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Improving treatment of neurodevelopmental disorders: recommendations based on preclinical studies

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  • Papers of special note have been highlighted as either of interest (•) or of considerable interest (••) to readers.
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•• An excellent review of genetic factors underlying NDDs.

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•• A timely and comprehensive review of pharmacotherapeutic strategies to treat autism.

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• An interesting translational study using human ADHD susceptibility candidate gene in a zebrafish model of this disorder.

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•• An important summary of the research domain criteria (RDoCs) concept that targets the cross-disorder nosology (rather than specific symptoms) of psychiatric disorders.

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•• An outstanding, anatomically comprehensive atlas of the mid-gestational human brain, including in situ hybridization, high-resolution magnetic resonance imaging and microarray analyses.

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• An important recent study showing conserved molecular signatures of transcriptional dynamics across brain development, with potential high clinical relevance.

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•• An important study showing the link between common neuropsychiatric disorders and upregulated prenatal gene expression, implicating neurodevelopmental trajectories in brain deficits, including common NDDs, such as ID and ASD.

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• An important study on the emerging “bigger” complexity of neuropsychiatric disorders.

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• A timely discussion on the role of serotonin and serotonin transporter in translational models of brain disorders, including NDDs.

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• An important discussion of developmental, neurotrophic role of serotonin, highly relevant to NDDs.

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•• An important translational “integrative” study linking animal social behaviors/learning to brain neurochemical phenotypes.

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• An interesting study showing potential neuroanatomical white matter-related biomarkers of NDDs.

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