542
Views
108
CrossRef citations to date
0
Altmetric
Review

Lung inflammation caused by inhaled toxicants: a review

, &
Pages 1391-1401 | Published online: 23 Jun 2016

References

  • TashkinDPMurrayRPSmoking cessation in chronic obstructive pulmonary diseaseRespir Med2009103796397419285850
  • ParikhRShahTGTandonRCOPD exacerbation care bundle improves standard of care, length of stay, and readmission ratesInt J Chron Obstruct Pulmon Dis20161157758327042046
  • BrusselleGBrackeKTargeting immune pathways for therapy in asthma and chronic obstructive pulmonary diseaseAnn Am Thorac Soc201411Suppl 5S322S32825525740
  • LaumbachRJKipenHMRespiratory health effects of air pollution: update on biomass smoke and traffic pollutionJ Allergy Clin Immunol20121291311 quiz 12–1322196520
  • AdlerKBLiYAirway epithelium and mucus: intracellular signaling pathways for gene expression and secretionAm J Respir Cell Mol Biol200125439740011694442
  • McCrayPBJrBentleyLHuman airway epithelia express a beta-defensinAm J Respir Cell Mol Biol19971633433499070620
  • KotaSSabbahAChangTHRole of human beta-defensin-2 during tumor necrosis factor-alpha/NF-kappaB-mediated innate antiviral response against human respiratory syncytial virusJ Biol Chem200828333224172242918567888
  • AarbiouJRabeKFHiemstraPSRole of defensins in inflammatory lung diseaseAnn Med20023429610112108580
  • HellermannGRNagySBKongXLockeyRFMohapatraSSMechanism of cigarette smoke condensate-induced acute inflammatory response in human bronchial epithelial cellsRespir Res200232212204101
  • TakizawaHTanakaMTakamiKIncreased expression of inflammatory mediators in small-airway epithelium from tobacco smokersAm J Physiol Lung Cell Mol Physiol20002785L906L91310781420
  • MillsPRDaviesRJDevaliaJLAirway epithelial cells, cytokines, and pollutantsAm J Respir Crit Care Med19991605 Pt 2S38S4310556168
  • HerfsMHubertPPoirrierALProinflammatory cytokines induce bronchial hyperplasia and squamous metaplasia in smokers: implications for chronic obstructive pulmonary disease therapyAm J Respir Cell Mol Biol2012471677922343222
  • TakizawaHTanakaMTakamiKIncreased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD)Am J Respir Crit Care Med200116361476148311371421
  • MeijerMRijkersGTvan OverveldFJNeutrophils and emerging targets for treatment in chronic obstructive pulmonary diseaseExpert Rev Clin Immunol20139111055106824168412
  • HoenderdosKCondliffeAThe neutrophil in chronic obstructive pulmonary diseaseAm J Respir Cell Mol Biol201348553153923328639
  • BarnesPJAlveolar macrophages as orchestrators of COPDCOPD200411597016997739
  • ShapiroSDThe macrophage in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med19991605 Pt 2S29S3210556166
  • PappasKPapaioannouAIKostikasKTzanakisNThe role of macrophages in obstructive airways disease: chronic obstructive pulmonary disease and asthmaCytokine201364361362524084332
  • BarnesPJMediators of chronic obstructive pulmonary diseasePharmacol Rev200456451554815602009
  • O’DonnellRBreenDWilsonSDjukanovicRInflammatory cells in the airways in COPDThorax200661544845416648353
  • KalathilSGLugadeAAPradhanVT-regulatory cells and programmed death 1+ T cells contribute to effector T-cell dysfunction in patients with chronic obstructive pulmonary diseaseAm J Respir Crit Care Med20141901405024825462
  • MillsKHDunneAImmune modulation: IL-1, master mediator or initiator of inflammationNat Med200915121363136419966773
  • SedgerLMMcDermottMFTNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants – past, present and futureCytokine Growth Factor Rev201425445347225169849
