PubMed Web of Science ®Google Scholar
• Locher, K. P., A. T. Lee, and D. C. Rees. 2002. The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism. Science 296:1091–1098.
   PubMed Web of Science ®Google Scholar
• Longtine, M. S., A. McKenzie III, D. J. Demarini, N. G. Shah, A. Wach, A. Brachat, P. Philippsen, and J. R. Pringle. 1998. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14:953–961.
   PubMed Web of Science ®Google Scholar
• Marton, M. J., D. Crouch, and A. G. Hinnebusch. 1993. GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2. Mol. Cell. Biol. 13:3541–3556.
   PubMedGoogle Scholar
• Marton, M. J., C. R. Vasquez de Aldana, H. Qiu, K. Charkraburtty, and A. G. Hinnebusch. 1997. Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of the eIF2α kinase GCN2. Mol. Cell. Biol. 17:4474–4489.
   PubMedGoogle Scholar
• McKeegan, K. S., M. I. Borges-Walmsley, and A. R. Walmsley. 2003. The structure and function of drug pumps: an update. Trends Microbiol. 11:21–29.
   PubMed Web of Science ®Google Scholar
• Milkereit, P., O. Gadal, A. Podtelejnikov, S. Trumtel, N. Gas, E. Petfalski, D. Tollervey, M. Mann, E. Hurt, and H. Tschochner. 2001. Maturation and intranuclear transport of pre-ribosomes requires Noc proteins. Cell 105:499–509.
   PubMedGoogle Scholar
• Moody, J. E., L. Millen, D. Binns, J. F. Hunt, and P. J. Thomas. 2002. Cooperative, ATP-dependent association of the nucleotide binding cassettes during the catalytic cycle of ATP-binding cassette transporters. J. Biol. Chem. 277:21111–21114.
   PubMedGoogle Scholar
• Neville, M., and M. Rosbash. 1999. The NES-Crm1p export pathway is not a major mRNA export route in Saccharomyces cerevisiae. EMBO J. 18:3746–3756.
   PubMed Web of Science ®Google Scholar
• Nissan, T. A., J. Bassler, E. Petfalski, D. Tollervey, and E. Hurt. 2002. 60S pre-ribosome formation viewed from assembly in the nucleolus until export to the cytoplasm. EMBO J. 21:5539–5547.
   PubMed Web of Science ®Google Scholar
• Park, E.-C., D. Finley, and J. W. Szostak. 1992. A strategy for the generation of conditional mutations by protein destabilization. Proc. Natl. Acad. Sci. USA 89:1249–1252.
   PubMedGoogle Scholar
• Paul, M. F., S. Ackerman, J. Yue, G. Arselin, J. Velours, A. Tzagolof, and S. Ackermann. 1994. Cloning of the yeast ATP3 gene coding for the gamma-subunit of F1 and characterization of atp3 mutants. J. Biol. Chem. 269:26158–26164.
   PubMedGoogle Scholar
• Phan, L., X. Zhang, K. Asano, J. Anderson, H. P. Vornlocher, J. R. Greenberg, J. Qin, and A. G. Hinnebusch. 1998. Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5. Mol. Cell. Biol. 18:4935–4946.
   PubMedGoogle Scholar
• Planta, R. J., and W. H. Mager. 1998. The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae. Yeast 14:471–477.
   PubMed Web of Science ®Google Scholar
• Powell, D. W., C. M. Weaver, J. L. Jennings, K. J. McAfee, Y. He, P. A. Weil, and A. J. Link. 2004. Cluster analysis of mass spectrometry data reveals a novel component of SAGA. Mol. Cell. Biol. 24:7249–7259.
   PubMed Web of Science ®Google Scholar
• Sanders, S. L., J. Jennings, A. Canutescu, A. J. Link, and P. A. Weil. 2002. Proteomics of the eukaryotic transcription machinery: identification of proteins associated with components of yeast TFIID by multidimensional mass spectrometry. Mol. Cell. Biol. 22:4723–4738.
   PubMed Web of Science ®Google Scholar
• Sasaki, T., E. A. Toh, and Y. Kikuchi. 2000. Yeast Krr1p physically and functionally interacts with a novel essential Kri1p, and both proteins are required for 40S ribosome biogenesis in the nucleolus. Mol. Cell. Biol. 20:7971–7979.
   PubMedGoogle Scholar
• Sato, H., and I. Miyakawa. 2004. A 22 kDa protein specific for yeast mitochondrial nucleoids is an unidentified putative ribosomal protein encoded in open reading frame YGL068W. Protoplasma 223:175–182.
   PubMedGoogle Scholar
• Saveanu, C., A. Namane, P. E. Gleizes, A. Lebreton, J. C. Rousselle, J. Noaillac-Depeyre, N. Gas, A. Jacquier, and M. Fromont-Racine. 2003. Sequential protein association with nascent 60S ribosomal particles. Mol. Cell. Biol. 23:4449–4460.
