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Gene Expression

Smooth Muscle-Specific Genes Are Differentially Sensitive to Inhibition by Elk-1

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Pages 9874-9885 | Received 14 Jun 2005, Accepted 08 Sep 2005, Published online: 27 Mar 2023

REFERENCES

  • Buchwalter, G., C. Gross, and B. Wasylyk. 2004. Ets ternary complex transcription factors. Gene 324:1–14.
  • Chen, J., C. M. Kitchen, J. W. Streb, and J. M. Miano. 2002. Myocardin: a component of a molecular switch for smooth muscle differentiation. J. Mol. Cell. Cardiol. 34:1345–1356.
  • Dandre, F., and G. K. Owens. 2004. Platelet-derived growth factor-BB and Ets-1 transcription factor negatively regulate transcription of multiple smooth muscle cell differentiation marker genes. Am. J. Physiol. Heart Circ. Physiol. 286:H2042–H2051.
  • Du, K. L., H. S. Ip, J. Li, M. Chen, F. Dandre, W. Yu, M. M. Lu, G. K. Owens, and M. S. Parmacek. 2003. Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation. Mol. Cell. Biol. 23:2425–2437.
  • Gallagher, P. J., and B. P. Herring. 1991. The carboxyl terminus of the smooth muscle myosin light chain kinase is expressed as an independent protein, telokin. J. Biol. Chem. 266:23945–23952.
  • Gallagher, P. J., B. P. Herring, S. A. Griffin, and J. T. Stull. 1991. Molecular characterization of a mammalian smooth muscle myosin light chain kinase. J. Biol. Chem. 266:23936–23944.
  • Gille, H., M. Kortenjann, O. Thomae, C. Moomaw, C. Slaughter, M. H. Cobb, and P. E. Shaw. 1995. ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J. 14:951–962.
  • Goetze, S., U. Kintscher, K. Kaneshiro, W. P. Meehan, A. Collins, E. Fleck, W. A. Hsueh, and R. E. Law. 2001. TNFα induces expression of transcription factors c-fos, Egr-1, and Ets-1 in vascular lesions through extracellular signal-regulated kinases 1/2. Atherosclerosis 159:93–101.
  • Hendrix, J. A., B. R. Wamhoff, O. G. McDonald, S. Sinha, T. Yoshida, and G. K. Owens. 2005. 5′ CArG degeneracy in smooth muscle alpha-actin is required for injury-induced gene suppression in vivo. J. Clin. Investig. 115:418–427.
  • Herring, B. P., S. Dixon, and P. J. Gallagher. 2000. Smooth muscle myosin light chain kinase expression in cardiac and skeletal muscle. Am. J. Physiol. 279:C1656–C1664.
  • Herring, B. P., G. E. Lyons, A. M. Hoggatt, and P. J. Gallagher. 2001. Telokin expression is restricted to smooth muscle tissues during mouse development. Am. J. Physiol. Cell Physiol. 280:C12–C21.
  • Herring, B. P., and A. F. Smith. 1997. Telokin expression in A10 smooth muscle cells requires serum response factor. Am. J. Physiol. 272:C1394–C1404.
  • Herring, B. P., and A. F. Smith. 1996. Telokin expression is mediated by a smooth muscle cell-specific promoter. Am. J. Physiol. 270:C1656–C1665.
  • Hoggatt, A. M., A. M. Kriegel, A. F. Smith, and B. P. Herring. 2000. Hepatocyte nuclear factor-3 homologue 1 (HFH-1) represses transcription of smooth muscle-specific genes. J. Biol. Chem. 275:31162–31170.
  • Hoggatt, A. M., G. M. Simon, and B. P. Herring. 2002. Cell-specific regulatory modules control expression of genes in vascular and visceral smooth muscle tissues. Circ. Res. 91:1151–1159.
  • Kasza, A., A. O'Donnell, K. Gascoigne, L. A. Zeef, A. Hayes, and A. D. Sharrocks. 2005. The ETS-domain transcription factor Elk-1 regulates the expression of its partner protein, SRF. J. Biol. Chem. 280:1149–1155.
  • Khurana, A., and C. S. Dey. 2002. Involvement of Elk-1 in L6E9 skeletal muscle differentiation. FEBS Lett. 527:119–124.
  • Kim, S., H. S. Ip, M. M. Lu, C. Clendenin, and M. S. Parmacek. 1997. A serum response factor-dependent transcriptional regulatory program identifies distinct smooth muscle cell sublineages. Mol. Cell. Biol. 17:2266–2278.
  • Latinkic, B. V., M. Zeremski, and L. F. Lau. 1996. Elk-1 can recruit SRF to form a ternary complex upon the serum response element. Nucleic Acids Res. 24:1345–1351.
  • Li, L., J. M. Miano, B. Mercer, and E. N. Olson. 1996. Expression of the SM22α promoter in transgenic mice provides evidence for distinct transcriptional regulatory programs in vascular and visceral smooth muscle cells. J. Cell Biol. 132:849–859.