  • StrizIBrabcovaEKolesarLSekerkovaACytokine networking of innate immunity cells: a potential target of therapyClin Sci (Lond)2014126959361224450743
  • HoriuchiKKimuraTMiyamotoTCutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shockJ Immunol200717952686268917709479
  • DarnayBGAggarwalBBEarly events in TNF signaling: a story of associations and dissociationsJ Leukoc Biol19976155595669129204
  • LiuZGMolecular mechanism of TNF signaling and beyondCell Res2005151242715686622
  • ChangLKarinMMammalian MAP kinase signalling cascadesNature20014106824374011242034
  • IchijoHFrom receptors to stress-activated MAP kinasesOncogene199918456087609310557099
  • GarringtonTPJohnsonGLOrganization and regulation of mitogen-activated protein kinase signaling pathwaysCurr Opin Cell Biol199911221121810209154
  • CargnelloMRouxPPActivation and function of the MAPKs and their substrates, the MAPK-activated protein kinasesMicrobiol Mol Biol Rev2011751508321372320
  • LatzEXiaoTSStutzAActivation and regulation of the inflammasomesNat Rev Immunol201313639741123702978
  • MartinonFTschoppJInflammatory caspases and inflammasomes: master switches of inflammationCell Death Differ2007141102216977329
  • StrowigTHenao-MejiaJElinavEFlavellRInflammasomes in health and diseaseNature2012481738127828622258606
  • JinCFlavellRAMolecular mechanism of NLRP3 inflammasome activationJ Clin Immunol201030562863120589420
  • LeemansJCCasselSLSutterwalaFSSensing damage by the NLRP3 inflammasomeImmunol Rev2011243115216221884174
  • MuroiMTanamotoKTRAF6 distinctively mediates MyD88- and IRAK-1-induced activation of NF-kappaBJ Leukoc Biol200883370270718070982
  • O’NeillLASignal transduction pathways activated by the IL-1 receptor/toll-like receptor superfamilyCurr Top Microbiol Immunol2002270476112467243
  • BowieAO’NeillLAThe interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial productsJ Leukoc Biol200067450851410770283
  • BauernfeindFBartokERiegerAFranchiLNunezGHornungVCutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasomeJ Immunol2011187261361721677136
  • VyletaMLWongJMagunBESuppression of ribosomal function triggers innate immune signaling through activation of the NLRP3 inflammasomePLoS One201275e3604422606244
  • PetrovskiGAynaGMajaiGPhagocytosis of cells dying through autophagy induces inflammasome activation and IL-1beta release in human macrophagesAutophagy20117332133021217200
  • QuYFranchiLNunezGDubyakGRNonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophagesJ Immunol200717931913192517641058
  • SolleMLabasiJPerregauxDGAltered cytokine production in mice lacking P2X(7) receptorsJ Biol Chem2001276112513211016935
  • AtherJLMartinRACklessKPoynterMEInflammasome activity in non-microbial lung inflammationJ Environ Immunol Toxicol20141310811725642415
  • De NardoDDe NardoCMLatzENew insights into mechanisms controlling the NLRP3 inflammasome and its role in lung diseaseAm J Pathol20141841425424183846
  • TamASinDDPathobiologic mechanisms of chronic obstructive pulmonary diseaseMed Clin North Am201296468169822793938
  • TrupinLEarnestGSan PedroMThe occupational burden of chronic obstructive pulmonary diseaseEur Respir J200322346246914516136
  • ShaheenSOBarkerDJHolgateSTDo lower respiratory tract infections in early childhood cause chronic obstructive pulmonary disease?Am J Respir Crit Care Med1995151516491651 discussion 1651–16527735628
  • LomasDASilvermanEKThe genetics of chronic obstructive pulmonary diseaseRespir Res200121202611686861
  • MayerASNewmanLSGenetic and environmental modulation of chronic obstructive pulmonary diseaseRespir Physiol2001128131111535256