   PubMed Web of Science ®Google Scholar
• Schafer, T., D. Strauss, E. Petfalski, D. Tollervey, and E. Hurt. 2003. The path from nucleolar 90S to cytoplasmic 40S pre-ribosomes. EMBO J. 22:1370–1380.
   PubMed Web of Science ®Google Scholar
• Schmees, G., A. Stein, S. Hunke, H. Landmesser, and E. Schneider. 1999. Functional consequences of mutations in the conserved “signature sequence” of the ATP-binding-cassette protein MalK. Eur. J. Biochem. 266:420–430.
   PubMedGoogle Scholar
• Scott, B. L., J. S. Van Komen, H. Irshad, S. Liu, K. A. Wilson, and J. A. McNew. 2004. Sec1p directly stimulates SNARE-mediated membrane fusion in vitro. J. Cell Biol. 167:75–85.
   PubMedGoogle Scholar
• Senger, B., D. L. Lafontaine, J. S. Graindorge, O. Gadal, A. Camasses, A. Sanni, J. M. Garnier, M. Breitenbach, E. Hurt, and F. Fasiolo. 2001. The nucle(ol)ar Tif6p and Efl1p are required for a late cytoplasmic step of ribosome synthesis. Mol. Cell 8:1363–1373.
   PubMedGoogle Scholar
• Si, K., and U. Maitra. 1999. The Saccharomyces cerevisiae homologue of mammalian translation initiation factor 6 does not function as a translation initiation factor. Mol. Cell. Biol. 19:1416–1426.
   PubMedGoogle Scholar
• Smith, P. C., N. Karpowich, L. Millen, J. E. Moody, J. Rosen, P. J. Thomas, and J. F. Hunt. 2002. ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer. Mol. Cell 10:139–149.
   PubMed Web of Science ®Google Scholar
• Stage-Zimmermann, T., U. Schmidt, and P. A. Silver. 2000. Factors affecting nuclear export of the 60S ribosomal subunit in vivo. Mol. Biol Cell 11:3777–3789.
   PubMedGoogle Scholar
• Triana-Alonso, F. J., K. Chakraburtty, and K. H. Nierhaus. 1995. The elongation factor unique in higher fungi and essential for protein biosynthesis is an E site factor. J. Biol. Chem. 270:20473–20478.
   PubMedGoogle Scholar
• Tschochner, H., and E. Hurt. 2003. Pre-ribosomes on the road from the nucleolus to the cytoplasm. Trends Cell Biol. 13:255–263.
   PubMed Web of Science ®Google Scholar
• Tyzack, J. K., X. Wang, G. J. Belsham, and C. G. Proud. 2000. ABC50 interacts with eukaryotic initiation factor 2 and associates with the ribosome in an ATP-dependent manner. J. Biol. Chem. 275:34131–34139.
   PubMedGoogle Scholar
• Valásek, L., L. Phan, L. W. Schoenfeld, V. Valásková, and A. G. Hinnebusch. 2001. Related eIF3 subunits TIF32 and HCR1 interact with an RNA recognition motif in PRT1 required for eIF3 integrity and ribosome binding. EMBO J. 20:891–904.
   PubMed Web of Science ®Google Scholar
• Vazquez de Aldana, C. R., M. J. Marton, and A. G. Hinnebusch. 1995. GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2α kinase GCN2 in amino acid-starved cells. EMBO J. 14:3184–3199.
   PubMedGoogle Scholar
• Wehner, K. A., and S. J. Baserga. 2002. The sigma(70)-like motif: a eukaryotic RNA binding domain unique to a superfamily of proteins required for ribosome biogenesis. Mol. Cell 9:329–339.
   PubMedGoogle Scholar
• Wenz, P., S. Schwank, U. Hoja, and H. J. Schuller. 2001. A downstream regulatory element located within the coding sequence mediates autoregulated expression of the yeast fatty acid synthase gene FAS2 by the FAS1 gene product. Nucleic Acids Res. 29:4625–4632.
   PubMedGoogle Scholar
• Yarunin, A., V. G. Panse, E. Petfalski, C. Dez, D. Tollervey, and E. Hurt. 2005. Functional link between ribosome formation and biogenesis of iron-sulfur proteins. EMBO J. 24:580–588.
   PubMed Web of Science ®Google Scholar
• Zelenaya-Troitskaya, O., P. S. Perlman, and R. A. Butow. 1995. An enzyme in yeast mitochondria that catalyzes a step in branched-chain amino acid biosynthesis also functions in mitochondrial DNA stability. EMBO J. 14:3268–3276.
   PubMedGoogle Scholar
• Zoll, W. L., L. E. Horton, A. A. Komar, J. O. Hensold, and W. C. Merrick. 2002. Characterization of mammalian eIF2A and identification of the yeast homolog. J. Biol. Chem. 277:37079–37087.
   PubMed Web of Science ®Google Scholar