  • Li, S., D. Z. Wang, Z. Wang, J. A. Richardson, and E. N. Olson. 2003. The serum response factor coactivator myocardin is required for vascular smooth muscle development. Proc. Natl. Acad. Sci. USA 100:9366–9370.
  • Mack, C. P., and G. K. Owens. 1999. Regulation of smooth muscle alpha-actin expression in vivo is dependent on CArG elements within the 5′ and first intron promoter regions. Circ. Res. 84:852–861.
  • Madsen, C. S., C. P. Regan, J. E. Hungerford, S. L. White, I. Manabe, and G. K. Owens. 1998. Smooth muscle-specific expression of the smooth muscle myosin heavy chain gene in transgenic mice requires 5′-flanking and first intronic DNA sequence. Circ. Res. 82:908–917.
  • Mano, T., Z. Luo, S. L. Malendowicz, T. Evans, and K. Walsh. 1999. Reversal of GATA-6 downregulation promotes smooth muscle differentiation and inhibits intimal hyperplasia in balloon-injured rat carotid artery. Circ. Res. 84:647–654.
  • Marais, R., J. Wynne, and R. Treisman. 1993. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73:381–393.
  • Miano, J. M. 2003. Serum response factor: toggling between disparate programs of gene expression. J. Mol. Cell. Cardiol. 35:577–593.
  • Oh, J., Z. Wang, D. Z. Wang, C. L. Lien, W. Xing, and E. N. Olson. 2004. Target gene-specific modulation of myocardin activity by GATA transcription factors. Mol. Cell. Biol. 24:8519–8528.
  • Owens, G. K., M. S. Kumar, and B. R. Wamhoff. 2004. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol. Rev. 84:767–801.
  • Salinas, S., A. Briancon-Marjollet, G. Bossis, M. A. Lopez, M. Piechaczyk, I. Jariel-Encontre, A. Debant, and R. A. Hipskind. 2004. SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1. J. Cell Biol. 165:767–773.
  • Shaw, P. E., H. Schroter, and A. Nordheim. 1989. The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter. Cell 56:563–572.
  • Shore, P., and A. D. Sharrocks. 1994. The transcription factors Elk-1 and serum response factor interact by direct protein-protein contacts mediated by a short region of Elk-1. Mol. Cell. Biol. 14:3283–3291.
  • Smith, A. F., R. M. Bigsby, R. A. Word, and B. P. Herring. 1998. A 310-bp minimal promoter mediates smooth muscle cell-specific expression of telokin. Am. J. Physiol. 274:C1188–C1195.
  • Vanhoutte, P., J. L. Nissen, B. Brugg, B. D. Gaspera, M. J. Besson, R. A. Hipskind, and J. Caboche. 2001. Opposing roles of Elk-1 and its brain-specific isoform, short Elk-1, in nerve growth factor-induced PC12 differentiation. J. Biol. Chem. 276:5189–5196.
  • Wang, D., P. S. Chang, Z. Wang, L. Sutherland, J. A. Richardson, E. Small, P. A. Krieg, and E. N. Olson. 2001. Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell 105:851–862.
  • Wang, Z., D. Z. Wang, D. Hockemeyer, J. McAnally, A. Nordheim, and E. N. Olson. 2004. Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. Nature 428:185–189.
  • Wasylyk, B., J. Hagman, and A. Gutierrez-Hartmann. 1998. Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway. Trends Biochem. Sci. 23:213–216.
  • Yang, S. H., E. Jaffray, R. T. Hay, and A. D. Sharrocks. 2003. Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity. Mol. Cell 12:63–74.
  • Yin, F., and B. P. Herring. 2005. GATA-6 can act as a positive or negative regulator of smooth muscle-specific gene expression. J. Biol. Chem. 280:4745–4752.
  • Yoshida, T., K. Kawai-Kowase, and G. K. Owens. 2004. Forced expression of myocardin is not sufficient for induction of smooth muscle differentiation in multipotential embryonic cells. Arterioscler. Thromb. Vasc. Biol. 24:1596–1601.
  • Yoshida, T., S. Sinha, F. Dandre, B. R. Wamhoff, M. H. Hoofnagle, B. E. Kremer, D. Z. Wang, E. N. Olson, and G. K. Owens. 2003. Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes. Circ. Res. 92:856–864.
  • Zhou, J., and B. P. Herring. 2005. Mechanisms responsible for the promoter-specific effects of myocardin. J. Biol. Chem. 280:10861–10869.
  • Zhou, J., A. M. Hoggatt, and B. P. Herring. 2004. Activation of the smooth muscle-specific telokin gene by thyrotroph embryonic factor (TEF). J. Biol. Chem. 279:15929–15937.

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