  • FischerBMVoynowJAGhioAJCOPD: balancing oxidants and antioxidantsInt J Chron Obstruct Pulmon Dis20151026127625673984
  • SparrowDO’ConnorGWeissSTThe relation of airways responsiveness and atopy to the development of chronic obstructive lung diseaseEpidemiol Rev19881029473066629
  • UlrikCSBackerVNonreversible airflow obstruction in life-long nonsmokers with moderate to severe asthmaEur Respir J199914489289610573238
  • PaulyJLSmithLARickertMHHutsonAPaszkiewiczGMReview: Is lung inflammation associated with microbes and microbial toxins in cigarette tobacco smoke?Immunol Res2010461–312713619763893
  • PaulyJLPaszkiewiczGCigarette smoke, bacteria, mold, microbial toxins, and chronic lung inflammationJ Oncol2011201181912921772847
  • Centers for Disease Control and Prevention (US), National Center for Chronic Disease Prevention and Health Promotion (US), Office on Smoking and Health (US)How tobacco smoke causes disease. 3, chemistry and toxicology of cigarette smoke and biomarkers of exposure and harmSidranskyDNormanLAMcCarthyATaylorPLThe Biology and Behavioral Basis for Smoking-Attributable Disease: A Report of the Surgeon GeneralAtlanta, GACenters for Disease Control and Prevention (US)2010 Available from: http://www.ncbi.nlm.nih.gov/books/NBK53014/Accessed June 10, 2016
  • FowlesJDybingEApplication of toxicological risk assessment principles to the chemical constituents of cigarette smokeTob Control200312442443014660781
  • MortazEHenricksPAKraneveldADGiviMEGarssenJFolkertsGCigarette smoke induces the release of CXCL-8 from human bronchial epithelial cells via TLRs and induction of the inflammasomeBiochim Biophys Acta2011181291104111021684332
  • MortazEAdcockIMItoKKraneveldADNijkampFPFolkertsGCigarette smoke induces CXCL8 production by human neutrophils via activation of TLR9 receptorEur Respir J20103651143115419840968
  • SmithLAPaszkiewiczGMHutsonADPaulyJLInflammatory response of lung macrophages and epithelial cells to tobacco smoke: a literature review of ex vivo investigationsImmunol Res2010461–39412620094822
  • HoltPGKeastDThe effect of tobacco smoke on protein synthesis in macrophagesProc Soc Exp Biol Med19731424124312474735152
  • LeffingwellCMLowRBCigarette smoke components and alveolar macrophage protein synthesisArch Environ Health197934297102434939
  • YeagerHJrAlveolar cells: depression effect of cigarette smoke on protein synthesisProc Soc Exp Biol Med196913112472505770113
  • Vargas-RojasMIRamirez-VenegasALimon-CamachoLOchoaLHernandez-ZentenoRSansoresRHIncrease of Th17 cells in peripheral blood of patients with chronic obstructive pulmonary diseaseRespir Med2011105111648165421763119
  • GreeneCMLowTBO’NeillSJMcElvaneyNGAnti-proline-glycine-proline or antielastin autoantibodies are not evident in chronic inflammatory lung diseaseAm J Respir Crit Care Med20101811313519762563
  • RinaldiMLehouckAHeulensNAntielastin B-cell and T-cell immunity in patients with chronic obstructive pulmonary diseaseThorax201267869470022442201
  • MarumoSHoshinoYKiyokawaHP38 mitogen-activated protein kinase determines the susceptibility to cigarette smoke-induced emphysema in miceBMC Pulm Med2014147924885161
  • van der VaartHPostmaDSTimensWten HackenNHAcute effects of cigarette smoke on inflammation and oxidative stress: a reviewThorax200459871372115282395
  • MukaroVRHodgeSAirway clearance of apoptotic cells in COPDCurr Drug Targets201112446046820450476
  • DozENoulinNBoichotECigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependentJ Immunol200818021169117818178857
