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Original Research

Supercritical carbon dioxide fractionation improves the antioxidative activity, anti-inflammatory activity, and therapeutic index of Panax ginseng

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Pages 9-15 | Published online: 04 May 2017

References

  • Kim HG, Yoo SR, Park HJ, et al. Antioxidant effects of Panax ginseng C.A. Meyer in healthy subjects: a randomized, placebo-controlled clinical trial. Food Chem Toxicol. 2011;49(9):2229–2235.
  • Yang X, Wang R, Zhang S, et al. Polysaccharides from Panax japonicus C.A. Meyer and their antioxidant activities. Carbohydr Polym. 2014;101:386–391.
  • Li J, Ichikawa T, Jin Y, et al. An essential role of Nrf2 in American ginseng-mediated anti-oxidative actions in cardiomyocytes. J Ethnopharmacol. 2010;130(2):222–230.
  • Wu Y, Xia ZY, Dou J, et al. Protective effect of ginsenoside Rb1 against myocardial ischemia/reperfusion injury in streptozotocin-induced diabetic rats. Mol Biol Rep. 2011;38(7):4327–4335.
  • Yuan SM. Potential cardioprotective effects of Ginseng preparations. Pak J Pharm Sci. 2015;28(3):963–968.
  • Park D, Bae DK, Jeon JH, et al. Immunopotentiation and antitumor effects of a ginsenoside Rg(3)-fortified red ginseng preparation in mice bearing H460 lung cancer cells. Environ Toxicol Pharmacol. 2011;31(3):397–405.
  • Jeon WJ, Oh JS, Park MS, Ji GE. Anti-hyperglycemic effect of fermented ginseng in type 2 diabetes mellitus mouse model. Phytother Res. 2013;27(2):166–172.
  • Liu Z, Li W, Li X, et al. Antidiabetic effects of malonyl ginsenosides from Panax ginseng on type 2 diabetic rats induced by high-fat diet and streptozotocin. J Ethnopharmacol. 2013;145(1):233–240.
  • Oh MR, Park SH, Kim SY, et al. Postprandial glucose-lowering effects of fermented red ginseng in subjects with impaired fasting glucose or type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial. BMC Complement Altern Med. 2014;14:237.
  • Qi LW, Wang CZ, Yuan CS. American ginseng: potential structure-function relationship in cancer chemoprevention. Biochem Pharmacol. 2010;80(7):947–954.
  • Nag SA, Qin JJ, Wang W, Wang MH, Wang H, Zhang R. Ginsenosides as anticancer agents: in vitro and in vivo activities, structure-activity relationships, and molecular mechanisms of action. Front Pharmacol. 2012;3:25.
  • Leung KW, Wong AS. Pharmacology of ginsenosides: a literature review. Chin Med. 2010;5:20.
  • Park E, Hwang I, Song JY, Jee Y. Acidic polysaccharide of Panax ginseng as a defense against small intestinal damage by whole-body gamma irradiation of mice. Acta Histochem. 2011;113(1):19–23.
  • Niu T, Smith DL, Yang Z, et al. Bioactivity and bioavailability of ginsenosides are dependent on the glycosidase activities of the A/J mouse intestinal microbiome defined by pyrosequencing. Pharm Res. 2013;30(3):836–846.
  • Ahn JY, Song JY, Yun YS, Jeong G, Choi IS. Protection of Staphylococcus aureus-infected septic mice by suppression of early acute inflammation and enhanced antimicrobial activity by ginsan. FEMS Immunol Med Microbiol. 2006;46(2):187–197.
  • Siddiqi MZ, Siddiqi MH, Kim YJ, Jin Y, Huq MA, Yang DC. Effect of fermented red ginseng extract enriched in ginsenoside Rg3 on the differentiation and mineralization of preosteoblastic MC3T3-E1 cells. J Med Food. 2015;18(5):542–548.
  • Chien YS, Yu ZR, Koo M, Wang BJ. Supercritical fluid extractive fractionation: study of the antioxidant activities of Panax ginseng. Sep Sci Technol. 2016;51(6):954–960.
  • Shimada K, Fujikawa K, Yahara K, Nakamura T. Antioxidative properties of xanthan on the autoxidation of soybean oil in cyclodextrin emulsion. J Agric Food Chem. 1992;40(6):945–948.
  • Yen GC, Hsieh CL. Reactive oxygen species scavenging activity of Du-zhong (Eucommia ulmoides oliv.) and its active compounds. J Agric Food Chem. 2000;48(8):3431–3436.
  • Yen GC, Chung DY. Antioxidant effects of extracts from Cassia tora L. prepared under different degrees of roasting on the oxidative damage to biomolecules. J Agric Food Chem. 1999;47(4):1326–1332.
  • Wang J, Hu S, Nie S, Yu Q, Xie M. Reviews on mechanisms of in vitro antioxidant activity of polysaccharides. Oxid Med Cell Longev. 2016;2016:5692852.
  • Tung NH, Song GY, Nhiem NX, et al. Dammarane-type saponins from the flower buds of Panax ginseng and their intracellular radical scavenging capacity. J Agric Food Chem. 2010;58(2):868–874.
  • Kang KS, Yokozawa T, Yamabe N, Kim HY, Park JH. ESR study on the structure and hydroxyl radical-scavenging activity relationships of ginsenosides isolated from Panax ginseng C A Meyer. Biol Pharm Bull. 2007;30(5):917–921.
  • Sun J, Hu S, Song X. Adjuvant effects of protopanaxadiol and protopanaxatriol saponins from ginseng roots on the immune responses to ovalbumin in mice. Vaccine. 2007;25(6):1114–1120.
  • Wang N, Wan JB, Chan SW, et al. Comparative study on saponin fractions from Panax notoginseng inhibiting inflammation-induced endothelial adhesion molecule expression and monocyte adhesion. Chin Med. 2011;6:37.
  • Helliwell RM, ShioukHuey CO, Dhuna K, et al. Selected ginsenosides of the protopanaxdiol series are novel positive allosteric modulators of P2×7 receptors. Br J Pharmacol. 2015;172(13):3326–3340.
  • Wei X, Chen J, Su F, Su X, Hu T, Hu S. Stereospecificity of ginsenoside Rg3 in promotion of the immune response to ovalbumin in mice. Int Immunol. 2012;24(7):465–471.