  • EltomSBelvisiMGStevensonCSRole of the inflammasome-caspase1/11-IL-1/18 axis in cigarette smoke driven airway inflammation: An insight into the pathogenesis of COPDPLoS One2014911e11282925405768
  • EltomSStevensonCSRastrickJP2X7 receptor and caspase 1 activation are central to airway inflammation observed after exposure to tobacco smokePLoS One201169e2409721915284
  • SubramanianNNatarajanKClatworthyMRWangZGermainRNThe adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activationCell2013153234836123582325
  • KangMJYoonCMKimBHSuppression of NLRX1 in chronic obstructive pulmonary diseaseJ Clin Invest201512562458246225938787
  • KarimiRTornlingGGrunewaldJEklundASkoldCMCell recovery in bronchoalveolar lavage fluid in smokers is dependent on cumulative smoking historyPLoS One201273e3423222479573
  • BarnesPJThe cytokine network in chronic obstructive pulmonary diseaseAm J Respir Cell Mol Biol200941663163819717810
  • Di StefanoACaramoriGBarczykAInnate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPDThorax201469651652424430176
  • ShangJZhaoJWuXXuYXieJZhaoJInterleukin-33 promotes inflammatory cytokine production in chronic airway inflammationBiochem Cell Biol201593435936626158865
  • XiaJZhaoJShangJIncreased IL-33 expression in chronic obstructive pulmonary diseaseAm J Physiol Lung Cell Mol Physiol20153087L619L62725595648
  • LefrancaisERogaSGautierVIL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin GProc Natl Acad Sci U S A201210951673167822307629
  • BaeSKangTHongJContradictory functions (activation/termination) of neutrophil proteinase 3 enzyme (PR3) in interleukin-33 biological activityJ Biol Chem2012287118205821322270365
  • LuthiAUCullenSPMcNeelaEASuppression of interleukin-33 bioactivity through proteolysis by apoptotic caspasesImmunity2009311849819559631
  • ShielsMSKatkiHAFreedmanNDCigarette smoking and variations in systemic immune and inflammation markersJ Natl Cancer Inst201410611dju 294 Print 2014
  • CosioMGSaettaMAgustiAImmunologic aspects of chronic obstructive pulmonary diseaseN Engl J Med2009360232445245419494220
  • Taraseviciene-StewartLDouglasISNana-SinkamPSIs alveolar destruction and emphysema in chronic obstructive pulmonary disease an immune disease?Proc Am Thorac Soc20063868769017065374
  • BarnesPJRole of HDAC2 in the pathophysiology of COPDAnnu Rev Physiol20097145146418817512
  • von NussbaumFLiVMNeutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophoresBioorg Med Chem Lett201525204370438126358162
  • LiangGBowenJPDevelopment of trypsin-like serine protease inhibitors as therapeutic agents: Opportunities, challenges, and their unique structure-based rationalesCurr Top Med Chem201616131506152926369819
  • EduardWFungal spores: a critical review of the toxicological and epidemiological evidence as a basis for occupational exposure limit settingCrit Rev Toxicol2009391079986419863384
  • BennettJWKlichMMycotoxinsClin Microbiol Rev200316349751612857779
  • RochaOAnsariKDoohanFMEffects of trichothecene mycotoxins on eukaryotic cells: a reviewFood Addit Contam200522436937816019807
  • PatersonRRFungi and fungal toxins as weaponsMycol Res2006110Pt 91003101016908123
  • BerekLPetriIBMesterhazyATerenJMolnarJEffects of mycotoxins on human immune functions in vitroToxicol In Vitro2001151253011259866
  • KankkunenPRintahakaJAaltoATrichothecene mycotoxins activate inflammatory response in human macrophagesJ Immunol2009182106418642519414795
  • KankkunenPValimakiERintahakaJTrichothecene mycotoxins activate NLRP3 inflammasome through a P2X7 receptor and Src tyrosine kinase dependent pathwayHum Immunol201475213414024269698
  • KonigsMLenczykMSchwerdtGHolzingerHGekleMHumpfHUCytotoxicity, metabolism and cellular uptake of the mycotoxin deoxynivalenol in human proximal tubule cells and lung fibroblasts in primary cultureToxicology20072401–2485917825972
  • IslamZGrayJSPestkaJJp38 Mitogen-activated protein kinase mediates IL-8 induction by the ribotoxin deoxynivalenol in human monocytesToxicol Appl Pharmacol2006213323524416364386
  • Ciacci-ZanellaJRJonesCFumonisin B1, a mycotoxin contaminant of cereal grains, and inducer of apoptosis via the tumour necrosis factor pathway and caspase activationFood Chem Toxicol199937770371210496371
  • DongWAzcona-OliveraJIBrooksKHLinzJEPestkaJJElevated gene expression and production of interleukins 2, 4, 5, and 6 during exposure to vomitoxin (deoxynivalenol) and cycloheximide in the EL-4 thymomaToxicol Appl Pharmacol199412722822908048072
  • MekyFAHardieLJEvansSWWildCPDeoxynivalenol-induced immunomodulation of human lymphocyte proliferation and cytokine productionFood Chem Toxicol200139882783611434990
  • OuyangYLAzcona-OliveraJIPestkaJJEffects of trichothecene structure on cytokine secretion and gene expression in murine CD4+ T-cellsToxicology19951041–31872028560498
  • WangHYadavJSGlobal gene expression changes underlying Stachybotrys chartarum toxin-induced apoptosis in murine alveolar macrophages: evidence of multiple signal transduction pathwaysApoptosis200712353554817186382
  • SchmeitsPCKatikaMRPeijnenburgAAvan LoverenHHendriksenPJDON shares a similar mode of action as the ribotoxic stress inducer anisomycin while TBTO shares ER stress patterns with the ER stress inducer thapsigargin based on comparative gene expression profiling in Jurkat T cellsToxicol Lett2014224339540624247028
  • AmuzieCJHarkemaJRPestkaJJTissue distribution and proinflammatory cytokine induction by the trichothecene deoxynivalenol in the mouse: comparison of nasal vs oral exposureToxicology20082481394418433975
  • HiranoSKataokaTDeoxynivalenol induces ectodomain shedding of TNF receptor 1 and thereby inhibits the TNF-alpha-induced NF-kappaB signaling pathwayEur J Pharmacol20137011–314415123357557
  • CapassoLLonghinECaloniFCamatiniMGualtieriMSynergistic inflammatory effect of PM10 with mycotoxin deoxynivalenol on human lung epithelial cellsToxicon2015104657226263889
  • ZhouHRHarkemaJRYanDPestkaJJAmplified proinflammatory cytokine expression and toxicity in mice coexposed to lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol)J Toxicol Environ Health A199957211513610344227
  • LichtensteinJHMolinaRMDonagheyTCPulmonary responses to Stachybotrys chartarum and its toxins: mouse strain affects clearance and macrophage cytotoxicityToxicol Sci2010116111312120385656
  • PangVFLambertRJFelsburgPJBeasleyVRBuckWBHaschekWMExperimental T-2 toxicosis in swine following inhalation exposure: effects on pulmonary and systemic immunity, and morphologic changesToxicol Pathol19871533083193685791
  • CreasiaDAThurmanJDWannemacherRWJrBunnerDLAcute inhalation toxicity of T-2 mycotoxin in the rat and guinea pigFundam Appl Toxicol199014154592307322
  • LiuCShenHYiLOral administration of aflatoxin G(1) induces chronic alveolar inflammation associated with lung tumorigenesisToxicol Lett2015232354755625445582
  • Guindon-KezisKAMulderJEMasseyTEIn vivo treatment with aflatoxin B1 increases DNA oxidation, base excision repair activity and 8-oxoguanine DNA glycosylase 1 levels in mouse lungToxicology2014321212624675474
  • CaloniFCortinovisCToxicological effects of aflatoxins in horsesVet J2011188327027320619706
  • ParikhSALitzowMRPhiladelphia chromosome-negative acute lymphoblastic leukemia: therapies under developmentFuture Oncol201410142201221225471034
  • BartaSKZouYSchindlerJSynergy of sequential administration of a deglycosylated ricin A chain-containing combined anti-CD19 and anti-CD22 immunotoxin (Combotox) and cytarabine in a murine model of advanced acute lymphoblastic leukemiaLeuk Lymphoma201253101999200322448921
  • AudiJBelsonMPatelMSchierJOsterlohJRicin poisoning: a comprehensive reviewJAMA2005294182342235116278363
  • BradberrySMDickersKJRicePGriffithsGDValeJARicin poisoningToxicol Rev2003221657014579548
  • BrownRFWhiteDEUltrastructure of rat lung following inhalation of ricin aerosolInt J Exp Pathol19977842672769505938
  • RoyCJHaleMHartingsJMPittLDunihoSImpact of inhalation exposure modality and particle size on the respiratory deposition of ricin in BALB/c miceInhal Toxicol200315661963812692733
  • WongJKorchevaVJacobyDBMagunBEProinflammatory responses of human airway cells to ricin involve stress-activated protein kinases and NF-kappaBAm J Physiol Lung Cell Mol Physiol20072936L1385L139417873006
  • CookDLDavidJGriffithsGDRetrospective identification of ricin in animal tissues following administration by pulmonary and oral routesToxicology20062231–2617016650517
  • DoeblerJAWiltshireNDMayerTWThe distribution of [125I]ricin in mice following aerosol inhalation exposureToxicology1995981–31371497740542
  • RamsdenCSDraysonMTBellEBThe toxicity, distribution and excretion of ricin holotoxin in ratsToxicology1989551–21611712711402
  • WongJKorchevaVJacobyDBMagunBIntrapulmonary delivery of ricin at high dosage triggers a systemic inflammatory response and glomerular damageAm J Pathol200717051497151017456757
  • GriffithsGDLeekMDGeeDJThe toxic plant proteins ricin and abrin induce apoptotic changes in mammalian lymphoid tissues and intestineJ Pathol198715132212293572616
  • KorchevaVWongJLindauerMJacobyDBIordanovMSMagunBRole of apoptotic signaling pathways in regulation of inflammatory responses to ricin in primary murine macrophagesMol Immunol200744102761277117257680
  • WangXMaderMMTothJEComplete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNAJ Biol Chem200528019192981930515737997
  • JandhyalaDMAhluwaliaAObrigTThorpeCMZAK: a MAP3Kinase that transduces Shiga toxin- and ricin-induced proinflammatory cytokine expressionCell Microbiol20081071468147718331592
  • DavidJWilkinsonLJGriffithsGDInflammatory gene expression in response to sub-lethal ricin exposure in Balb/c miceToxicology20092641–211913019682533
  • DaSilvaLCoteDRoyCPulmonary gene expression profiling of inhaled ricinToxicon200341781382212782081
  • LindauerMLWongJIwakuraYMagunBEPulmonary inflammation triggered by ricin toxin requires macrophages and IL-1 signalingJ Immunol200918321419142619561099
  • LindauerMWongJMagunBRicin toxin activates the NALP3 inflammasomeToxins (Basel)2010261500151420862209
  • LiangJZhaoHYaoLPhosphatidylinositol 3-kinases pathway mediates lung caspase-1 activation and high mobility group box 1 production in a toluene-diisocyanate induced murine asthma modelToxicol Lett20152361253325929181
  • CarterABTephlyLAVenkataramanSHigh levels of catalase and glutathione peroxidase activity dampen H2O2 signaling in human alveolar macrophagesAm J Respir Cell Mol Biol2004311435314962975
  • GeistLJPowersLSMonickMMHunninghakeGWAsbestos stimulation triggers differential cytokine release from human monocytes and alveolar macrophagesExp Lung Res2000261415610660835
  • LiPLiuTKampDWThe c-Jun N-terminal kinase signaling pathway mediates chrysotile asbestos-induced alveolar epithelial cell apoptosisMol Med Rep20151153626363425530474
  • LiXHuYJinZJiangHWenJSilica-induced TNF-alpha and TGF-beta1 expression in RAW264.7 cells are dependent on Src-ERK/AP-1 pathwaysToxicol Mech Methods2009191515819778233
  • JiangYZhangHWangYModulation of apoptotic pathways of macrophages by surface-functionalized multi-walled carbon nanotubesPLoS One201386e6575623755279
  • DostertCPetrilliVVan BruggenRSteeleCMossmanBTTschoppJInnate immune activation through Nalp3 inflammasome sensing of asbestos and silicaScience2008320587667467718403674
  • CasselSLEisenbarthSCIyerSSThe Nalp3 inflammasome is essential for the development of silicosisProc Natl Acad Sci U S A2008105269035904018577586
  • Luna-GomesTSantanaPTCoutinho-SilvaRSilica-induced inflammasome activation in macrophages: role of ATP and P2X7 receptorImmunobiology201522091101110626024943
  • CaicedoMSDesaiRMcAllisterKReddyAJacobsJJHallabNJSoluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: a novel mechanism for implant debris reactivityJ Orthop Res200927784785419105226
  • MeunierECosteAOlagnierDDouble-walled carbon nanotubes trigger IL-1beta release in human monocytes through Nlrp3 inflammasome activationNanomedicine20128698799522100755
  • LiMGunterMEFukagawaNKDifferential activation of the inflammasome in THP-1 cells exposed to chrysotile asbestos and Libby “six-mix” amphiboles and subsequent activation of BEAS-2B cellsCytokine201260371873023017228
  • SweeneySBerhanuDMisraSKThorleyAJValsami-JonesETetleyTDMulti-walled carbon nanotube length as a critical determinant of bioreactivity with primary human pulmonary alveolar cellsCarbon N Y201478263725780270
  • De BackerLNaessensTDe KokerSHybrid pulmonary surfactant-coated nanogels mediate efficient in vivo delivery of siRNA to murine alveolar macrophagesJ Control Release2015217536326307350
  • TangJLobattoMEHassingLInhibiting macrophage proliferation suppresses atherosclerotic plaque inflammationSci Adv201513e140022326295063
  • PaunovicVHarnettMMMitogen-activated protein kinases as therapeutic targets for rheumatoid arthritisDrugs201373210111523371304
  • ArthurJSLeySCMitogen-activated protein kinases in innate immunityNat Rev Immunol201313967969223954936
  • GilmoreTDHerscovitchMInhibitors of NF-kappaB signaling: 785 and countingOncogene200625516887689917072334
  • MadonnaRDe CaterinaRRelevance of new drug discovery to reduce NF-kappaB activation in cardiovascular diseaseVascul Pharmacol2012571414722366375
  • CraigEAStevensMVVaillancourtRRCamenischTDMAP3Ks as central regulators of cell fate during developmentDev Dyn2008237113102311418855897
  • DavisMIHuntJPHerrgardSComprehensive analysis of kinase inhibitor selectivityNat Biotechnol201129111046105122037378
  • KaramanMWHerrgardSTreiberDKA quantitative analysis of kinase inhibitor selectivityNat Biotechnol200826112713218183025
  • ManleyPWDrueckesPFendrichGExtended kinase profile and properties of the protein kinase inhibitor nilotinibBiochim Biophys Acta20101804344545319922818
  • VinHChingGOjedaSSSorafenib suppresses JNK-dependent apoptosis through inhibition of ZAKMol Cancer Ther201413122122924170769
  • RixURemsing RixLLTerkerASA comprehensive target selectivity survey of the BCR-ABL kinase inhibitor INNO-406 by kinase profiling and chemical proteomics in chronic myeloid leukemia cellsLeukemia2010241445019890374
  • PeraTAtmajCvan der VegtMHalaykoAJZaagsmaJMeursHRole for TAK1 in cigarette smoke-induced proinflammatory signaling and IL-8 release by human airway smooth muscle cellsAm J Physiol Lung Cell Mol Physiol20123033L272L27822523282
  • BaudeletDLipkaEMilletRGhinetAInvolvement of the P2X7 purinergic receptor in inflammation: an update of antagonists series since 2009 and their promising therapeutic potentialCurr Med Chem201522671372925515510
  • ChurgAZhouSWangXWangRWrightJLThe role of interleukin-1beta in murine cigarette smoke-induced emphysema and small airway remodelingAm J Respir Cell Mol Biol200940448249018931327
  • RennardSIFogartyCKelsenSThe safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2007175992693417290043
  • JulianaCFernandes-AlnemriTWuJAnti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasomeJ Biol Chem2010285139792980220093358
  • LamkanfiMMuellerJLVitariACGlyburide inhibits the Cryopyrin/Nalp3 inflammasomeJ Cell Biol20091871617019805629
  • MarchettiCChojnackiJToldoSA novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouseJ Cardiovasc Pharmacol201463431632224336017
  • HondaHNagaiYMatsunagaTIsoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammationJ Leukoc Biol20149661087110025210146
  • BarbieriSSZacchiEAmadioPCytokines present in smokers’ serum interact with smoke components to enhance endothelial dysfunctionCardiovasc Res201190347548321285293
  • CozenWDiaz-SanchezDJames GaudermanWTh1 and Th2 cytokines and IgE levels in identical twins with varying levels of cigarette consumptionJ Clin Immunol200424661762215622446
  • FlemmingJHudsonBRandTGComparison of inflammatory and cytotoxic lung responses in mice after intratracheal exposure to spores of two different Stachybotrys chartarum strainsToxicol Sci200478226727514718650
  • MaestrelliPdi StefanoAOccariPCytokines in the airway mucosa of subjects with asthma induced by toluene diisocyanateAm J Respir Crit Care Med19951513 Pt 16076127533600
  • JohnsonVJYucesoyBLusterMIPrevention of IL-1 signaling attenuates airway hyper responsiveness and inflammation in a murine model of toluene diisocyanate-induced asthmaJ Allergy Clin Immunol2005116485185816210060
  • ZhangYLeeTCGuilleminBYuMCRomWNEnhanced IL-1 beta and tumor necrosis factor-alpha release and messenger RNA expression in macrophages from idiopathic pulmonary fibrosis or after asbestos exposureJ Immunol19931509418841968473757
  • KodavantiUPAndrewsDSchladweilerMCGavettSHDoddDECyphertJMEarly and delayed effects of naturally occurring asbestos on serum biomarkers of inflammation and metabolismJ Toxicol Environ Health A201477171024103925072823
  • PorterDWYeJMaJTime course of pulmonary response of rats to inhalation of crystalline silica: NF-kappa B activation, inflammation, cytokine production, and damageInhal Toxicol200214434936712028809
  • HubbardAKTimblinCRShuklaARinconMMossmanBTActivation of NF-kappaB-dependent gene expression by silica in lungs of luciferase reporter miceAm J Physiol Lung Cell Mol Physiol20022825L968L97511943661
  • JohnstonCJDriscollKEFinkelsteinJNPulmonary chemokine and mutagenic responses in rats after subchronic inhalation of amorphous and crystalline silicaToxicol Sci200056240541310911000
  • RydmanEMIlvesMKoivistoAJInhalation of rod-like carbon nanotubes causes unconventional allergic airway inflammationPart Fibre Toxicol2014114825318534
  • KidoTTsunodaMKasaiTThe increases in relative mRNA expressions of inflammatory cytokines and chemokines in splenic macrophages from rats exposed to multi-walled carbon nanotubes by whole-body inhalation for 13 weeksInhal Toxicol2014261275075825265050
  • KobayashiNNayaMMizunoKYamamotoKEmaMNakanishiJPulmonary and systemic responses of highly pure and well-dispersed single-wall carbon nanotubes after intratracheal instillation in ratsInhal Toxicol2011231381482822004357
  • HanSGAndrewsRGairolaCGAcute pulmonary response of mice to multi-wall carbon nanotubesInhal Toxicol201022434034720064106